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21 条记录 (耗时 0.018 秒)

    Production method of optically active dephenylalanine compounds
    1.
    发明授权
    Production method of optically active dephenylalanine compounds 失效
    光学活性苯丙氨酸化合物的制备方法

    公开(公告)号：US07321055B2

    公开(公告)日：2008-01-22

    申请号：US11498752

    申请日：2006-08-04

    申请人： Takayuki Hamada ,  Masayuki Oshita ,  Masanobu Yatagai

    发明人： Takayuki Hamada ,  Masayuki Oshita ,  Masanobu Yatagai

    IPC分类号： C07C229/00

    CPC分类号： C07C233/47 ,  C07C227/34 ,  C07C271/22 ,  C07C229/36

    摘要： Optically active diphenylalanine compounds may be conveniently prepared in a good yield by reacting a diphenylalanine compound represented by formula (1) with an optically active amine compound represented by formula (2) in the presence of an organic solvent to give a diastereomeric salt represented by formula (5) and then treating the diastereomeric salt under acidic conditions to give an optically active diphenylalanine compound represented by formula (3): wherein each symbol is as defined in the specification.

    摘要翻译： 通过使由式（1）表示的二苯基丙氨酸化合物与由式（2）表示的光学活性胺化合物在有机溶剂的存在下反应，可以以良好的收率方便地制备光活性二苯丙氨酸化合物，得到式 （5），然后在酸性条件下处理非对映体盐，得到由式（3）表示的光学活性二苯丙氨酸化合物：其中每个符号如说明书中所定义。

    Production method of optically active dephenylalanine compounds
    2.
    发明申请
    Production method of optically active dephenylalanine compounds 失效
    光学活性苯丙氨酸化合物的制备方法

    公开(公告)号：US20070032658A1

    公开(公告)日：2007-02-08

    申请号：US11498752

    申请日：2006-08-04

    申请人： Takayuki Hamada ,  Masayuki Oshita ,  Masanobu Yatagai

    发明人： Takayuki Hamada ,  Masayuki Oshita ,  Masanobu Yatagai

    IPC分类号： C07D213/56 ,  C07C311/45

    CPC分类号： C07C233/47 ,  C07C227/34 ,  C07C271/22 ,  C07C229/36

    摘要： Optically active diphenylalanine compounds may be conveniently prepared in a good yield by reacting a diphenylalanine compound represented by formula (1) with an optically active amine compound represented by formula (2) in the presence of an organic solvent to give a diastereomeric salt represented by formula (5) and then treating the diastereomeric salt under acidic conditions to give an optically active diphenylalanine compound represented by formula (3): wherein each symbol is as defined in the specification.

    摘要翻译： 通过使由式（1）表示的二苯基丙氨酸化合物与由式（2）表示的光学活性胺化合物在有机溶剂的存在下反应，可以以良好的收率方便地制备光活性二苯丙氨酸化合物，得到式 （5），然后在酸性条件下处理非对映体盐，得到由式（3）表示的光学活性二苯丙氨酸化合物：其中每个符号如说明书中所定义。

    Production method of optically active diphenylalanine compounds
    3.
    发明申请
    Production method of optically active diphenylalanine compounds 失效
    光学活性二苯丙氨酸化合物的制备方法

    公开(公告)号：US20060270869A1

    公开(公告)日：2006-11-30

    申请号：US11430909

    申请日：2006-05-10

    申请人： Takayuki Hamada ,  Masanobu Yatagai

    发明人： Takayuki Hamada ,  Masanobu Yatagai

    IPC分类号： C07C237/20

    CPC分类号： C07C227/20 ,  C07C231/12 ,  C07C229/36 ,  C07C233/47 ,  C07C233/51

    摘要： The present invention provides a production method including reacting a diphenylmethylene halide compound represented by the following formula (1) with a malonic acid diester compound represented by the following formula (2) in an organic solvent selected from N-methyl-2-pyrrolidone, N-ethyl-2-pyrrolidone and N,N-dimethylformamide, in the presence of a base selected from an alkali metal hydride and an alkali metal t-butoxide to give a diester compound represented by the following formula (3), and then subjecting the diester compound to hydrolysis and decarboxylation to give a diphenylalanine compound represented by the following formula (4). According to the present invention, diphenylalanine compound (4) can be obtained industrially advantageously in a high yield. wherein each symbol is as defined in the specification.

