公开(公告)号：US20050020483A1

公开(公告)日：2005-01-27

申请号：US10868048

申请日：2004-06-14

申请人： Donna Oksenberg ,  Mattias Rickhag ,  Mehrdad Shamloo ,  Karoly Nikolich ,  Roman Urfer ,  Tadeusz Wieloch

发明人： Donna Oksenberg ,  Mattias Rickhag ,  Mehrdad Shamloo ,  Karoly Nikolich ,  Roman Urfer ,  Tadeusz Wieloch

IPC分类号： A61K31/00 ,  A61K31/195 ,  A61K31/438 ,  A61K31/473 ,  A61K31/485 ,  A61K31/495 ,  A61K38/17 ,  C07D295/096 ,  G06F21/00 ,  H04L29/06

CPC分类号： C07D295/096 ,  A61K31/00 ,  A61K31/438 ,  A61K31/495

摘要： The invention discloses methods and compositions useful for facilitating neuronal regeneration and functional recovery in neurodegenerative diseases. The methods and compositions utilize ligands for the sigma receptors. These molecules can be delivered alone or in combination with agents which treat or prevent neurodegenerative diseases such as those caused by ischemic stroke, diabetic peripheral neuropathy, cancer therapy induced neuropathy, multiple sclerosis, amyotrophic lateral sclerosis, traumatic brain injury, spinal cord injury, Huntington's disease or Parkinson's disease. In other methods, the sigma receptor ligands are administered after stroke to facilitate functional recovery. The administration of the sigma receptor ligands effects faster functional recovery.

摘要翻译： 本发明公开了用于促进神经退行性疾病中的神经元再生和功能恢复的方法和组合物。 该方法和组合物利用了σ受体的配体。 这些分子可以单独递送或与治疗或预防神经变性疾病如由缺血性卒中，糖尿病性周围神经病变，癌症治疗诱发的神经病变，多发性硬化，肌萎缩性侧索硬化，创伤性脑损伤，脊髓损伤，亨廷顿舞蹈症 疾病或帕金森病。 在其他方法中，σ受体配体在中风后施用以促进功能恢复。 σ受体配体的施用使功能恢复更快。

公开(公告)号：US20110152284A1

公开(公告)日：2011-06-23

申请号：US12656182

申请日：2010-01-20

申请人： Tadeusz Wieloch ,  Donna Oksenberg ,  Roman Urfer

发明人： Tadeusz Wieloch ,  Donna Oksenberg ,  Roman Urfer

IPC分类号： A61K31/495 ,  A61K31/438 ,  A61P25/16 ,  A61P25/28

CPC分类号： A61K31/495 ,  A61K9/2018 ,  A61K31/485

摘要： The invention discloses methods and compositions useful for facilitating neuronal regeneration and functional recovery in neurodegenerative diseases. The methods and compositions utilize ligands for the sigma receptor, wherein the ligand is preferable AGY-94806, or salts or solvates thereof. These molecules can be delivered alone or in combination with agents which treat or prevent neurodegenerative diseases such as those caused by ischemic stroke, multiple sclerosis, amyotrophic lateral sclerosis, traumatic brain injury, Huntington's disease, or Parkinson's disease. In other methods, the sigma receptor ligands are administered after stroke to facilitate functional recovery. The administration of the sigma receptor ligands effects functional recovery.

摘要翻译： 本发明公开了用于促进神经退行性疾病中的神经元再生和功能恢复的方法和组合物。 所述方法和组合物利用了σ受体的配体，其中配体优选为AGY-94806，或其盐或溶剂化物。 这些分子可以单独或与治​​疗或预防神经变性疾病如由缺血性卒中，多发性硬化，肌萎缩性侧索硬化，创伤性脑损伤，亨廷顿病或帕金森病引起的疾病的药物组合递送。 在其他方法中，σ受体配体在中风后施用以促进功能恢复。 σ受体配体的施用会影响功能恢复。

公开(公告)号：US20060052386A1

公开(公告)日：2006-03-09

申请号：US11264957

申请日：2005-11-01

申请人： Tadeusz Wieloch ,  Donna Oksenberg ,  Roman Urfer

发明人： Tadeusz Wieloch ,  Donna Oksenberg ,  Roman Urfer

IPC分类号： A61K31/495

CPC分类号： A61K31/495 ,  A61K9/2018 ,  A61K31/485

摘要： The invention discloses methods and compositions useful for facilitating neuronal regeneration and functional recovery in neurodegenerative diseases. The methods and compositions utilize ligands for the sigma receptor, wherein the ligand is preferably AGY-94806, or salts, or solvates thereof. These molecules can be delivered alone or in combination with agents which treat or prevent neurodegenerative diseases such as those caused by ischemic stroke, diabetic peripheral neuropathy, cancer therapy induced neuropathy, multiple sclerosis, amyotrophic lateral sclerosis, traumatic brain injury, spinal cord injury, Huntington's disease or Parkinson's disease. In other methods, the sigma receptor ligands are administered after stroke to facilitate functional recovery. The administration of the sigma receptor ligands effects faster functional recovery.

