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    Method for treatment of kidney diseases
    1.
    发明授权
    Method for treatment of kidney diseases 失效
    肾脏疾病治疗方法

    公开(公告)号：US07423009B2

    公开(公告)日：2008-09-09

    申请号：US10673380

    申请日：2003-09-30

    申请人： Takashi Nakagawa ,  Hiroyuki Ishiwata ,  Toshiaki Takizawa ,  Toru Kanke ,  Yasushi Wada ,  Junichi Kawagoe

    发明人： Takashi Nakagawa ,  Hiroyuki Ishiwata ,  Toshiaki Takizawa ,  Toru Kanke ,  Yasushi Wada ,  Junichi Kawagoe

    IPC分类号： A61K38/00 ,  A61K38/43 ,  A61K38/48

    CPC分类号： A61K38/4846 ,  A61K38/08 ,  A61K38/482 ,  A61K38/4826 ,  G01N33/6893 ,  G01N2500/00 ,  G01N2800/347

    摘要： The present invention relates to a composition for prevention and treatment of kidney diseases comprising one or more effective component(s) of a PAR-2 activating agent which is able to activate PAR-2 and a pharmaceutically acceptable carrier. The present invention further relates to a method for prevention and treatment of kidney diseases comprising administration of a composition for prevention and treatment of kidney diseases containing a PAR-2 activating agent which is able to activate PAR-2 to patients suffering from kidney diseases, and also relates to the use of a PAR-2 activating agent which is able to activate PAR-2 for the manufacture of a composition for prevention and treatment of kidney diseases. The present invention furthermore relates to a method for screening an effective ingredient for prevention and treatment of kidney diseases comprising screening of the activating action of the test substance to PAR-2.

    摘要翻译： 本发明涉及一种用于预防和治疗肾脏疾病的组合物，其包含能够激活PAR-2的PAR-2活化剂的一种或多种有效成分和药学上可接受的载体。 本发明还涉及一种用于预防和治疗肾脏疾病的方法，其包括给予含有能够使患有肾脏疾病的患者PAR-2的PAR-2激活剂的肾脏疾病的预防和治疗组合物，以及 还涉及能够激活PAR-2用于制备用于预防和治疗肾脏疾病的组合物的PAR-2活化剂的用途。 本发明还涉及筛选用于预防和治疗肾脏疾病的有效成分的方法，其包括将测试物质的活化作用筛选到PAR-2。

    Pharmaceutical composition for delayed hypersensitivity
    2.
    发明申请
    Pharmaceutical composition for delayed hypersensitivity 审中-公开
    用于延迟超敏反应的药物组合物

    公开(公告)号：US20060183664A1

    公开(公告)日：2006-08-17

    申请号：US10496851

    申请日：2002-12-13

    申请人： Toshiaki Takizawa ,  Masaki Tamiya ,  Naohiro Saito ,  Toru Kanke ,  Jiro Matsumoto ,  Yasushi Wada ,  Junichi Kawagoe ,  William Ferrell ,  John Lockhart

    发明人： Toshiaki Takizawa ,  Masaki Tamiya ,  Naohiro Saito ,  Toru Kanke ,  Jiro Matsumoto ,  Yasushi Wada ,  Junichi Kawagoe ,  William Ferrell ,  John Lockhart

    IPC分类号： A61K38/54

    CPC分类号： A61K45/06 ,  A61K31/00 ,  Y02A50/423 ,  A61K2300/00

    摘要： The present invention provides a pharmaceutical composition by a novel action mechanism without serious side effects for delayed hypersensitivity and a screening method of the same. The invention also provides a novel assay method of inhibitors/suppressive agents of PAR-2. The invention relates to a pharmaceutical composition for delayed hypersensitivity containing one or two or more active ingredients selected from the group consisting of inhibitors of PAR-2 and suppressive agents of PAR-2 gene expression and a pharmaceutically acceptable carrier, and to a method for screening active ingredients for pharmaceutical composition for delayed hypersensitivity by contacting a subject substance with cells expressing PAR-2 and by determining expression or activity of PAR-2. The invention also relates to a method for detecting or quantifying actions of the subject substance for PAR-2 using cells expressing PAR-2 in a culture containing inositol.

