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    Hybrid of itraconazole, cyclosporine or carvedilol with a layered silicate and a process for preparing the same
    1.
    发明申请
    Hybrid of itraconazole, cyclosporine or carvedilol with a layered silicate and a process for preparing the same 审中-公开
    伊曲康唑，环孢素或卡维地洛与层状硅酸盐的混合物及其制备方法

    公开(公告)号：US20060013877A1

    公开(公告)日：2006-01-19

    申请号：US10522230

    申请日：2003-07-22

    申请人： Taeun Park ,  Hyun Jung ,  Hyun Kim ,  Jin Choy ,  Chi Lee

    发明人： Taeun Park ,  Hyun Jung ,  Hyun Kim ,  Jin Choy ,  Chi Lee

    IPC分类号： A61K9/14 ,  A61K38/13 ,  A61K31/496 ,  A61K31/403

    CPC分类号： A61K31/403 ,  A61K9/143 ,  A61K31/496 ,  A61K38/13

    摘要： The present invention provides the hybrids wherein itraconazole, cyclosporine or carvedilol are intercalated into the interlayers and/or absorbed onto the surfaces of layered silicates. The hybrids according to the present invention enable the maximization of bioavailability of drugs by dissolving the drugs from the layered silicates. Furthermore, the present invention provides the preparing methods of the hybrids. The process comprises: (1) dispersing a layered silicate in an aqueous solution to form an aqueous solution containing the layered silicate; (2) dissolving a drug in a organic solvent to form an organic solution containing the drug, the organic solvent having a solubility higher than that in the aqueous solution; and (3) mixing and hybridizing in the inerrface of the aqueous solution containing the layered silicate and the organic phase solution containing the drug in order to intercalate the drug into the interlayers of the layered silicate and/or to absorb the drug onto the surface of the layered silicate.

    摘要翻译： 本发明提供了伊曲康唑，环孢菌素或卡维地洛插入中间层和/或吸收到层状硅酸盐表面上的杂交体。 根据本发明的杂交体能够通过从层状硅酸盐中溶解药物使药物的生物利用度最大化。 此外，本发明提供了杂种的制备方法。 该方法包括：（1）将层状硅酸盐分散在水溶液中以形成含有层状硅酸盐的水溶液; （2）将药物溶解在有机溶剂中以形成含有药物的有机溶液，所述有机溶剂的溶解度高于所述水溶液中的溶解度; 和（3）在含有层状硅酸盐的水溶液和含有药物的有机相溶液的表面中混合和杂交，以将药物插入层状硅酸盐的夹层中和/或将药物吸收到 层状硅酸盐。

    INFORMATION INPUT SYSTEM AND METHOD USING EXTENSION KEY
    2.
    发明申请
    INFORMATION INPUT SYSTEM AND METHOD USING EXTENSION KEY 审中-公开
    信息输入系统和使用扩展键的方法

    公开(公告)号：US20120149477A1

    公开(公告)日：2012-06-14

    申请号：US13391875

    申请日：2010-08-23

    申请人： Taeun Park ,  Sangjung Shim ,  Hee-Myong Ro ,  Eun-Soo Park ,  Minsub Shim

    发明人： Taeun Park ,  Sangjung Shim ,  Hee-Myong Ro ,  Eun-Soo Park ,  Minsub Shim

    IPC分类号： A63F9/24 ,  G06F3/041 ,  G06F3/02

    CPC分类号： G06F3/0219 ,  G06F3/018 ,  G06F3/0202 ,  G06F3/0236 ,  G06F3/0237 ,  G06F3/04883 ,  G06F3/04886 ,  H04M1/23 ,  H04M2250/22 ,  H04M2250/70

    摘要： The present invention relates to an information input system and method using an extension key. The information input system comprises: an input unit including a plurality of divided regions, for detecting a user selected divided region among the plurality of divided regions; and an input analysis unit for allocating corresponding information to the plurality of divided regions, and analyzing, if the input unit detects a user selected divided region among the plurality of divided regions, whether or not information allocated to the divided region is input. The input analysis unit allocates an extension key to at least one divided region out of the plurality of divided regions; and once the extension key is selected, the input analysis unit allocates new information to an extended region which is a divided region determined according to the extension key.

