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    X-ray CT apparatus and myocardial perfusion image generating system
    1.
    发明申请
    X-ray CT apparatus and myocardial perfusion image generating system 有权
    X射线CT装置和心肌灌注图像生成系统

    公开(公告)号：US20060241402A1

    公开(公告)日：2006-10-26

    申请号：US11075667

    申请日：2005-03-10

    申请人： Takashi Ichihara ,  Toshihiro Rifu ,  Joao Lima

    发明人： Takashi Ichihara ,  Toshihiro Rifu ,  Joao Lima

    IPC分类号： A61B5/05

    CPC分类号： A61B6/504 ,  A61B6/481 ,  A61B6/503 ,  A61B6/507 ,  A61B6/541

    摘要： An X-ray CT apparatus 1 comprises a blood-flow information acquisition unit, a correction value calculating unit and a blood-flow image generating unit 24e. The blood-flow information acquisition unit obtains information of a relative blood flow rate in the myocardium of the subject P based on the CT image. The correction value calculating unit obtains a correction value based on the CT image in a concentration transition period defined to be a period from immediately after starting of a continuously injection of a contrast medium into the subject P until the contrast medium injected reaches to the myocardium, increases, and will be in a state where it can be considered that the contrast medium is saturated in a constant value. The blood-flow image generating unit 24e generating a blood flow value image in the myocardium by correcting the information of the relative blood flow rate with the correction value.

    摘要翻译： X射线CT装置1包括血流信息获取单元，校正值计算单元和血流图像生成单元24e。 血流信息获取单元基于CT图像获取被检体P的心肌的相对血流量的信息。 校正值计算单元获得校正值，该校正值基于定义为从连续注入造影剂开始到被摄体P之后的周期的浓度过渡期，直到注入的造影剂到达心肌， 并且将处于可以认为造影剂饱和为常数的状态。 血流图像生成单元24e，用校正值校正相对血流量的信息，生成心肌血流值图像。

    System and method for magnetic-resonance-guided electrophysiologic and ablation procedures
    2.
    发明申请
    System and method for magnetic-resonance-guided electrophysiologic and ablation procedures 有权
    磁共振引导电生理和消融手术的系统和方法

    公开(公告)号：US20060100506A1

    公开(公告)日：2006-05-11

    申请号：US11314241

    申请日：2005-12-22

    申请人： Henry Halperin ,  Ronald Berger ,  Ergin Atalar ,  Elliot McVeigh ,  Albert Lardo ,  Hugh Calkins ,  Joao Lima

    发明人： Henry Halperin ,  Ronald Berger ,  Ergin Atalar ,  Elliot McVeigh ,  Albert Lardo ,  Hugh Calkins ,  Joao Lima

    IPC分类号： A61B5/05

    CPC分类号： A61B5/055 ,  A61B5/415 ,  A61B5/418 ,  A61B18/1492 ,  A61B90/36 ,  A61B2017/00039 ,  A61B2017/00053 ,  A61B2090/374 ,  G01R33/285 ,  G01R33/34084 ,  G01R33/4808 ,  G01R33/5601

    摘要： A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures includes an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures, such as ablation of cardiac arrhythmias. The combined electrophysiology and imaging antenna catheter may further include an ablation tip, and be used as an intracardiac device to deliver energy to selected areas of tissue and visualize the resulting ablation lesions. The antenna utilized in the combined electrophysiology and imaging catheter for receiving MR signals is preferably of the coaxial or “loopless” type. High-resolution images from the antenna may be combined with low-resolution images from surface coils of the MR scanner to produce a composite image. A system for eliminating the pickup of RF energy in which intracardiac wires are detuned by filtering so that they become very inefficient antennas. An RF filtering system is provided for suppressing the MR imaging signal while not attenuating the RF ablative current. Steering means may be provided for steering the invasive catheter under MR guidance. Other ablative methods can be used such as laser, ultrasound, and low temperatures.

