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公开(公告)号：US09116111B2
公开(公告)日：2015-08-25
申请号：US14123234
申请日：2012-07-11
申请人： Takao Nakajima , Yasufumi Asao
发明人： Takao Nakajima , Yasufumi Asao
CPC分类号： G01N29/2418 , A61B5/0095 , G01H9/00 , G01H9/002 , G01N21/1702
摘要： There is used an acoustic signal receiving apparatus including a wavelength-tunable light source for irradiating measurement light, a controller for controlling a wavelength of the measurement light, a Fabry-Perot probe having a first mirror on a side where the measurement light enters, a second mirror on a side where an elastic wave from an object enters, and a spacer film positioned between the first and second mirrors and deforms in response to the elastic wave, an array photosensor for detecting a reflected light amount of the measurement light by the Fabry-Perot probe, and a signal processor for acquiring an intensity of the incident elastic wave based on a change in the reflected light amount. The controller sweeps the wavelength of the measurement light, and the signal processor determines the wavelength based on the reflected light amount at each wavelength subjected to the sweep.
摘要翻译： 使用包括用于照射测量光的波长可调光源的声信号接收装置，用于控制测量光的波长的控制器，在测量光进入的一侧具有第一反射镜的法布里 - 珀罗探头， 来自物体的弹性波的一侧的第二反射镜和位于第一和第二反射镜之间并且响应于弹性波而变形的间隔膜，用于通过法布里检测测量光的反射光量的阵列光电传感器 -Perot探针和用于基于反射光量的变化获取入射弹性波的强度的信号处理器。 控制器扫描测量光的波长，并且信号处理器基于经受扫描的每个波长处的反射光量确定波长。
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公开(公告)号：US20110239766A1
公开(公告)日：2011-10-06
申请号：US13132998
申请日：2009-12-10
申请人： Takao Nakajima , Kazuhiko Fukutani , Yasufumi Asao
发明人： Takao Nakajima , Kazuhiko Fukutani , Yasufumi Asao
IPC分类号： G01H17/00
CPC分类号： A61B5/0095 , A61B5/0073 , G01N21/1702 , G01N2021/1706
摘要： A photoacoustic imaging apparatus performs imaging of an optical absorber. The photoacoustic imaging apparatus includes a light source, a detector configured to detect an acoustic wave generated from the optical absorber that has absorbed energy of light emitted from the light source, and a signal processing unit configured to form an image of the optical absorber. The signal processing unit stores information indicating whether a rate of change in pressure of the acoustic wave detected by the detector is positive or negative before performing a waveform process on the acoustic wave.
摘要翻译： 光声成像装置执行光吸收体的成像。 光声成像装置包括光源，检测器，其被配置为检测从吸收器产生的吸收了从光源发射的光的能量的声波;以及信号处理单元，被配置为形成光吸收体的图像。 信号处理单元存储指示在对声波执行波形处理之前，检测器检测到的声波的压力变化是正还是负的信息。
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3.发明授权公开(公告)号：US07916283B2
公开(公告)日：2011-03-29
申请号：US12876336
申请日：2010-09-07
申请人： Kazuhiko Fukutani , Takao Nakajima , Yasufumi Asao , Toru Den
发明人： Kazuhiko Fukutani , Takao Nakajima , Yasufumi Asao , Toru Den
IPC分类号： G01N21/00
CPC分类号： A61B5/0073 , A61B5/0035 , A61B5/0095
摘要： A biological information imaging apparatus includes: a light source; an acoustic wave detector that detects an acoustic wave generated from a light absorption material in a living body that has absorbed a part of energy of light irradiated from the light source to the living body, and converts it into a first electric signal; a photodetector that detects optical intensity of a portion of the light irradiated from the light source to the living body and propagating in the living body, and converts it into a second electric signal; and a calculation unit that calculates optical property distribution information on the living body by making use of an analytical result of one of the first electric signal and the second electric signal for analysis of the other electric signal.
摘要翻译： 生物信息成像装置包括：光源; 声波检测器，其检测从吸收从光源照射到生物体的光的一部分能量的生物体中的光吸收材料产生的声波，并将其转换为第一电信号; 光检测器，其检测从光源照射到生物体并在生物体中传播的光的一部分的光强度，并将其转换为第二电信号; 以及计算单元，其通过利用第一电信号和第二电信号中的一个的分析结果来计算其他电信号的分析结果来计算生物体的光学性质分布信息。
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公开(公告)号：US20080306371A1
公开(公告)日：2008-12-11
申请号：US12130331
申请日：2008-05-30
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0095 , A61B8/08 , G01N21/1702
摘要： An intravital-information imaging apparatus includes light sources for irradiating a living body with light, and acoustic-wave detectors that detect acoustic waves generated from a light absorber having absorbed part of energy of the light from the light sources, the light absorber existing in the living body. Furthermore, the intravital-information imaging apparatus includes signal processors that calculate information representing a distribution of optical characteristic values of the living body using sound pressures of the acoustic waves generated from the light absorber.
