公开(公告)号：US10189785B2

公开(公告)日：2019-01-29

申请号：US15565891

申请日：2016-04-19

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Yasutomi Asano ,  Takuto Kojima ,  Osamu Kurasawa ,  Tzu-Tshin Wong ,  Yasuhiro Hirata ,  Naoki Iwamura ,  Bunnai Saito ,  Yuta Tanaka ,  Ryosuke Arai ,  Shinichi Imamura ,  Kazuko Yonemori ,  Yasufumi Miyamoto ,  Shuji Kitamura ,  Osamu Sano

IPC分类号： C07D211/58 ,  C07D215/42 ,  C07D401/02 ,  C07D413/06 ,  C07D413/14 ,  A61K31/444 ,  A61K31/4709 ,  C07F9/6509 ,  C07D401/14 ,  A61K31/437 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/4468 ,  A61K31/451 ,  A61K31/452 ,  A61K31/498 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5355 ,  A61K31/661 ,  A61K33/22 ,  C07D401/06 ,  C07D401/12 ,  C07D409/12 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  C07F5/02 ,  A61P3/00 ,  A61P35/00 ,  C07B59/00 ,  C07D405/06

摘要： The present invention relates to a compound which can be useful for the treatment or prevention of SPT-related diseases including cancer and congenital diseases associated with sphingolipid accumulation (including Niemann-Pick disease).

公开(公告)号：US10519110B2

公开(公告)日：2019-12-31

申请号：US16175144

申请日：2018-10-30

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Yasutomi Asano ,  Takuto Kojima ,  Osamu Kurasawa ,  Tzu-Tshin Wong ,  Yasuhiro Hirata ,  Naoki Iwamura ,  Bunnai Saito ,  Yuta Tanaka ,  Ryosuke Arai ,  Shinichi Imamura ,  Kazuko Yonemori ,  Yasufumi Miyamoto ,  Shuji Kitamura ,  Osamu Sano

IPC分类号： C07D211/58 ,  C07F9/6509 ,  C07D401/14 ,  A61K31/437 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4468 ,  A61K31/451 ,  A61K31/452 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5355 ,  A61K31/661 ,  A61K33/22 ,  C07D215/42 ,  C07D401/06 ,  C07D401/12 ,  C07D409/12 ,  C07D413/06 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  C07F5/02 ,  A61P3/00 ,  A61P35/00 ,  C07B59/00 ,  C07D405/06 ,  C07D413/14

摘要： The present invention relates to a compound which can be useful for the treatment or prevention of SPT-related diseases including cancer and congenital diseases associated with sphingolipid accumulation (including Niemann-Pick disease).

公开(公告)号：US10774083B2

公开(公告)日：2020-09-15

申请号：US16333296

申请日：2017-09-14

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Takaharu Hirayama ,  Yasuhiro Hirata ,  Yusuke Tominari ,  Naoki Iwamura ,  Yusuke Sasaki ,  Moriteru Asano ,  Terufumi Takagi ,  Masanori Okaniwa ,  Shinichi Imamura

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D473/28 ,  C07D405/14 ,  C07D413/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/40 ,  C07D519/00 ,  A61P35/00 ,  A61K31/506 ,  A61K31/444 ,  A61K31/4439 ,  C07D473/00 ,  C07D473/32 ,  A61K31/5377 ,  A61K31/501 ,  A61K31/52 ,  A61P43/00 ,  A61K31/437 ,  C12N9/99

摘要： Provided is a heterocyclic amide compound that may have a PRS inhibitory action and is expected to be useful as a prophylactic or therapeutic agent for PRS associated diseases and the like including cancer. A compound represented by the following formula (I): wherein a group represented by is a group represented by the following formula (II) or the following formula (III): and other symbols are as described in the DESCRIPTION, or a salt thereof.

公开(公告)号：US10800754B2

公开(公告)日：2020-10-13

申请号：US16332993

申请日：2017-09-14

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Takaharu Hirayama ,  Yasuhiro Hirata ,  Yusuke Tominari ,  Naoki Iwamura ,  Yusuke Sasaki ,  Moriteru Asano ,  Terufumi Takagi ,  Masanori Okaniwa ,  Masato Yoshida ,  Shinichi Imamura

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D407/14 ,  C07D409/14 ,  C07D417/14 ,  A61P35/00

摘要： Provided is a heterocyclic amide compound that may have a PRS inhibitory action and is expected to be useful as a prophylactic or therapeutic agent for PRS associated diseases and the like including cancer. A compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

公开(公告)号：US09745325B2

公开(公告)日：2017-08-29

申请号：US15304727

申请日：2015-04-16

申请人： Takeda Pharmaceutical Company Limited

发明人： Masanori Okaniwa ,  Hiroshi Banno ,  Takaharu Hirayama ,  Douglas Robert Cary ,  Koji Ono ,  Naoki Iwamura

IPC分类号： C07D513/04 ,  A61K31/429 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/455 ,  A61K31/5377

CPC分类号： C07D513/04 ,  A61K31/429 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/455 ,  A61K31/5377

摘要： The present invention provides a fused heterocyclic compound that has CDK 8 and/or CDK 19 inhibitory activity. The present invention provides a compound represented by formula (I) (wherein the symbols are as defined in the description) or a salt thereof.