公开(公告)号：US08319496B2

公开(公告)日：2012-11-27

申请号：US12751062

申请日：2010-03-31

Applicant: Yigitcan Eryaman ,  Ergin Atalar

Inventor： Yigitcan Eryaman ,  Ergin Atalar

IPC: G01V3/00

CPC classification number: G01R33/34076 ,  G01R33/285 ,  G01R33/288 ,  G01R33/3415 ,  G01R33/36 ,  G01R33/5612

Abstract: In a magnetic resonance data acquisition method and system for acquiring data from a patient who carries, either intracorporeally or extracorporeally, a foreign object at least partially composed of electrically conductive material, RF heating to the patient due to the presence of the foreign object is minimized by radiating the patient with RF energy by an RF coil that has a coil design. The sequence of pulses to which the patient is subjected to acquire magnetic resonance data from the patient is configured, in combination with the coil design of the RF coil to steer or modify the electric field that arises in the patient so that RF heating in the patient due to the presence of the foreign object is minimized.

Abstract translation: 在磁共振数据采集方法和系统中，用于从患者体内或体外携带至少部分由导电材料构成的异物的患者获取数据，由于异物的存在而对患者的RF加热最小化 通过具有线圈设计的RF线圈向患者辐射RF能量。 患者经受从患者获取磁共振数据的脉冲序列与RF线圈的线圈设计相结合，以引导或改变患者中出现的电场，使患者的RF加热 由于异物的存在被最小化。

公开(公告)号：US20120101364A1

公开(公告)日：2012-04-26

申请号：US13341266

申请日：2011-12-30

Applicant: Henry R. HALPERIN ,  Ronald D. Berger ,  Ergin ATALAR ,  Elliott R. McVeigh ,  Albert LARDO ,  Hugh CAIKINS ,  Joao LIMA

Inventor： Henry R. HALPERIN ,  Ronald D. Berger ,  Ergin ATALAR ,  Elliott R. McVeigh ,  Albert LARDO ,  Hugh CAIKINS ,  Joao LIMA

IPC: A61B18/14 ,  A61B5/02 ,  A61B5/055

CPC classification number: A61B5/055 ,  A61B5/415 ,  A61B5/418 ,  A61B18/1492 ,  A61B90/36 ,  A61B2017/00039 ,  A61B2017/00053 ,  A61B2090/374 ,  G01R33/285 ,  G01R33/34084 ,  G01R33/4808 ,  G01R33/5601

Abstract: A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures includes an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures, such as ablation of cardiac arrhythmias. The combined electrophysiology and imaging antenna catheter may further include an ablation tip, and be used as an intracardiac device to deliver energy to selected areas of tissue and visualize the resulting ablation lesions.

Abstract translation: 使用磁共振成像来提高电生理过程精度的系统和方法包括侵入性组合电生理学和成像天线导管，其包括用于接收磁共振信号的RF天线和用于接收电位的诊断电极。 组合的电生理学和成像天线导管与磁共振成像扫描仪组合使用以在电生理诊断或治疗过程（例如心律失常消融）中引导和提供可视化。 组合的电生理学和成像天线导管还可以包括消融尖端，并且用作心内装置以将能量传递到组织的选定区域并且可视化所得到的消融损伤。

公开(公告)号：US07822460B2

公开(公告)日：2010-10-26

申请号：US11924877

申请日：2007-10-26

Applicant: Henry R. Halperin ,  Ronald D. Berger ,  Ergin Atalar ,  Elliot R. McVeigh ,  Albert Lardo ,  Hugh Calkins ,  Joao Lima

Inventor： Henry R. Halperin ,  Ronald D. Berger ,  Ergin Atalar ,  Elliot R. McVeigh ,  Albert Lardo ,  Hugh Calkins ,  Joao Lima

IPC: A61B5/05 ,  G01V3/00

CPC classification number: A61B5/055 ,  A61B5/415 ,  A61B5/418 ,  A61B18/1492 ,  A61B90/36 ,  A61B2017/00039 ,  A61B2017/00053 ,  A61B2090/374 ,  G01R33/285 ,  G01R33/34084 ,  G01R33/4808 ,  G01R33/5601

Abstract: A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures is disclosed. The system in its preferred embodiment provides an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures. The invention further provides a system for eliminating the pickup of RF energy in which intracardiac wires are detuned by filtering so that they become very inefficient antennas. An RF filtering system is provided for suppressing the MR imaging signal while not attenuating the RF ablative current. Steering means may be provided for steering the invasive catheter under MR guidance.

