公开(公告)号：US07812160B2

公开(公告)日：2010-10-12

申请号：US10554668

申请日：2004-04-14

申请人： Tai-wei Ly ,  Yuji Koriyama ,  Takashi Yoshino ,  Hiroki Sato ,  Kazuho Tanaka ,  Hiromi Sugimoto ,  Yoshihisa Manabe ,  Kevin Bacon ,  Klaus Urbahns ,  Masanori Seki ,  Takuya Shintani

发明人： Tai-wei Ly ,  Yuji Koriyama ,  Takashi Yoshino ,  Hiroki Sato ,  Kazuho Tanaka ,  Hiromi Sugimoto ,  Yoshihisa Manabe ,  Kevin Bacon ,  Klaus Urbahns ,  Masanori Seki ,  Takuya Shintani

IPC分类号： C07D239/42 ,  C07D239/34 ,  C07D239/48 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D407/12 ,  A61K31/505 ,  A61K31/506 ,  A61P11/06

CPC分类号： C07D239/42 ,  C07D239/30 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12

摘要： The present invention relates to a pyrimidine derivative of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.

摘要翻译： 本发明涉及式（I）的嘧啶衍生物及其盐，其可用作药物制剂的活性成分。 本发明的嘧啶衍生物具有优异的CRTH2（G蛋白偶联化学引诱物受体，在Th2细胞上表达）拮抗活性，可用于预防和治疗与CRTH2活性相关的疾病，特别是用于治疗过敏性疾病 ，如哮喘，过敏性鼻炎，特应性皮炎和过敏性结膜炎; 嗜酸性粒细胞相关疾病，如中华综合征和鼻窦炎; 嗜碱性粒细胞相关疾病，如嗜碱性白血病，慢性荨麻疹和人类和其他哺乳动物的嗜碱性白细胞增多症; 以T淋巴细胞为特征的炎性疾病和白血球浸润如银屑病，湿疹，炎性肠病，溃疡性结肠炎，克罗恩病，COPD（慢性阻塞性肺病）和关节炎等。

公开(公告)号：US20070129355A1

公开(公告)日：2007-06-07

申请号：US10554668

申请日：2004-04-14

申请人： Tai-wei Ly ,  Yuji Koriyama ,  Takashi Yoshino ,  Hiroki Sato ,  Kazuho Tanaka ,  Hiromi Sugimoto ,  Yoshihisa Manabe ,  Kevin Bacon ,  Klaus Urbahns ,  Masanori Seki ,  Takuya Shintani

发明人： Tai-wei Ly ,  Yuji Koriyama ,  Takashi Yoshino ,  Hiroki Sato ,  Kazuho Tanaka ,  Hiromi Sugimoto ,  Yoshihisa Manabe ,  Kevin Bacon ,  Klaus Urbahns ,  Masanori Seki ,  Takuya Shintani

IPC分类号： A61K31/541 ,  A61K31/5377 ,  A61K31/506 ,  C07D417/02 ,  C07D413/02 ,  C07D403/02

CPC分类号： C07D239/42 ,  C07D239/30 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12

摘要： The present invention relates to a pyrimidine derivative of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.

摘要翻译： 本发明涉及式（I）的嘧啶衍生物及其盐，其可用作药物制剂的活性成分。 本发明的嘧啶衍生物具有优异的CRTH2（G蛋白偶联化学引诱物受体，在Th2细胞上表达）拮抗活性，可用于预防和治疗与CRTH2活性相关的疾病，特别是用于治疗过敏性疾病 ，如哮喘，过敏性鼻炎，特应性皮炎和过敏性结膜炎; 嗜酸性粒细胞相关疾病，如中华综合征和鼻窦炎; 嗜碱性粒细胞相关疾病，如嗜碱性白血病，慢性荨麻疹和人类和其他哺乳动物的嗜碱性白细胞增多症; 以T淋巴细胞为特征的炎性疾病和白血球浸润如银屑病，湿疹，炎性肠病，溃疡性结肠炎，克罗恩病，COPD（慢性阻塞性肺病）和关节炎等。