    摘要翻译： 本发明提供一种制造方法，其特征在于，使下述式（1）表示的二苯基亚甲基卤化物与下述式（2）所示的丙二酸二酯化合物在选自N-甲基-2-吡咯烷酮，N - 乙基-2-吡咯烷酮和N，N-二甲基甲酰胺，在选自碱金属氢化物和碱金属叔丁醇盐的碱存在下，得到下式（3）表示的二酯化合物，然后 二酯化合物进行水解和脱羧，得到由下式（4）表示的二苯丙氨酸化合物。 根据本发明，可以在工业上有利地以高产率获得二苯丙氨酸化合物（4）。 其中每个符号如说明书中所定义。

    Production method of O-substituted tyrosine compound
    4.
    发明申请
    Production method of O-substituted tyrosine compound 失效
    O-取代酪氨酸化合物的制备方法

    公开(公告)号：US20050283021A1

    公开(公告)日：2005-12-22

    申请号：US10937345

    申请日：2004-09-10

    申请人： Takayuki Hamada ,  Masanobu Yatagai

    发明人： Takayuki Hamada ,  Masanobu Yatagai

    IPC分类号： C07C227/16 ,  C07C229/36

    CPC分类号： C07C227/16 ,  C07C229/36

    摘要： The present invention relates to a method of producing a compound represented by the formula [I] or a salt thereof, which comprises reacting a compound represented by the formula [II] or a salt thereof with a compound represented by the formula [III] or a salt thereof, in the presence of a base, in alcohol, and provides a production method of an O-substituted tyrosine compound, which is superior in productivity, versatility and safety, and economically and industrially useful: wherein each symbol is as defined in the specification.

    摘要翻译： 本发明涉及制备由式[I]表示的化合物或其盐的方法，该方法包括使式[Ⅱ]表示的化合物或其盐与式[Ⅲ]表示的化合物或式 其盐，在碱的存在下，在醇中，并且提供了生产率，通用性和安全性优异的O取代的酪氨酸化合物的制备方法，并且在经济和工业上有用：其中每个符号如 规格。

    Production method of optically active diphenylalanine compounds
    5.
    发明授权
    Production method of optically active diphenylalanine compounds 失效
    光学活性二苯丙氨酸化合物的制备方法

    公开(公告)号：US07427688B2

    公开(公告)日：2008-09-23

    申请号：US11430909

    申请日：2006-05-10

    申请人： Takayuki Hamada ,  Masanobu Yatagai

    发明人： Takayuki Hamada ,  Masanobu Yatagai

    IPC分类号： C07C51/16

    CPC分类号： C07C227/20 ,  C07C231/12 ,  C07C229/36 ,  C07C233/47 ,  C07C233/51

    摘要： The present invention provides a production method including reacting a diphenylmethylene halide compound represented by the following formula (1) with a malonic acid diester compound represented by the following formula (2) in an organic solvent selected from N-methyl-2-pyrrolidone, N-ethyl-2-pyrrolidone and N,N-dimethylformamide, in the presence of a base selected from an alkali metal hydride and an alkali metal t-butoxide to give a diester compound represented by the following formula (3), and then subjecting the diester compound to hydrolysis and decarboxylation to give a diphenylalanine compound represented by the following formula (4).According to the present invention, diphenylalanine compound (4) can be obtained industrially advantageously in a high yield. wherein each symbol is as defined in the specification.

    摘要翻译： 本发明提供一种制造方法，其特征在于，使下述式（1）表示的二苯基亚甲基卤化物与下述式（2）所示的丙二酸二酯化合物在选自N-甲基-2-吡咯烷酮，N - 乙基-2-吡咯烷酮和N，N-二甲基甲酰胺，在选自碱金属氢化物和碱金属叔丁醇盐的碱存在下，得到下式（3）表示的二酯化合物，然后 二酯化合物进行水解和脱羧，得到由下式（4）表示的二苯丙氨酸化合物。 根据本发明，可以在工业上有利地以高产率获得二苯丙氨酸化合物（4）。 其中每个符号如说明书中所定义。

    Production methods of thiazoline compounds and optically active alpha-alkylcysteine
    6.
    发明申请
    Production methods of thiazoline compounds and optically active alpha-alkylcysteine 审中-公开
    噻唑啉化合物和光学活性α-烷基半胱氨酸的制备方法