Abstract translation: 公开了一种使用磁共振成像来提高电生理过程精度的系统和方法。 该系统在其优选实施例中提供了一种侵入性组合电生理学和成像天线导管，其包括用于接收磁共振信号的RF天线和用于接收电位的诊断电极。 组合的电生理和成像天线导管与磁共振成像扫描仪结合使用以在电生理诊断或治疗过程中引导和提供可视化。 本发明还提供一种用于消除射频能量的拾取的系统，其中心内线通过滤波失谐，使得它们变得非常低效的天线。 提供RF滤波系统，用于抑制MR成像信号，同时不衰减RF消融电流。 可以提供转向装置用于在MR引导下转导侵入性导管。

公开(公告)号：US20100198049A1

公开(公告)日：2010-08-05

申请号：US12757961

申请日：2010-04-09

Applicant: Parag V. Karmarkar ,  Ergin Atalar

Inventor： Parag V. Karmarkar ,  Ergin Atalar

IPC: A61B5/055 ,  A61M5/158

CPC classification number: G01R33/287 ,  A61M25/0127 ,  A61M25/0136 ,  A61M25/0138 ,  A61M25/0147 ,  G01R33/34084

Abstract: A deflectable tip catheter that is safe and effective for use in a magnetic resonance imaging environment. The deflectable tip catheter is configured such that it includes a built-in antenna, such as a loopless antenna or a loop antenna. The built-in antenna permits the deflectable tip catheter to be actively tracked and/or visualized. Depending upon the specific configuration of the deflectable tip catheter, the catheter may be tracked and/or visualized as a single unit, it may be tracked and/or visualized separate and independent of other components or instruments associated with the catheter, such as pull wires, injection needles, surgical instruments, and the like. The catheters described herein include injection type catheters and/or guidance type catheters.

Abstract translation: 一种可偏转的尖端导管，可安全有效地用于磁共振成像环境。 可偏转尖端导管被配置为使得其包括内置天线，例如无凹凸天线或环形天线。 内置天线允许可偏转的尖端导管被主动跟踪和/或可视化。 根据可偏转尖端导管的具体构造，导管可以作为单个单元进行跟踪和/或可视化，其可被跟踪和/或可视化分开并独立于与导管相关联的其它部件或器械，例如拉线 ，注射针，外科器械等。 本文所述的导管包括注射型导管和/或引导型导管。

公开(公告)号：US07561906B2

公开(公告)日：2009-07-14

申请号：US11417594

申请日：2006-05-04

Applicant: Ergin Atalar ,  Onur Ferhanoglu

Inventor： Ergin Atalar ,  Onur Ferhanoglu

IPC: A61B5/04

CPC classification number: A61N1/08 ,  A61N1/05 ,  A61N1/086 ,  A61N1/3718

Abstract: A lead for an electronic device which resists the induction of a current from an electromagnetic field external to said lead includes one or more pairs of adjacent segments of electrical wire, each of the pairs including a first segment of electrical wire and a second segment of electrical wire. The lead also includes one or more shielded RF chokes, wherein each of the shielded RF chokes is provided between the first segment of electrical wire and the second segment of electrical wire of a respective one of the one or more pairs of adjacent segments. Also, an implantable device that includes a generator for generating one or more electrical pulse and a lead as described for delivering the pulses to tissue within a patient's body. A method for making the described implantable device is also provided.

Abstract translation: 用于抵抗从所述引线外部的电磁场感应电流的电子装置的引线包括一对或多对相邻的电线段，每对电极包括电线的第一段和电线的第二段 线。 引线还包括一个或多个屏蔽RF扼流圈，其中屏蔽RF扼流圈中的每一个被设置在电线的第一段和一对或多对相邻段之间相应的一对的电线的第二段之间。 而且，一种可植入装置，其包括用于产生一个或多个电脉冲的发生器和如所描述的用于将脉冲传送到患者体内的组织的引线。 还提供了制造所述可植入装置的方法。

公开(公告)号：US07412276B2

公开(公告)日：2008-08-12

申请号：US10791622

申请日：2004-03-02

Applicant: Henry R. Halperin ,  Ronald D. Berger ,  Ergin Atalar ,  Elliot R. McVeigh ,  Albert C. Lardo ,  Hugh Calkins ,  Joao Lima

