摘要:
The present invention provides compounds represented by the general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 is cyano or the like; R2 and R3 are hydrogen or the like; R4 is C1-6 alkyl or the like; R5 is C1-6 alkyl, halo-C1-6 alkyl, cycloalkyl, cycloalkyl-C1-6 alkyl, aralkyl or the like; R6 and R7 are each hydrogen, C1-6 alkyl, halo-C1-6 alkyl, cycloalkyl, C1-6 alkoxy-C1-6 alkyl, R12R13N—C1-6 alkyl or the like, which exhibit potent dopamine D2 receptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.
摘要翻译:本发明提供由通式(I)表示的化合物或其药学上可接受的盐,其中R 1为氰基等; R2和R3是氢等; R4是C1-6烷基等; R 5是C 1-6烷基,卤代C 1-6烷基,环烷基,环烷基-C 1-6烷基,芳烷基等; R 6和R 7各自为氢,C 1-6烷基,卤代C 1-6烷基,环烷基,C 1-6烷氧基-C 1-6烷基,R 12 R 13 N-C 1-6烷基等,其表现出有效的多巴胺D2受体刺激活性。 本发明还提供含有所述化合物的药物组合物及其用途。
摘要:
The present invention provides compounds represented by the general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 is cyano or the like; R2 and R3 are hydrogen or the like; R4 is C1-6 alkyl or the like; R5 is C1-6 alkyl, halo-C1-6 alkyl, cycloalkyl, cycloalkyl-C1-6 alkyl, aralkyl or the like; R6 and R7 are each hydrogen, C1-6 alkyl, halo-C1-6 alkyl, cycloalkyl, C1-6 alkoxy-C1-6 alkyl, R12R13N—C1-6 alkyl or the like, which exhibit potent dopamine D2 receptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.
摘要翻译:本发明提供由通式(I)表示的化合物或其药学上可接受的盐,其中R 1是氰基等; R2和R3是氢等; R4是C1-6烷基等; R 5是C 1-6烷基,卤代C 1-6烷基,环烷基,环烷基-C 1-6烷基,芳烷基等; R 6和R 7各自为氢,C 1-6烷基,卤代C 1-6烷基,环烷基,C 1-6烷氧基-C 1-6烷基,R 12 R 13 N-C 1-6烷基等,其表现出有效的多巴胺D2受体刺激活性。 本发明还提供含有所述化合物的药物组合物及其用途。
摘要:
The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen, lower acyl, lower alkoxycarbonyl or the like; R3 is halo-lower alkyl, lower acyl, halo-lower alkylcarbonyl, cycloalkylcarbonyl, optionally substituted arylcarbonyl, lower alkoxycarbonyl or the like; R4 is lower alkyl, halo-lower alkyl, cycloalkyl, lower alkoxy-lower alkyl or the like, which exhibit potent COMT inhibitory activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.
摘要:
The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen, lower acyl, lower alkoxycarbonyl or the like; R3 is lower alkyl, halo-lower alkyl, cycloalkyl, heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl or the like; R4 is cyano, lower alkoxycarbonyl, carboxy or the like, which exhibit potent COMT inhibitory activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.
摘要翻译:本发明提供由通式(I)表示的化合物或其药学上可接受的盐,其中R 1和R 2各自为氢,低级酰基,低级烷氧基羰基等; R 3是低级烷基,卤素 - 低级烷基,环烷基,杂环烷基,任选取代的芳基,任选取代的杂芳基等; R4是氰基,低级烷氧基羰基,羧基等,其表现出强烈的COMT抑制活性。 本发明还提供含有所述化合物的药物组合物及其用途。
摘要:
The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen, lower acyl, lower alkoxycarbonyl or the like; R3 is halo-lower alkyl, lower acyl, halo-lower alkylcarbonyl, cycloalkylcarbonyl, optionally substituted arylcarbonyl, lower alkoxycarbonyl or the like; R4 is lower alkyl, halo-lower alkyl, cycloalkyl, lower alkoxy-lower alkyl or the like, which exhibit potent COMT inhibitory activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.
摘要:
The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen, lower acyl, lower alkoxycarbonyl or the like; R3 is lower alkyl, halo-lower alkyl, cycloalkyl, heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl or the like; R4 is cyano, lower alkoxycarbonyl, carboxy or the like, which exhibit potent COMT inhibitory activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.
摘要翻译:本发明提供由通式(I)表示的化合物或其药学上可接受的盐,其中R 1和R 2各自为氢,低级酰基,低级烷氧基羰基等; R 3是低级烷基,卤素 - 低级烷基,环烷基,杂环烷基,任选取代的芳基,任选取代的杂芳基等; R4是氰基,低级烷氧基羰基,羧基等,其表现出强烈的COMT抑制活性。 本发明还提供含有所述化合物的药物组合物及其用途。
摘要:
The present invention is intended to provide acidic gel foods containing soybean protein to diversify means of taking soybean protein in daily eating habits. Using the acid-soluble soybean protein as specified in the description, an aqueous solution or an alcohol-containing aqueous solution of the protein is adjusted to pH 3 to 4.5. Then an acid having 2 or more acid groups per molecule or its salt or a salt of another acid is added thereto and the mixture is heated to form a gel. Thus, acidic gel foods including a jelly-like food favorable as a food can be obtained.
摘要:
[Problem] To provide: a water-insoluble plant fibrous material derived from soybeans that has both the functions of imparting viscosity to liquid batter and of stabilizing viscosity; a method for imparting viscosity to liquid batter using said raw material; and a method for stabilizing viscosity. [Solution] The provision of an agent for imparting viscosity to liquid batter was achieved by using a water-insoluble plant fibrous raw material obtained by: heating a slurry, prepared by adding water to bean curd lees, to more than 100° C. and up to 150° C.; then substantially removing the water-soluble component thereof.
摘要:
In a semiconductor memory device wherein a plurality of memory cell units formed by connecting a plurality of memory cells in series are provided and each of the memory cell units is connected to a bit line, the semiconductor memory device comprises control circuit for directly reading data of a register cell during a reading operation when the previous row address designates the same memory cell as the present row address, and a data changing controlling circuit for changing data of an arbitrary memory cell of the memory cell unit to data of the memory cell closest to the bit line contact in the memory cell unit, and a row decoder for corresponding row addresses which select the memory of memory cell units, to the upper addresses than the parts of the row addresses which select a memory unit among the memory cell units.
摘要:
There is provided a coating material comprising a mixture of a water-based resin composition of a thermoplastic elastomer (A) and/or a thermoplastic elastomer (B) in which at least one moiety is modified with a functional group; one of a water-based resin composition of a resin (G) formed from a copolymerizable monomer (G-1) which includes a monomer having an α,β-monoethylenic unsaturated group and other copolymerizable monomer, and a water-based resin composition of an urethane resin (U); and a water-based resin composition of a petroleum-based hydrocarbon resin (D) and/or a rosin-based resin (E) and/or a terpene-based resin (F). The coating material causing no separation phenomenon provides a coating composition or a primer with which spray coating is possible, and is a completely water-based coating material exhibiting an excellent adhesivity to a molded article of various resins such as polyolefin and a synthetic rubber or to metals such as a steel plate and aluminum.