公开(公告)号：US5960208A

公开(公告)日：1999-09-28

申请号：US862450

申请日：1997-05-23

申请人： Takao Obata ,  Mitsuaki Kumagai ,  Akihiko Iura ,  Akio Murata ,  Shinji Yamamoto ,  Makoto Sato ,  Akira Okawado ,  Shinichiro Tsurumaru ,  Maki Miyata ,  Toshiyuki Kobayashi ,  Nobuaki Akasawa ,  Masahiko Okano ,  Takao Miyanaga

发明人： Takao Obata ,  Mitsuaki Kumagai ,  Akihiko Iura ,  Akio Murata ,  Shinji Yamamoto ,  Makoto Sato ,  Akira Okawado ,  Shinichiro Tsurumaru ,  Maki Miyata ,  Toshiyuki Kobayashi ,  Nobuaki Akasawa ,  Masahiko Okano ,  Takao Miyanaga

IPC分类号： G06F1/16 ,  G06K7/00 ,  G06K7/10 ,  G06K13/08 ,  G06K17/00 ,  G06F1/26

CPC分类号： G06K7/10881 ,  G06F1/1626 ,  G06F1/1632 ,  G06F1/1656 ,  G06F1/1696 ,  G06K13/08 ,  G06K17/0022 ,  G06K7/0021 ,  G06K7/006 ,  G06K7/1098

摘要： In an information processing system having a portable terminal unit, such as a hand-held computer, driven by a rechargeable battery and a data communication adaptor for enabling communication between the portable terminal unit and a host computer of the system, the terminal unit and the data communication adaptor are designed to minimize the size thereof in the following five ways. First, a memory card holding mechanism for connecting the memory card of the portable terminal unit is provided between a swinging back lid and a recess of the back casing. Second, a normal interface and a high-speed interface are both provided in the portable terminal unit and the data communication adaptor respectively. Third, an auxiliary connector for an optional device to extend a function of the portable terminal unit is provided in the opening of the casing of the portable terminal unit movable in three dimensions mounted on a printed circuit board. Fourth, a moisture resistant seal made of rubber or resin is molded integrally onto one of the joining edges of an upper casing and a lower casing. Fifth, an electric power source portion of the data communication adaptor is used not only for charging the battery of the portable terminal unit but also supplying a power adequate for enabling a data transmission operation thereof.

摘要翻译： 在具有由可再充电电池驱动的便携式终端单元（例如手持式计算机）和数据通信适配器的信息处理系统中，用于实现便携式终端单元与系统的主计算机之间的通信，终端单元和 数据通信适配器被设计为以下五种方式使其大小最小化。 首先，在摆动后盖和后壳体的凹部之间设置用于连接便携式终端单元的存储卡的存储卡保持机构。 第二，分别在便携终端单元和数据通信适配器中分别提供正常接口和高速接口。 第三，用于扩展便携式终端单元的功能的可选设备的辅助连接器设置在可安装在印刷电路板上的三维可移动的便携式终端单元的壳体的开口中。 第四，由橡胶或树脂制成的防潮密封件一体地模制在上壳体和下壳体的一个接合边缘上。 第五，数据通信适配器的电源部分不仅用于为便携式终端单元的电池充电，而且还提供足以使其进行数据传输操作的电力。

公开(公告)号：US6163268A

公开(公告)日：2000-12-19

申请号：US862694

申请日：1997-05-23

申请人： Takao Obata ,  Mitsuaki Kumagai ,  Akihiko Iura ,  Akio Murata ,  Shinji Yamamoto ,  Makoto Sato ,  Akira Okawado ,  Shinichiro Tsurumaru ,  Maki Miyata ,  Toshiyuki Kobayashi ,  Nobuaki Akasawa ,  Masahiko Okano ,  Takao Miyanaga

发明人： Takao Obata ,  Mitsuaki Kumagai ,  Akihiko Iura ,  Akio Murata ,  Shinji Yamamoto ,  Makoto Sato ,  Akira Okawado ,  Shinichiro Tsurumaru ,  Maki Miyata ,  Toshiyuki Kobayashi ,  Nobuaki Akasawa ,  Masahiko Okano ,  Takao Miyanaga

