公开(公告)号：US20110152284A1

公开(公告)日：2011-06-23

申请号：US12656182

申请日：2010-01-20

申请人： Tadeusz Wieloch ,  Donna Oksenberg ,  Roman Urfer

发明人： Tadeusz Wieloch ,  Donna Oksenberg ,  Roman Urfer

IPC分类号： A61K31/495 ,  A61K31/438 ,  A61P25/16 ,  A61P25/28

CPC分类号： A61K31/495 ,  A61K9/2018 ,  A61K31/485

摘要： The invention discloses methods and compositions useful for facilitating neuronal regeneration and functional recovery in neurodegenerative diseases. The methods and compositions utilize ligands for the sigma receptor, wherein the ligand is preferable AGY-94806, or salts or solvates thereof. These molecules can be delivered alone or in combination with agents which treat or prevent neurodegenerative diseases such as those caused by ischemic stroke, multiple sclerosis, amyotrophic lateral sclerosis, traumatic brain injury, Huntington's disease, or Parkinson's disease. In other methods, the sigma receptor ligands are administered after stroke to facilitate functional recovery. The administration of the sigma receptor ligands effects functional recovery.

摘要翻译： 本发明公开了用于促进神经退行性疾病中的神经元再生和功能恢复的方法和组合物。 所述方法和组合物利用了σ受体的配体，其中配体优选为AGY-94806，或其盐或溶剂化物。 这些分子可以单独或与治​​疗或预防神经变性疾病如由缺血性卒中，多发性硬化，肌萎缩性侧索硬化，创伤性脑损伤，亨廷顿病或帕金森病引起的疾病的药物组合递送。 在其他方法中，σ受体配体在中风后施用以促进功能恢复。 σ受体配体的施用会影响功能恢复。

公开(公告)号：US20060052386A1

公开(公告)日：2006-03-09

申请号：US11264957

申请日：2005-11-01

申请人： Tadeusz Wieloch ,  Donna Oksenberg ,  Roman Urfer

发明人： Tadeusz Wieloch ,  Donna Oksenberg ,  Roman Urfer

IPC分类号： A61K31/495

CPC分类号： A61K31/495 ,  A61K9/2018 ,  A61K31/485

摘要： The invention discloses methods and compositions useful for facilitating neuronal regeneration and functional recovery in neurodegenerative diseases. The methods and compositions utilize ligands for the sigma receptor, wherein the ligand is preferably AGY-94806, or salts, or solvates thereof. These molecules can be delivered alone or in combination with agents which treat or prevent neurodegenerative diseases such as those caused by ischemic stroke, diabetic peripheral neuropathy, cancer therapy induced neuropathy, multiple sclerosis, amyotrophic lateral sclerosis, traumatic brain injury, spinal cord injury, Huntington's disease or Parkinson's disease. In other methods, the sigma receptor ligands are administered after stroke to facilitate functional recovery. The administration of the sigma receptor ligands effects faster functional recovery.

摘要翻译： 本发明公开了用于促进神经退行性疾病中的神经元再生和功能恢复的方法和组合物。 所述方法和组合物利用了σ受体的配体，其中配体优选为AGY-94806，或其盐或溶剂化物。 这些分子可以单独递送或与治疗或预防神经变性疾病如由缺血性卒中，糖尿病性周围神经病变，癌症治疗诱发的神经病变，多发性硬化，肌萎缩性侧索硬化，创伤性脑损伤，脊髓损伤，亨廷顿舞蹈症 疾病或帕金森病。 在其他方法中，σ受体配体在中风后施用以促进功能恢复。 σ受体配体的施用使功能恢复更快。

公开(公告)号：US20050020483A1

公开(公告)日：2005-01-27

申请号：US10868048

申请日：2004-06-14

申请人： Donna Oksenberg ,  Mattias Rickhag ,  Mehrdad Shamloo ,  Karoly Nikolich ,  Roman Urfer ,  Tadeusz Wieloch

发明人： Donna Oksenberg ,  Mattias Rickhag ,  Mehrdad Shamloo ,  Karoly Nikolich ,  Roman Urfer ,  Tadeusz Wieloch

IPC分类号： A61K31/00 ,  A61K31/195 ,  A61K31/438 ,  A61K31/473 ,  A61K31/485 ,  A61K31/495 ,  A61K38/17 ,  C07D295/096 ,  G06F21/00 ,  H04L29/06

CPC分类号： C07D295/096 ,  A61K31/00 ,  A61K31/438 ,  A61K31/495

摘要： The invention discloses methods and compositions useful for facilitating neuronal regeneration and functional recovery in neurodegenerative diseases. The methods and compositions utilize ligands for the sigma receptors. These molecules can be delivered alone or in combination with agents which treat or prevent neurodegenerative diseases such as those caused by ischemic stroke, diabetic peripheral neuropathy, cancer therapy induced neuropathy, multiple sclerosis, amyotrophic lateral sclerosis, traumatic brain injury, spinal cord injury, Huntington's disease or Parkinson's disease. In other methods, the sigma receptor ligands are administered after stroke to facilitate functional recovery. The administration of the sigma receptor ligands effects faster functional recovery.

