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公开(公告)号：US11254917B2
公开(公告)日：2022-02-22
申请号：US16104533
申请日：2018-08-17
Applicant: TOPPAN PRINTING CO., LTD. , OSAKA UNIVERSITY
Inventor： Kei Tsukamoto , Shinji Irie , Michiya Matsusaki
Abstract: A method of promoting spheroid formation, including: a preparation step of preparing a mixture obtained by mixing a cell sample with a promoter; and a culture step of culturing, inside a spheroid formation-culture vessel, the mixture obtained in the preparation step, in which the promoter is a polymer in which one or more selected from the group consisting of D-glucosamine, D-galactosamine, D-glucuronic acid, L-iduronic acid, and D-galactose are polymerized.
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公开(公告)号：US11179495B2
公开(公告)日：2021-11-23
申请号：US16480114
申请日：2018-01-31
Applicant: TOPPAN PRINTING CO., LTD. , OSAKA UNIVERSITY
Inventor： Michiya Matsusaki , Shinji Irie , Shiro Kitano
Abstract: Disclosed is a three-dimensional tissue comprising cells and collagen including endogenous collagen, wherein at least a portion of the cells is adhered to the collagen, and the content of the collagen is from 10 wt % to 90 wt % based on the three-dimensional tissue.
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公开(公告)号：US20180355308A1
公开(公告)日：2018-12-13
申请号：US16105625
申请日：2018-08-20
Applicant: Osaka University , Toppan Printing Co., Ltd.
Inventor： Michiya Matsusaki , Shinji Irie , Shiro Kitano
CPC classification number: C12N5/0062 , C12N5/0656 , C12N5/0693 , C12N2501/91 , C12N2501/998 , C12N2513/00
Abstract: A method of producing a three-dimensional cell tissue, including: a step A of mixing cells with a cationic substance and an extracellular matrix component to obtain a mixture; a step B of gathering the cells from the obtained mixture to form a cell aggregate on a substrate; and a step C of culturing the cells to obtain a three-dimensional cell tissue.
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Patent Agency Ranking
4.发明申请公开(公告)号：US20190049431A1
公开(公告)日：2019-02-14
申请号：US16164914
申请日：2018-10-19
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Shiro KITANO , Kei Tsukamoto , Shinji Irie
IPC: G01N33/50
Abstract: A method of producing drug resistant cells including contacting exosomes from a living organism exhibiting drug resistance with cells exhibiting no drug resistance such that drug resistant cells are formed, and culturing the drug resistant cells.
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公开(公告)号：US20190048387A1
公开(公告)日：2019-02-14
申请号：US16165074
申请日：2018-10-19
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Shiro Kitano , Kei Tsukamoto , Shinji Irie
IPC: C12Q1/02
Abstract: A method of assessing a possibility of cancerization including culturing a cell structure including normal cells and having a vascular network structure in a presence of a biological specimen from a subject, and assessing a possibility of cancerization in the subject based on a state of vessels in the cell structure after the culturing. The biological specimen is a body fluid specimen from the subject, a cell extract of cells from the subject, or a culture supernatant of cells from the subject, and the possibility of cancerization is assessed as high in the subject when a number of cells forming the vessels in the cell structure is larger than a number of cells cultured in an absence of the body fluid specimen, or when the vascular network structure in the cell structure extends.
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公开(公告)号：US11492652B2
公开(公告)日：2022-11-08
申请号：US16165074
申请日：2018-10-19
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Shiro Kitano , Kei Tsukamoto , Shinji Irie
IPC: C12Q1/02
Abstract: A method of assessing a possibility of cancerization including culturing a cell structure including normal cells and having a vascular network structure in a presence of a biological specimen from a subject, and assessing a possibility of cancerization in the subject based on a state of vessels in the cell structure after the culturing. The biological specimen is a body fluid specimen from the subject, a cell extract of cells from the subject, or a culture supernatant of cells from the subject, and the possibility of cancerization is assessed as high in the subject when a number of cells forming the vessels in the cell structure is larger than a number of cells cultured in an absence of the body fluid specimen, or when the vascular network structure in the cell structure extends.
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公开(公告)号：US11249070B2
公开(公告)日：2022-02-15
申请号：US16164989
申请日：2018-10-19
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Shiro Kitano , Kei Tsukamoto , Shinji Irie
Abstract: A method of assessing an anti-cancer drug including culturing a cell structure including cancer cells and stromal cells in a presence of at least one anti-cancer drug, and assessing an anti-cancer effect of the at least one anti-cancer drug based on a number of viable cancer cells in the cell structure after the culturing.
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公开(公告)号：US11221326B2
公开(公告)日：2022-01-11
申请号：US16164914
申请日：2018-10-19
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Shiro Kitano , Kei Tsukamoto , Shinji Irie
Abstract: A method of producing drug resistant cells including contacting exosomes from a living organism exhibiting drug resistance with cells exhibiting no drug resistance such that drug resistant cells are formed, and culturing the drug resistant cells.
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