公开(公告)号：US20100322980A1

公开(公告)日：2010-12-23

申请号：US12868663

申请日：2010-08-25

申请人： Tai-wei Ly ,  Yuji Koriyama ,  Takashi Yoshino ,  Hiroki Sato ,  Kazuho Tanaka ,  Hiromi Sugimoto ,  Yoshihisa Manabe ,  Kevin Bacon ,  Klaus Urbahns ,  Masanori Seki ,  Takuya Shintani

发明人： Tai-wei Ly ,  Yuji Koriyama ,  Takashi Yoshino ,  Hiroki Sato ,  Kazuho Tanaka ,  Hiromi Sugimoto ,  Yoshihisa Manabe ,  Kevin Bacon ,  Klaus Urbahns ,  Masanori Seki ,  Takuya Shintani

IPC分类号： A61K9/00 ,  A61K31/505 ,  A61K31/5377 ,  A61K31/506

CPC分类号： C07D239/42 ,  C07D239/30 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12

摘要： The present invention relates to a pyrimidine derivative of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.

摘要翻译： 本发明涉及式（I）的嘧啶衍生物及其盐，其可用作药物制剂的活性成分。 本发明的嘧啶衍生物具有优异的CRTH2（G蛋白偶联化学引诱物受体，在Th2细胞上表达）拮抗活性，可用于预防和治疗与CRTH2活性相关的疾病，特别是用于治疗过敏性疾病 ，如哮喘，过敏性鼻炎，特应性皮炎和过敏性结膜炎; 嗜酸性粒细胞相关疾病，如中华综合征和鼻窦炎; 嗜碱性粒细胞相关疾病，如嗜碱性白血病，慢性荨麻疹和人类和其他哺乳动物的嗜碱性白细胞增多症; 以T淋巴细胞为特征的炎性疾病和白血球浸润如银屑病，湿疹，炎性肠病，溃疡性结肠炎，克罗恩病，COPD（慢性阻塞性肺病）和关节炎等。

公开(公告)号：US07960393B2

公开(公告)日：2011-06-14

申请号：US12868663

申请日：2010-08-25

申请人： Tai-wei Ly ,  Yuji Koriyama ,  Takashi Yoshino ,  Hiroki Sato ,  Kazuho Tanaka ,  Hiromi Sugimoto ,  Yoshihisa Manabe ,  Kevin Bacon ,  Klaus Urbahns ,  Masanori Seki ,  Takuya Shintani

发明人： Tai-wei Ly ,  Yuji Koriyama ,  Takashi Yoshino ,  Hiroki Sato ,  Kazuho Tanaka ,  Hiromi Sugimoto ,  Yoshihisa Manabe ,  Kevin Bacon ,  Klaus Urbahns ,  Masanori Seki ,  Takuya Shintani

IPC分类号： A61K31/505 ,  A61K31/506 ,  A61P11/06 ,  C07D239/34 ,  C07D239/42 ,  C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D407/12

CPC分类号： C07D239/42 ,  C07D239/30 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12

摘要： The present invention relates to a pyrimidine derivative of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.

摘要翻译： 本发明涉及式（I）的嘧啶衍生物及其盐，其可用作药物制剂的活性成分。 本发明的嘧啶衍生物具有优异的CRTH2（G蛋白偶联化学引诱物受体，在Th2细胞上表达）拮抗活性，可用于预防和治疗与CRTH2活性相关的疾病，特别是用于治疗过敏性疾病 ，如哮喘，过敏性鼻炎，特应性皮炎和过敏性结膜炎; 嗜酸性粒细胞相关疾病，如中华综合征和鼻窦炎; 嗜碱性粒细胞相关疾病，如嗜碱性白血病，慢性荨麻疹和人类和其他哺乳动物的嗜碱性白细胞增多症; 以T淋巴细胞为特征的炎性疾病和白血球浸润如银屑病，湿疹，炎性肠病，溃疡性结肠炎，克罗恩病，COPD（慢性阻塞性肺病）和关节炎等。

