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    Method for preserving reduced coenzyme Q10
    1.
    发明授权
    Method for preserving reduced coenzyme Q10 有权
    保留还原型辅酶Q10的方法

    公开(公告)号：US08067217B2

    公开(公告)日：2011-11-29

    申请号：US11315161

    申请日：2005-12-23

    申请人： Takahiro Ueda ,  Tadao Ono ,  Shiro Kitamura ,  Yasuyoshi Ueda

    发明人： Takahiro Ueda ,  Tadao Ono ,  Shiro Kitamura ,  Yasuyoshi Ueda

    IPC分类号： C12N9/98

    CPC分类号： A61K9/4816

    摘要： The present invention has its object to provide a method for stably preserving a capsule containing reduced coenzyme Q10, which is useful as foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, animal drugs, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc. The present invention relates to a method for preserving reduced coenzyme Q10 which comprises producing or obtaining a capsule containing reduced coenzyme Q10, and controlling environment surrounding the capsule to a relative humidity of not less than 0% but not more than 60%. According to this method, reduced coenzyme Q10 can be preserved stably, without requiring huge cost and labor, or special equipment.

    摘要翻译： 本发明的目的是提供一种用于稳定保存含有还原型辅酶Q10的胶囊的方法，所述还原型辅酶Q10可用作食品，功能营养食品，特定保健食品，营养补充剂，营养物质，动物药物，饮料，饲料，化妆品，药​​物， 补救剂，预防药物等。本发明涉及一种保存还原型辅酶Q10的方法，其包括制备或获得含有还原型辅酶Q10的胶囊，并且将胶囊周围的环境控制在相对湿度不小于0％但不超过 超过60％。 根据该方法，可以稳定地保持还原型辅酶Q10，而不需要巨大的成本和劳动力，或特殊设备。

    Method of stabilizing reduced coenzyme q10
    2.
    发明授权
    Method of stabilizing reduced coenzyme q10 有权
    稳定还原型辅酶Q10的方法

    公开(公告)号：US08703155B2

    公开(公告)日：2014-04-22

    申请号：US10492122

    申请日：2002-10-10

    申请人： Takahiro Ueda ,  Tadao Ono ,  Mitsutoshi Moro ,  Shiro Kitamura ,  Yasuyoshi Ueda

    发明人： Takahiro Ueda ,  Tadao Ono ,  Mitsutoshi Moro ,  Shiro Kitamura ,  Yasuyoshi Ueda

    IPC分类号： A61K38/43 ,  A61K9/00

    CPC分类号： A61K31/122 ,  A61K9/4866 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/22 ,  B01D9/00 ,  C07C41/26 ,  C07C41/40 ,  C07C41/46 ,  C07C43/23

    摘要： The present invention provides a stabilization method, a preservation method and the like method of reduced coenzyme Q10, which is useful as functional nutritive foods, specific health foods and the like. Furthermore, the present invention provides a method for efficiently obtaining reduced coenzyme Q10 of high quality and by a method suitable for a commercial production. It is possible to handle and stably preserve reduced coenzyme Q10 under a condition that oxidation by a molecular oxygen is inhibited by contacting reduced coenzyme Q10 with an ascorbic acid and citric acid or a related compound thereof, and thus a stabilized composition is obtained. Moreover, reduced coenzyme Q10 is converted into a crystalline state in such a condition that the formation of oxidized coenzyme Q10 as a byproduct is minimized by crystallizing reduced coenzyme Q10 in the presence of ascorbic acid or a related compound thereof, etc., and thus a reduced coenzyme Q10 crystal of high quality is produced. Furthermore, by successively crystallizing the generated reduced coenzyme Q10, in the presence of ascorbic acid or related compound thereof after reducing oxidized coenzyme Q10 to reduced coenzyme Q10 using ascorbic acid or a related compound thereof, operations are simplified and minimized, and thus reduced coenzyme Q10 of high quality is produced.

