公开(公告)号：US20130136724A1

公开(公告)日：2013-05-30

申请号：US13699056

申请日：2011-05-20

申请人： Takaaki Ohara ,  Shinichi Tani ,  Kazunori Hosoe ,  Tomohito Uemura

发明人： Takaaki Ohara ,  Shinichi Tani ,  Kazunori Hosoe ,  Tomohito Uemura

IPC分类号： A61K31/122 ,  A23K1/16

CPC分类号： A61K31/122 ,  A23K20/111 ,  A23K50/30

摘要： An object of the present invention is to provide a method for improving a farrowing rate of sows or improving growth and productivity of postnatal piglets, and a feed used in the method. The present invention relates to a method for improving a farrowing rate of a sow or improving growth and productivity of postnatal piglets, the method comprising administering coenzyme Q to a swine.

摘要翻译： 本发明的目的是提供一种提高母猪分娩率或改善产仔仔猪生长和生产力的方法，以及该方法中使用的饲料。 本发明涉及一种改善母猪分娩率或提高产仔仔猪生长和生产力的方法，所述方法包括向猪施用辅酶Q。

公开(公告)号：US20110070213A1

公开(公告)日：2011-03-24

申请号：US12954356

申请日：2010-11-24

申请人： Kenji FUJII ,  Taizo Kawabe ,  Kazunori Hosoe ,  Takayoshi Hidaka

发明人： Kenji FUJII ,  Taizo Kawabe ,  Kazunori Hosoe ,  Takayoshi Hidaka

IPC分类号： A61K31/09 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61P17/08

CPC分类号： A61Q19/00 ,  A61K8/347 ,  A61K8/355 ,  A61K8/86 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/05 ,  A61K31/122 ,  A61K47/10 ,  A61K2800/70 ,  A61L15/44 ,  A61L2300/216 ,  A61Q19/10

摘要： The present invention provides a composition for dermal application which comprises, as an active ingredient, an oxidized coenzyme Q represented by the formula (1): in which n represents an integer of 1 to 12, and/or a reduced coenzyme Q represented by the formula (2): in which n represents an integer of 1 to 12, the total content of the oxidized coenzyme Q and reduced coenzyme Q being 0.01 to 99% by weight relative to the whole amount of the composition. The present invention also provides a therapeutic composition for skin diseases, a cosmetic composition, a skin health care composition and a bath salt composition, each comprising the above composition for dermal application.The present invention is further provides a method for the treatment of skin diseases which comprises applying, to a patient suffering from a skin disease, the above-mentioned therapeutic composition for skin diseases, or a method for the treatment of skin diseases which comprises applying, to a patient suffering from a skin disease, the above therapeutic agent for skin diseases other than the oxidized coenzyme Q represented by the formula (1) and other than the reduced coenzyme Q represented by the formula (2) in parallel with a therapeutic composition for skin diseases.

摘要翻译： 本发明提供了一种用于真皮应用的组合物，其包含作为活性成分的由式（1）表示的氧化型辅酶Q：其中n表示1〜12的整数，和/或由下式表示的还原型辅酶Q 式（2）：其中n表示1〜12的整数，相对于组合物的总量，氧化型辅酶Q和还原型辅酶Q的总含量为0.01〜99重量％。 本发明还提供了一种皮肤病的治疗组合物，化妆品组合物，皮肤保健组合物和浴盐组合物，每种组合物包含上述用于真皮应用的组合物。 本发明还提供了一种治疗皮肤病的方法，其包括向患有皮肤病的患者应用上述皮肤病治疗组合物或皮肤病治疗方法， 对于患有皮肤病的患者，除了由式（1）表示的氧化型辅酶Q以外，除了式（2）所示的还原型辅酶Q以外，还可以使用与上述治疗组合物平行的上述皮肤病治疗剂， 皮肤病。

公开(公告)号：US20090246185A1

公开(公告)日：2009-10-01

申请号：US12282448

申请日：2007-03-09

申请人： Hideyuki Kishida ,  Kenji Fujii ,  Hiroshi Kubo ,  Kazunori Hosoe

发明人： Hideyuki Kishida ,  Kenji Fujii ,  Hiroshi Kubo ,  Kazunori Hosoe

IPC分类号： A61K31/122 ,  C07C43/23 ,  A61P9/00

CPC分类号： A61K31/122 ,  A23K20/111 ,  A23K20/174 ,  A23L33/10 ,  A23L33/15 ,  A23V2002/00 ,  A61K45/06 ,  A23V2200/326 ,  A23V2250/314

摘要： An object of the present invention is to provide a highly safe oral composition superior in a cardiac dysfunction-ameliorating or cardiac function-maintaining action. The present inventors have conducted intensive studies in an attempt to solve the aforementioned problems and found that use of, particularly, reduced coenzyme Q10 from among highly safe coenzyme Q affords a composition useful for amelioration of cardiac dysfunction and maintenance of cardiac function. Accordingly, the present invention provides a cardiac dysfunction-ameliorating agent or cardiac function-maintaining agent containing reduced coenzyme Q as an active ingredient, and a pharmaceutical product, a food, an animal drug, a feed and the like, which contain the agent.

