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公开(公告)号：US20070144928A1
公开(公告)日：2007-06-28
申请号：US10580014
申请日：2004-11-12
申请人： Naruhito Higo , Tetsuro Tateishi , Takeshi Ito
发明人： Naruhito Higo , Tetsuro Tateishi , Takeshi Ito
CPC分类号： A61F15/001 , A61J1/067 , B65D75/30 , B65D77/26
摘要： A packaging bag 1 according to the present invention comprises a pair of packaging films 7x, 7y that are disposed facing one another, and are sealed together around a perimeter thereof so as to form a housing portion 9 housing a plaster. On one of the packaging films 7x is provided a protrusion 10 that protrudes toward the other packaging film 7y. When the plaster 2 is packaged, only the protrusion 10 of the packaging film 7x contacts a plaster body 5. The portion contacted by the protrusion 10 is a portion, on the inside of the plaster body 5, that excludes an outer periphery of the plaster body 5. Therefore, even if adhesive sticks out of the outer periphery of the plaster body 5, this adhesive does not contact the packaging film 7x. As a result, the plaster 2 can be easily removed from the packaging bag 1.
摘要翻译： 根据本发明的包装袋1包括一对彼此相对设置并且围绕其周边密封在一起的包装膜7x，7y，以形成容纳石膏的壳体部分9。 在其中一个包装薄膜7x上设置有朝向另一个包装膜7y突出的突起10。 当石膏2被包装时，只有包装膜7 x的突起10接触石膏体5。 由突起10接触的部分是石膏体5的内部排除石膏体5的外周的部分。 因此，即使粘合剂从膏体5的外周伸出，该粘合剂也不会与包装膜7 x接触。 结果，可以容易地从包装袋1中取出石膏2。
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公开(公告)号：US07785622B2
公开(公告)日：2010-08-31
申请号：US10527710
申请日：2003-09-12
申请人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
发明人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61K31/445 , A61K9/70
CPC分类号： A61K31/4453 , A61K9/7053 , A61K9/7076
摘要： An adhesive patch for percutaneous fentanyl administration which is easily produced, has long-term continuity, and is excellent in adhesion and conformability to the skin. The adhesive patch comprises a backing layer and a pressure-sensitive adhesive layer formed on one side thereof, wherein the pressure-sensitive adhesive layer comprises fentanyl as an active ingredient, a pressure-sensitive adhesive base, and a tackifier resin, the pressure-sensitive adhesive base comprising polyisobutylene and a styrene/isoprene/styrene block copolymer, the proportion of the polyisobutylene in the adhesive base being, 8 to 15 wt. %, and the ratio of the concentration of the polyisobutylene to that of the styrene/isoprene/styrene block copolymer being from 2:3 to 3:2.
摘要翻译： 用于经皮芬太尼给药的粘合贴剂易于生产，具有长期的连续性，并且具有优异的粘附性和对皮肤的适应性。 粘合贴剂包括背衬层和在其一侧形成的压敏粘合剂层，其中压敏粘合剂层包含芬太尼作为活性成分，压敏粘合剂基底和增粘树脂，压敏粘合剂层 包含聚异丁烯和苯乙烯/异戊二烯/苯乙烯嵌段共聚物的粘合剂基料，粘合剂基质中聚异丁烯的比例为8〜15wt。 ％，聚异丁烯与苯乙烯/异戊二烯/苯乙烯嵌段共聚物的浓度比例为2：3〜3：2。
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公开(公告)号：US20060165763A1
公开(公告)日：2006-07-27
申请号：US10525644
申请日：2003-08-07
申请人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
发明人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/221 , A61K47/12 , A61K47/32
摘要： A patch comprising a backing layer and an adhesive layer disposed on the backing layer and compounded with an adhesive agent and oxybutynin and/or a pharmaceutically acceptable salt thereof, wherein the adhesive agent comprises an acrylic polymer substantially free of both carboxyl group and hydroxyl group and a rubber polymer, in which weight ratio of content of the acrylic polymer to content of the rubber polymer is from 1:4 to 1:19.