    摘要翻译： 本发明提供还原型辅酶Q10的稳定化方法，保存方法等，其作为功能性营养食品，特定健康食品等有用。 此外，本发明提供了一种有效地获得高质量的还原型辅酶Q10的方法，以及适用于商业生产的方法。 在减少的辅酶Q10与抗坏血酸和柠檬酸或其相关化合物接触的条件下，通过分子氧的氧化被抑制的条件下，可以处理和稳定地保持还原型辅酶Q10，从而得到稳定的组合物。 此外，将还原型辅酶Q10转化为结晶状态，使得在抗坏血酸或其相关化合物等的存在下使还原型辅酶Q10结晶化，使作为副产物的氧化型辅酶Q10的形成最小化， 生产高品质的还原型辅酶Q10晶体。 此外，通过使生成的还原型辅酶Q10连续结晶，在使用抗坏血酸或其相关化合物还原氧化型辅酶Q10至还原型辅酶Q10后，在抗坏血酸或其相关化合物的存在下，操作简化并最小化，从而减少了辅酶Q10 生产高品质。

    Solid preparation containing reduced coenzyme Q10 and method for producing the same
    3.
    发明申请
    Solid preparation containing reduced coenzyme Q10 and method for producing the same 审中-公开
    含有还原型辅酶Q10的固体制剂及其制备方法

    公开(公告)号：US20060147542A1

    公开(公告)日：2006-07-06

    申请号：US11315159

    申请日：2005-12-23

    申请人： Tadao Ono ,  Takahiro Ueda ,  Shiro Kitamura ,  Yasuyoshi Ueda

    发明人： Tadao Ono ,  Takahiro Ueda ,  Shiro Kitamura ,  Yasuyoshi Ueda

    IPC分类号： A61K38/43 ,  A61K9/50 ,  A61K9/16

    CPC分类号： A61K9/2054 ,  A61K9/286 ,  A61K9/2866

    摘要： The present invention has its object to provide a solid preparation containing reduced coenzyme Q10 with high stability by protecting reduced coenzyme Q10 against oxidization to oxidized coenzyme Q10 by molecular oxygen. The present invention provides a solid preparation containing reduced coenzyme Q10 which comprises a solid composition containing reduced coenzyme Q10 coated with at least one coating medium selected from among oil-soluble coating media and water-soluble coating media. The present invention also provides a method for stabilizing a solid preparation containing reduced coenzyme Q10, wherein a solid composition containing reduced coenzyme Q10 is coated with at least one coating medium selected from among oil-soluble coating media and water-soluble coating media to thereby stabilize the resulting solid preparation containing reduced coenzyme Q10.

    摘要翻译： 本发明的目的是提供一种含有还原型辅酶Q 10的固体制剂，其具有高度的稳定性，通过将还原型辅酶Q 10保护氧化成氧化型辅酶Q 10， / SUB>。 本发明提供了含有还原型辅酶Q 10固体制剂，其包含含有还原型辅酶Q 10的固体组合物，所述还原型辅酶包被至少一种选自油溶性涂层 介质和水溶性涂料介质。 本发明还提供了一种用于稳定含有还原型辅酶Q 10 N的固体制剂的方法，其中含有还原型辅酶Q 10的固体组合物涂覆有至少一种选择的涂层介质 从油溶性涂层介质和水溶性涂层介质中，由此使得到的含有还原型辅酶Q 10的固体制剂稳定。

    Method for preserving reduced coenzyme Q10
    5.
    发明申请
    Method for preserving reduced coenzyme Q10 有权
    保留还原型辅酶Q10的方法

    公开(公告)号：US20060153911A1

    公开(公告)日：2006-07-13

    申请号：US11315161

    申请日：2005-12-23

    申请人： Takahiro Ueda ,  Tadao Ono ,  Shiro Kitamura ,  Yasuyoshi Ueda

    发明人： Takahiro Ueda ,  Tadao Ono ,  Shiro Kitamura ,  Yasuyoshi Ueda

    IPC分类号： A61K9/48 ,  C07C29/94 ,  C12N9/00 ,  C07C37/88

    CPC分类号： A61K9/4816

    摘要： The present invention has its object to provide a method for stably preserving a capsule containing reduced coenzyme Q10, which is useful as foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, animal drugs, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc. The present invention relates to a method for preserving reduced coenzyme Q10 which comprises producing or obtaining a capsule containing reduced coenzyme Q10, and controlling environment surrounding the capsule to a relative humidity of not less than 0% but not more than 60%. According to this method, reduced coenzyme Q10 can be preserved stably, without requiring huge cost and labor, or special equipment.