摘要翻译： 本发明的目的是提供在心脏功能障碍改善或心脏功能保持作用方面优异的高度安全的口服组合物。 本发明人为了解决上述问题进行了深入研究，发现特别是来自高度安全性的辅酶Q中的还原型辅酶Q10的使用提供了用于改善心脏功能障碍和维持心脏功能的组合物。 因此，本发明提供含有还原型辅酶Q作为活性成分的心脏功能障碍改善剂或心脏功能维持剂，以及含有该药剂的药物，食品，动物药物，饲料等。

公开(公告)号：US20090226408A1

公开(公告)日：2009-09-10

申请号：US11993743

申请日：2006-06-21

申请人： Hideyuki Kishida ,  Taizo Kawabe ,  Kazunori Hosoe

发明人： Hideyuki Kishida ,  Taizo Kawabe ,  Kazunori Hosoe

IPC分类号： A61K38/44 ,  A61K31/122 ,  A61K31/385 ,  A61K38/45 ,  A61P43/00

CPC分类号： A61K45/06 ,  A61K31/09 ,  A61K31/122 ,  A61K31/19 ,  A61K31/385 ,  A61K2300/00

摘要： A method of preventing or treating fatigue in a subject mammal comprises administering an effective amount of a composition comprising (a) reduced coenzyme Q represented by the following formula (1): wherein n is an integer of 1 to 12, and (b) lipoic acid or a derivative thereof, to the mammal.

摘要翻译： 预防或治疗受试者哺乳动物疲劳的方法包括施用有效量的组合物，其包含（a）由下式（1）表示的还原型辅酶Q：其中n为1至12的整数，和（b）硫辛酸 酸或其衍生物。

公开(公告)号：US20090087420A1

公开(公告)日：2009-04-02

申请号：US12328293

申请日：2008-12-04

申请人： Kenji FUJII ,  Taizo Kawabe ,  Kazunori Hosoe ,  Takayoshi Hidaka

发明人： Kenji FUJII ,  Taizo Kawabe ,  Kazunori Hosoe ,  Takayoshi Hidaka

IPC分类号： A61K31/122 ,  A61K8/35 ,  A61P43/00 ,  A61Q90/00 ,  A23L3/34 ,  C05F11/00

CPC分类号： C07C50/28 ,  A23D9/007 ,  A23K20/10 ,  A23K20/111 ,  A23K20/158 ,  A61K8/14 ,  A61K8/347 ,  A61K8/355 ,  A61K9/127 ,  A61K2800/52 ,  A61Q5/00 ,  A61Q19/00 ,  C07C41/46 ,  C07C43/23

摘要： The present invention provides a composition of a practically usable solution capable of stably maintaining, against oxidation, reduced coenzyme Q, which has not been employed in practice so far because of being liable to undergo oxidation and hydrophobic, a method of preparing the solution and a method of storing the solution. A solution of reduced coenzyme Q which can be stored at a low temperature or room temperature over a long time can be prepared by coating reduced coenzyme Q with liposome made of refined soybean lecithin, etc, and solubilizing, or solubilizing or emulsifying reduced coenzyme Q by using a surfactant at a low temperature.

摘要翻译： 本发明提供一种能够稳定地维持抗氧化还原型辅酶Q的组合物，该辅酶Q由于易于发生氧化和疏水而迄今尚未用于实践中，制备溶液的方法和 存储解决方法。 可以在低温或室温下长时间储存​​的还原型辅酶Q的溶液可以通过用由精制大豆卵磷脂等制成的脂质体涂布还原型辅酶Q，并通过将增溶或乳化还原型辅酶Q 在低温下使用表面活性剂。