IPC分类号： G06F1/16 ,  G06K7/00 ,  G06K7/10 ,  G06K13/08 ,  G06K17/00 ,  G08B23/00

CPC分类号： G08B23/00 ,  G06F1/16 ,  G06F1/1626 ,  G06F1/1632 ,  G06F1/1656 ,  G06F1/1696 ,  G06F1/26 ,  G06F13/14 ,  G06K7/0021 ,  G06K7/006 ,  G06K7/10881 ,  G06K7/1098 ,  G06K13/08 ,  G06K17/0022

摘要： In an information processing system having a portable terminal unit, such as a hand-held computer, driven by a rechargeable battery and a data communication adaptor for enabling communication between the portable terminal unit and a host computer of the system, the terminal unit and the data communication adaptor are designed to minimize the size thereof in the following five ways. First, a memory card holding mechanism for connecting the memory card of the portable terminal unit is provided between a swinging back lid and a recess of the back casing. Second, a normal interface and a high-speed interface are both provided in the portable terminal unit and the the data communication adaptor respectively. Third, an auxiliary connector for an optional device to extend a function of the portable terminal Unit is provided in the opening of the casing of the portable terminal unit movable in three dimensions mounted on a printed circuit board. Fourth, a moisture resistant seal made of rubber or resin is molded integrally onto one of the joining edges of an upper casing and a lower casing. Fifth, an electric power source portion of the data communication adaptor is used not only for charging the battery of the portable terminal unit but also supplying a power adequate for enabling a data transmission operation thereof.

摘要翻译： 在具有由可再充电电池驱动的便携式终端单元（例如手持式计算机）和数据通信适配器的信息处理系统中，用于实现便携式终端单元与系统的主计算机之间的通信，终端单元和 数据通信适配器被设计为以下五种方式使其大小最小化。 首先，在摆动后盖和后壳体的凹部之间设置用于连接便携式终端单元的存储卡的存储卡保持机构。 第二，分别在便携式终端单元和数据通信适配器中分别提供正常接口和高速接口。 第三，用于扩展便携式终端单元的功能的可选设备的辅助连接器设置在可安装在印刷电路板上的三维可移动的便携式终端单元的壳体的开口中。 第四，由橡胶或树脂制成的防潮密封件一体地模制在上壳体和下壳体的一个接合边缘上。 第五，数据通信适配器的电源部分不仅用于为便携式终端单元的电池充电，而且还提供足以使其进行数据传输操作的电力。

公开(公告)号：US5983290A

公开(公告)日：1999-11-09

申请号：US862700

申请日：1997-05-23

申请人： Takao Obata ,  Mitsuaki Kumagai ,  Akihiko Iura ,  Akio Murata ,  Shinji Yamamoto ,  Makoto Sato ,  Akira Okawado ,  Shinichiro Tsurumaru ,  Maki Miyata ,  Toshiyuki Kobayashi ,  Nobuaki Akasawa ,  Masahiko Okano ,  Takao Miyanaga

发明人： Takao Obata ,  Mitsuaki Kumagai ,  Akihiko Iura ,  Akio Murata ,  Shinji Yamamoto ,  Makoto Sato ,  Akira Okawado ,  Shinichiro Tsurumaru ,  Maki Miyata ,  Toshiyuki Kobayashi ,  Nobuaki Akasawa ,  Masahiko Okano ,  Takao Miyanaga

IPC分类号： G06F1/16 ,  G06K7/00 ,  G06K7/10 ,  G06K13/08 ,  G06K17/00 ,  G06F13/14

CPC分类号： G06K7/10881 ,  G06F1/1626 ,  G06F1/1632 ,  G06F1/1656 ,  G06F1/1696 ,  G06K13/08 ,  G06K17/0022 ,  G06K7/0021 ,  G06K7/006 ,  G06K7/1098