    摘要翻译： 本发明的目的是提供一种用于稳定保存含有还原型辅酶Q 10的胶囊的方法，所述还原型辅酶Q 10可用作食品，功能营养食品，特定保健食品，营养补充剂，营养物质，动物药物， 饮料，饲料，化妆品，药​​物，补救剂，预防药物等。本发明涉及一种保存还原型辅酶Q 10的方法，其包括制备或获得含有还原型辅酶Q 10的胶囊 并且将胶囊周围的环境控制在不小于0％但不大于60％的相对湿度。 根据该方法，可以稳定地保持还原型辅酶Q 10，而不需要巨大的成本和劳动力或专用设备。

    Method of stabilizing reduced coenzyme q10
    7.
    发明申请
    Method of stabilizing reduced coenzyme q10 有权
    稳定还原型辅酶Q10的方法

    公开(公告)号：US20050008630A1

    公开(公告)日：2005-01-13

    申请号：US10492122

    申请日：2002-10-10

    申请人： Takahiro Ueda ,  Tadao Ono ,  Mitsutoshi Moro ,  Shiro Kitamura ,  Yasuyoshi Ueda

    发明人： Takahiro Ueda ,  Tadao Ono ,  Mitsutoshi Moro ,  Shiro Kitamura ,  Yasuyoshi Ueda

    IPC分类号： A61K31/122 ,  A61K47/12 ,  A61K47/22 ,  A61K47/34 ,  A61P3/02 ,  A61K38/43 ,  C07C43/20

    CPC分类号： A61K31/122 ,  A61K9/4866 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/22 ,  B01D9/00 ,  C07C41/26 ,  C07C41/40 ,  C07C41/46 ,  C07C43/23

    摘要： The present invention provides a stabilization method, a preservation method and the like method of reduced coenzyme Q10, which is useful as functional nutritive foods, specific health foods and the like. Furthermore, the present invention provides a method for efficiently obtaining reduced coenzyme Q10 of high quality and by a method suitable for a commercial production. It is possible to handle and stably preserve reduced coenzyme Q10 under a condition that oxidation by a molecular oxygen is inhibited by contacting reduced coenzyme Q10 with an ascorbic acid and citric acid or a related compound thereof, and thus a stabilized composition is obtained. Moreover, reduced coenzyme Q10 is converted into a crystalline state in such a condition that the formation of oxidized coenzyme Q10 as a byproduct is minimized by crystallizing reduced coenzyme Q10 in the presence of ascorbic acid or a related compound thereof, etc., and thus a reduced coenzyme Q10 crystal of high quality is produced. Furthermore, by successively crystallizing the generated reduced coenzyme Q10 in the presence of ascorbic acid or a related compound thereof after reducing oxidized coenzyme Q10 to reduced coenzyme Q10 using ascorbic acid or a related compound thereof, operations are simplified and minimized, and thus reduced coenzyme Q10 of high quality is produced.

    摘要翻译： 本发明提供还原型辅酶Q10的稳定化方法，保存方法等，其作为功能性营养食品，特定健康食品等有用。 此外，本发明提供了一种有效地获得高质量的还原型辅酶Q10的方法，以及适用于商业生产的方法。 在减少的辅酶Q10与抗坏血酸和柠檬酸或其相关化合物接触的条件下，通过分子氧的氧化被抑制的条件下，可以处理和稳定地保持还原型辅酶Q10，从而得到稳定的组合物。 此外，将还原型辅酶Q10转化为结晶状态，使得在抗坏血酸或其相关化合物等的存在下使还原型辅酶Q10结晶化，使作为副产物的氧化型辅酶Q10的形成最小化， 生产高品质的还原型辅酶Q10晶体。 此外，通过使用抗坏血酸或其相关化合物将氧化型辅酶Q 10还原为还原型辅酶Q10后，在抗坏血酸或其相关化合物的存在下，依次结晶生成的还原型辅酶Q10，操作简化，最小化，从而减少了辅酶Q10 生产高品质。

    METHOD OF PRODUCING REDUCED COENZYME Q10 CRYSTALS WITH EXCELLENT HANDLING PROPERTIES
    8.
    发明申请
    METHOD OF PRODUCING REDUCED COENZYME Q10 CRYSTALS WITH EXCELLENT HANDLING PROPERTIES 有权
    生产具有优异处理性能的还原型COYZYME Q10水晶的方法

    公开(公告)号：US20110263906A1

    公开(公告)日：2011-10-27

    申请号：US13176479

    申请日：2011-07-05

    申请人： Takahiro Ueda ,  Shiro Kitamura ,  Yasuyoshi Ueda

    发明人： Takahiro Ueda ,  Shiro Kitamura ,  Yasuyoshi Ueda

    IPC分类号： C07C41/40

    CPC分类号： C07C41/40 ,  C07C43/23

    摘要： The present invention provides a method of producing reduced coenzyme Q10 crystals suitable for commercial scale production thereof.According to a method of the present invention of producing a reduced coenzyme Q10 crystal which comprises a crystallization of reduced coenzyme Q10 in a solution of alcohols and/or ketones, reduced coenzyme Q10 crystal excellent in slurry properties and crystalline properties maybe obtained. Moreover, an isolation process including a crystal separation or the whole process including the isolation process maybe minimized and simplified. Thus, highly pure reduced coenzyme Q10 may be obtained in a high yield.