公开(公告)号：US20080145411A1

公开(公告)日：2008-06-19

申请号：US11867347

申请日：2007-10-04

申请人： Yoshiyuki Shinagawa ,  Taizo Kawabe ,  Hideyuki Kishida ,  Kazunori Hosoe

发明人： Yoshiyuki Shinagawa ,  Taizo Kawabe ,  Hideyuki Kishida ,  Kazunori Hosoe

IPC分类号： A61K9/00 ,  A61K38/43 ,  A61K9/48 ,  A61K31/122

CPC分类号： A61K31/122 ,  A23K20/10 ,  A23K20/111 ,  A23K20/158 ,  A23K50/40 ,  A23L29/06 ,  A23L29/10 ,  A23L33/10 ,  A23L33/17 ,  A61K9/4858

摘要： The present invention provides a method of increasing the absorbability of oxidized coenzyme Q10 by preparing the oxidized coenzyme Q10 as a composition in the presence of a lysolecithin and an oil and fat. The composition of the present invention comprising oxidized coenzyme Q10, a lysolecithin and an oil and fat, wherein the weight ratio of the lysolecithin to the oxidized coenzyme Q10 is not less than 0.7, shows superior absorption of oxidized coenzyme Q10 and can be utilized for food, food with nutrient function, food for specified health uses, nutritional supplement, nutritional product, animal drug, beverage, feed, pet food, cosmetics, pharmaceutical product, therapeutic drug, preventive drug and the like.

摘要翻译： 本发明提供了通过在溶血卵磷脂和油脂中存在下制备氧化型辅酶Q 10作为组合物来提高氧化型辅酶Q 10的吸收性的方法 。 包含氧化型辅酶Q 10，溶血卵磷脂和油脂的本发明组合物，其中溶血卵磷脂与氧化型辅酶Q 10重量比不小于 超过0.7，表现出优异的氧化型辅酶Q 10的吸收，可用于食品，具有营养功能的食物，特定健康用途的食物，营养补充剂，营养产品，动物药物，饮料，饲料，宠物 食品，化妆品，医药产品，治疗药物，预防药物等。

公开(公告)号：US20070196349A1

公开(公告)日：2007-08-23

申请号：US11653974

申请日：2007-01-17

申请人： Shiro Kitamura ,  Takahiro Ueda ,  Yasuyoshi Ueda ,  Hideyuki Kishida ,  Kenji Fujii ,  Kazunori Hosoe

发明人： Shiro Kitamura ,  Takahiro Ueda ,  Yasuyoshi Ueda ,  Hideyuki Kishida ,  Kenji Fujii ,  Kazunori Hosoe

IPC分类号： A61K8/18

CPC分类号： A61Q19/02 ,  A23L33/10 ,  A23V2002/00 ,  A61K8/355 ,  A23V2200/318 ,  A23V2250/314

摘要： The present invention provides a cosmetic or food composition which is excellent in a skincare effect, particularly an effect of whitening the skin browned due to ultraviolet radiation or aging, and which can be safely used for many mammals. The present invention provides a whitening composition comprising reduced coenzyme Q represented by formula (1) as an effective component: wherein n represents an integer of 1 to 12. The present invention also provides a whitening composition further comprising oxidized coenzyme Q represented by formula (2) as an effective component: wherein n represents an integer of 1 to 12. The present invention also provides a method for whitening the skin of a mammal, the method comprising administering the mammal with the composition.

摘要翻译： 本发明提供一种护肤效果优异的化妆品或食品组合物，特别是由于紫外线照射或老化而使皮肤变白而变白的效果，可以安全地用于许多哺乳动物。 本发明提供一种美白组合物，其包含由式（1）表示的还原型辅酶Q作为有效成分：其中n表示1〜12的整数。本发明还提供了还含有由式（2）表示的氧化型辅酶Q ）作为有效成分：其中n表示1至12的整数。本发明还提供了一种使哺乳动物的皮肤变白的方法，所述方法包括给哺乳动物施用该组合物。

公开(公告)号：US06939897B2

公开(公告)日：2005-09-06

申请号：US10892164

申请日：2004-07-16

申请人： Kenji Fujii ,  Taizo Kawabe ,  Kazunori Hosoe ,  Takayoshi Hidaka

发明人： Kenji Fujii ,  Taizo Kawabe ,  Kazunori Hosoe ,  Takayoshi Hidaka

IPC分类号： A61K31/05 ,  A61K45/00 ,  A61K45/06 ,  A61P9/10 ,  A61P43/00 ,  A61K31/12 ,  A61K31/35 ,  A61K31/405

CPC分类号： A61K45/06 ,  A61K31/09 ,  A61K31/22 ,  A61K2300/00

摘要： The present invention has for its object to provide a method and a composition for achieving a more efficient recovery of the antioxidant activity of plasma LDL, or even augmentation thereof, which has been depressed by the use of an antihyperlipidemic or cholesterol-lowering drug to thereby insure a potentiated antiarteriosclerotic efficacy. A method for inhibiting arteriosclerosis, which comprises using a combination of a cholesterol-lowering agent and a reduced coenzyme Q10 represented by the following formula (1), and a composition for inhibiting arteriosclerosis containing both a cholesterol-lowering agent and said reduced coenzyme Q10.