摘要翻译： 活体信息成像装置包括用于对生物体照射光的光源，以及声波检测器，其检测由吸收了来自光源的光的能量的光吸收体产生的声波，存在于 活体。 此外，活体内信息成像装置包括使用从光吸收体产生的声波的声压来计算表示生物体的光学特性值的分布的信息的信号处理器。
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公开(公告)号：US20140076055A1
公开(公告)日：2014-03-20
申请号：US14115970
申请日：2012-05-23
申请人： Yasufumi Asao , Takao Nakajima
发明人： Yasufumi Asao , Takao Nakajima
IPC分类号： G01H9/00
CPC分类号： G01H9/00 , A61B5/0059
摘要： Use of an acoustic wave receiving apparatus which includes: a resonator including a first mirror on which measurement light is incident, a second mirror which is arranged to face the first mirror and on which acoustic waves from an object are incident, an acoustic wave reception layer interposed between the first mirror and the second mirror, and a compensation layer; and a detector for detecting a variation in an optical path length between the first mirror and the second mirror that occurs in response to deformation of the acoustic wave reception layer caused by incidence of the acoustic waves, wherein the variation in the optical path length due to a film thickness distribution of the acoustic wave reception layer is compensated by refraction in the compensation layer.
摘要翻译： 一种声波接收装置的应用，包括：谐振器，包括测量光入射的第一反射镜，布置成面对第一反射镜的第二反射镜，来自物体的声波入射;声波接收层 插入在第一反射镜和第二反射镜之间，以及补偿层; 以及检测器，用于检测响应于由声波入射引起的声波接收层的变形而发生的第一反射镜和第二反射镜之间的光路长度的变化，其中由于 通过在补偿层中的折射来补偿声波接收层的膜厚分布。
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公开(公告)号：US20120133941A1
公开(公告)日：2012-05-31
申请号：US13367894
申请日：2012-02-07
IPC分类号： G01N21/55
CPC分类号： G01N21/1702 , A61B5/0059 , A61B5/0095 , A61B8/4281 , G01N2021/1706
摘要： A photoacoustic apparatus obtains information on a specimen by receiving photoacoustic waves which are generated from the specimen resulting from light irradiated to the specimen. The apparatus includes a light source for irradiating light to the specimen, an acoustic wave receiver for receiving the photoacoustic waves, and a light reflection member for causing the light, which is radiated out of the specimen by optical diffusion thereof after having entered an interior of the specimen from the light source, to reenter the interior of the specimen, wherein the light reflection member allows elastic waves to pass therethrough. As a result, a photoacoustic apparatus and a probe are provided which can confine scattered light from the specimen into the specimen, and which can reliably prevent photoacoustic waves from being generated from a receiving element region of the probe by the scattered light.
摘要翻译： 光声设备通过接收由照射到样本的光产生的样本产生的光声来获得关于样本的信息。 该装置包括用于向样本照射光的光源，用于接收光声波的声波接收器，以及光反射构件，其用于使得通过其进入其内部的光学扩散而从样本中辐射出的光 来自光源的样本，重新进入样本的内部，其中光反射构件允许弹性波通过。 结果，提供了一种光声装置和探针，其可以将来自样本的散射光限制在样本中，并且可以可靠地防止通过散射光从探测器的接收元件区域产生光声波。
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公开(公告)号：US20100053618A1
公开(公告)日：2010-03-04
申请号：US12548084
申请日：2009-08-26
IPC分类号： G01N21/64
CPC分类号： G01N21/1702 , A61B5/0059 , A61B5/0095 , A61B8/4281 , G01N2021/1706
摘要： A photoacoustic apparatus obtains information on a specimen by receiving photoacoustic waves which are generated from the specimen resulting from light irradiated to the specimen. The apparatus includes a light source for irradiating light to the specimen, an acoustic wave receiver for receiving the photoacoustic waves, and a light reflection member for causing the light, which is radiated out of the specimen by optical diffusion thereof after having entered an interior of the specimen from the light source, to reenter the interior of the specimen, wherein the light reflection member allows elastic waves to pass therethrough. As a result, a photoacoustic apparatus and a probe are provided which can confine scattered light from the specimen into the specimen, and which can reliably prevent photoacoustic waves from being generated from a receiving element region of the probe by the scattered light.