摘要翻译： 一种贴剂，其包括背衬层和设置在背衬层上并与粘合剂和奥昔布宁和/或其药学上可接受的盐复合的粘合剂层，其中所述粘合剂包含基本上不含羧基和羟基的丙烯酸聚合物， 橡胶聚合物，其中丙烯酸类聚合物的含量与橡胶聚合物的含量的重量比为1:4至1:19。
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公开(公告)号：US07883719B2
公开(公告)日：2011-02-08
申请号：US10525644
申请日：2003-08-07
申请人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
发明人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/221 , A61K47/12 , A61K47/32
摘要： A patch comprising a backing layer and an adhesive layer disposed on the backing layer and compounded with an adhesive agent and oxybutynin and/or a pharmaceutically acceptable salt thereof, wherein the adhesive agent comprises an acrylic polymer substantially free of both carboxyl group and hydroxyl group and a rubber polymer, in which weight ratio of content of the acrylic polymer to content of the rubber polymer is from 1:4 to 1:19.
摘要翻译： 一种贴剂，其包括背衬层和设置在背衬层上并与粘合剂和奥昔布宁和/或其药学上可接受的盐复合的粘合剂层，其中所述粘合剂包含基本上不含羧基和羟基的丙烯酸聚合物， 橡胶聚合物，其中丙烯酸类聚合物的含量与橡胶聚合物的含量的重量比为1:4至1:19。
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公开(公告)号：US20070009588A1
公开(公告)日：2007-01-11
申请号：US10527710
申请日：2003-09-12
申请人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
发明人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61K31/445 , A61K9/70
CPC分类号： A61K31/4453 , A61K9/7053 , A61K9/7076
摘要： An adhesive patch for percutaneous fentanyl administration which is easily produced, has long-term continuity, and is excellent in adhesion and conformability to the skin. The adhesive patch comprises a backing layer and a pressure-sensitive adhesive layer formed on one side thereof, wherein the pressure-sensitive adhesive layer comprises fentanyl as an active ingredient, a pressure-sensitive adhesive base, and a tackifier resin, the pressure-sensitive adhesive base comprising polyisobutylene and a styrene/isoprene/styrene block copolymer, the proportion of the polyisobutylene in the adhesive base being, 8 to 15 wt. %, and the ratio of the concentration of the polyisobutylene to that of the styrene/isoprene/styrene block copolymer being from 2/3 to 3/2.
摘要翻译： 用于经皮芬太尼给药的粘合贴剂易于生产，具有长期的连续性，并且具有优异的粘附性和对皮肤的适应性。 粘合贴剂包括背衬层和在其一侧形成的压敏粘合剂层，其中压敏粘合剂层包含芬太尼作为活性成分，压敏粘合剂基底和增粘树脂，压敏粘合剂层 包含聚异丁烯和苯乙烯/异戊二烯/苯乙烯嵌段共聚物的粘合剂基料，粘合剂基质中聚异丁烯的比例为8〜15wt。 ％，聚异丁烯的浓度与苯乙烯/异戊二烯/苯乙烯嵌段共聚物的浓度的比例为2/3〜3/2。
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公开(公告)号：US07718188B2
公开(公告)日：2010-05-18
申请号：US10531433
申请日：2003-10-17
申请人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
发明人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
CPC分类号： A61K9/7053 , A61K31/4468
摘要： A transdermal patch for external use having a backing layer and a pressure-sensitive adhesive layer formed on one surface of the backing layer, which contains polyisobutylene, a mineral oil and fentanyl employed as the active ingredient in the pressure-sensitive adhesive layer and in which the contents of polyisobutylene and fentanyl in the pressure-sensitive adhesive layer respectively range from 75.2 to 94.2% by mass and 1 to 6% by mass while the content of the mineral oil is from 0.25 to 0.05 parts by mass based on polyisobutylene. This patch can be easily produced, has a long-lasting effect and is excellent in adhesion to the skin and tolerability against movement to the body parts.
