公开(公告)号：US07361737B2

公开(公告)日：2008-04-22

申请号：US11437734

申请日：2006-05-22

申请人： Tadamitsu Kishimoto ,  Takashi Nagasawa ,  Kazunobu Tachibana ,  Hisashi Iizasa ,  Nobuaki Yoshida ,  Toshihiro Nakajima ,  Osamu Yoshie

发明人： Tadamitsu Kishimoto ,  Takashi Nagasawa ,  Kazunobu Tachibana ,  Hisashi Iizasa ,  Nobuaki Yoshida ,  Toshihiro Nakajima ,  Osamu Yoshie

IPC分类号： C07K14/00 ,  C07K14/47 ,  C07K14/705 ,  C07H21/00 ,  C07H21/04

CPC分类号： C07K14/7158 ,  A61K38/00

摘要： The present invention pertains to a DNA encoding a polypeptide including an entire sequence of the amino acid sequence as shown by SEQ ID NO: 2 or a partial sequence thereof, or a polypeptide including the polypeptide described above, wherein any of the polypeptides has an activity of a receptor capable of binding to a murine PBSF/SDF-1; a polypeptide encoded by the DNA described above, wherein the polypeptide has an activity of a receptor capable of binding to a murine PBSF/SDF-1; cells expressing the polypeptide described above and a human CD4 protein; and a method of screening an AIDS onset inhibitor or an HIV-1 infection inhibitor, characterized by the use of the cells described above. According to the present invention, there can be provided a novel murine CXC chemokine receptor gene, a method of screening an HIV-1 infection inhibitor, and the like, each of which is useful in studies of a therapeutic agent for AIDS and the functional mechanism of HIV-1 infection.

摘要翻译： 本发明涉及编码包含如SEQ ID NO：2或其部分序列所示的氨基酸序列的整个序列或包含上述多肽的多肽的多肽的DNA，其中任何多肽具有活性 的能够结合小鼠PBSF / SDF-1的受体; 由上述DNA编码的多肽，其中所述多肽具有能够结合小鼠PBSF / SDF-1的受体的活性; 表达上述多肽的细胞和人CD4蛋白; 以及筛选艾滋病起病抑制剂或HIV-1感染抑制剂的方法，其特征在于使用上述细胞。 根据本发明，可以提供新的鼠CXC趋化因子受体基因，筛选HIV-1感染抑制剂的方法等，其可用于AIDS治疗剂的研究和功能机制 的HIV-1感染。

公开(公告)号：US20060211037A1

公开(公告)日：2006-09-21

申请号：US11437734

申请日：2006-05-22

申请人： Tadamitsu Kishimoto ,  Takashi Nagasawa ,  Kazunobu Tachibana ,  Hisashi Iizasa ,  Nobuaki Yoshida ,  Toshihiro Nakajima ,  Osamu Yoshie

发明人： Tadamitsu Kishimoto ,  Takashi Nagasawa ,  Kazunobu Tachibana ,  Hisashi Iizasa ,  Nobuaki Yoshida ,  Toshihiro Nakajima ,  Osamu Yoshie

IPC分类号： C12Q1/70 ,  C12Q1/68

CPC分类号： C07K14/7158 ,  A61K38/00

摘要： The present invention pertains to a DNA encoding a polypeptide including an entire sequence of the amino acid sequence as shown by SEQ ID NO: 2 or a partial sequence thereof, or a polypeptide including the polypeptide described above, wherein any of the polypeptides has an activity of a receptor capable of binding to a murine PBSF/SDF-1; a polypeptide encoded by the DNA described above, wherein the polypeptide has an activity of a receptor capable of binding to a murine PBSF/SDF-1; cells expressing the polypeptide described above and a human CD4 protein; and a method of screening an AIDS onset inhibitor or an HIV-1 infection inhibitor, characterized by the use of the cells described above. According to the present invention, there can be provided a novel murine CXC chemokine receptor gene, a method of screening an HIV-1 infection inhibitor, and the like, each of which is useful in studies of a therapeutic agent for AIDS and the functional mechanism of HIV-1 infection.