摘要翻译： 本发明的目的是提供一种方法和组合物，其通过使用抗高脂血症或降胆固醇药物抑制血浆LDL的抗氧化活性或甚至增加，从而更有效地回收 确保增强的抗动脉硬化功效。 一种抑制动脉硬化的方法，其包括使用降胆固醇剂和由下式（1）表示的还原型辅酶Q 10的组合，以及抑制动脉硬化的组合物，其含有胆固醇 - 降低剂和所述还原型辅酶Q 10。

公开(公告)号：US20050070481A1

公开(公告)日：2005-03-31

申请号：US10492167

申请日：2002-10-10

申请人： Kenji Fujii ,  Taizo Kawabe ,  Kazunori Hosoe ,  Takayoshi Hidaka

发明人： Kenji Fujii ,  Taizo Kawabe ,  Kazunori Hosoe ,  Takayoshi Hidaka

IPC分类号： A61K9/08 ,  A61K9/127 ,  A61K31/05 ,  A61K31/085 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/20 ,  A61K47/22 ,  A61K47/46 ,  A61P3/02 ,  A61P9/00 ,  A61P43/00 ,  C07C43/23 ,  A61K38/05 ,  A61K31/075 ,  A61K31/198 ,  A61K31/375

CPC分类号： A61K47/18 ,  A61K9/127 ,  A61K31/085 ,  A61K47/183 ,  A61K47/22 ,  C07C43/23

摘要： The present invention provides a reduced coenzyme Q-containing solution capable of being retained more stably against oxidation, by using a reduced coenzyme Q which is hydrophobic and susceptible to oxidation and thus unstable. The aqueous solution containing a reduced coenzyme Q obtained in the present invention is a solution containing a reduced coenzyme Q and an antioxidant such as vitamin C and/or a chelating agent such as ethylenediaminetetraacetic acid.

摘要翻译： 本发明提供一种还原型辅酶Q溶液，其能够通过使用疏水性并易受氧化并因此不稳定的还原型辅酶Q而更加稳定地保持抗氧化。 含有本发明得到的还原型辅酶Q的水溶液是含有还原型辅酶Q和抗氧化剂如维生素C和/或螯合剂如乙二胺四乙酸的溶液。

公开(公告)号：US06362169B1

公开(公告)日：2002-03-26

申请号：US09622712

申请日：2000-08-22

申请人： Kenji Fujii ,  Katsuji Yamashita ,  Kazunori Hosoe ,  Takayoshi Hidaka

发明人： Kenji Fujii ,  Katsuji Yamashita ,  Kazunori Hosoe ,  Takayoshi Hidaka

IPC分类号： A61K3170

CPC分类号： A61K45/00 ,  A61K31/395 ,  A61K31/415 ,  A61K31/44 ,  A61K31/60 ,  A61K33/245 ,  A61K2300/00

摘要： Antibacterial compositions comprising (1) a rifamycin derivative represented by the formula (I) or its physiologically acceptable salt, and (2) a proton pump inhibitor (a) or a bismuth preparation (b) wherein the components (1) and (2) are used in such amounts as producing a synergistic effect against Helicobacter pylori, drugs and remedies for digestive organ diseases which contain the antibacterial compositions, process for producing them, and pharmaceutical preparations related to the antibacterial compositions. The compositions can be administered to patients with digestive diseases caused by infection of Helicobacter pylori in a smaller dose and at a lower administration frequency as compared with conventional remedies.

摘要翻译： 抗菌组合物，其包含（1）由式（I）表示的利福霉素衍生物或其生理学上可接受的盐，和（2）质子泵抑制剂（a）或铋制剂（b），其中组分（1）和（2） 用于产生对幽门螺杆菌的协同效应，含有抗菌组合物的消化器官疾病的药物和补救剂，其制备方法和与抗菌组合物相关的药物制剂。 与常规治疗相比，组合物可以以较小的剂量和较低的施用频率施用于由幽门螺杆菌感染引起的消化系统疾病的患者。