    摘要翻译： 本发明通过新颖的作用机理提供药物组合物，对迟发性超敏反应没有严重的副作用及其筛选方法。 本发明还提供了PAR-2抑制剂/抑制剂的新型测定方法。 本发明涉及一种用于延迟超敏反应的药物组合物，其含有选自PAR-2的抑制剂和PAR-2基因表达的抑制剂的一种或两种以上活性成分和药学上可接受的载体，以及筛选方法 通过使受试物质与表达PAR-2的细胞接触并通过测定PAR-2的表达或活性来延迟超敏反应的药物组合物的活性成分。 本发明还涉及使用含有肌醇的培养物中表达PAR-2的细胞检测或定量PAR-2的物质的作用的方法。

    Tetrazole derivatives
    3.
    发明授权
    Tetrazole derivatives 失效
    四唑衍生物

    公开(公告)号：US6121286A

    公开(公告)日：2000-09-19

    申请号：US158774

    申请日：1998-09-23

    申请人： Hendrik Timmerman ,  Mingqiang Zang ,  Kazuhiro Onogi ,  Takeo Deushi ,  Masahiro Tamura ,  Tsutomu Tohma ,  Yasushi Wada ,  Jiro Matsumoto ,  Toru Kanke

    发明人： Hendrik Timmerman ,  Mingqiang Zang ,  Kazuhiro Onogi ,  Takeo Deushi ,  Masahiro Tamura ,  Tsutomu Tohma ,  Yasushi Wada ,  Jiro Matsumoto ,  Toru Kanke

    IPC分类号： A61P11/06 ,  C07D401/14 ,  A61K31/47

    CPC分类号： C07D401/14

    摘要： The present invention is directed to a tetrazole derivative represented by the following formula (1) or a salt thereof: ##STR1## wherein R.sup.1 and R.sup.2 independently represent a hydrogen atom, a hydroxyl group, a lower alkyl group, a substituted or unsubstituted alkoxy group, or a substituted or unsubstituted alkanoyloxy group; R.sup.3 represents a hydrogen atom or a substituted or unsubstituted lower alkyl group; A represents a methyleneoxy group or a vinylene group; B represents a substituted or unsubstituted quinolyl group, a substituted or unsubstituted quinazolyl group, or a substituted or unsubstituted benzimidazolyl group; and a broken line indicates that there may be a double bond; and to a medicine containing the compound as an active ingredient. The medicine according to the present invention is endowed with excellent antileukotriene activity and antihistaminic activity, and is useful for the prevention and treatment of, for example, asthma.

    摘要翻译： 本发明涉及由下式（1）表示的四唑衍生物或其盐：其中R1和R2独立地表示氢原子，羟基，低级烷基，取代或未取代的烷氧基或 取代或未取代的烷酰氧基; R3表示氢原子或取代或未取代的低级烷基; A表示亚甲氧基或亚乙烯基; B表示取代或未取代的喹啉基，取代或未取代的喹唑基，或取代或未取代的苯并咪唑基; 虚线表示可能存在双键; 和含有该化合物作为活性成分的药物。 根据本发明的药物具有优异的抗白三烯活性和抗组胺活性，可用于预防和治疗例如哮喘。

    Tetrazole derivatives
    4.
    发明授权
    Tetrazole derivatives 失效
    四唑衍生物

    公开(公告)号：US6117886A

    公开(公告)日：2000-09-12

    申请号：US357156

    申请日：1999-07-19

    申请人： Hendrik Timmerman ,  Mingqiang Zang ,  Kazuhiro Onogi ,  Takeo Deushi ,  Masahiro Tamura ,  Tsutomu Tohma ,  Yasushi Wada ,  Jiro Matsumoto ,  Toru Kanke

    发明人： Hendrik Timmerman ,  Mingqiang Zang ,  Kazuhiro Onogi ,  Takeo Deushi ,  Masahiro Tamura ,  Tsutomu Tohma ,  Yasushi Wada ,  Jiro Matsumoto ,  Toru Kanke

    IPC分类号： A61P11/06 ,  C07D401/14 ,  A61K31/4709

    CPC分类号： C07D401/14

    摘要： The present invention is directed to a tetrazole derivative represented by the following formula (1) or a salt thereof: ##STR1## wherein R.sup.1 and R.sup.2 independently represent a hydrogen atom, a hydroxyl group, a lower alkyl group, a substituted or unsubstituted alkoxy group, or a substituted or unsubstituted alkanoyloxy group; R.sup.3 represents a hydrogen atom or a substituted or unsubstituted lower alkyl group; A represents a methyleneoxy group or a vinylene group; Z represents a substituted or unsubstituted benzimidazolyl group; and a broken line indicates that there may be a double bond; and to a medicine containing the compound as an active ingredient. The medicine according to the present invention is endowed with excellent antileukotriene activity and antihistaminic activity, and is useful for the prevention and treatment of, for example, asthma.

