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公开(公告)号：US20170151297A1
公开(公告)日：2017-06-01
申请号：US15364235
申请日：2016-11-29
发明人： Han-Chung CHENG , Chi-Tang TU , Szu-Ting LIU
IPC分类号： A61K36/185 , A61K9/00
CPC分类号： A61K36/185 , A61K9/0053 , A61K36/47
摘要： The present disclosure is related to a method for improving mitochondria in a cell, comprising step of treating the cell with an extraction of Emblica officinalis, for improving ability of mitochondria to perform oxidative phosphorylation and synthesize adenosine triphosphate. The present disclosure is also related to a method for promoting proliferation of a stem cell, comprising step of treating the stem cell with an extraction of Emblica officinalis, for improving division rate of the stem cell.
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公开(公告)号：US20240342219A1
公开(公告)日：2024-10-17
申请号：US18753332
申请日：2024-06-25
发明人： Han-Chung CHENG , Chi-Tang Tu , Chih-Kai Hsu
CPC分类号： A61K35/30 , A61P25/28 , A61K9/0012
摘要： The present invention is related to a method for treating and/or preventing Alzheimer's disease, especially using mitochondria for treatment and/or prevention of Alzheimer's disease.
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公开(公告)号：US20230023438A1
公开(公告)日：2023-01-26
申请号：US17948007
申请日：2022-09-19
发明人： Han-Chung CHENG , Chih-Kai HSU , Shun-Chieh YANG , An-Ling CHENG , Chi-Tang TU
摘要： The embodiments of the present disclosure provide a composition including mitochondria. By providing the mitochondria to cartilage, the composition can improve the mitochondrial function of the chondrocytes in the cartilage so as to increase the repair ability of the chondrocytes and repair the cartilage damage caused by aging of the chondrocytes, thereby achieving the purpose of treating osteoarthritis.
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4.发明申请公开(公告)号：US20180008657A1
公开(公告)日：2018-01-11
申请号：US15715056
申请日：2017-09-25
发明人： Han-Chung CHENG , Chi-Tang TU , Shun-Chieh YANG , Man-Ching SHEN
IPC分类号： A61K36/185 , A61K9/08 , A61K9/00
CPC分类号： A61K36/185 , A61K9/0053 , A61K9/08 , A61K9/4875 , A61K36/47
摘要： A use of an emblica extract in preparing a pharmaceutical composition for protecting mitochondria in retina is provided. When the pharmaceutical composition, which comprises the emblica extract, is provided to retinal cells, a use of the pharmaceutical composition comprises improvement of the ability of performing the oxidative phosphorylation for the synthesis of the adenosine triphosphate (ATP) by the mitochondria in the retinal cells under or exposed to ultraviolet light, and improvement of the coupling efficiency of the synthesis of the adenosine triphosphate by the mitochondria.
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公开(公告)号：US20230165899A1
公开(公告)日：2023-06-01
申请号：US17912458
申请日：2021-03-19
发明人： Han-Chung CHENG , Chih-Kai HSU , Hui-Ching TSENG , An-Ling CHENG
摘要： The present invention provides a second use of mitochondria, which can cure a tendon injury-related disease and prevent a disease caused by a tendon injury. Specifically, the mitochondria disclosed in the present invention have the effect of repairing injured tendon cells and accelerating the healing of the tendon cells. Therefore, by administering a predetermined amount of mitochondria or a composition containing a predetermined amount of mitochondria to a part with a tendon injury, wound healing of the part with the tendon injury can be promoted, thus achieving the effect of repairing the injured tendon and further preventing a joint disease caused by the tendon injury or inflammation.
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公开(公告)号：US20230085499A1
公开(公告)日：2023-03-16
申请号：US17982805
申请日：2022-11-08
发明人： Han-Chung CHENG , Chih-Kai HSU , Chi-Tang TU , Shun-Chieh YANG , An-Ling CHENG
摘要： The composition for improving liver function of the present disclosure includes at least one of mitochondria from autologous cells and exogenous mitochondria, and stem cells. The composition may decrease GOT and GPT indices, indicating the composition of the present disclosure may repair damaged liver and improve the regeneration ability of the damaged liver. The composition of the present disclosure may improve albumin synthesis, prothrombin synthesis and bilirubin metabolism of the liver, indicating the composition of the present disclosure may improve liver's ability of synthesis and metabolism.
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公开(公告)号：US20230042445A1
公开(公告)日：2023-02-09
申请号：US17912336
申请日：2021-03-19
发明人： Han-Chung CHENG , Chih-Kai HSU , Hui-Ching TSENG
IPC分类号： A61K35/28 , C12N5/0775 , A61K35/19 , A61K38/36 , A61P17/02
摘要： The present invention discloses a use of mitochondria to promote wound repair and/or healing. Specifically, when a certain amount of mitochondria or a composition containing a certain amount of mitochondria is administered to a wound, the effect of promoting wound repair or accelerating wound healing can be effectively achieved.
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公开(公告)号：US20190142889A1
公开(公告)日：2019-05-16
申请号：US16242173
申请日：2019-01-08
发明人： Han-Chung CHENG , Chi-Tang TU , Szu-Ting LIU
IPC分类号： A61K36/185 , A61K9/00
CPC分类号： A61K36/185 , A61K9/0053 , A61K36/47
摘要： The present disclosure is related to a method for improving mitochondria in a cell, comprising step of treating the cell with an extraction of Emblica officinalis, for improving ability of mitochondria to perform oxidative phosphorylation and synthesize adenosine triphosphate. The present disclosure is also related to a method for promoting proliferation of a stem cell, comprising step of treating the stem cell with an extraction of Emblica officinalis, for improving division rate of the stem cell.
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公开(公告)号：US20240285706A1
公开(公告)日：2024-08-29
申请号：US18658120
申请日：2024-05-08
发明人： Han-Chung CHENG , Shun-Chieh YANG , An-Ling CHENG
IPC分类号： A61K36/185 , A61K31/192 , A61P3/00
CPC分类号： A61K36/185 , A61K31/192 , A61P3/00 , A61K2236/15 , A61K2236/331
摘要： A use of a ramie extract in preparing a composition for anti-aging is provided. The composition containing ramie extract can improve the function and activity of mitochondria and telomerase and protect mitochondria from oxidative stress, including decrease in the proton leakage, increase in the ATP production, increase in the spare respiratory capacity, increase in the maximal respiratory capacity, or increase in the ATP coupling efficiency.
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公开(公告)号：US20230023218A1
公开(公告)日：2023-01-26
申请号：US17947994
申请日：2022-09-19
发明人： Han-Chung CHENG , Chih-Kai HSU , Hui-Ching TSENG , Shun-Chieh YANG , Chi-Tang TU , Szu-Ting LIU , Li-Hsin YAO
IPC分类号： C12N5/00 , C12N5/0775 , C12N5/073
摘要： The embodiments of the present disclosure provide a cell culture composition and a use thereof, and the cell culture composition includes a culture medium and mitochondria. The cell culture composition including mitochondria can promote cell growth and improve the function of the damaged or aged stem cells, thereby improving overall cell growth.
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