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公开(公告)号:US5036055A
公开(公告)日:1991-07-30
申请号:US362555
申请日:1989-06-07
申请人: Takeshi Ohnuma , Rika Obata , Hideo Kamei , Takayuki Naito
发明人: Takeshi Ohnuma , Rika Obata , Hideo Kamei , Takayuki Naito
IPC分类号: A61K31/70 , A61K31/7042 , A61K31/7048 , A61P35/00 , C07H17/04
CPC分类号: C07H17/04
摘要: The epipodophyllotoxin glucosides disclosed are acylated at herein one or both sugar hydroxyl groups. These compounds exhibit significant activity against P388 murine leukemia.
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公开(公告)号:US5066645A
公开(公告)日:1991-11-19
申请号:US401712
申请日:1989-09-01
申请人: Takeshi Ohnuma , Hideaki Hoshi , Hideo Kamei , Takayuki Naito
发明人: Takeshi Ohnuma , Hideaki Hoshi , Hideo Kamei , Takayuki Naito
IPC分类号: A61K31/70 , A61K31/7042 , A61K31/7048 , A61P35/00 , C07H17/04
CPC分类号: C07H17/04
摘要: The present invention provides antitumor 4'-Demethylepipodophyllotoxin glycosides characterized by the fact that the glycoside moiety is altrose.
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公开(公告)号:US4912204A
公开(公告)日:1990-03-27
申请号:US240971
申请日:1988-09-06
申请人: Takeshi Ohnuma , Tetsuro Yamasaki , Hideo Kamei , Takayuki Naito
发明人: Takeshi Ohnuma , Tetsuro Yamasaki , Hideo Kamei , Takayuki Naito
IPC分类号: A61K31/70 , A61K31/7042 , A61K31/7048 , A61P35/00 , C07D493/04 , C07H17/04
摘要: The present invention provides antitumor fluoro-substituted 4'-demethylepipodophyllotoxin glucosides.
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公开(公告)号:US5034380A
公开(公告)日:1991-07-23
申请号:US438829
申请日:1989-11-20
申请人: Takeshi Ohnuma , Takayuki Naito , Hideo Kamei
发明人: Takeshi Ohnuma , Takayuki Naito , Hideo Kamei
IPC分类号: A61K31/70 , A61K31/7042 , A61K31/7048 , A61P35/00 , C07H17/04
CPC分类号: C07H17/04
摘要: Novel cyclic orthoesters and orthocarbonates of 4'-demethylepipodophyllotoxin glucoside are disclosed in the present invention. These compounds are active against experimental murine P388 leukemia.
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公开(公告)号:US5410029A
公开(公告)日:1995-04-25
申请号:US209687
申请日:1994-03-10
申请人: Shimpei Aburaki , Tetsuro Yamasaki , Toshikazu Oki , Seiji Iimura , Hajime Kamachi , Hideo Kamei , Takayuki Naito
发明人: Shimpei Aburaki , Tetsuro Yamasaki , Toshikazu Oki , Seiji Iimura , Hajime Kamachi , Hideo Kamei , Takayuki Naito
IPC分类号: C07H15/24 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P31/04 , C07C231/12 , C07C235/84 , C07H15/244 , C07H15/252
CPC分类号: C07H15/244 , C07C235/84 , C07C2103/90
摘要: The present invention concerns neutral sugar derivatives of pradimicins, their use as antifungal agents, methods for their preparation, and intermediates for their synthesis.
摘要翻译: 本发明涉及普拉德霉素的中性糖衍生物,它们作为抗真菌剂的用途,其制备方法及其合成中间体。
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公开(公告)号:US5837828A
公开(公告)日:1998-11-17
申请号:US378201
申请日:1995-05-02
申请人: Shimpei Aburaki , Tetsuro Yamasaki , Toshikazu Oki , Seiji Iimura , Hajime Kamachi , Hideo Kamei , Takayuki Naito
发明人: Shimpei Aburaki , Tetsuro Yamasaki , Toshikazu Oki , Seiji Iimura , Hajime Kamachi , Hideo Kamei , Takayuki Naito
IPC分类号: C07H15/252 , C07H1/00 , C07H15/24
CPC分类号: C07H15/252
摘要: The present invention concerns neutral sugar derivatives of pradimicins, their use as antifungal agents, methods for their preparation, and intermediates for their synthesis.
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公开(公告)号:US20120119723A1
公开(公告)日:2012-05-17
申请号:US13322771
申请日:2010-07-14
IPC分类号: G05F3/08
摘要: A voltage conversion apparatus is disclosed in which a current passes through first and second loop circuits alternately in accordance with ON/OFF operation of a first switching element provided in the first circuit. The direction of a magnetic field through the first loop circuit formed at the ON operation is the same as a direction of a magnetic field through the second loop circuit formed at the OFF operation. The first loop circuit and the second loop circuit are provided on opposite sides of a printed circuit board, respectively, in such a manner that the first loop circuit and the second loop circuit are opposed to each other. A heat sink is provided on a surface of the printed circuit board. A solid pattern of a metal material is provided on an inner layer of the printed circuit board to be connected to the heat sink via a through hole.