Inventor： Henry R. Halperin ,  Ronald D. Berger ,  Ergin Atalar ,  Elliot R. McVeigh ,  Albert C. Lardo ,  Hugh Calkins ,  Joao Lima

IPC: A61B5/05

CPC classification number: A61B5/055 ,  A61B5/415 ,  A61B5/418 ,  A61B18/1492 ,  A61B90/36 ,  A61B2017/00039 ,  A61B2017/00053 ,  A61B2090/374 ,  G01R33/285 ,  G01R33/34084 ,  G01R33/4808 ,  G01R33/5601

Abstract: A method of performing brain therapy may include placing a subject in a main magnetic field, introducing into the subject's brain a combination imaging and therapeutic probe, the probe including a magnetic resonance imaging antenna and an electrical energy application element, acquiring a first magnetic resonance image from the antenna of the combination probe, acquiring a second magnetic resonance image from a surface coil, combining the first and second magnetic resonance images to produce a composite image, positioning the combination probe within the brain with guidance from at least one of the images, and delivering electrical energy to the brain from the electrical energy application element of the combination probe thus positioned.

Abstract translation: 执行脑部治疗的方法可以包括将受试者放置在主磁场中，将主体脑中的组合成像和治疗探针引入，所述探针包括磁共振成像天线和电能应用元件，获取第一磁共振图像 从组合探针的天线，从表面线圈获取第二磁共振图像，组合第一和第二磁共振图像以产生合成图像，通过来自至少一个图像的引导将组合探针定位在脑内， 以及从如此定位的组合探针的电能施加元件向大脑递送电能。

公开(公告)号：US20070239151A1

公开(公告)日：2007-10-11

申请号：US11697239

申请日：2007-04-05

Applicant: Ergin Atalar ,  Anil Arat ,  Tonguc Tasci

Inventor： Ergin Atalar ,  Anil Arat ,  Tonguc Tasci

IPC: A61B18/04

CPC classification number: A61B17/12022 ,  A61B17/00491 ,  A61B17/12186 ,  A61B17/1219 ,  A61B17/12195 ,  A61B2017/1205 ,  A61B2017/12054 ,  A61B2017/12059 ,  A61B2017/12068 ,  A61B2017/12072

Abstract: The disclosed methods and devices utilize various techniques to detach the distal end of a catheter from an obstruction with minimal invasiveness and effort by the surgeon. As reflux of an embolic agent or hardening material over the catheter tip is a major causative factor in the increased morbidity/mortality of embolization procedures and also a technical limitation preventing a better cure rate, a method has been developed for the detachment of the distal end of catheters within the body, preferably with no regard to the amount of reflux, and preferably at the proximal edge of the reflux, in order to be able to make embolization procedures safer and more effective.

Abstract translation: 所公开的方法和装置利用各种技术，以最小的外科医生的侵入力和努力将导管的远端与障碍物分开。 由于栓塞剂或硬化材料在导管尖端上的回流是栓塞程序增加的发病率/死亡率以及防止更好治愈率的技术限制的主要致病因素，已经开发了用于远端脱离的方法 的导管，优选不考虑回流量，优选在回流的近端缘处，以便能够使栓塞过程更安全和更有效。

公开(公告)号：US20060252314A1

公开(公告)日：2006-11-09

申请号：US11417594

申请日：2006-05-04

Applicant: Ergin Atalar ,  Onur Ferhanoglu

Inventor： Ergin Atalar ,  Onur Ferhanoglu

IPC: H01R4/02

CPC classification number: A61N1/08 ,  A61N1/05 ,  A61N1/086 ,  A61N1/3718

Abstract: A lead for an electronic device which resists the induction of a current from an electromagnetic field external to said lead includes one or more pairs of adjacent segments of electrical wire, each of the pairs including a first segment of electrical wire and a second segment of electrical wire. The lead also includes one or more shielded RF chokes, wherein each of the shielded RF chokes is provided between the first segment of electrical wire and the second segment of electrical wire of a respective one of the one or more pairs of adjacent segments. Also, an implantable device that includes a generator for generating one or more electrical pulse and a lead as described for delivering the pulses to tissue within a patient's body. A method for making the described implantable device is also provided.

