公开(公告)号：US20070038289A1

公开(公告)日：2007-02-15

申请号：US10563488

申请日：2004-07-23

申请人： Takuji Nishide ,  Ryoji Nakano ,  Shinya Yoshida ,  Kohei Fukaya ,  Masaji Kawatsu

发明人： Takuji Nishide ,  Ryoji Nakano ,  Shinya Yoshida ,  Kohei Fukaya ,  Masaji Kawatsu

IPC分类号： A61F2/90

CPC分类号： A61F2/915 ,  A61F2/91 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/9155 ,  A61F2002/91558 ,  A61F2230/0054

摘要： As a treatment for angiostenosis, angioplasty (PTA or PTCA) of expanding a small-sized balloon in a vessel has been commonly conducted. However, this treatment easily causes repeated stenosis (restenosis) after the treatment. Placement of a stent in a vessel is also effective in decreasing restenosis, but this treatment may also cause restenosis. The present invention provides a stent containing a poly (lactide-co-glycolide) or both a poly (lactide-co-glycolide) and an immunosuppressive agent in at least a portion of a surface of the stent, and further containing a material nondegradable in vivo.

摘要翻译： 作为血管狭窄症的治疗方法，通常进行血管成形术（PTA或PTCA）扩大血管中的小型气球。 然而，这种治疗容易导致治疗后重复狭窄（再狭窄）。 支架置于血管中也有效减少再狭窄，但这种治疗也可能引起再狭窄。 本发明提供一种在支架表面的至少一部分中含有聚（丙交酯 - 共 - 乙交酯）或聚（丙交酯 - 共 - 乙交酯）和免疫抑制剂两者的支架，并且还含有不可降解的材料 体内。

公开(公告)号：US20070250157A1

公开(公告)日：2007-10-25

申请号：US11574879

申请日：2005-09-01

申请人： Takuji Nishide ,  Yuki Takiguchi ,  Ryoji Nakano ,  Kohei Fukaya ,  Masaji Kawatsu

发明人： Takuji Nishide ,  Yuki Takiguchi ,  Ryoji Nakano ,  Kohei Fukaya ,  Masaji Kawatsu

IPC分类号： A61F2/06

CPC分类号： A61L31/148 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/9155 ,  A61F2210/0076 ,  A61F2230/0054 ,  A61F2250/0035 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2300/61

摘要： It is intended to easily provide a stent for placement in body which can hold an increased amount of a drug without causing cracking or peeling in the coating layer with the dilation of the stent and from which the drug can be sustainedly released as far as possible. Namely, a stent for placement in body having a coating layer mainly comprising a drug and a polymer in at least a part of the stent surface wherein the coating layer consists of an inner layer and an outer layer, the weight ratio of drug/polymer, which is defined based on the weights of the drug and the polymer contained in each layer, of the inner layer is higher than that of the outer layer, and the outer layer contains an efficacious amount of the drug.

摘要翻译： 旨在容易地提供用于放置在体内的支架，其能够容纳增加量的药物，而不会随着支架的扩张而在涂层中引起裂纹或剥离，并且药物可以尽可能地持续释放。 即，用于放置在本体中的支架，其具有主要包含药物的涂层和在支架表面的至少一部分中的聚合物，其中所述涂层由内层和外层组成，药物/聚合物的重量比， 内层中含有的药物重量和各层中所含的聚合物的含量高于外层，外层含有有效量的药物。

公开(公告)号：US06613066B1

公开(公告)日：2003-09-02

申请号：US09787930

申请日：2001-04-03

申请人： Kohei Fukaya ,  Hiromi Maeda ,  Takuji Nishide ,  Shogo Miki ,  Ryoji Nakano ,  Masato Hashiba

发明人： Kohei Fukaya ,  Hiromi Maeda ,  Takuji Nishide ,  Shogo Miki ,  Ryoji Nakano ,  Masato Hashiba

IPC分类号： A61M2900

CPC分类号： A61M25/1029 ,  A61M25/0043 ,  A61M25/0052 ,  A61M25/1034 ,  A61M2025/0004 ,  A61M2025/006 ,  A61M2025/1056 ,  A61M2025/1068 ,  A61M2025/1088 ,  A61M2029/025

摘要： A balloon catheter 1 is configured so as to comprise a catheter shaft 2 formed by joining a proximal-side tubular member 3 and a distal-side tubular member 4, an adapter member 6 connected to the base end of the catheter shaft 2, and a balloon 5 joined to the distal end of the catheter shaft 2. A metal coiled elastic member 10 is deployed in the internal space in the adapter member 6, so that it can move toward the distal end. This coiled elastic body 10 abuts on a ring-shaped wall part 11a formed on the outer circumferential surface of the base end of an elastic force transmitting member 11 and supports the elastic force transmitting member 11 to the distal side. The leading end of a linear member 12 that is one of the components of the elastic force transmitting member 11 reaches to an internal space 5f in the balloon and is bonded to the outer circumferential surface of a guide wire passing tube 7. Thus the elastic supporting force of the coiled elastic body 10 is transmitted via the elastic force transmitting member 11 to the distal-side sleeve part 5d of the balloon 5, and tension is imparted to the balloon 5 in the axial direction.