摘要翻译： 本发明公开了用于促进神经退行性疾病中的神经元再生和功能恢复的方法和组合物。 该方法和组合物利用了σ受体的配体。 这些分子可以单独递送或与治疗或预防神经变性疾病如由缺血性卒中，糖尿病性周围神经病变，癌症治疗诱发的神经病变，多发性硬化，肌萎缩性侧索硬化，创伤性脑损伤，脊髓损伤，亨廷顿舞蹈症 疾病或帕金森病。 在其他方法中，σ受体配体在中风后施用以促进功能恢复。 σ受体配体的施用使功能恢复更快。

公开(公告)号：US07863272B2

公开(公告)日：2011-01-04

申请号：US10868423

申请日：2004-06-14

申请人： Donna Oksenberg ,  Roman Urfer

发明人： Donna Oksenberg ,  Roman Urfer

IPC分类号： A61K31/50 ,  A01N43/60

CPC分类号： C07D295/096 ,  A61K31/00 ,  A61K31/438 ,  A61K31/495

摘要： The invention discloses methods and compositions useful for facilitating neuronal regeneration and functional recovery in neurodegenerative diseases. The methods and compositions utilize ligands for the sigma receptor, wherein the ligand is preferably SA-4503, or salts, or solvates thereof. These molecules can be delivered alone or in combination with agents which treat or prevent neurodegenerative diseases such as those caused by ischemic stroke, diabetic peripheral neuropathy, cancer therapy induced neuropathy, multiple sclerosis, amyotrophic lateral sclerosis, traumatic brain injury, spinal cord injury, Huntington's disease or Parkinson's disease. In other methods, the sigma receptor ligands are administered after stroke to facilitate functional recovery. The administration of the sigma receptor ligands effects faster functional recovery.

摘要翻译： 本发明公开了用于促进神经退行性疾病中的神经元再生和功能恢复的方法和组合物。 所述方法和组合物利用配体用于σ受体，其中配体优选为SA-4503，或其盐或溶剂化物。 这些分子可以单独递送或与治疗或预防神经变性疾病如由缺血性卒中，糖尿病性周围神经病变，癌症治疗诱发的神经病变，多发性硬化，肌萎缩性侧索硬化，创伤性脑损伤，脊髓损伤，亨廷顿舞蹈症 疾病或帕金森病。 在其他方法中，σ受体配体在中风后施用以促进功能恢复。 σ受体配体的施用使功能恢复更快。

公开(公告)号：US20060014753A1

公开(公告)日：2006-01-19

申请号：US11228694

申请日：2005-09-16

申请人： Mehrdad Shamloo ,  Donna Oksenberg ,  Roman Urfer

发明人： Mehrdad Shamloo ,  Donna Oksenberg ,  Roman Urfer

IPC分类号： A61K31/495

CPC分类号： A61K31/00 ,  A61K31/438 ,  A61K31/495 ,  C07D295/096

摘要： The invention discloses methods and compositions useful for facilitating neuronal regeneration and functional recovery in neurodegenerative diseases. The methods and compositions utilize ligands for the sigma receptor, wherein the ligand is preferably AGY-94806, or salts, or solvates thereof. These molecules can be delivered alone or in combination with agents which treat or prevent neurodegenerative diseases such as those caused by multiple sclerosis. In other methods, the sigma receptor ligands are administered after MS to facilitate functional recovery. The administration of the sigma receptor ligands causes faster functional recovery.

摘要翻译： 本发明公开了用于促进神经退行性疾病中的神经元再生和功能恢复的方法和组合物。 所述方法和组合物利用了σ受体的配体，其中配体优选为AGY-94806，或其盐或溶剂化物。 这些分子可单独递送或与治疗或预防神经变性疾病如由多发性硬化引起的疾病的药物组合递送。 在其他方法中，σ受体配体在MS后施用以促进功能恢复。 σ受体配体的施用导致更快的功能恢复。

公开(公告)号：US20050064385A1

公开(公告)日：2005-03-24

申请号：US10669382

申请日：2003-09-23

申请人： Shu-Gui Huang ,  Donna Oksenberg ,  Roman Urfer

发明人： Shu-Gui Huang ,  Donna Oksenberg ,  Roman Urfer

IPC分类号： C12Q1/00 ,  C12Q1/26 ,  C12Q1/533

CPC分类号： C12Q1/533 ,  C12Q1/26

摘要： Methods for performing an end-point assay of protein disulfide isomerase activity. The method may be based on the enzyme-catalyzed reduction of insulin in the presence of dithiothreitol; measuring the aggregation of reduced insulin chains at 650 nm; and using hydrogen peroxide as a stop reagent.