    摘要翻译： 使用磁共振成像来提高电生理过程精度的系统和方法包括侵入性组合电生理学和成像天线导管，其包括用于接收磁共振信号的RF天线和用于接收电位的诊断电极。 组合的电生理学和成像天线导管与磁共振成像扫描仪组合使用以在电生理诊断或治疗过程（例如心律失常消融）中引导和提供可视化。 组合的电生理学和成像天线导管还可以包括消融尖端，并且用作心内装置以将能量传递到组织的选定区域并且可视化所得到的消融损伤。 在组合的电生理学和成像导管中用于接收MR信号的天线优选地是同轴的或“无绒毛”的。 来自天线的高分辨率图像可以与来自MR扫描器的表面线圈的低分辨率图像组合以产生合成图像。 用于消除RF能量的拾取的系统，其中心内线通过滤波失谐，使得它们变得非常低效的天线。 提供RF滤波系统，用于抑制MR成像信号，同时不衰减RF消融电流。 可以提供转向装置用于在MR引导下转导侵入性导管。 可以使用其他烧蚀方法，如激光，超声和低温。

    System and method for magnetic-resonance-guided electrophysiologic and ablation procedures
    3.
    发明授权
    System and method for magnetic-resonance-guided electrophysiologic and ablation procedures 有权
    磁共振引导电生理和消融手术的系统和方法

    公开(公告)号：US08099151B2

    公开(公告)日：2012-01-17

    申请号：US11314241

    申请日：2005-12-22

    申请人： Henry R Halperin ,  Ronald D. Berger ,  Ergin Atalar ,  Elliot R McVeigh ,  Albert Lardo ,  Hugh Calkins ,  Joao Lima

    发明人： Henry R Halperin ,  Ronald D. Berger ,  Ergin Atalar ,  Elliot R McVeigh ,  Albert Lardo ,  Hugh Calkins ,  Joao Lima

    IPC分类号： A61B5/05

    CPC分类号： A61B5/055 ,  A61B5/415 ,  A61B5/418 ,  A61B18/1492 ,  A61B90/36 ,  A61B2017/00039 ,  A61B2017/00053 ,  A61B2090/374 ,  G01R33/285 ,  G01R33/34084 ,  G01R33/4808 ,  G01R33/5601

    摘要： A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures includes an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures, such as ablation of cardiac arrhythmias. The combined electrophysiology and imaging antenna catheter may further include an ablation tip, and be used as an intracardiac device to deliver energy to selected areas of tissue and visualize the resulting ablation lesions. The antenna utilized in the combined electrophysiology and imaging catheter for receiving MR signals is preferably of the coaxial or “loopless” type. High-resolution images from the antenna may be combined with low-resolution images from surface coils of the MR scanner to produce a composite image. A system for eliminating the pickup of RF energy in which intracardiac wires are detuned by filtering so that they become very inefficient antennas. An RF filtering system is provided for suppressing the MR imaging signal while not attenuating the RF ablative current. Steering means may be provided for steering the invasive catheter under MR guidance. Other ablative methods can be used such as laser, ultrasound, and low temperatures.

    摘要翻译： 使用磁共振成像来提高电生理过程精度的系统和方法包括侵入性组合电生理学和成像天线导管，其包括用于接收磁共振信号的RF天线和用于接收电位的诊断电极。 组合的电生理学和成像天线导管与磁共振成像扫描仪组合使用以在电生理诊断或治疗过程（例如心律失常消融）中引导和提供可视化。 组合的电生理学和成像天线导管还可以包括消融尖端，并且用作心内装置以将能量传递到组织的选定区域并且可视化所得到的消融损伤。 在组合的电生理学和成像导管中用于接收MR信号的天线优选地是同轴的或“无绒毛”的。 来自天线的高分辨率图像可以与来自MR扫描器的表面线圈的低分辨率图像组合以产生合成图像。 用于消除RF能量的拾取的系统，其中心内线通过滤波失谐，使得它们变得非常低效的天线。 提供RF滤波系统，用于抑制MR成像信号，同时不衰减RF消融电流。 可以提供转向装置用于在MR引导下转导侵入性导管。 可以使用其他烧蚀方法，如激光，超声和低温。

    System and method for magnetic-resonance-guided electrophysiologic and ablation procedures
    4.
    发明授权
    System and method for magnetic-resonance-guided electrophysiologic and ablation procedures 有权

    公开(公告)号：US07155271B2

    公开(公告)日：2006-12-26

    申请号：US10424093

    申请日：2003-04-28

    申请人： Henry R. Halperin ,  Ronald D. Berger ,  Ergin Atalar ,  Elliot R. McVeigh ,  Albert Lardo ,  Hugh Calkins ,  Joao Lima