摘要翻译： 光声设备通过接收由照射到样本的光产生的样本产生的光声来获得关于样本的信息。 该装置包括用于向样本照射光的光源，用于接收光声波的声波接收器，以及光反射构件，其用于使得通过其进入其内部的光学扩散而从样本中辐射出的光 来自光源的样本，重新进入样本的内部，其中光反射构件允许弹性波通过。 结果，提供了一种光声装置和探针，其可以将来自样本的散射光限制在样本中，并且可以可靠地防止通过散射光从探测器的接收元件区域产生光声波。
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8.发明申请公开(公告)号：US20090002685A1
公开(公告)日：2009-01-01
申请号：US12204445
申请日：2008-09-04
申请人： Kazuhiko Fukutani , Takao Nakajima , Yasufumi Asao , Toru Den
发明人： Kazuhiko Fukutani , Takao Nakajima , Yasufumi Asao , Toru Den
CPC分类号： A61B5/0073 , A61B5/0035 , A61B5/0095
摘要： A biological information imaging apparatus includes: a light source; an acoustic, wave detector that detects an acoustic wave generated from a light absorption material in a living body that has absorbed a part of energy of light irradiated from the light source to the living body, and converts it into a first electric signal; a photodetector that detects optical intensity of a portion of the light irradiated from the light source to the living body and propagating in the living body, and converts it into a second electric signal; and a calculation unit that calculates optical property distribution information on the living body by making use of an analytical result of one of the first electric signal and the second electric signal for analysis of the other electric signal.
摘要翻译： 生物信息成像装置包括：光源; 声波检测器，其检测从吸收从光源照射到生物体的光的一部分能量的生物体中的光吸收材料产生的声波，并将其转换为第一电信号; 光检测器，其检测从光源照射到生物体并在生物体中传播的光的一部分的光强度，并将其转换为第二电信号; 以及计算单元，其通过利用第一电信号和第二电信号中的一个的分析结果来计算其他电信号的分析结果来计算生物体的光学性质分布信息。
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9.发明授权公开(公告)号：US09131851B2
公开(公告)日：2015-09-15
申请号：US12365237
申请日：2009-02-04
申请人： Kazuhiko Fukutani , Takao Nakajima , Yasufumi Asao
发明人： Kazuhiko Fukutani , Takao Nakajima , Yasufumi Asao
CPC分类号： A61B5/0095 , A61B5/0091 , A61B5/4312 , A61B5/4887 , A61B5/489 , A61B8/0825 , A61B8/4416 , A61B8/5223 , G01N29/2418
摘要： There are provided a biological information imaging apparatus that can measure ultrasound generated from an optical absorber in a deep part of a subject living body with high sensitivity, and a method for analyzing biological information using the biological information imaging apparatus. The biological information imaging apparatus that detects ultrasound and images biological information, includes: a light source that irradiates the subject with light for generating ultrasound from an optical absorber existing in the subject; an ultrasound transmission unit that transmits focused ultrasound to a specific region where the optical absorber exists; and an ultrasound detection unit that detects an ultrasound synthesized signal due to interaction between ultrasound generated from the optical absorber that absorbs the light and the focused ultrasound transmitted to the specific region.
摘要翻译： 本发明提供一种生物信息成像装置，其能够高灵敏度地测量本体体内深部的光吸收体产生的超声波，以及使用该生物体信息成像装置分析生物信息的方法。 检测超声波和图像生物信息的生物信息成像装置包括：从存在于被检体内的光吸收体照射被检体的光用于产生超声的光源; 超声波发送单元，其将聚焦超声波发送到存在光吸收体的特定区域; 以及超声波检测单元，其检测由吸收光的光吸收体产生的超声波与发送到特定区域的聚焦超声波之间的相互作用引起的超声合成信号。
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公开(公告)号：US20140118749A1
公开(公告)日：2014-05-01
申请号：US14123234
申请日：2012-07-11
申请人： Takao Nakajima , Yasufumi Asao
发明人： Takao Nakajima , Yasufumi Asao
IPC分类号： G01N29/24
CPC分类号： G01N29/2418 , A61B5/0095 , G01H9/00 , G01H9/002 , G01N21/1702
摘要： There is used an acoustic signal receiving apparatus including a wavelength-tunable light source for irradiating measurement light, a controller for controlling a wavelength of the measurement light, a Fabry-Perot probe having a first mirror on a side where the measurement light enters, a second mirror on a side where an elastic wave from an object enters, and a spacer film positioned between the first and second mirrors and deforms in response to the elastic wave, an array photosensor for detecting a reflected light amount of the measurement light by the Fabry-Perot probe, and a signal processor for acquiring an intensity of the incident elastic wave based on a change in the reflected light amount. The controller sweeps the wavelength of the measurement light, and the signal processor determines the wavelength based on the reflected light amount at each wavelength subjected to the sweep.
摘要翻译： 使用包括用于照射测量光的波长可调光源的声信号接收装置，用于控制测量光的波长的控制器，在测量光进入的一侧具有第一反射镜的法布里 - 珀罗探头， 来自物体的弹性波的一侧的第二反射镜和位于第一和第二反射镜之间并且响应于弹性波而变形的间隔膜，用于通过法布里检测测量光的反射光量的阵列光电传感器 -Perot探针和用于基于反射光量的变化获取入射弹性波的强度的信号处理器。 控制器扫描测量光的波长，并且信号处理器基于经受扫描的每个波长处的反射光量确定波长。
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