    摘要翻译： 本发明涉及使用扩展密钥的信息输入系统和方法。 信息输入系统包括：输入单元，包括多个分割区域，用于检测多个分割区域中的用户选择的分割区域; 以及输入分析单元，用于将对应的信息分配给所述多个分割区域，并且如果所述输入单元检测到所述多个分割区域中的用户选择的分割区域，则分析是否输入了分配给所述分割区域的信息。 输入分析单元将分机密钥分配给多个分割区域中的至少一个分割区域; 并且一旦选择了扩展密钥，则输入分析单元将新信息分配给作为根据扩展密钥确定的划分区域的扩展区域。

    Base Forming Drug-Layered Silicate Hybrid Containing Basic Polymer and its Synthesis Method
    4.
    发明申请
    Base Forming Drug-Layered Silicate Hybrid Containing Basic Polymer and its Synthesis Method 审中-公开
    含有碱性聚合物的基底成型药物层状硅酸盐混合物及其合成方法

    公开(公告)号：US20080119519A1

    公开(公告)日：2008-05-22

    申请号：US11816756

    申请日：2006-02-21

    申请人： Jin-Ho Choy ,  Taeun Park ,  Yoon-joo Lee ,  Dong-Youn Kim ,  Jin-Kuen Park

    发明人： Jin-Ho Choy ,  Taeun Park ,  Yoon-joo Lee ,  Dong-Youn Kim ,  Jin-Kuen Park

    IPC分类号： A61K47/48 ,  A61K31/4525 ,  A61K31/451

    CPC分类号： A61K31/4525 ,  A61K9/1611 ,  A61K9/1635 ,  A61K31/137 ,  A61K31/445

    摘要： Provided are a hybrid of a poorly soluble basic drug and a layered silicate, including a water-soluble basic polymer, and a method of preparing the same. The water-soluble basic polymer may be an aminoalkylmethacrylate copolymer (e.g., Eudragit E 100: a copolymer composed of 1:2:1 ratio of butyl methacrylate, (2,2-dimethylaminoethyl)methacrylate, and methyl methacrylate, Degussa) or polyvinylacetal diethylaminoacetate (AEA). In an oral formulation including the hybrid, a short-term dissolution of the poorly soluble drug can be increased to 90%, thereby increasing drug bioavailability.

    摘要翻译： 提供了一种难溶性碱性药物和层状硅酸盐，包括水溶性碱性聚合物的混合物及其制备方法。 水溶性碱性聚合物可以是甲基丙烯酸氨基烷基酯共聚物（例如，Eudragit E 100：由甲基丙烯酸丁酯，（2,2-二甲基氨基乙基）甲基丙烯酸酯和甲基丙烯酸甲酯，Degussa的比例为1:2:1的聚合物）或聚乙烯醇缩二乙基氨基乙酸酯 （AEA）。 在包含杂交体的口服制剂中，难溶性药物的短期溶解可以提高到90％，从而提高药物生物利用度。

    Injectable drug carrier comprising layered double hydroxide
    5.
    发明授权
    Injectable drug carrier comprising layered double hydroxide 有权
    包含层状双氢氧化物的可注射药物载体

    公开(公告)号：US09017719B2

    公开(公告)日：2015-04-28

    申请号：US13541413

    申请日：2012-07-03

    申请人： Taeun Park ,  Jin-Ho Choy ,  Jae-Min Oh ,  Ji-Sun Jung

    发明人： Taeun Park ,  Jin-Ho Choy ,  Jae-Min Oh ,  Ji-Sun Jung

    IPC分类号： A61K9/127 ,  A61K9/00 ,  A61K9/14 ,  A61K47/02

    CPC分类号： A61K9/0019 ,  A61K9/143 ,  A61K47/02

    摘要： Provided is an injectable drug carrier including a non-toxic Layered Double Hydroxide (LDH) and pharmaceutically acceptable excipients. Provided is also a method of preparing the injectable drug carrier, the method including: synthesizing LDH with various compositions and controlling the size and shape of the LDH at a level that the LDH has no adverse effect in vivo. A solution obtained by dispersing the LDH in a solvent is injected in vivo. According to the method, nano-size LDH that does not affect a blood vessel in vivo can be synthesized. The LDH thus synthesized has no adverse effect in vivo even at a concentration of 400 mg/kg, and thus can contribute to establishment of a drug delivery system capable of improving the delivery efficiency of a specific drug.