    发明人： Henry R. Halperin ,  Ronald D. Berger ,  Ergin Atalar ,  Elliot R. McVeigh ,  Albert Lardo ,  Hugh Calkins ,  Joao Lima

    IPC分类号： A61B5/055

    CPC分类号： A61B5/055 ,  A61B5/415 ,  A61B5/418 ,  A61B18/1492 ,  A61B90/36 ,  A61B2017/00039 ,  A61B2017/00053 ,  A61B2090/374 ,  G01R33/285 ,  G01R33/34084 ,  G01R33/4808 ,  G01R33/5601

    摘要： A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures is disclosed. The system in its preferred embodiment provides an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures. The invention is particularly applicable to catheter ablation, e.g., ablation of atrial fibrillation. In embodiments which are useful for catheter ablation, the combined electrophysiology and imaging antenna catheter may further include an ablation tip, and such embodiment may be used as an intracardiac device to both deliver energy to selected areas of tissue and visualize the resulting ablation lesions, thereby greatly simplifying production of continuous linear lesions. The invention further includes embodiments useful for guiding electrophysiologic diagnostic and therapeutic procedures other than ablation. Imaging of ablation lesions may be further enhanced by use of MR contrast agents. The antenna utilized in the combined electrophysiology and imaging catheter for receiving MR signals is preferably of the coaxial or “loopless” type. High-resolution images from the antenna may be combined with low-resolution images from surface coils of the MR scanner to produce a composite image. The invention further provides a system for eliminating the pickup of RF energy in which intracardiac wires are detuned by filtering so that they become very inefficient antennas. An RF filtering system is provided for suppressing the MR imaging signal while not attenuating the RF ablative current. Steering means may be provided for steering the invasive catheter under MR guidance. Other ablative methods can be used such as laser, ultrasound, and low temperatures.

    MRI-GUIDED THERAPY METHODS AND RELATED SYSTEMS
    6.
    发明申请
    MRI-GUIDED THERAPY METHODS AND RELATED SYSTEMS 有权

    公开(公告)号：US20080058635A1

    公开(公告)日：2008-03-06

    申请号：US11924877

    申请日：2007-10-26

    申请人： Henry Halperin ,  Ronald Berger ,  Ergin Atalar ,  Elliot McVeigh ,  Albert Lardo ,  Hugh Calkins ,  Joao Lima

    发明人： Henry Halperin ,  Ronald Berger ,  Ergin Atalar ,  Elliot McVeigh ,  Albert Lardo ,  Hugh Calkins ,  Joao Lima

    IPC分类号： A61B5/055 ,  A61B18/12

    CPC分类号： A61B5/055 ,  A61B5/415 ,  A61B5/418 ,  A61B18/1492 ,  A61B90/36 ,  A61B2017/00039 ,  A61B2017/00053 ,  A61B2090/374 ,  G01R33/285 ,  G01R33/34084 ,  G01R33/4808 ,  G01R33/5601

    摘要： A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures is disclosed. The system in its preferred embodiment provides an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures. The invention is particularly applicable to catheter ablation, e.g., ablation of atrial fibrillation. In embodiments which are useful for catheter ablation, the combined electrophysiology and imaging antenna catheter may further include an ablation tip, and such embodiment may be used as an intracardiac device to both deliver energy to selected areas of tissue and visualize the resulting ablation lesions, thereby greatly simplifying production of continuous linear lesions. The invention further includes embodiments useful for guiding electrophysiologic diagnostic and therapeutic procedures other than ablation. Imaging of ablation lesions may be further enhanced by use of MR contrast agents. The antenna utilized in the combined electrophysiology and imaging catheter for receiving MR signals is preferably of the coaxial or “loopless” type. High-resolution images from the antenna may be combined with low-resolution images from surface coils of the MR scanner to produce a composite image. The invention further provides a system for eliminating the pickup of RF energy in which intracardiac wires are detuned by filtering so that they become very inefficient antennas. An RF filtering system is provided for suppressing the MR imaging signal while not attenuating the RF ablative current. Steering means may be provided for steering the invasive catheter under MR guidance. Other ablative methods can be used such as laser, ultrasound, and low temperatures.