摘要： In an information processing system having a portable terminal unit, such as a hand-held computer, driven by a rechargeable battery and a data communication adaptor for enabling communication between the portable terminal unit and a host computer of the system, the terminal unit and the data communication adaptor are designed to minimize the size thereof in the following five ways. First, a memory card holding mechanism for connecting the memory card of the portable terminal unit is provided between a swinging back lid and a recess of the back casing. Second, a normal interface and a high-speed interface are both provided in the portable terminal unit and the data communication adaptor respectively. Third, an auxiliary connector for an optional device to extend a function of the portable terminal unit is provided in the opening of the casing of the portable terminal unit movable in three dimensions mounted on a printed circuit board. Fourth, a moisture resistant seal made of rubber or resin is molded integrally onto one of the joining edges of an upper casing and a lower casing. Fifth, an electric power source portion of the data communication adaptor is used not only for charging the battery of the portable terminal unit but also supplying a power adequate for enabling a data transmission operation thereof.

摘要翻译： 在具有由可再充电电池驱动的便携式终端单元（例如手持式计算机）和数据通信适配器的信息处理系统中，用于实现便携式终端单元与系统的主计算机之间的通信，终端单元和 数据通信适配器被设计为以下五种方式使其大小最小化。 首先，在摆动后盖和后壳体的凹部之间设置用于连接便携式终端单元的存储卡的存储卡保持机构。 第二，分别在便携终端单元和数据通信适配器中分别提供正常接口和高速接口。 第三，用于扩展便携式终端单元的功能的可选设备的辅助连接器设置在可安装在印刷电路板上的三维可移动的便携式终端单元的壳体的开口中。 第四，由橡胶或树脂制成的防潮密封件一体地模制在上壳体和下壳体的一个接合边缘上。 第五，数据通信适配器的电源部分不仅用于为便携式终端单元的电池充电，而且还提供足以使其进行数据传输操作的电力。

公开(公告)号：US5854737A

公开(公告)日：1998-12-29

申请号：US862711

申请日：1997-05-23

申请人： Takao Obata ,  Mitsuaki Kumagai ,  Akihiko Iura ,  Akio Murata ,  Shinji Yamamoto ,  Makoto Sato ,  Akira Okawado ,  Shinichiro Tsurumaru ,  Maki Miyata ,  Toshiyuki Kobayashi ,  Nobuaki Akasawa ,  Masahiko Okano ,  Takao Miyanaga

发明人： Takao Obata ,  Mitsuaki Kumagai ,  Akihiko Iura ,  Akio Murata ,  Shinji Yamamoto ,  Makoto Sato ,  Akira Okawado ,  Shinichiro Tsurumaru ,  Maki Miyata ,  Toshiyuki Kobayashi ,  Nobuaki Akasawa ,  Masahiko Okano ,  Takao Miyanaga

IPC分类号： G06F1/16 ,  G06K7/00 ,  G06K7/10 ,  G06K13/08 ,  G06K17/00 ,  H05K7/12

CPC分类号： G06K7/10881 ,  G06F1/1626 ,  G06F1/1632 ,  G06F1/1656 ,  G06F1/1696 ,  G06K13/08 ,  G06K17/0022 ,  G06K7/0021 ,  G06K7/006 ,  G06K7/1098

摘要： In an information processing system having a portable terminal unit, such as a hand-held computer, driven by a rechargeable battery and a data communication adaptor for enabling communication between the portable terminal unit and a host computer of the system, the terminal unit and the data communication adaptor are designed to minimize the size by having an auxiliary connector for an optional device extend a function of the portable terminal unit. This is provided in the opening of the casing of the portable terminal unit movable in three dimensions mounted on a printed circuit board.

摘要翻译： 在具有由可再充电电池驱动的便携式终端单元（例如手持式计算机）和数据通信适配器的信息处理系统中，用于实现便携式终端单元与系统的主计算机之间的通信，终端单元和 数据通信适配器被设计为通过具有用于可选设备的辅助连接器来扩展便携式终端单元的功能来最小化尺寸。 这设置在可安装在印刷电路板上的三维可移动的便携式终端单元的壳体的开口中。