公开(公告)号：US07750014B2

公开(公告)日：2010-07-06

申请号：US10585429

申请日：2005-01-19

申请人： Tai-Wei Ly ,  Takashi Yoshino ,  Yuki Takekawa ,  Takuya Shintani ,  Hiromi Sugimoto ,  Kevin Bacon ,  Klaus Urbahns

发明人： Tai-Wei Ly ,  Takashi Yoshino ,  Yuki Takekawa ,  Takuya Shintani ,  Hiromi Sugimoto ,  Kevin Bacon ,  Klaus Urbahns

IPC分类号： A01N43/90 ,  A61K31/519 ,  C07D487/00

CPC分类号： C07D487/04

摘要： The present invention relates to an imidazo[1,2-c]pyrimidinylacetic acid derivative and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The imidazo[1,2-c]pyrimidinylacetic acid derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.

摘要翻译： 本发明涉及可用作药物制剂活性成分的咪唑并[1,2-c]嘧啶基乙酸衍生物及其盐。 本发明的咪唑并[1,2-c]嘧啶基乙酸衍生物具有优异的CRTH2（G蛋白偶联化学引诱物受体，在Th2细胞上表达）拮抗活性，可用于预防和治疗与CRTH2活性相关的疾病 特别是用于治疗过敏性疾病如哮喘，过敏性鼻炎，特应性皮炎和过敏性结膜炎; 嗜酸性粒细胞相关疾病，如中华综合征和鼻窦炎; 嗜碱性粒细胞相关疾病，如嗜碱性白血病，慢性荨麻疹和人类和其他哺乳动物的嗜碱性白细胞增多症; 以T淋巴细胞为特征的炎性疾病和白血球浸润如银屑病，湿疹，炎性肠病，溃疡性结肠炎，克罗恩病，COPD（慢性阻塞性肺病）和关节炎等。

公开(公告)号：US20090012102A1

公开(公告)日：2009-01-08

申请号：US10585429

申请日：2005-01-19

申请人： Tai-wei Ly ,  Takashi Yoshino ,  Yuki Takekawa ,  Takuya Shintani ,  Hiromi Sugimoto ,  Kevin Bacon ,  Klaus Urbahns

发明人： Tai-wei Ly ,  Takashi Yoshino ,  Yuki Takekawa ,  Takuya Shintani ,  Hiromi Sugimoto ,  Kevin Bacon ,  Klaus Urbahns

IPC分类号： A61K31/519 ,  C07D487/04 ,  A61P11/06 ,  A61P37/08 ,  A61P35/00

CPC分类号： C07D487/04

摘要： The present invention relates to an imidazo[1,2-c]pyrimidinylacetic acid derivative and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The imidazo[1,2-c]pyrimidinylacetic acid derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattractant receptor, expressed on Th2 cells) antagonistic activity and can be used for the prophylaxis and treatment of diseases associated with CRTH2 activity, in particular for the treatment of allergic diseases, such as asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis; eosinophil-related diseases, such as Churg-Strauss syndrome and sinusitis; basophil-related diseases, such as basophilic leukemia, chronic urticaria and basophilic leukocytosis in human and other mammals; and inflammatory diseases characterized by T lymphocytes and profuse leukocyte infiltrates such as psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohn's disease, COPD (chronic obstructive pulmonary disorder) and arthritis.

摘要翻译： 本发明涉及可用作药物制剂活性成分的咪唑并[1,2-c]嘧啶基乙酸衍生物及其盐。 本发明的咪唑并[1,2-c]嘧啶基乙酸衍生物具有优异的CRTH2（G蛋白偶联化学引诱物受体，在Th2细胞上表达）拮抗活性，可用于预防和治疗与CRTH2活性相关的疾病 特别是用于治疗过敏性疾病如哮喘，过敏性鼻炎，特应性皮炎和过敏性结膜炎; 嗜酸性粒细胞相关疾病，如中华综合征和鼻窦炎; 嗜碱性粒细胞相关疾病，如嗜碱性白血病，慢性荨麻疹和人类和其他哺乳动物的嗜碱性白细胞增多症; 以T淋巴细胞为特征的炎性疾病和白血球浸润如银屑病，湿疹，炎性肠病，溃疡性结肠炎，克罗恩病，COPD（慢性阻塞性肺病）和关节炎等。