摘要翻译： 进行蛋白质二硫键异构酶活性终点测定的方法。 该方法可以基于在二硫苏糖醇存在下酶催化的胰岛素还原; 测量650 nm处的胰岛素链减少的聚集; 并使用过氧化氢作为终止试剂。

公开(公告)号：US20110015209A1

公开(公告)日：2011-01-20

申请号：US12923504

申请日：2010-09-24

申请人： Mehrdad Shamloo ,  Donna Oksenberg ,  Roman Urfer

发明人： Mehrdad Shamloo ,  Donna Oksenberg ,  Roman Urfer

IPC分类号： A61K31/495 ,  A61P25/00

CPC分类号： A61K31/00 ,  A61K31/438 ,  A61K31/495 ,  C07D295/096

摘要： The invention discloses methods and compositions useful for facilitating neuronal regeneration and functional recovery in neurodegenerative diseases. The methods and compositions utilize ligands for the sigma receptor, wherein the ligand is preferably AGY-94806, or salts, or solvates thereof. These molecules can be delivered alone or in combination with agents which treat or prevent neurodegenerative diseases such as those caused by multiple sclerosis. In other methods, the sigma receptor ligands are administered after MS to facilitate functional recovery. The administration of the sigma receptor ligands causes fasted functional recovery.

摘要翻译： 本发明公开了用于促进神经退行性疾病中的神经元再生和功能恢复的方法和组合物。 所述方法和组合物利用了σ受体的配体，其中配体优选为AGY-94806，或其盐或溶剂化物。 这些分子可单独递送或与治疗或预防神经变性疾病如由多发性硬化引起的疾病的药物组合递送。 在其他方法中，σ受体配体在MS后施用以促进功能恢复。 σ受体配体的施用引起禁食功能恢复。

公开(公告)号：US07829562B2

公开(公告)日：2010-11-09

申请号：US11228694

申请日：2005-09-16

申请人： Mehrdad Shamloo ,  Donna Oksenberg ,  Roman Urfer

发明人： Mehrdad Shamloo ,  Donna Oksenberg ,  Roman Urfer

IPC分类号： A61K31/50 ,  A01N43/60

CPC分类号： A61K31/00 ,  A61K31/438 ,  A61K31/495 ,  C07D295/096

摘要： The invention discloses methods and compositions useful for facilitating neuronal regeneration and functional recovery in neurodegenerative diseases. The methods and compositions utilize ligands for the sigma receptor, wherein the ligand is preferably AGY-94806, or salts, or solvates thereof. These molecules can be delivered alone or in combination with agents which treat or prevent neurodegenerative diseases such as those caused by multiple sclerosis. In other methods, the sigma receptor ligands are administered after MS to facilitate functional recovery. The administration of the sigma receptor ligands causes faster functional recovery.

摘要翻译： 本发明公开了用于促进神经退行性疾病中的神经元再生和功能恢复的方法和组合物。 所述方法和组合物利用了σ受体的配体，其中配体优选为AGY-94806，或其盐或溶剂化物。 这些分子可单独递送或与治疗或预防神经变性疾病如由多发性硬化引起的疾病的药物组合递送。 在其他方法中，σ受体配体在MS后施用以促进功能恢复。 σ受体配体的施用导致更快的功能恢复。

公开(公告)号：US20110082154A1

公开(公告)日：2011-04-07

申请号：US12926594

申请日：2010-11-29

申请人： Donna Oksenberg ,  Roman Urfer

发明人： Donna Oksenberg ,  Roman Urfer

IPC分类号： A61K31/495 ,  A61P25/28 ,  A61P25/00

CPC分类号： C07D295/096 ,  A61K31/00 ,  A61K31/438 ,  A61K31/495

摘要： The invention discloses methods and compositions useful for facilitating neuronal regeneration and functional recovery in neurodegenerative diseases. The methods and compositions utilize ligands for the sigma receptor, wherein the ligand is preferably SA-4503, or salts, or solvates thereof. These molecules can be delivered alone or in combination with agents which treat or prevent neurodegenerative diseases such as those caused by ischemic stroke, diabetic peripheral neuropathy, cancer therapy induced neuropathy, multiple sclerosis, amyotrophic lateral sclerosis, traumatic brain injury, spinal cord injury, Huntington's disease or Parkinson's disease. In other methods, the sigma receptor ligands are administered after stroke to facilitate functional recovery. The administration of the sigma receptor ligands effects faster functional recovery.

公开(公告)号：US06977142B2

公开(公告)日：2005-12-20

申请号：US10669382

申请日：2003-09-23

申请人： Shu-Gui Huang ,  Donna Oksenberg ,  Roman Urfer

发明人： Shu-Gui Huang ,  Donna Oksenberg ,  Roman Urfer

IPC分类号： C12Q1/00 ,  C12Q1/26 ,  C12Q1/533

CPC分类号： C12Q1/533 ,  C12Q1/26

摘要： Methods for performing an end-point assay of protein disulfide isomerase activity. The method may be based on the enzyme-catalyzed reduction of insulin in the presence of dithiothreitol; measuring the aggregation of reduced insulin chains at 650 nm; and using hydrogen peroxide as a stop reagent.