公开(公告)号：US20090312770A1

公开(公告)日：2009-12-17

申请号：US12483313

申请日：2009-06-12

申请人： Takashi Daniel Yoshida Kozai ,  Daryl R. Kipke ,  Jeyakumar Subbaroyan

发明人： Takashi Daniel Yoshida Kozai ,  Daryl R. Kipke ,  Jeyakumar Subbaroyan

IPC分类号： A61B17/00

CPC分类号： A61B17/3468 ,  A61B5/0478 ,  A61B5/6846 ,  A61B5/6868 ,  A61B17/1604 ,  A61B90/10 ,  A61B2017/0084 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/0539

摘要： A probe insertion device for implanting a probe into tissue includes a rigid base that selectively attaches to the probe due to a bond between the base and the probe, that provides a structural backbone to the probe, is longitudinally aligned with the probe, and can be adapted to receive a fluid between the base and the probe. The probe insertion device can include a surface covering at least a portion of the base that reduces the bond between the base and the probe in the presence of the fluid.

摘要翻译： 用于将探针植入组织中的探针插入装置包括由基底和探针之间的接合选择性地附接到探针的刚性基底，其提供了探针的结构骨架，与探针纵向对齐，并且可以是 适于在基部和探针之间接收流体。 探针插入装置可以包括覆盖基底的至少一部分的表面，其在流体存在的情况下减少基部和探针之间的结合。

公开(公告)号：US08852206B2

公开(公告)日：2014-10-07

申请号：US12483313

申请日：2009-06-12

申请人： Takashi Daniel Yoshida Kozai ,  Daryl R. Kipke ,  Jeyakumar Subbaroyan

发明人： Takashi Daniel Yoshida Kozai ,  Daryl R. Kipke ,  Jeyakumar Subbaroyan

IPC分类号： A61B5/04 ,  A61B5/00 ,  A61B17/34 ,  A61B17/00 ,  A61B17/16 ,  A61N1/05 ,  A61B19/00

CPC分类号： A61B17/3468 ,  A61B5/0478 ,  A61B5/6846 ,  A61B5/6868 ,  A61B17/1604 ,  A61B90/10 ,  A61B2017/0084 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/0539

摘要： A probe insertion device for implanting a probe into tissue includes a rigid base that selectively attaches to the probe due to a bond between the base and the probe, that provides a structural backbone to the probe, is longitudinally aligned with the probe, and can be adapted to receive a fluid between the base and the probe. The probe insertion device can include a surface covering at least a portion of the base that reduces the bond between the base and the probe in the presence of the fluid.

摘要翻译： 用于将探针植入组织中的探针插入装置包括由基底和探针之间的接合选择性地附接到探针的刚性基底，其提供了探针的结构骨架，与探针纵向对齐，并且可以是 适于在基部和探针之间接收流体。 探针插入装置可以包括覆盖基底的至少一部分的表面，其在流体存在的情况下减少基部和探针之间的结合。

公开(公告)号：US20110270360A1

公开(公告)日：2011-11-03

申请号：US12980659

申请日：2010-12-29

申请人： Jason L. Harris ,  Nicholas Stylopoulos ,  Lee M. Kaplan ,  Tamara C. Baynham ,  Jeyakumar Subbaroyan ,  James W. Voegele ,  Taylor W. Aronhalt ,  Anthony Diubaldi ,  David N. Plescia ,  Mark S. Ortiz ,  Theodore L. Stephens

发明人： Jason L. Harris ,  Nicholas Stylopoulos ,  Lee M. Kaplan ,  Tamara C. Baynham ,  Jeyakumar Subbaroyan ,  James W. Voegele ,  Taylor W. Aronhalt ,  Anthony Diubaldi ,  David N. Plescia ,  Mark S. Ortiz ,  Theodore L. Stephens

IPC分类号： A61N1/36

CPC分类号： A61N1/0456 ,  A61N1/0492 ,  A61N1/0504 ,  A61N1/36 ,  A61N1/36014 ,  A61N1/3605 ,  A61N1/3606 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36192 ,  A61N1/36196 ,  A61N1/3787

摘要： Methods and devices are provided for activating brown adipose tissue (BAT). Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss. In one embodiment, a medical device is provided that activates BAT by electrically stimulating nerves that activate the BAT and/or electrically stimulating brown adipocytes directly, thereby increasing thermogenesis in the BAT and inducing weight loss through energy expenditure.