    摘要翻译： 本发明涉及由下式（1）表示的四唑衍生物或其盐：其中R1和R2独立地表示氢原子，羟基，低级烷基，取代或未取代的烷氧基或 取代或未取代的烷酰氧基; R3表示氢原子或取代或未取代的低级烷基; A表示亚甲氧基或亚乙烯基; Z表示取代或未取代的苯并咪唑基; 虚线表示可能存在双键; 和含有该化合物作为活性成分的药物。 根据本发明的药物具有优异的抗白三烯活性和抗组胺活性，可用于预防和治疗例如哮喘。

    Subirrigation system
    6.
    发明授权
    Subirrigation system 有权
    子灌溉系统

    公开(公告)号：US09011041B2

    公开(公告)日：2015-04-21

    申请号：US12675531

    申请日：2008-08-25

    申请人： Naoki Ono ,  Hiroaki Sakamoto ,  Kazuhiro Hirao ,  Toshinobu Kakita ,  Yasushi Wada ,  Yoshihito Fujii ,  Tsuneo Onodera

    发明人： Naoki Ono ,  Hiroaki Sakamoto ,  Kazuhiro Hirao ,  Toshinobu Kakita ,  Yasushi Wada ,  Yoshihito Fujii ,  Tsuneo Onodera

    IPC分类号： E02B11/00 ,  A01G25/06

    CPC分类号： A01G25/06

    摘要： A subirrigation system 10 includes a water-impervious member 16, and keeps water content in soil of a cultivated land 200 in a proper state for growing a plant. The water-impervious member 16 is formed into an upper opening vessel shape, and has a water reserving function. Water is fed to an inner portion of the water-impervious member 16 from a water tank 12 via a feed water pipe 14, whereby a soil portion 26 in a gravitational water state is formed. A water level 28 of the gravitational water within the water-impervious member 16 is properly controlled to a desired water level by a water level controller 18 provided in the feed water pipe 14. The gravitational water within the water-impervious member 16 controlled to the desired water level is appropriately sucked up to the soil in an upper layer in accordance with a capillary phenomenon. Accordingly, a soil portion 30 in a capillary water state having proper water content is formed in the cultivated land 200.

    摘要翻译： 子灌溉系统10包括不透水构件16，并且在适当的状态下将耕地200的土壤中的含水量保持在植物生长中。 防水构件16形成为上开口容器形状，并具有储水功能。 水通过给水管14从水箱12供给到不透水构件16的内部，由此形成重力水状态的土壤部分26。 不透水构件16内的重力水的水位28被设置在给水管14中的水位控制器18适当地控制到期望的水位。防水构件16内的重力控制到 根据毛细管现象，期望的水位被适当吸入上层的土壤。 因此，在耕地200中形成具有适当含水量的毛细水分状态的土壤部分30。

    Multiplier, and fixed coefficient FIR digital filter having plural multipliers
    7.
    发明授权
    Multiplier, and fixed coefficient FIR digital filter having plural multipliers 失效
    具有多个乘法器的乘法器和固定系数FIR数字滤波器

    公开(公告)号：US06311203B1

    公开(公告)日：2001-10-30

    申请号：US09203373

    申请日：1998-12-02

    申请人： Yasushi Wada ,  Shuji Murakami

    发明人： Yasushi Wada ,  Shuji Murakami

    IPC分类号： G06F752

    CPC分类号： H03H17/06 ,  G06F7/523

    摘要： A multiplication device for performing a multiplication operation on a multiplicand X and two fixed coefficients C1 and C2 where C1>C2. The multiplication device comprises a multiplier for multiplying multiplicand X and the average CA of the two fixed coefficients C1 and C2; a shift register for obtaining a sum of the multiplicand X data after being shifted up according to a position of a “1” bit in bit data where the bit data is the remainder coefficient obtained by subtracting average CA from fixed coefficient C1; and a selector for selecting a product obtained for one of the fixed coefficients C1 and C2. When the fixed coefficient C1 is selected, the selector outputs the sum of the product returned by the multiplier and the accumulated value obtained by the shift register; when fixed coefficient C2 is selected, the selector outputs the difference of the product returned by the multiplier minus the accumulated value obtained by the shift register. A fixed coefficient FIR digital filter having a plurality of multiplication devices above-mentioned is also disclosed.