摘要翻译： 本发明涉及编码包含如SEQ ID NO：2或其部分序列所示的氨基酸序列的整个序列或包含上述多肽的多肽的多肽的DNA，其中任何多肽具有活性 的能够结合小鼠PBSF / SDF-1的受体; 由上述DNA编码的多肽，其中所述多肽具有能够结合小鼠PBSF / SDF-1的受体的活性; 表达上述多肽的细胞和人CD4蛋白; 以及筛选艾滋病起病抑制剂或HIV-1感染抑制剂的方法，其特征在于使用上述细胞。 根据本发明，可以提供新的鼠CXC趋化因子受体基因，筛选HIV-1感染抑制剂的方法等，其可用于AIDS治疗剂的研究和功能机制 的HIV-1感染。

公开(公告)号：US07074616B1

公开(公告)日：2006-07-11

申请号：US09367052

申请日：1997-02-07

申请人： Tadamitsu Kishimoto ,  Takashi Nagasawa ,  Kazunobu Tachibana ,  Hisashi Iizasa ,  Nobuaki Yoshida ,  Toshihiro Nakajima ,  Osamu Yoshie

发明人： Tadamitsu Kishimoto ,  Takashi Nagasawa ,  Kazunobu Tachibana ,  Hisashi Iizasa ,  Nobuaki Yoshida ,  Toshihiro Nakajima ,  Osamu Yoshie

IPC分类号： C12N5/00 ,  C12N5/10 ,  C12N15/00 ,  C12N15/12 ,  C12N15/63

CPC分类号： C07K14/7158 ,  A61K38/00

摘要： The present invention pertains to a DNA encoding a polypeptide comprising an entire sequence of the amino acid sequence as shown by SEQ ID NO:2 of Sequence Listing or a partial sequence thereof, or a polypeptide comprising the polypeptide described above, wherein any of the polypeptides has an activity of a receptor capable of binding to a murine PBSF/SDF-1; a polypeptide encoded by the DNA described above, wherein the polypeptide has an activity of a receptor capable of binding to a murine PBSF/SDF-1; cells expressing the polypeptide described above and a human CD4 protein; and a method of screening an AIDS onset inhibitor or an HIV-1 infection inhibitor, characterized by the use of the cells described above. According to the present invention, there can be provided a novel murine CXC chemokine receptor gene, a method of screening an HIV-1 infection inhibitor, and the like, each of which is useful in studies of a therapeutic agent for AIDS and the functional mechanism of HIV-1 infection.

摘要翻译： 本发明涉及编码多肽的DNA，其包含序列表的SEQ ID NO：2所示的氨基酸序列的整个序列或其部分序列，或包含上述多肽的多肽，其中任何多肽 具有能够结合小鼠PBSF / SDF-1的受体的活性; 由上述DNA编码的多肽，其中所述多肽具有能够结合小鼠PBSF / SDF-1的受体的活性; 表达上述多肽的细胞和人CD4蛋白; 以及筛选艾滋病起病抑制剂或HIV-1感染抑制剂的方法，其特征在于使用上述细胞。 根据本发明，可以提供新的鼠CXC趋化因子受体基因，筛选HIV-1感染抑制剂的方法等，其可用于AIDS治疗剂的研究和功能机制 的HIV-1感染。

公开(公告)号：US20060129358A1

公开(公告)日：2006-06-15

申请号：US11330266

申请日：2006-01-12

申请人： Osamu Yoshie ,  Nobuyoshi Sato ,  Tatsuya Fukunaga

发明人： Osamu Yoshie ,  Nobuyoshi Sato ,  Tatsuya Fukunaga

IPC分类号： G06F11/00

CPC分类号： G05B23/0229 ,  G05B23/0272 ,  G05B23/0275 ,  G05B2219/31205 ,  G05B2219/31434 ,  G05B2219/31448

摘要： The present invention relates to a system for managing and diagnosing a state of a facility apparatus, and an object thereof is to provide a system for diagnosing the facility apparatus wherein, if information falling under a level of abnormality is extracted from gathered information on an operating state of the facility apparatus, an advanced analysis and diagnosis section on a facility diagnosis center side performs an advanced analysis and diagnosis process and promptly notifies a user side of the information on the best way of dealing with the facility apparatus determined to be abnormal, and further uploads a facility management data analysis program from the advanced analysis and diagnosis section to a facility monitoring section on the user side so that raw information of a large information amount can be analyzed on the user side without sending it to the facility diagnosis center side. A facility management data processing section (3a) signal-processes facility state detecting information detected by facility state detectors (2a, 2b) mounted on a facility apparatus (1), a facility state determining section (4) determines a level of the signal-processed information comparing with a management reference value and outputs it, the facility monitoring section (5) gathers and processes the information related to the level-determined facility apparatus (1) and sends it to the advanced analysis and diagnosis section (6) via a communication network (10), and the advanced analysis and diagnosis section (6) performs an advanced analysis of the information and identifies a cause of the abnormality of the facility apparatus (1) concerned and improvement measures thereof to send the identified results to the facility monitoring section (5). In addition, it is characterized in that the facility management data analysis program is uploaded from the advanced analysis and diagnosis section (6) to the facility monitoring section (5) so that the advanced analysis can be performed on the user side B.