公开(公告)号：US20090286771A1

公开(公告)日：2009-11-19

申请号：US12504606

申请日：2009-07-16

申请人： Yingfu Li ,  Kevin Bacon ,  Hiromi Sugimoto ,  Keiko Fukushima ,  Kentaro Hashimoto ,  Makiko Marumo ,  Toshiya Moriwaki ,  Noriko Nunami ,  Naoki Tsuno ,  Klaus Urbahns ,  Nagahiro Yoshida

发明人： Yingfu Li ,  Kevin Bacon ,  Hiromi Sugimoto ,  Keiko Fukushima ,  Kentaro Hashimoto ,  Makiko Marumo ,  Toshiya Moriwaki ,  Noriko Nunami ,  Naoki Tsuno ,  Klaus Urbahns ,  Nagahiro Yoshida

IPC分类号： A61K31/496 ,  A61K31/439 ,  A61K31/551 ,  A61K31/55 ,  A61P9/10 ,  A61P25/28 ,  A61P31/18

CPC分类号： C07D487/04 ,  A61K31/439 ,  C07C311/29 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D207/40 ,  C07D207/404 ,  C07D207/48 ,  C07D211/54 ,  C07D223/12 ,  C07D241/04 ,  C07D243/08 ,  C07D257/04 ,  C07D295/13 ,  C07D295/22 ,  C07D295/26 ,  C07D303/06 ,  C07D303/36 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D453/02 ,  C07D487/02 ,  C07D487/08

摘要： Provided herein are 2-phenoxy- and 2-phenylsulfonamide derivatives with CCR3 antagonistic activity. These compounds are useful for the treatment of diseases associated with CCR3 activity, including but not limited to, atopic dermatitis, allergic rhinitis, rheumatoid arthritis, Grave's disease, HIV infection, Alzheimer's disease, atherosclerosis and other inflammatory and/or immunological disorders.

摘要翻译： 本文提供具有CCR3拮抗活性的2-苯氧基 - 和2-苯基磺酰胺衍生物。 这些化合物可用于治疗与CCR3活性相关的疾病，包括但不限于特应性皮炎，过敏性鼻炎，类风湿性关节炎，格雷夫氏病，艾滋病毒感染，阿尔茨海默病，动脉粥样硬化和其他炎症和/或免疫学疾病。

公开(公告)号：US07674797B2

公开(公告)日：2010-03-09

申请号：US10550482

申请日：2004-03-11

申请人： Yingfu Li ,  Kevin Bacon ,  Hiromi Sugimoto ,  Keiko Fukushima ,  Kentaro Hashimoto ,  Makiko Marumo ,  Toshiya Moriwaki ,  Noriko Nunami ,  Naoki Tsuno ,  Klaus Urbahns ,  Nagahiro Yoshida

发明人： Yingfu Li ,  Kevin Bacon ,  Hiromi Sugimoto ,  Keiko Fukushima ,  Kentaro Hashimoto ,  Makiko Marumo ,  Toshiya Moriwaki ,  Noriko Nunami ,  Naoki Tsuno ,  Klaus Urbahns ,  Nagahiro Yoshida

IPC分类号： A01N43/42 ,  A61K31/496 ,  C07D221/18 ,  C07D221/22

CPC分类号： C07D487/04 ,  A61K31/439 ,  C07C311/29 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D207/40 ,  C07D207/404 ,  C07D207/48 ,  C07D211/54 ,  C07D223/12 ,  C07D241/04 ,  C07D243/08 ,  C07D257/04 ,  C07D295/13 ,  C07D295/22 ,  C07D295/26 ,  C07D303/06 ,  C07D303/36 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D453/02 ,  C07D487/02 ,  C07D487/08

摘要： The present invention relates to a benzenesulfonamide derivative of formula (I), which is useful as an active ingredient of pharmaceutical preparations. The benzenesulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders. In said formula, X represents O or S; R4 represents formulae (a), (b), (c), (d), (e), (f), (g), (h), (i) or (j), the other substituents are as defined in claim 1.