摘要翻译： 本发明公开了用于促进神经退行性疾病中的神经元再生和功能恢复的方法和组合物。 所述方法和组合物利用了σ受体的配体，其中配体优选为AGY-94806，或其盐或溶剂化物。 这些分子可以单独递送或与治疗或预防神经变性疾病如由缺血性卒中，糖尿病性周围神经病变，癌症治疗诱发的神经病变，多发性硬化，肌萎缩性侧索硬化，创伤性脑损伤，脊髓损伤，亨廷顿舞蹈症 疾病或帕金森病。 在其他方法中，σ受体配体在中风后施用以促进功能恢复。 σ受体配体的施用使功能恢复更快。

公开(公告)号：US06670138B2

公开(公告)日：2003-12-30

申请号：US10001051

申请日：2001-10-31

申请人： Mirella Gonzalez-Zulueta ,  Mehrdad Shamloo ,  K.C. McFarland ,  Daniel Chin ,  Tadeusz Wieloch ,  Thorsten Melcher

发明人： Mirella Gonzalez-Zulueta ,  Mehrdad Shamloo ,  K.C. McFarland ,  Daniel Chin ,  Tadeusz Wieloch ,  Thorsten Melcher

IPC分类号： C12Q170

CPC分类号： C12Q1/6883 ,  C12Q2600/158

摘要： The present invention identifies a gene whose gene product provides a protective effect against neurological disorders or neuronal injuries. Further, the invention provides methods for diagnosing or assessing an individual's susceptibility to a neuronal injury such as stroke. Also provided are therapeutic methods for treating patients, and methods for prophylactically treating individuals susceptible to various neurological disorders or neuronal injuries. Additionally, the invention describes screening methods for identifying agents that can be administered to treat individuals that have suffered or are at risk to suffer such disorders or injuries.

摘要翻译： 本发明鉴定其基因产物对神经系统疾病或神经元损伤具有保护作用的基因。 此外，本发明提供了用于诊断或评估个体对诸如中风的神经元损伤的易感性的方法。 还提供了用于治疗患者的治疗方法，以及用于预防性治疗对各种神经障碍或神经元损伤敏感的个体的方法。 另外，本发明描述了用于鉴定可以被施用以治疗遭受或有遭受这种障碍或损伤风险的个体的药剂的筛选方法。

公开(公告)号：US20060052854A1

公开(公告)日：2006-03-09

申请号：US10502574

申请日：2003-02-05

申请人： Mats Allers ,  Anders Lunderquist ,  Fredrik Boris-Moller ,  Tadeusz Wieloch

发明人： Mats Allers ,  Anders Lunderquist ,  Fredrik Boris-Moller ,  Tadeusz Wieloch

IPC分类号： A61F7/00 ,  A61F7/12

CPC分类号： A61M1/369 ,  A61M1/1698 ,  A61M2205/3606

摘要： The present invention relates to a method and equipment for controlling the temperature of the brain or brain hemisphere. More specifically the present invention refers to a method and equipment for quick and efficient control of the temperature of the brain and for maintaining a low temperature in the brain. The inventive concept can be divided into three phases. Firstly, an emergency whole body temperature control phase providing a quick temperature control at for example a scene of accident. Secondly, a brain-selective temperature control phase providing a more efficient temperature control at for example an emergency room and thirdly, a maintained temperature control phase providing an even more efficient temperature control for a selected period of time.

公开(公告)号：US06846641B2

公开(公告)日：2005-01-25

申请号：US10131731

申请日：2002-04-23

申请人： Tadeusz Wieloch ,  Anna Rytter ,  Tobias Cronberg

发明人： Tadeusz Wieloch ,  Anna Rytter ,  Tobias Cronberg

IPC分类号： C12N5/02 ,  C12N5/08 ,  G01N33/50 ,  G01N37/00 ,  C12N5/00

CPC分类号： G01N33/5058 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5088 ,  G01N2510/00

摘要： A tissue culture model of oxygen/glucose deprivation induced cell death is provided, which is useful in the analysis of the mechanisms of cell death following brain ischemia, and for screening anti-ischemic drugs. By adopting the in vivo concentrations of calcium, potassium and hydrogen ions to the incubation medium a model is established that shows conspicuous similarities with the temporal and special development of cell death in vivo: selective and delayed CA1 damage, a damage mitigated by blockade of the NMDA and AMPA receptors, and a striking augmentation of damage by high levels of glucose.

摘要翻译： 提供氧/葡萄糖剥夺诱导的细胞死亡的组织培养模型，其可用于脑缺血后细胞死亡机制的分析和用于筛选抗缺血药物。 通过将体内浓度的钙，钾和氢离子应用于培养基中，建立了与体内细胞死亡的时间和特殊发展显着相似的模型：选择性和延迟CA1损伤，通过阻断 NMDA和AMPA受体，以及高水平葡萄糖引起的惊人的损伤增加。