    公开(公告)号：US20060270857A1

    公开(公告)日：2006-11-30

    申请号：US11418218

    申请日：2006-05-05

    申请人： Takayuki Hamada ,  Masanobu Yatagai

    发明人： Takayuki Hamada ,  Masanobu Yatagai

    IPC分类号： C07D277/28 ,  C07D277/26

    CPC分类号： C07C319/06 ,  C07D277/12 ,  C07D277/18 ,  C07C323/58

    摘要： An optically active compound (I) is reacted with compound (II) to give optically active compound (III), which is subjected to alkali hydrolysis and deprotection when R1 is alkyl: wherein X is a chlorine atom and the like, and R1, R2 and R3 are each an alkyl group and the like, or racemic compound (I) is reacted with compound (II) to give racemic compound (III), which is asymmetrically hydrolyzed by an enzyme to perform optical resolution, and subjected to alkali hydrolysis and deprotection: wherein X is a chlorine atom and the like and R1, R2 and R3 are each an alkyl group and the like.

    摘要翻译： 使光学活性化合物（I）与化合物（II）反应，得到光学活性化合物（III），当R 1为烷基时，其进行碱水解和脱保护：其中X为氯原子 R 1，R 2，R 3和R 3各自为烷基等，外消旋化合物（I）为 与化合物（II）反应，得到外消旋化合物（III），其由酶不对称水解以进行光学拆分，并进行碱水解和脱保护：其中X是氯原子等，R 1， R 2，R 2和R 3各自为烷基等。

    Production method of O-substituted tyrosine compound
    7.
    发明授权
    Production method of O-substituted tyrosine compound 失效
    O-取代酪氨酸化合物的制备方法

    公开(公告)号：US07217835B2

    公开(公告)日：2007-05-15

    申请号：US10937345

    申请日：2004-09-10

    申请人： Takayuki Hamada ,  Masanobu Yatagai

    发明人： Takayuki Hamada ,  Masanobu Yatagai

    IPC分类号： C07C229/00

    CPC分类号： C07C227/16 ,  C07C229/36

    摘要： The present invention relates to a method of producing a compound represented by the formula [I] or a salt thereof, which comprises reacting a compound represented by the formula [II] or a salt thereof with a compound represented by the formula [III] or a salt thereof, in the presence of a base, in alcohol, and provides a production method of an O-substituted tyrosine compound, which is superior in productivity, versatility and safety, and economically and industrially useful: wherein each symbol is as defined in the specification.

    摘要翻译： 本发明涉及制备由式[I]表示的化合物或其盐的方法，该方法包括使式[Ⅱ]表示的化合物或其盐与式[Ⅲ]表示的化合物或式 其盐，在碱的存在下，在醇中，并且提供了生产率，通用性和安全性优异的O取代的酪氨酸化合物的制备方法，并且在经济和工业上有用：其中每个符号如 规格。

    Panel instrument
    9.
    发明授权
    Panel instrument 失效
    面板仪

    公开(公告)号：US6020824A

    公开(公告)日：2000-02-01

    申请号：US730428

    申请日：1996-10-15

    申请人： Hiroshi Tamura ,  Shigeru Shibasaki ,  Minoru Murayama ,  Takayuki Hamada

    发明人： Hiroshi Tamura ,  Shigeru Shibasaki ,  Minoru Murayama ,  Takayuki Hamada

    IPC分类号： G09F13/04 ,  G09F13/14 ,  G09F3/04

    CPC分类号： G09F13/14 ,  G09F13/04 ,  G09F2013/0422 ,  G09F2013/145

    摘要： A panel instrument apparatus of reduced size, comprising a printed circuit board on which light emitting elements and switches are mounted, and a panel cover to the rear of which the front face of the printed circuit board is attached. The panel cover comprises reflecting holes arranged in positions corresponding to the light emitting elements on the printed circuit board to guide light from the light emitting elements to the surface of the panel cover; and furthermore comprises resilient links and coupled thereto keys which are located in positions corresponding to the switches on the printed circuit board.

    摘要翻译： 一种尺寸减小的面板仪器装置，包括安装有发光元件和开关的印刷电路板，并且其后面安装有印刷电路板的前表面的面板盖。 面板盖包括布置在印刷电路板上对应于发光元件的位置的反射孔，以将来自发光元件的光引导到面板盖的表面; 并且还包括位于对应于印刷电路板上的开关的位置的弹性连接件和与其连接的键。