公开(公告)号：US07143011B2

公开(公告)日：2006-11-28

申请号：US11330354

申请日：2006-01-12

申请人： Osamu Yoshie ,  Nobuyoshi Sato ,  Tatsuya Fukunaga

发明人： Osamu Yoshie ,  Nobuyoshi Sato ,  Tatsuya Fukunaga

IPC分类号： G06F19/00

CPC分类号： G05B23/0229 ,  G05B2223/06

摘要： The present invention relates to a system for managing and diagnosing a state of a facility apparatus, and an object thereof is to provide a system for diagnosing the facility apparatus wherein, if information falling under a level of abnormality is extracted from gathered information on an operating state of the facility apparatus, an advanced analysis and diagnosis section on a facility diagnosis center side performs an advanced analysis and diagnosis process and promptly notifies a user side of the information on the best way of dealing with the facility apparatus determined to be abnormal, and further uploads a facility management data analysis program from the advanced analysis and diagnosis section to a facility monitoring section on the user side so that raw information of a large information amount can be analyzed on the user side without sending it to the facility diagnosis center side.

摘要翻译： 本发明涉及一种用于管理和诊断设施设备的状态的系统，其目的是提供一种用于诊断设备设备的系统，其中如果从收集到的关于操作的信息中提取属于异常水平的信息 设备设备的状态，设备诊断中心侧的高级分析和诊断部分进行高级分析和诊断处理，并且迅速地向用户侧通知关于被确定为异常的设备设备的最佳处理方式的信息，以及 进一步将设备管理数据分析程序从高级分析和诊断部分上传到用户侧的设施监视部分，使得可以在用户侧分析大信息量的原始信息而不将其发送到设施诊断中心侧。

公开(公告)号：US06793917B1

公开(公告)日：2004-09-21

申请号：US09043861

申请日：1998-03-27

申请人： Toshio Imai ,  Tetsuya Yoshida ,  Osamu Yoshie

发明人： Toshio Imai ,  Tetsuya Yoshida ,  Osamu Yoshie

IPC分类号： C12N516

CPC分类号： C07K14/523 ,  A61K38/00 ,  G01N33/6863 ,  G01N2500/00

摘要： An isolated novel type CC chemokine-like protein which is expressed from peripheral blood mononuclear cells under an immunological stimulus and has a cell migration activity; a DNA encoding the protein; an expression vector and a transformant containing the DNA; a process for producing a recombinant protein by using the transformant; and a pharmaceutical composition containing the protein.

摘要翻译： 一种分离的新型CC趋化因子样蛋白，其在免疫刺激下由外周血单核细胞表达并具有细胞迁移活性; 编码蛋白质的DNA; 表达载体和含有该DNA的转化体; 通过使用转化体生产重组蛋白的方法; 和含有该蛋白质的药物组合物。