公开(公告)号：US5661634A

公开(公告)日：1997-08-26

申请号：US333559

申请日：1994-10-31

申请人： Takao Obata ,  Mitsuaki Kumagai ,  Akihiko Iura ,  Akio Murata ,  Shinji Yamamoto ,  Makoto Sato ,  Akira Okawado ,  Shinichiro Tsurumaru ,  Maki Miyata ,  Toshiyuki Kobayashi ,  Nobuaki Akasawa ,  Masahiko Okano ,  Takao Miyanaga

发明人： Takao Obata ,  Mitsuaki Kumagai ,  Akihiko Iura ,  Akio Murata ,  Shinji Yamamoto ,  Makoto Sato ,  Akira Okawado ,  Shinichiro Tsurumaru ,  Maki Miyata ,  Toshiyuki Kobayashi ,  Nobuaki Akasawa ,  Masahiko Okano ,  Takao Miyanaga

IPC分类号： G06F1/16 ,  G06K7/00 ,  G06K7/10 ,  G06K13/08 ,  G06K17/00 ,  H05K7/16

CPC分类号： G06K7/10881 ,  G06F1/1626 ,  G06F1/1632 ,  G06F1/1656 ,  G06F1/1696 ,  G06K13/08 ,  G06K17/0022 ,  G06K7/0021 ,  G06K7/006 ,  G06K7/1098

摘要： In an information processing system having a portable terminal unit, such as a hand-held computer, driven by a rechargeable battery and a data communication adaptor for enabling communication between the portable terminal unit and a host computer of the system, the terminal unit and the data communication adaptor are designed to minimize the size thereof in the following five ways. First, a memory card holding mechanism for connecting the memory card of the portable terminal unit is provided between a swinging back lid and a recess of the back casing. Second, a normal interface and a high-speed interface are both provided in the portable terminal unit and the the data communication adaptor respectively. Third, an auxiliary connector for an optimal device to extend a function of the portable terminal unit is provided in the opening of the casing of the portable terminal unit movable in three dimensions mounted on a printed circuit board. Fourth, a moisture resistant seal made of rubber or resin is molded integrally onto one of the joining edges of an upper casing and a lower casing. Fifth, an electric power source portion of the data communication adaptor is used not only for charging the battery of the portable terminal unit but also supplying a power adequate for enabling a data transmission operation thereof.

摘要翻译： 在具有由可再充电电池驱动的便携式终端单元（例如手持式计算机）和数据通信适配器的信息处理系统中，用于实现便携式终端单元与系统的主计算机之间的通信，终端单元和 数据通信适配器被设计为以下五种方式使其大小最小化。 首先，在摆动后盖和后壳体的凹部之间设置用于连接便携式终端单元的存储卡的存储卡保持机构。 第二，分别在便携式终端单元和数据通信适配器中分别提供正常接口和高速接口。 第三，在安装在印刷电路板上的三维可移动的便携式终端单元的壳体的开口中提供用于扩展便携式终端单元的功能的最佳设备的辅助连接器。 第四，由橡胶或树脂制成的防潮密封件一体地模制在上壳体和下壳体的一个接合边缘上。 第五，数据通信适配器的电源部分不仅用于为便携式终端单元的电池充电，而且还提供足以使其进行数据传输操作的电力。

公开(公告)号：US08431586B2

公开(公告)日：2013-04-30

申请号：US12089087

申请日：2006-10-03

申请人： Masahiko Okano ,  Tatsuya Oyama

发明人： Masahiko Okano ,  Tatsuya Oyama

IPC分类号： A61K31/517

CPC分类号： C07D239/94 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14

摘要： The present invention relates to novel quinazoline derivatives with less skin irritation and an excellent action of strongly suppressing scratching behavior, and pharmaceutical compositions containing a quinazoline derivative as an active ingredient. The present invention is directed to the quinazoline derivatives represented by the general formula [1] or pharmaceutically acceptable salts thereof. In the general formula [1], R1 represents hydrogen or the like; R2 represents hydrogen or the like; R3 and R4 are the same or different and represent hydrogen, alkyl, alkoxy or halogen; R5 is combined with R6 to represent alkylene or represents hydrogen, hydroxy, alkyl, phenyl or alkoxy; R6 represents alkyl, cycloalkyl, phenyl, a 5- to 10-membered aromatic heterocyclic group containing one to three heteroatoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, or —N(R6-1)(R6-2).