摘要翻译： 本发明涉及式（I）的苯磺酰胺衍生物，其可用作药物制剂的活性成分。 本发明的苯磺酰胺衍生物具有CCR3（CC型趋化因子受体）拮抗活性，可用于预防和治疗与CCR3活性有关的疾病，特别是用于治疗哮喘，特应性皮炎，过敏性鼻炎等炎症 /免疫学障碍。 在所述式中，X表示O或S; R4代表式（a），（b），（c），（d），（e），（f），（g），（h），（i）或（j） 权利要求1。

公开(公告)号：US20070155725A1

公开(公告)日：2007-07-05

申请号：US10550482

申请日：2004-03-11

申请人： Yingfu Li ,  Kevin Bacon ,  Hiromi Sugimoto ,  Keiko Fukushima ,  Kentaro Hashimoto ,  Makiko Marumo ,  Toshiya Moriwaki ,  Noriko Nunami ,  Naoki Tsuno ,  Klaus Urbahns ,  Nagahiro Yoshida

发明人： Yingfu Li ,  Kevin Bacon ,  Hiromi Sugimoto ,  Keiko Fukushima ,  Kentaro Hashimoto ,  Makiko Marumo ,  Toshiya Moriwaki ,  Noriko Nunami ,  Naoki Tsuno ,  Klaus Urbahns ,  Nagahiro Yoshida

IPC分类号： A61K31/551 ,  A61K31/495 ,  A61K31/4745 ,  A61K31/445 ,  A61K31/4025 ,  A61K31/18 ,  C07D211/54 ,  C07D403/02 ,  C07D453/02

CPC分类号： C07D487/04 ,  A61K31/439 ,  C07C311/29 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D207/40 ,  C07D207/404 ,  C07D207/48 ,  C07D211/54 ,  C07D223/12 ,  C07D241/04 ,  C07D243/08 ,  C07D257/04 ,  C07D295/13 ,  C07D295/22 ,  C07D295/26 ,  C07D303/06 ,  C07D303/36 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D453/02 ,  C07D487/02 ,  C07D487/08

摘要： The present invention relates to a benzenesulfonamide derivative of formula (I), which is useful as an active ingredient of pharmaceutical preparations. The benzenesulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders. In said formula, X represents O or S; R4 represents formulae (a), (b), (c), (d), (e), (f), (g), (h), (i) or (j), the other substituents are as defined in claim 1.

摘要翻译： 本发明涉及式（I）的苯磺酰胺衍生物，其可用作药物制剂的活性成分。 本发明的苯磺酰胺衍生物具有CCR3（CC型趋化因子受体）拮抗活性，可用于预防和治疗与CCR3活性有关的疾病，特别是用于治疗哮喘，特应性皮炎，过敏性鼻炎等炎症 /免疫学障碍。 在所述式中，X表示O或S; R 4表示式（a），（b），（c），（d），（e），（f），（g），（h），（i）或（j） ，其它取代基如权利要求1中所定义。

公开(公告)号：US20050221153A1

公开(公告)日：2005-10-06

申请号：US10520267

申请日：2003-12-16

申请人： Hiromi Sugimoto ,  Itaru Shibata ,  Mitsugu Yamanaka

发明人： Hiromi Sugimoto ,  Itaru Shibata ,  Mitsugu Yamanaka

IPC分类号： H01M4/86 ,  B32B15/04 ,  H01M8/02 ,  H01M8/06 ,  H01M8/12 ,  H01M8/24

CPC分类号： H01M8/0232 ,  H01M4/9033 ,  H01M4/9066 ,  H01M8/025 ,  H01M8/0625 ,  H01M8/1231

摘要： A gas permeable substrate comprises a porous metallic plate having a plurality of pores which form openings in an uppers surface and/or a lower surface thereof, and particles filled in the pores. In the gas permeable substrate, at least one of the upper surface and the lower surface of the porous metallic plate is substantially smooth.

摘要翻译： 透气性基材包括具有多个孔的多孔金属板，其在上表面和/或下表面形成开口，以及填充在孔中的颗粒。 在透气基材中，多孔金属板的上表面和下表面中的至少一个基本上是平滑的。