公开(公告)号：US07139681B2

公开(公告)日：2006-11-21

申请号：US11330266

申请日：2006-01-12

申请人： Osamu Yoshie ,  Nobuyoshi Sato ,  Tatsuya Fukunaga

发明人： Osamu Yoshie ,  Nobuyoshi Sato ,  Tatsuya Fukunaga

IPC分类号： G06F19/00

CPC分类号： G05B23/0229 ,  G05B23/0272 ,  G05B23/0275 ,  G05B2219/31205 ,  G05B2219/31434 ,  G05B2219/31448

摘要： The present invention relates to a system for managing and diagnosing a state of a facility apparatus, and an object thereof is to provide a system for diagnosing the facility apparatus wherein, if information falling under a level of abnormality is extracted from gathered information on an operating state of the facility apparatus, an advanced analysis and diagnosis section on a facility diagnosis center side performs an advanced analysis and diagnosis process and promptly notifies a user side of the information on the best way of dealing with the facility apparatus determined to be abnormal, and further uploads a facility management data analysis program from the advanced analysis and diagnosis section to a facility monitoring section on the user side so that raw information of a large information amount can be analyzed on the user side without sending it to the facility diagnosis center side.A facility management data processing section (3a) signal-processes facility state detecting information detected by facility state detectors (2a, 2b) mounted on a facility apparatus (1), a facility state determining section (4) determines a level of the signal-processed information comparing with a management reference value and outputs it, the facility monitoring section (5) gathers and processes the information related to the level-determined facility apparatus (1) and sends it to the advanced analysis and diagnosis section (6) via a communication network (10), and the advanced analysis and diagnosis section (6) performs an advanced analysis of the information and identifies a cause of the abnormality of the facility apparatus (1) concerned and improvement measures thereof to send the identified results to the facility monitoring section (5). In addition, it is characterized in that the facility management data analysis program is uploaded from the advanced analysis and diagnosis section (6) to the facility monitoring section (5) so that the advanced analysis can be performed on the user side B.

公开(公告)号：US07085684B2

公开(公告)日：2006-08-01

申请号：US10332007

申请日：2001-07-04

申请人： Osamu Yoshie ,  Nobuyoshi Sato ,  Tatsuya Fukunaga

发明人： Osamu Yoshie ,  Nobuyoshi Sato ,  Tatsuya Fukunaga

IPC分类号： G06F19/00

CPC分类号： G05B23/0229 ,  G05B23/0272 ,  G05B23/0275 ,  G05B2219/31205 ,  G05B2219/31434 ,  G05B2219/31448

摘要： A system for managing and diagnosing a state of a facility apparatus. If information falling under a level of abnormality is extracted from gathered information on an operating state of the facility apparatus, an advanced analysis and diagnosis section on a facility diagnosis center side performs an advanced analysis and diagnosis process and promptly notifies a user side of the information on the best way of dealing with the facility apparatus determined to be abnormal, and further uploads a facility management data analysis program from the advanced analysis and diagnosis section to a facility monitoring section on the user side so that raw information of a large information amount can be analyzed on the user side without sending it to the facility diagnosis center side.

摘要翻译： 一种用于管理和诊断设备装置的状态的系统。 如果从设备装置的运行状态的收集信息中提取落入异常水平的信息，则设备诊断中心侧的高级分析诊断部进行高级分析诊断处理，并且迅速地向用户侧通知信息 在处理被判定为异常的设备装置的最佳方式中，进一步将设备管理数据分析程序从高级分析诊断部上传到用户侧的设备监视部，使得信息量大的原始信息可以 在用户端进行分析，而不将其发送到设施诊断中心侧。

公开(公告)号：US20060116836A1

公开(公告)日：2006-06-01

申请号：US11330354

申请日：2006-01-12

申请人： Osamu Yoshie ,  Nobuyoshi Sato ,  Tatsuya Fukunaga

发明人： Osamu Yoshie ,  Nobuyoshi Sato ,  Tatsuya Fukunaga

IPC分类号： G01R35/00 ,  G01D21/00

CPC分类号： G05B23/0229 ,  G05B2223/06

摘要： The present invention relates to a system for managing and diagnosing a state of a facility apparatus, and an object thereof is to provide a system for diagnosing the facility apparatus wherein, if information falling under a level of abnormality is extracted from gathered information on an operating state of the facility apparatus, an advanced analysis and diagnosis section on a facility diagnosis center side performs an advanced analysis and diagnosis process and promptly notifies a user side of the information on the best way of dealing with the facility apparatus determined to be abnormal, and further uploads a facility management data analysis program from the advanced analysis and diagnosis section to a facility monitoring section on the user side so that raw information of a large information amount can be analyzed on the user side without sending it to the facility diagnosis center side. A facility management data processing section (3a) signal-processes facility state detecting information detected by facility state detectors (2a, 2b) mounted on a facility apparatus (1), a facility state determining section (4) determines a level of the signal-processed information comparing with a management reference value and outputs it, the facility monitoring section (5) gathers and processes the information related to the level-determined facility apparatus (1) and sends it to the advanced analysis and diagnosis section (6) via a communication network (10), and the advanced analysis and diagnosis section (6) performs an advanced analysis of the information and identifies a cause of the abnormality of the facility apparatus (1) concerned and improvement measures thereof to send the identified results to the facility monitoring section (5). In addition, it is characterized in that the facility management data analysis program is uploaded from the advanced analysis and diagnosis section (6) to the facility monitoring section (5) so that the advanced analysis can be performed on the user side B.