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公开(公告)号：US20170151297A1
公开(公告)日：2017-06-01
申请号：US15364235
申请日：2016-11-29
发明人： Han-Chung CHENG , Chi-Tang TU , Szu-Ting LIU
IPC分类号： A61K36/185 , A61K9/00
CPC分类号： A61K36/185 , A61K9/0053 , A61K36/47
摘要： The present disclosure is related to a method for improving mitochondria in a cell, comprising step of treating the cell with an extraction of Emblica officinalis, for improving ability of mitochondria to perform oxidative phosphorylation and synthesize adenosine triphosphate. The present disclosure is also related to a method for promoting proliferation of a stem cell, comprising step of treating the stem cell with an extraction of Emblica officinalis, for improving division rate of the stem cell.
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2.发明申请公开(公告)号：US20230003625A1
公开(公告)日：2023-01-05
申请号：US17897011
申请日：2022-08-26
发明人： Chi-Tang TU , Szu-Ting LIU , Li-Hsin YAO , Han-Chung CHENG
摘要： An agent for cryopreservation includes trehalose, HEPES and serum albumin. The agent for cryopreservation does not include potassium chloride, sodium chloride, ethylene glycol, ethylene glycol tetraacetic acid and ethylenediaminetetraacetic acid.
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公开(公告)号：US20230023438A1
公开(公告)日：2023-01-26
申请号：US17948007
申请日：2022-09-19
发明人： Han-Chung CHENG , Chih-Kai HSU , Shun-Chieh YANG , An-Ling CHENG , Chi-Tang TU
摘要： The embodiments of the present disclosure provide a composition including mitochondria. By providing the mitochondria to cartilage, the composition can improve the mitochondrial function of the chondrocytes in the cartilage so as to increase the repair ability of the chondrocytes and repair the cartilage damage caused by aging of the chondrocytes, thereby achieving the purpose of treating osteoarthritis.
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4.发明申请公开(公告)号：US20180008657A1
公开(公告)日：2018-01-11
申请号：US15715056
申请日：2017-09-25
发明人： Han-Chung CHENG , Chi-Tang TU , Shun-Chieh YANG , Man-Ching SHEN
IPC分类号： A61K36/185 , A61K9/08 , A61K9/00
CPC分类号： A61K36/185 , A61K9/0053 , A61K9/08 , A61K9/4875 , A61K36/47
摘要： A use of an emblica extract in preparing a pharmaceutical composition for protecting mitochondria in retina is provided. When the pharmaceutical composition, which comprises the emblica extract, is provided to retinal cells, a use of the pharmaceutical composition comprises improvement of the ability of performing the oxidative phosphorylation for the synthesis of the adenosine triphosphate (ATP) by the mitochondria in the retinal cells under or exposed to ultraviolet light, and improvement of the coupling efficiency of the synthesis of the adenosine triphosphate by the mitochondria.
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公开(公告)号：US20230085499A1
公开(公告)日：2023-03-16
申请号：US17982805
申请日：2022-11-08
发明人： Han-Chung CHENG , Chih-Kai HSU , Chi-Tang TU , Shun-Chieh YANG , An-Ling CHENG
摘要： The composition for improving liver function of the present disclosure includes at least one of mitochondria from autologous cells and exogenous mitochondria, and stem cells. The composition may decrease GOT and GPT indices, indicating the composition of the present disclosure may repair damaged liver and improve the regeneration ability of the damaged liver. The composition of the present disclosure may improve albumin synthesis, prothrombin synthesis and bilirubin metabolism of the liver, indicating the composition of the present disclosure may improve liver's ability of synthesis and metabolism.
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公开(公告)号：US20190142889A1
公开(公告)日：2019-05-16
申请号：US16242173
申请日：2019-01-08
发明人： Han-Chung CHENG , Chi-Tang TU , Szu-Ting LIU
IPC分类号： A61K36/185 , A61K9/00
CPC分类号： A61K36/185 , A61K9/0053 , A61K36/47
摘要： The present disclosure is related to a method for improving mitochondria in a cell, comprising step of treating the cell with an extraction of Emblica officinalis, for improving ability of mitochondria to perform oxidative phosphorylation and synthesize adenosine triphosphate. The present disclosure is also related to a method for promoting proliferation of a stem cell, comprising step of treating the stem cell with an extraction of Emblica officinalis, for improving division rate of the stem cell.
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公开(公告)号：US20230023218A1
公开(公告)日：2023-01-26
申请号：US17947994
申请日：2022-09-19
发明人： Han-Chung CHENG , Chih-Kai HSU , Hui-Ching TSENG , Shun-Chieh YANG , Chi-Tang TU , Szu-Ting LIU , Li-Hsin YAO
IPC分类号： C12N5/00 , C12N5/0775 , C12N5/073
摘要： The embodiments of the present disclosure provide a cell culture composition and a use thereof, and the cell culture composition includes a culture medium and mitochondria. The cell culture composition including mitochondria can promote cell growth and improve the function of the damaged or aged stem cells, thereby improving overall cell growth.
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公开(公告)号：US20200306314A1
公开(公告)日：2020-10-01
申请号：US16832081
申请日：2020-03-27
发明人： Han-Chung CHENG , Chi-Tang TU , Chih-Kai HSU
摘要： The present invention is related to a method for treating and/or preventing Alzheimer's disease, especially using mitochondria for treatment and/or prevention of Alzheimer's disease.
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9.发明申请公开(公告)号：US20180117090A1
公开(公告)日：2018-05-03
申请号：US15857270
申请日：2017-12-28
发明人： Shinn-Zong LIN , Horng-Jyh HARN , Shih-Ping LIU , Han-Chung CHENG , Chi-Tang TU
IPC分类号： A61K35/28 , C12N5/0775 , C07K14/575 , A61P25/16 , A61K9/00
CPC分类号： A61K35/28 , A01K67/027 , A01K2207/20 , A01K2227/105 , A01K2267/0318 , A61K9/0019 , A61K9/0085 , A61K35/35 , A61K35/50 , A61K36/232 , A61K38/185 , A61P25/16 , C07K14/575 , C12N5/0667 , C12N2500/16 , C12N2500/30 , C12N2500/38 , C12N2500/76 , C12N2501/11 , C12N2501/999 , C12N2506/13 , C12N2506/1369
摘要： A cell for treating neurodegenerative disease treated with angelica extract is provided. The pharmaceutical composition comprises the cell for treating neurodegenerative disease and can significantly increase and recover the number of dopaminergic neurons to achieve the goal for treating neurodegenerative disease.
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10.发明申请PHARMACEUTICAL COMPOSITIONS FOR TREATING DEGENERATIVE NEUROLOGICAL DISEASE WITH MITOCELLS 审中-公开用MITOCELLS治疗退行性神经疾病的药物组合物公开(公告)号：US20160074438A1
公开(公告)日：2016-03-17
申请号：US14851402
申请日：2015-09-11
发明人： Shinn-Zong LIN , Horng-Jyh HARN , Shih-Ping LIU , Han-Chung CHENG , Chi-Tang TU
IPC分类号： A61K35/35 , C12N5/0775
CPC分类号： A61K35/35 , A61K35/28 , C12N5/0667 , C12N2500/76 , C12N2501/999
摘要： A MitoCells treated with angelica extract is provided. The pharmaceutical composition comprise MitoCells and can significantly achieve the goal for treating degenerative neurological disease.
摘要翻译： 提供用当归提取物处理的MitoCells。 该药物组合物包含MitoCell，并可显着地达到治疗退行性神经疾病的目的。
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