    MRI-guided therapy methods and related systems
    7.
    发明授权
    MRI-guided therapy methods and related systems 有权
    MRI指导治疗方法及相关系统

    公开(公告)号：US07822460B2

    公开(公告)日：2010-10-26

    申请号：US11924877

    申请日：2007-10-26

    申请人： Henry R. Halperin ,  Ronald D. Berger ,  Ergin Atalar ,  Elliot R. McVeigh ,  Albert Lardo ,  Hugh Calkins ,  Joao Lima

    发明人： Henry R. Halperin ,  Ronald D. Berger ,  Ergin Atalar ,  Elliot R. McVeigh ,  Albert Lardo ,  Hugh Calkins ,  Joao Lima

    IPC分类号： A61B5/05 ,  G01V3/00

    CPC分类号： A61B5/055 ,  A61B5/415 ,  A61B5/418 ,  A61B18/1492 ,  A61B90/36 ,  A61B2017/00039 ,  A61B2017/00053 ,  A61B2090/374 ,  G01R33/285 ,  G01R33/34084 ,  G01R33/4808 ,  G01R33/5601

    摘要： A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures is disclosed. The system in its preferred embodiment provides an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures. The invention further provides a system for eliminating the pickup of RF energy in which intracardiac wires are detuned by filtering so that they become very inefficient antennas. An RF filtering system is provided for suppressing the MR imaging signal while not attenuating the RF ablative current. Steering means may be provided for steering the invasive catheter under MR guidance.

    摘要翻译： 公开了一种使用磁共振成像来提高电生理过程精度的系统和方法。 该系统在其优选实施例中提供了一种侵入性组合电生理学和成像天线导管，其包括用于接收磁共振信号的RF天线和用于接收电位的诊断电极。 组合的电生理和成像天线导管与磁共振成像扫描仪结合使用以在电生理诊断或治疗过程中引导和提供可视化。 本发明还提供一种用于消除射频能量的拾取的系统，其中心内线通过滤波失谐，使得它们变得非常低效的天线。 提供RF滤波系统，用于抑制MR成像信号，同时不衰减RF消融电流。 可以提供转向装置用于在MR引导下转导侵入性导管。

    Magnetic-resonance-guided imaging, electrophysiology, and ablation
    9.
    发明授权
    Magnetic-resonance-guided imaging, electrophysiology, and ablation 有权

    公开(公告)号：US06701176B1

    公开(公告)日：2004-03-02

    申请号：US09428990

    申请日：1999-10-29

    申请人： Henry R. Halperin ,  Ronald D. Berger ,  Ergin Atalar ,  Elliot R. McVeigh ,  Albert Lardo ,  Hugh Calkins ,  Joao Lima

    发明人： Henry R. Halperin ,  Ronald D. Berger ,  Ergin Atalar ,  Elliot R. McVeigh ,  Albert Lardo ,  Hugh Calkins ,  Joao Lima

    IPC分类号： A61B5055

    CPC分类号： A61B5/055 ,  A61B5/415 ,  A61B5/418 ,  A61B18/1492 ,  A61B90/36 ,  A61B2017/00039 ,  A61B2017/00053 ,  A61B2090/374 ,  G01R33/285 ,  G01R33/34084 ,  G01R33/4808 ,  G01R33/5601

    摘要： A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures is disclosed. The system in its preferred embodiment provides an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures. The invention is particularly applicable to catheter ablation, e.g., ablation of atrial fibrillation. In embodiments which are useful for catheter ablation, the combined electrophysiology and imaging antenna catheter may further include an ablation tip, and such embodiment may be used as an intracardiac device to both deliver energy to selected areas of tissue and visualize the resulting ablation lesions, thereby greatly simplifying production of continuous linear lesions. The invention further includes embodiments useful for guiding electrophysiologic diagnostic and therapeutic procedures other than ablation. Imaging of ablation lesions may be further enhanced by use of MR contrast agents. The antenna utilized in the combined electrophysiology and imaging catheter for receiving MR signals is preferably of the coaxial or “loopless” type. High-resolution images from the antenna may be combined with low-resolution images from surface coils of the MR scanner to produce a composite image. The invention further provides a system for eliminating the pickup of RF energy in which intracardiac wires are detuned by filtering so that they become very inefficient antennas. An RF filtering system is provided for suppressing the MR imaging signal while not attenuating the RF ablative current. Steering means may be provided for steering the invasive catheter under MR guidance. Other ablative methods can be used such as laser, ultrasound, and low temperatures.