    摘要翻译： 本发明提供了适合于商业规模生产的还原型辅酶Q10晶体的制造方法。 根据本发明的制备还原型辅酶Q10晶体的方法，所述还原型辅酶Q10晶体包括在醇和/或酮溶液中结晶还原型辅酶Q10，可得到浆料性能和结晶性能优异的还原型辅酶Q10晶体。 此外，包括晶体分离的分离过程或包括隔离过程的整个过程可以被最小化和简化。 因此，可以高产率获得高纯度还原型辅酶Q10。

    Method of producing reduced coenzyme Q10 as oily product
    9.
    发明申请
    Method of producing reduced coenzyme Q10 as oily product 有权

    公开(公告)号：US20070161825A1

    公开(公告)日：2007-07-12

    申请号：US11716828

    申请日：2007-03-12

    申请人： Takahiro Ueda ,  Shiro Kitamura ,  Yasuyoshi Ueda

    发明人： Takahiro Ueda ,  Shiro Kitamura ,  Yasuyoshi Ueda

    IPC分类号： C07C43/20

    CPC分类号： C07C41/26 ,  C07C41/34 ,  C07C43/23

    摘要： The present invention provides a method for obtaining reduced coenzyme Q10 which is useful as an ingredient in foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc. suited for a commercial scale production in high quality and efficiently. The high-quality oily reduced coenzyme Q10 which has low viscosity and thereby easily handled may be produced by separating an aqueous phase from the reaction mixture obtainable by oily reacting oxidized coenzyme Q10 with a reducing agent in water, or by distilling off an coexisting organic solvent at or above the melting temperature of reduced coenzyme Q10 in concentrating the organic phase containing reduced coenzyme Q10. Moreover, a solution or slurry of reduced coenzyme Q10 may be obtained by adding a desired solvent to the obtained oily product, or a solid of reduced coenzyme Q10 may be produced by contacting the oily product with a seed crystal.

    Method of producing reduced coenzyme Q10 as oily product
    10.
    发明授权
    Method of producing reduced coenzyme Q10 as oily product 有权
    还原型辅酶Q10作为油性产品的生产方法

    公开(公告)号：US07208639B2

    公开(公告)日：2007-04-24

    申请号：US10483870

    申请日：2002-07-15

    申请人： Takahiro Ueda ,  Shiro Kitamura ,  Yasuyoshi Ueda

    发明人： Takahiro Ueda ,  Shiro Kitamura ,  Yasuyoshi Ueda

    IPC分类号： C07C41/18

    CPC分类号： C07C41/26 ,  C07C41/34 ,  C07C43/23

    摘要： The present invention provides a method for obtaining reduced coenzyme Q10 which is useful as an ingredient in foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc. suited for a commercial scale production in high quality and efficiently.The high-quality oily reduced coenzyme Q10 which has low viscosity and thereby easily handled may be produced by separating an aqueous phase from the reaction mixture obtainable by oily reacting oxidized coenzyme Q10 with a reducing agent in water, or by distilling off an coexisting organic solvent at or above the melting temperature of reduced coenzyme Q10 in concentrating the organic phase containing reduced coenzyme Q10. Moreover, a solution or slurry of reduced coenzyme Q10 may be obtained by adding a desired solvent to the obtained oily product, or a solid of reduced coenzyme Q10 may be produced by contacting the oily product with a seed crystal.

    摘要翻译： 本发明提供一种用于获得还原型辅酶Q 10的方法，其可用作食品，功能营养食品，特定保健食品，营养补充剂，营养物质，饮料，饲料，化妆品，药​​物，补救剂中的成分 ，预防药物等，适用于高质量，高效的商业规模生产。 具有低粘度并因此容易处理的高品质油性还原型辅酶Q 10 N可以通过将水相从可通过油性反应氧化型辅酶Q 10 在还原型辅酶Q 10的有机相中浓缩还原型辅酶Q 10的有机相，或者通过在还原型辅酶Q 10的熔解温度下蒸馏掉共存的有机溶剂， >。 此外，可以通过向得到的油性产品中加入所需的溶剂，或者可以生产还原型辅酶Q 10的固体来获得还原型辅酶Q 10 N的溶液或浆液 通过将油状产物与晶种接触。