摘要翻译: 公开了一种电压转换装置,其中根据设置在第一电路中的第一开关元件的ON / OFF操作,电流交替地通过第一和第二回路电路。 通过在ON操作时形成的第一回路电路的磁场的方向与通过在OFF操作形成的第二回路电路的磁场方向相同。 第一回路电路和第二回路电路分别设置在印刷电路板的相对侧上,使得第一回路电路和第二回路电路彼此相对。 散热器设置在印刷电路板的表面上。 金属材料的固体图案设置在印刷电路板的内层上,以经由通孔连接到散热器。
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公开(公告)号:US20120007530A1
公开(公告)日:2012-01-12
申请号:US13257717
申请日:2010-03-17
IPC分类号: H02P6/14
CPC分类号: H02M7/003
摘要: An object of the present invention is to effectively reduce noise generated when driving a three-phase brushless motor. A noise reduction arrangement applied to a three-phase brushless motor is disclosed, wherein respective current loops, which are generated when two switching elements Q1 and Q2 related to U-phase are turned on or off in reversed phase with respect to each other, are opposed to each other in a direction of the normal to a board; respective current loops, which are generated when two switching elements Q3 and Q4 related to V-phase are turned on or off in reversed phase with respect to each other, are opposed to each other in a direction of the normal to the board; and respective current loops, which are generated when two switching elements Q5 and Q6 related to W-phase are turned on or off in reversed phase with respect to each other, are opposed to each other in a direction of the normal to the board.
摘要翻译: 本发明的目的是有效地减少驱动三相无刷电动机时产生的噪音。 公开了一种应用于三相无刷电动机的降噪装置,其中当与U相相关的两个开关元件Q1和Q2相互相连时产生的各个电流回路相互相反地接通或断开, 在董事会的正常方向上彼此相反; 当与V相相关的两个开关元件Q3和Q4相对于彼此反相地接通或断开时产生的各个电流回路在板的法线方向上彼此相对; 并且当与W相相关的两个开关元件Q5和Q6相对于彼此反相地导通或截止时产生的各个电流回路在板的法线方向上彼此相对。
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公开(公告)号:US4751295A
公开(公告)日:1988-06-14
申请号:US920933
申请日:1986-10-17
申请人: Masahisa Oka , Haruhiro Yamashita , Jun Okumura , Takayuki Naito
发明人: Masahisa Oka , Haruhiro Yamashita , Jun Okumura , Takayuki Naito
IPC分类号: C07C45/79 , C07D285/08 , C07D501/24 , C07D501/46 , A61K31/545
CPC分类号: C07D285/08 , C07C45/79
摘要: 7-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(substituted)-iminoacetamido]-3-[3-(quaternaryammonio)-1-propen-1-yl]-3-cephem-4-carboxylates of the formula ##STR1## in which R.sup.1 and R.sup.2 are defined herein and --.sup..sym. N.tbd.Q is a quaternary ammonio group as defined herein, and salts, solvates, hydrates and esters thereof, are potent antibacterial agents. Processes for their preparation and intermediates in such processes are described.
摘要翻译: 7- [2-(5-氨基-1,2,4-噻二唑-3-基)-2-(取代的) - 亚氨基乙酰氨基] -3- [3-(季铵)-1-丙烯-1-基] 其中R 1和R 2在本文中定义,并且 - (+)N 3BOND Q是如本文所定义的季铵基,并且其盐,溶剂合物,水合物和酯类的3-头孢烯-4-羧酸酯 是有效的抗菌剂。 描述了其制备方法和中间体在这些方法中的用途。
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公开(公告)号:US4500526A
公开(公告)日:1985-02-19
申请号:US541593
申请日:1983-10-13
申请人: Kiyoto Imae , Shimpei Aburaki , Yukio Narita , Jun Okumura , Takayuki Naito
发明人: Kiyoto Imae , Shimpei Aburaki , Yukio Narita , Jun Okumura , Takayuki Naito
IPC分类号: C07D277/20 , C07D501/46 , C07D501/36 , A61K31/545
CPC分类号: C07D277/587 , Y02P20/55
摘要: Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or a conventional amino-protecting group, R.sup.2 is one of various alkyl, alkenyl, alkynyl, cycloalkyl, carboxyalkyl or carboxycycloalkyl moieties described herein, and R.sup.5 is hydrogen, amino, carboxy, formyl, carbamoyl, guanidino, amidino or one of various alkyl, alkoxy, alkylthio or substituted amino moieties described herein, and nontoxic pharmaceutically acceptable acid addition salts, physiologically hydrolyzable esters and solvates thereof, as well as processes for their preparation, are disclosed. The compounds in which R.sup.1 is hydrogen are potent antibacterial agents.
摘要翻译: 其中R 1是氢或常规的氨基保护基,R 2是本文所述的各种烷基,烯基,炔基,环烷基,羧基烷基或羧基环烷基部分之一,R 5是氢,氨基, 羧基,甲酰基,氨基甲酰基,胍基,脒基或本文所述的各种烷基,烷氧基,烷硫基或取代的氨基部分之一,以及无毒的药学上可接受的酸加成盐,其生理上可水解的酯和溶剂合物,以及其制备方法 。 其中R1是氢的化合物是有效的抗菌剂。
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