    摘要翻译： 用于对被乘数X和两个固定系数C1和C2执行乘法运算的乘法装置，其中C1> C2。 乘法装置包括用于将被乘数X与两个固定系数C1和C2的平均CA相乘的乘法器; 移位寄存器，用于根据比特数据中的“1”位的位置向上移位被乘数X数据，其中比特数据是通过从固定系数C1减去平均CA而获得的余数系数; 以及选择器，用于选择为固定系数C1和C2之一获得的乘积。 当选择固定系数C1时，选择器输出由乘法器返回的乘积和由移位寄存器获得的累加值之和; 当选择固定系数C2时，选择器输出由乘数返回的乘积的差值减去由移位寄存器获得的累加值。 还公开了具有上述多个乘法装置的固定系数FIR数字滤波器。

    Logic optimization device for automatically designing integrated circuits
    9.
    发明授权
    Logic optimization device for automatically designing integrated circuits 失效
    用于自动设计集成电路的逻辑优化装置

    公开(公告)号：US06834376B2

    公开(公告)日：2004-12-21

    申请号：US10212768

    申请日：2002-08-07

    申请人： Yasushi Wada

    发明人： Yasushi Wada

    IPC分类号： G06F1750

    CPC分类号： G06F17/505

    摘要： A logic optimization device refers to hierarchical circuit-design descriptions representing multiple layers of an integrated circuit, and decides whether or not each output terminal at each lower layer is connected with its upper layer. If an output terminal at a lower layer has been decided to be unconnected with its upper layer, the logic optimization device deletes from the hierarchical circuit-design descriptions an information part describing the output terminal, and deletes from the hierarchical circuit-design descriptions an information part describing an element at the lower layer connected with the deleted output terminal, thereby producing a gate-level net-list of an integrated circuit without ineffectual elements.

    摘要翻译： 逻辑优化装置是指表示集成电路的多层的分层电路设计描述，并且判定每个下层的每个输出端是否与其上层连接。 如果下层的输出端子决定与其上层不连接，则逻辑优化装置从分层电路设计描述中删除描述输出端子的信息部分，并从分层电路设计描述中删除信息 描述与删除的输出端子连接的下层的元件的部分，由此产生集成电路的门级网络列表，而没有无效元件。

    Formal logic verification system and method
    10.
    发明授权
    Formal logic verification system and method 失效
    正式逻辑验证系统及方法

    公开(公告)号：US06453449B1

    公开(公告)日：2002-09-17

    申请号：US09360641

    申请日：1999-07-26

    申请人： Yasushi Wada

    发明人： Yasushi Wada

    IPC分类号： G06F1750

    CPC分类号： G06F17/504

    摘要： There is described a means of shortening of the time required for verification by a formal logic verification system which compares details of a circuit represented in the form of a register transfer level (RTL) description with details of the circuit represented in the form of a gate level netlist. Logical equivalence between an RTL description and a gate level netlist obtained through logical compilation of the RTL descriptions is verified. In a case where a plurality of blocks having the same function are included in the circuit, one of a plurality of descriptions that are included in the netlist and relate to the function is compared with the RTL description relating to the functional blocks (comparison {circle around (1)}). If one of the descriptions of the netlist has already been verified, a plurality of descriptions included in the netlist are compared with the description that is taken as the first reference description.

    摘要翻译： 描述了通过形式逻辑验证系统来缩短验证所需的时间的手段，该系统比较以寄存器传送级（RTL）描述形式表示的电路的细节与以门的形式表示的电路的细节 级别网表。 验证通过RTL描述的逻辑编译获得的RTL描述和门级网表之间的逻辑等价性。 在具有相同功能的多个块包括在电路中的情况下，将包括在网表中并涉及功能的多个描述之一与与功能块相关的RTL描述进行比较（比较{circle around（1）}）。 如果网表的描述之一已经被验证，则将包括在网表中的多个描述与作为第一参考描述的描述进行比较。