摘要翻译： 本发明涉及具有较少皮肤刺激性和强烈抑制划伤行为的优异作用的新型喹唑啉衍生物以及含有喹唑啉衍生物作为活性成分的药物组合物。 本发明涉及由通式[1]表示的喹唑啉衍生物或其药学上可接受的盐。 在通式[1]中，R 1表示氢等; R2表示氢等; R3和R4相同或不同，代表氢，烷基，烷氧基或卤素; R5与R6结合表示亚烷基或代表氢，羟基，烷基，苯基或烷氧基; R6表示烷基，环烷基，苯基，含有1至3个选自氮原子，氧原子和硫原子的杂原子的5至10元芳族杂环基或-N（R 6-1）（ R6-2）。

公开(公告)号：US07718663B2

公开(公告)日：2010-05-18

申请号：US10512954

申请日：2003-04-28

申请人： Masahiko Okano ,  Tatsuya Oyama

发明人： Masahiko Okano ,  Tatsuya Oyama

IPC分类号： A61K31/517 ,  C07D239/94

CPC分类号： A61K31/517 ,  A61K31/357 ,  A61K31/5377 ,  A61K31/541 ,  C07D239/84 ,  C07D239/95

摘要： An object of the present invention is to provide an antipruritic agent having a novel action mechanism.The present invention provides an antipruritic agent comprising a compound represented by the following general formula (1): wherein R1 represents a hydrogen atom or alkyl; the ring Q represents a cyclohexylene group or a phenylene group; A1 and A2 represent a single bond or an alkylene group; E represents —NHCO—; A3 represents a single bond or a divalent saturated or unsaturated aliphatic hydrocarbon group; R3 represents a non-cyclic aliphatic hydrocarbon group; and R4 and R5 are the same or different and each represents a hydrogen atom or alkyl, or a pharmaceutically acceptable salt thereof as an active ingredient.

摘要翻译： 本发明的目的是提供具有新颖作用机理的止痒剂。 本发明提供含有由以下通式（1）表示的化合物的止痒剂：其中R1表示氢原子或烷基; 环Q表示亚环己基或亚苯基; A1和A2表示单键或亚烷基; E表示-NHCO-; A3表示单键或二价饱和或不饱和脂族烃基; R3表示非环状脂族烃基; R 4和R 5相同或不同，各自表示氢原子或烷基，或其药学上可接受的盐作为活性成分。

公开(公告)号：US20050176741A1

公开(公告)日：2005-08-11

申请号：US10512954

申请日：2003-04-28

申请人： Masahiko Okano ,  Tatsuya Oyama

发明人： Masahiko Okano ,  Tatsuya Oyama

IPC分类号： A61K31/357 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/541 ,  A61P17/04 ,  C07D239/84 ,  C07D239/95

CPC分类号： A61K31/517 ,  A61K31/357 ,  A61K31/5377 ,  A61K31/541 ,  C07D239/84 ,  C07D239/95

摘要： An object of the present invention is to provide an antipruritic agent having a novel action mechanism. The present invention provides an antipruritic agent comprising a compound represented by the following general formula (1): wherein R1 represents a hydrogen atom or alkyl; the ring Q represents a cyclohexylene group or a phenylene group; A1 and A2 represent a single bond or an alkylene group; E represents —NHCO—; A3 represents a single bond or a divalent saturated or unsaturated aliphatic hydrocarbon group; R3 represents a non-cyclic aliphatic hydrocarbon group; and R4 and R5 are the same or different and each represents a hydrogen atom or alkyl, or a pharmaceutically acceptable salt thereof as an active ingredient.