公开(公告)号：US06701176B1

公开(公告)日：2004-03-02

申请号：US09428990

申请日：1999-10-29

Applicant: Henry R. Halperin ,  Ronald D. Berger ,  Ergin Atalar ,  Elliot R. McVeigh ,  Albert Lardo ,  Hugh Calkins ,  Joao Lima

Inventor： Henry R. Halperin ,  Ronald D. Berger ,  Ergin Atalar ,  Elliot R. McVeigh ,  Albert Lardo ,  Hugh Calkins ,  Joao Lima

IPC: A61B5055

CPC classification number: A61B5/055 ,  A61B5/415 ,  A61B5/418 ,  A61B18/1492 ,  A61B90/36 ,  A61B2017/00039 ,  A61B2017/00053 ,  A61B2090/374 ,  G01R33/285 ,  G01R33/34084 ,  G01R33/4808 ,  G01R33/5601

Abstract: A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures is disclosed. The system in its preferred embodiment provides an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures. The invention is particularly applicable to catheter ablation, e.g., ablation of atrial fibrillation. In embodiments which are useful for catheter ablation, the combined electrophysiology and imaging antenna catheter may further include an ablation tip, and such embodiment may be used as an intracardiac device to both deliver energy to selected areas of tissue and visualize the resulting ablation lesions, thereby greatly simplifying production of continuous linear lesions. The invention further includes embodiments useful for guiding electrophysiologic diagnostic and therapeutic procedures other than ablation. Imaging of ablation lesions may be further enhanced by use of MR contrast agents. The antenna utilized in the combined electrophysiology and imaging catheter for receiving MR signals is preferably of the coaxial or “loopless” type. High-resolution images from the antenna may be combined with low-resolution images from surface coils of the MR scanner to produce a composite image. The invention further provides a system for eliminating the pickup of RF energy in which intracardiac wires are detuned by filtering so that they become very inefficient antennas. An RF filtering system is provided for suppressing the MR imaging signal while not attenuating the RF ablative current. Steering means may be provided for steering the invasive catheter under MR guidance. Other ablative methods can be used such as laser, ultrasound, and low temperatures.

公开(公告)号：US5928145A

公开(公告)日：1999-07-27

申请号：US638934

申请日：1996-04-25

Applicant: Ogan Ocali ,  Ergin Atalar

Inventor： Ogan Ocali ,  Ergin Atalar

IPC: A61B5/055 ,  A61B10/00 ,  A61B10/02 ,  A61B19/00 ,  G01R33/32 ,  G01R33/34 ,  G01R33/54

CPC classification number: G01R33/34084 ,  A61B10/0275 ,  A61B2090/374

Abstract: The invention provides a method for magnetic resonance imaging and spectroscopic analysis of a specimen which includes positioning the specimen within a main magnetic field and introducing an antenna having a loopless antenna portion in close proximity to the specimen. Radio frequency pulses are provided to the region of interest to excite magnetic resonance signals, gradient magnetic pulses are applied to the region of interest with the antenna receiving magnetic resonance signals and emitting responsive output signals. A processor processes the responsive output signals to provide image information for display in a desired manner. The method in a preferred form involves employing a flexible antenna. The method in another preferred form involves employing an impedance matching circuit electrically interposed between the loopless antenna and the processor to enhance radio frequency power transfer and magnetic resonance signal-to-noise ratio from the loopless antenna to the processor. The method may be used on a wide variety of specimens and in a preferred use is introduced into small blood vessels of a patient to facilitate determination of atherosclerotic plaque. Medical intervention procedures, such as plaque removal, may be employed generally simultaneously with the imaging of the present invention. Corresponding apparatus and magnetic resonance antenna assembly are provided.

Abstract translation: 本发明提供了一种用于试样的磁共振成像和光谱分析的方法，其包括将试样定位在主磁场内，并且将具有无孔天线部分的天线引入到靠近试样的位置。 将射频脉冲提供给感兴趣的区域以激励磁共振信号，梯度磁脉冲被施加到感兴趣的区域，天线接收磁共振信号并发射响应输出信号。 处理器处理响应输出信号以提供用于以所需方式显示的图像信息。 优选形式的方法涉及采用柔性天线。 另一优选形式中的方法涉及使用电绝缘天线和处理器之间的阻抗匹配电路来增强从无孔天线到处理器的射频功率传递和磁共振信噪比。 该方法可以用于各种各样的样品，并且优选的用途被引入到患者的小血管中以便于确定动脉粥样硬化斑块。 医疗干预程序，例如除斑，可以与本发明的成像通常同时使用。 提供相应的装置和磁共振天线组件。