    摘要翻译： 提供了包含无毒层状双氢氧化物（LDH）和药学上可接受的赋形剂的可注射药物载体。 还提供了一种制备可注射药物载体的方法，该方法包括：以各种组成合成LDH，并以LDH在体内没有不利影响的水平控制LDH的大小和形状。 将LDH分散在溶剂中得到的溶液体内注射。 根据该方法，可以合成不影响体内血管的纳米级LDH。 如此合成的LDH即使在400mg / kg的浓度下也不会在体内产生不利影响，因此有助于建立能够提高特定药物的输送效率的药物输送系统。

    Virtual Keyboard Input System Using Pointing Apparatus In Digital Device
    6.
    发明申请
    Virtual Keyboard Input System Using Pointing Apparatus In Digital Device 审中-公开
    使用数字设备中的指点设备的虚拟键盘输入系统

    公开(公告)号：US20100103127A1

    公开(公告)日：2010-04-29

    申请号：US12546393

    申请日：2009-08-24

    申请人： Taeun Park ,  Sangjung Shim

    发明人： Taeun Park ,  Sangjung Shim

    IPC分类号： G06F3/041

    CPC分类号： G06F3/04886 ,  G06F1/1624 ,  G06F3/03547 ,  G06F3/0414

    摘要： A virtual keyboard input system using a pointing device in a digital device. The virtual keyboard input system includes: a sensor unit sensing a contact and a two-dimensional contact position; a switch unit; and a control unit dividing a contact sensitive region of the sensor unit into multiple division regions according to XY coordinates, assigning virtual keys of a virtual keyboard to the division regions, and when the switch unit is turned on, controlling an input of information for a virtual key assigned to a division region which is contacted among the division regions.

    摘要翻译： 在数字设备中使用指点设备的虚拟键盘输入系统。 虚拟键盘输入系统包括：感测触点和二维接触位置的传感器单元; 开关单元; 以及控制单元，其根据XY坐标将所述传感器单元的接触敏感区域划分为多个分割区域，将虚拟键盘的虚拟键分配给所述划分区域，并且当所述开关单元被接通时，控制所述信息输入 分配给分割区域之间的分割区域的虚拟键。

    INJECTABLE DRUG CARRIER COMPRISING LAYERED DOUBLE HYDROXIDE
    7.
    发明申请
    INJECTABLE DRUG CARRIER COMPRISING LAYERED DOUBLE HYDROXIDE 审中-公开
    包含层状双氢氧化物的注射式药物载体

    公开(公告)号：US20100047307A1

    公开(公告)日：2010-02-25

    申请号：US11915922

    申请日：2005-06-03

    申请人： Taeun Park ,  Jin-ho Choy ,  Jae-Min Oh ,  Ji-Sun Jung

    发明人： Taeun Park ,  Jin-ho Choy ,  Jae-Min Oh ,  Ji-Sun Jung

    IPC分类号： A61K9/14 ,  A61K31/519 ,  A61P35/00 ,  A61P37/02

    CPC分类号： A61K9/0019 ,  A61K9/143 ,  A61K47/02

    摘要： Provided is an injectable drug carrier including a non-toxic Layered Double Hydroxide (LDH) and pharmaceutically acceptable excipients. Provided is also a method of preparing the injectable drug carrier, the method including: synthesizing LDH with various compositions and controlling the size and shape of the LDH at a level that the LDH has no adverse effect in vivo. A solution obtained by dispersing the LDH in a solvent is injected in vivo. According to the method, nano-size LDH that does not affect a blood vessel in vivo can be synthesized. The LDH thus synthesized has no adverse effect in vivo even at a concentration of 400 mg/kg, and thus can contribute to establishment of a drug delivery system capable of improving the delivery efficiency of a specific drug.

    摘要翻译： 提供了包含无毒层状双氢氧化物（LDH）和药学上可接受的赋形剂的可注射药物载体。 还提供了一种制备可注射药物载体的方法，该方法包括：以各种组成合成LDH，并以LDH在体内没有不利影响的水平控制LDH的大小和形状。 将LDH分散在溶剂中得到的溶液体内注射。 根据该方法，可以合成不影响体内血管的纳米级LDH。 如此合成的LDH即使在400mg / kg的浓度下也不会在体内产生不利影响，因此有助于建立能够提高特定药物的输送效率的药物输送系统。