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    PROTON PUMP INHIBITORS
    1.
    发明申请
    PROTON PUMP INHIBITORS 审中-公开
    PROTON PUMP抑制剂

    公开(公告)号：US20140343070A1

    公开(公告)日：2014-11-20

    申请号：US14450191

    申请日：2014-08-01

    Applicant: Takeda Pharmaceutical Company Limited

    Inventor： Masahiro Kajino ,  Atsushi Hasuoka ,  Naoki Tarui ,  Terufumi Takagi

    IPC: C07D207/48 ,  C07D409/04 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D401/04 ,  C07D405/12

    CPC classification number: C07D207/48 ,  A61K31/4025 ,  A61K31/41 ,  A61K31/4439 ,  A61K31/501 ,  A61K31/506 ,  C07D207/335 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D417/12 ,  C07D487/04

    Abstract: A proton pump inhibitor containing a compound represented by the formula (I) wherein X and Y are the same or different and each is a bond or a spacer having 1 to 20 carbon atoms in the main chain, R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, R2, R3 and R4 are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted thienyl group, an optionally substituted benzo[b]thienyl group, an optionally substituted furyl group, an optionally substituted pyridyl group, an optionally substituted pyrazolyl group, an optionally substituted pyrimidinyl group, an acyl group, a halogen atom, a cyano group or a nitro group, R5 and R6 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, which has a superior proton pump action and shows an antiulcer activity and the like after conversion to a proton pump inhibitor in the body, or a salt thereof, or a prodrug thereof is provided.

    Abstract translation: 一种含有式（I）表示的化合物的质子泵抑制剂，其中X和Y相同或不同，并且各自是主链中的键或具有1至20个碳原子的间隔基，R 1是任选取代的烃基或 任选取代的杂环基，R 2，R 3和R 4相同或不同，各自为氢原子，任选取代的烃基，任选取代的噻吩基，任选取代的苯并[b]噻吩基，任选取代的呋喃基 ，任选取代的吡啶基，任选取代的吡唑基，任选取代的嘧啶基，酰基，卤素原子，氰基或硝基，R 5和R 6相同或不同，各自为氢原子或 任选取代的烃基，其具有优异的质子泵作用，并且在体内转化为质子泵抑制剂之后显示出抗溃疡活性等，或其中的盐 或其前药。

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