摘要翻译： 本发明的目的是提供具有新颖作用机理的止痒剂。 本发明提供含有由以下通式（1）表示的化合物的止痒药：其中R 1表示氢原子或烷基; 环Q表示亚环己基或亚苯基; A 1和A 2代表单键或亚烷基; E表示-NHCO-; A 3表示单键或二价饱和或不饱和脂族烃基; R 3表示非环状脂族烃基; R 4和R 5相同或不同，各自表示氢原子或烷基或其药学上可接受的盐作为活性成分。

公开(公告)号：US20100022566A1

公开(公告)日：2010-01-28

申请号：US12089087

申请日：2006-10-03

申请人： Masahiko Okano ,  Tatsuya Oyama

发明人： Masahiko Okano ,  Tatsuya Oyama

IPC分类号： A61K31/517 ,  C07D239/72 ,  A61P17/02 ,  A61P17/06

CPC分类号： C07D239/94 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14

摘要： The present invention relates to novel quinazoline derivatives with less skin irritation and an excellent action of strongly suppressing scratching behavior, and pharmaceutical compositions containing a quinazoline derivative as an active ingredient. The present invention is directed to the quinazoline derivatives represented by the general formula [1] or pharmaceutically acceptable salts thereof. In the general formula [1], R1 represents hydrogen or the like; R2 represents hydrogen or the like; R3 and R4 are the same or different and represent hydrogen, alkyl, alkoxy or halogen; R5 is combined with R6 to represent alkylene or represents hydrogen, hydroxy, alkyl, phenyl or alkoxy; R6 represents alkyl, cycloalkyl, phenyl, a 5- to 10-membered aromatic heterocyclic group containing one to three heteroatoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, or —N(R6-1)(R6-2).

摘要翻译： 本发明涉及具有较少皮肤刺激性和强烈抑制划伤行为的优异作用的新型喹唑啉衍生物以及含有喹唑啉衍生物作为活性成分的药物组合物。 本发明涉及由通式[1]表示的喹唑啉衍生物或其药学上可接受的盐。 在通式[1]中，R 1表示氢等; R2表示氢等; R3和R4相同或不同，代表氢，烷基，烷氧基或卤素; R5与R6结合表示亚烷基或代表氢，羟基，烷基，苯基或烷氧基; R6表示烷基，环烷基，苯基，含有1至3个选自氮原子，氧原子和硫原子的杂原子的5至10元芳族杂环基或-N（R 6-1）（ R6-2）。

公开(公告)号：US07220751B2

公开(公告)日：2007-05-22

申请号：US10399803

申请日：2001-11-01

申请人： Masahiko Okano ,  Kazuya Mori

发明人： Masahiko Okano ,  Kazuya Mori

IPC分类号： A61K31/517 ,  C07D413/02 ,  C07D209/36 ,  C07C29/20 ,  C07C275/00

CPC分类号： C07D401/06 ,  C07D239/94

摘要： The invention provides an excellent novel analgesic which acts on a nociceptin receptor to exhibit a wide range of the analgesic effect for example on a chronic pain as well as an allodynia accompanied with a herpes zoster.The invention relates to a nociceptin receptor agonist comprising as an active ingredient a compound represented by Formula (I) or a salt thereof: wherein R1 represents a hydrogen atom or alkyl; A1 and A2 are the same or different and each represents a single bond or a divalent aliphatic hydrocarbon group; Q represents a single bond, cycloalkylene group, phenylene group or a divalent heterocyclic group; R2A and R2B are the same or different and each represents a hydrogen atom or alkyl; R3 represents an optionally substituted phenyl group or heterocyclic group; R4 and R5 are the same or different and each represents a hydrogen atom, alkyl, alkoxy, aralkyloxy, halogen, nitro, hydroxy, alkoxycarbonyl, —NR6R7 and the like.

摘要翻译： 本发明提供了一种优异的新颖止痛剂，其作用于伤害感受肽受体以表现出广泛的止痛效果，例如慢性疼痛以及伴随带状疱疹的异常性疼痛。 本发明涉及一种伤害感受肽受体激动剂，其包含作为活性成分的由式（I）表示的化合物或其盐：其中R 1表示氢原子或烷基; A 1和A 2相同或不同，各自表示单键或二价脂族烃基; Q表示单键，亚环烷基，亚苯基或二价杂环基; R 2A和R 2B相同或不同，各自表示氢原子或烷基; R 3表示任选取代的苯基或杂环基; R 4和R 5相同或不同，各自表示氢原子，烷基，烷氧基，芳烷氧基，卤素，硝基，羟基，烷氧基羰基，-NR 6＆lt; 7＆gt;等等。