摘要翻译： 一种用于外用的透皮贴剂，其具有背衬层和形成在背衬层的一个表面上的压敏粘合剂层，该背衬层包含聚异丁烯，在压敏粘合剂层中用作活性成分的矿物油和芬太尼，其中 粘合剂层中聚异丁烯和芬太尼的含量分别为75.2〜94.2质量％和1〜6质量％，相对于聚异丁烯，矿物油的含量为0.25〜0.05质量份。 该贴剂可以容易地制造，具有持久的效果，并且对皮肤的粘附性和对身体部位的运动的耐受性都优异。
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公开(公告)号：US07631759B2
公开(公告)日：2009-12-15
申请号：US10580014
申请日：2004-11-12
申请人： Naruhito Higo , Tetsuro Tateishi , Takeshi Ito
发明人： Naruhito Higo , Tetsuro Tateishi , Takeshi Ito
CPC分类号： A61F15/001 , A61J1/067 , B65D75/30 , B65D77/26
摘要： A packaging bag 1 according to the present invention comprises a pair of packaging films 7x, 7y that are disposed facing one another, and are sealed together around a perimeter thereof so as to form a housing portion 9 housing a plaster. On one of the packaging films 7x is provided a protrusion 10 that protrudes toward the other packaging film 7y. When the plaster 2 is packaged, only the protrusion 10 of the packaging film 7x contacts a plaster body 5. The portion contacted by the protrusion 10 is a portion, on the inside of the plaster body 5, that excludes an outer periphery of the plaster body 5. Therefore, even if adhesive sticks out of the outer periphery of the plaster body 5, this adhesive does not contact the packaging film 7x. As a result, the plaster 2 can be easily removed from the packaging bag 1.
摘要翻译： 根据本发明的包装袋1包括一对彼此相对设置并且围绕其周边密封在一起的包装膜7x，7y，以形成容纳石膏的壳体部分9。 在一个包装膜7x上设置有朝向另一个包装膜7y突出的突起10。 当石膏2被包装时，只有包装膜7x的突起10接触石膏体5.由突起10接触的部分是石膏体5的内部排除石膏外周的部分 因此，即使粘合剂从膏体5的外周伸出，该粘合剂也不会与包装膜7x接触。 结果，可以容易地从包装袋1中取出石膏2。
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公开(公告)号：USD558062S1
公开(公告)日：2007-12-25
申请号：US29205831
申请日：2004-05-21
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公开(公告)号：US20060013865A1
公开(公告)日：2006-01-19
申请号：US10531433
申请日：2003-10-17
申请人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
发明人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61K31/445 , A61K9/70
CPC分类号： A61K9/7053 , A61K31/4468
摘要： A transdermal patch for external use having a backing layer and a pressure-sensitive adhesive layer formed on one surface of the backing layer, which contains polyisobutylene, a mineral oil and fentanyl employed as the active ingredient in the pressure-sensitive adhesive layer and in which the contents of polyisobutylene and fentanyl in the pressure-sensitive adhesive layer respectively range from 75.2 to 94.2% by mass and 1 to 6% by mass while the content of the mineral oil is from 0.25 to 0.05 parts by mass based on polyisobutylene. This patch can be easily produced, has a long-lasting effect and is excellent in adhesion to the skin and tolerability against movement to the body parts.
摘要翻译： 一种用于外用的透皮贴剂，其具有背衬层和形成在背衬层的一个表面上的压敏粘合剂层，该背衬层包含聚异丁烯，在压敏粘合剂层中用作活性成分的矿物油和芬太尼，其中 粘合剂层中聚异丁烯和芬太尼的含量分别为75.2〜94.2质量％和1〜6质量％，相对于聚异丁烯，矿物油的含量为0.25〜0.05质量份。 该贴剂可以容易地制造，具有持久的效果，并且对皮肤的粘附性和对身体部位的运动的耐受性都优异。
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公开(公告)号：USRE45936E1
公开(公告)日：2016-03-22
申请号：US12108934
申请日：2008-04-24
CPC分类号： A61K9/7061 , A61K9/7069
摘要： An adhesive which comprises aqueous and nonaqueous polymers suitable for holding an lipophilic drug, etc., and has tackiness and cohesiveness which are sufficient for the plaster of a patch; and a patch employing the adhesive. The adhesive contains a polymer which comprises one or more kinds of acrylic or methacrylic monomer units, at least one kind of the monomer units having a hydroxy group, and which has been crosslinked with a boron compound.
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