摘要翻译： 提供了用于激活棕色脂肪组织（BAT）的方法和装置。 通常，方法和装置可以激活BAT以增加产热，例如增加患者的热量产生，其随着时间的推移可导致体重减轻。 在一个实施方案中，提供了通过电刺激直接激活BAT和/或电刺激棕色脂肪细胞的神经来激活BAT的医疗装置，从而增加BAT中的产热并通过能量消耗引起体重减轻。

公开(公告)号：US20140277324A1

公开(公告)日：2014-09-18

申请号：US13796883

申请日：2013-03-12

申请人： Anthony R. DiUbaldi ,  Jeyakumar Subbaroyan ,  Tamara C. Baynham ,  Michael A. Luedtke ,  James Gamgort

发明人： Anthony R. DiUbaldi ,  Jeyakumar Subbaroyan ,  Tamara C. Baynham ,  Michael A. Luedtke ,  James Gamgort

IPC分类号： A61N1/04

CPC分类号： A61N1/0472 ,  A61N1/0456 ,  A61N1/0484 ,  A61N1/0492 ,  A61N1/36021

摘要： A device for providing transdermal electrical stimulation at an adjustable position on a head. The device including a supporting member ergonomically shaped and configured to be fixedly supported about an anatomical body part; the supporting member being adjustably positionable in only two directions substantially perpendicular to one another. No electrical stimulation is provided by the supporting member. Alternatively, the device includes at least one pair of electrodes for producing the transdermal electrical stimulation to the head. The electrodes are mounted to a securing member shaped and configured to be releasably securable only about a plurality of strands of hair at a predetermined fixed orientation without being secured about any anatomical body part.

摘要翻译： 用于在头部的可调整位置提供透皮电刺激的装置。 该装置包括符合人体工程学形状并构造成围绕解剖体部分被固定地支撑的支撑构件; 支撑构件可以仅在基本上彼此垂直的两个方向上可调整地定位。 不支撑构件提供电刺激。 或者，该装置包括用于产生对头部的透皮电刺激的至少一对电极。 电极被安装到固定构件上，该固定构件成形并构造成仅在围绕任何解剖体部分固定的预定固定取向的多束头发处可释放地固定。

公开(公告)号：US09044606B2

公开(公告)日：2015-06-02

申请号：US12980659

申请日：2010-12-29

申请人： Jason L. Harris ,  Nicholas Stylopoulos ,  Lee M. Kaplan ,  Tamara C. Baynham ,  Jeyakumar Subbaroyan ,  James W. Voegele ,  Taylor Aronhalt ,  Anthony Diubaldi ,  David N. Plescia ,  Mark S. Ortiz ,  Theodore L. Stephens

发明人： Jason L. Harris ,  Nicholas Stylopoulos ,  Lee M. Kaplan ,  Tamara C. Baynham ,  Jeyakumar Subbaroyan ,  James W. Voegele ,  Taylor Aronhalt ,  Anthony Diubaldi ,  David N. Plescia ,  Mark S. Ortiz ,  Theodore L. Stephens

IPC分类号： A61N1/00 ,  A61N1/36

CPC分类号： A61N1/0456 ,  A61N1/0492 ,  A61N1/0504 ,  A61N1/36 ,  A61N1/36014 ,  A61N1/3605 ,  A61N1/3606 ,  A61N1/36153 ,  A61N1/36157 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36192 ,  A61N1/36196 ,  A61N1/3787

摘要： Methods and devices are provided for activating brown adipose tissue (BAT). Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss. In one embodiment, a medical device is provided that activates BAT by electrically stimulating nerves that activate the BAT and/or electrically stimulating brown adipocytes directly, thereby increasing thermogenesis in the BAT and inducing weight loss through energy expenditure.

摘要翻译： 提供了用于激活棕色脂肪组织（BAT）的方法和装置。 通常，方法和装置可以激活BAT以增加产热，例如增加患者的热量产生，其随着时间的推移可导致体重减轻。 在一个实施方案中，提供了通过电刺激直接激活BAT和/或电刺激棕色脂肪细胞的神经来激活BAT的医疗装置，从而增加BAT中的产热并通过能量消耗引起体重减轻。

公开(公告)号：US08880173B2

公开(公告)日：2014-11-04

申请号：US13796883

申请日：2013-03-12

申请人： Anthony R. DiUbaldi ,  Jeyakumar Subbaroyan ,  Tamara C. Baynham

发明人： Anthony R. DiUbaldi ,  Jeyakumar Subbaroyan ,  Tamara C. Baynham

IPC分类号： A61N1/04

CPC分类号： A61N1/0472 ,  A61N1/0456 ,  A61N1/0484 ,  A61N1/0492 ,  A61N1/36021

摘要： A device for providing transdermal electrical stimulation at an adjustable position on a head. The device including a supporting member economically shaped and configured to be fixedly supported about an anatomical body part; the supporting member being adjustably positionable in only two directions substantially perpendicular to one another. No electrical stimulation is provided by the supporting member. Alternatively, the device includes at least one pair of electrodes for producing the transdermal electrical stimulation to the head. The electrodes are mounted to a securing member shaped and configured to be releasably securable only about a plurality of strands of hair at a predetermined fixed orientation without being secured about any anatomical body part.

摘要翻译： 用于在头部的可调整位置提供透皮电刺激的装置。 所述装置包括经济地成形并被构造为围绕解剖体部分被固定地支撑的支撑构件; 支撑构件可以仅在基本上彼此垂直的两个方向上可调整地定位。 不支撑构件提供电刺激。 或者，该装置包括用于产生对头部的透皮电刺激的至少一对电极。 电极被安装到固定构件上，该固定构件成形并构造成仅在围绕任何解剖体部分固定的预定固定取向的多束头发处可释放地固定。