摘要翻译： 球囊导管1被构造成包括通过连接近侧管状构件3和远端侧管状构件4形成的导管轴2，连接到导管轴2的基端的适配构件6和 气囊5连接到导管轴2的远端。金属螺旋弹性构件10展开在适配构件6的内部空间中，使得其可以朝向远端移动。 该螺旋弹性体10与形成在弹性力传递构件11的基端的外周面上的环状壁部11a抵接，并且将弹力传递构件11支撑在远侧。 作为弹力传递部件11的一个部件的直线部件12的前端到达球囊内的内部空间5f，并且与导丝管7的外周面接合。因此，弹性支撑 螺旋弹性体10的力经由弹力传递部件11传递到球囊5的前侧侧套筒部5d，并且沿轴向向球囊5施加张力。

公开(公告)号：US06960186B1

公开(公告)日：2005-11-01

申请号：US09980979

申请日：2000-05-11

申请人： Kohei Fukaya ,  Takuji Nishide ,  Ryoji Nakano ,  Hiromi Maeda ,  Shogo Miki

发明人： Kohei Fukaya ,  Takuji Nishide ,  Ryoji Nakano ,  Hiromi Maeda ,  Shogo Miki

IPC分类号： A61F2/958 ,  A61M25/00 ,  A61M29/02 ,  A61M31/00 ,  A61M37/00

CPC分类号： A61M25/1027 ,  A61M25/0045 ,  A61M25/0068 ,  A61M25/1002 ,  A61M25/1038 ,  A61M25/104 ,  A61M2025/0004 ,  A61M2025/0183 ,  A61M2025/1056 ,  A61M2025/1093

摘要： The present invention is a balloon catheter used primarily in treatment and surgery for the purpose of dilating lesion sites such as strictures or blockages in passages in the human body. The balloon catheter of the present invention has a structure wherein a guide wire passing tubular member is deployed passing through the interior of the expansion body, and the outer surface of the tubular member and the expansion body are concentrically fused near the distal end of the catheter. This is a balloon catheter that is characterized by the fact that the Shore hardness of the material configuring the outermost surface of the tubular member is smaller than the Shore hardness of the material configuring the expansion body. It is therefore possible to flexibly adjust the tip portion formed by securing the expansion body and the guide wire passing tubular member.

摘要翻译： 本发明是一种主要用于治疗和手术的气囊导管，用于在人体的通道中扩张病变部位如狭窄或阻塞。 本发明的气囊导管具有通过管状构件的导丝管穿过膨胀体内部的结构，并且管状构件和膨胀体的外表面在导管的远端附近同心地熔合 。 这是一种球囊导管，其特征在于，构成管状构件的最外表面的材料的肖氏硬度小于构成膨胀体的材料的肖氏硬度。 因此，可以灵活地调节通过固定膨胀体和导丝通过管状构件形成的尖端部分。

公开(公告)号：US06706010B1

公开(公告)日：2004-03-16

申请号：US09529081

申请日：2000-04-07

申请人： Shogo Miki ,  Kohei Fukaya ,  Takuji Nishide ,  Masato Hashiba ,  Ryoji Nakano ,  Hiromi Maeda

发明人： Shogo Miki ,  Kohei Fukaya ,  Takuji Nishide ,  Masato Hashiba ,  Ryoji Nakano ,  Hiromi Maeda

IPC分类号： A61M300

CPC分类号： A61M25/1034 ,  A61M25/0054 ,  A61M25/1036 ,  A61M25/1038 ,  A61M2025/1061 ,  A61M2025/1093

摘要： It is an object of the present invention to provide a balloon catheter in which the inner tube is prevented from slackening after balloon inflation, improving the rewrapping of the balloon, discontinuity in the rigidity of the joined portions of the outer tube and the balloon is lessened, which prevents breakage, and the catheter advances through blood vessels better and passes more easily through narrow segments, preventing the catheter from “accordioning” and enhancing insertion force transmission. The balloon catheter pertaining to the present invention has a catheter shaft (1) with a double-tube structure comprising an outer tube (4) and an inner tube (5), and a balloon (3) disposed at the distal end portion of this catheter shaft (1). A guide tube (11) having an outside diameter smaller than the inside diameter of the outer tube (4) and having an inside diameter larger than the outside diameter of the inner tube (5) is disposed at least at the distal end portion of the outer tube (4) so as to form a double-tube with the outer tube (4), and the inner tube (5) is not fixed, but passes through the interior of the guide tube (11) in the axial direction.

摘要翻译： 本发明的目的是提供一种球囊导管，其中防止内囊在球囊膨胀后松弛，改善球囊的重新包裹，外管和球囊的接合部分的刚度不连续性减小 防止断裂，并且导管更好地前进通过血管，并且更容易地通过狭窄的区段，防止导管“手风琴”并增强插入力传递。 本发明的气囊导管具有导管轴（1），其具有包括外管（4）和内管（5）的双管结构，以及设置在该管的前端部的气囊（3） 导管轴（1）。 具有比外管（4）的内径小的内径比内管（5）的外径大的外径的导管（11）至少设置在内管 外管（4）形成与外管（4）的双管，内管（5）不固定，但沿轴向通过导管（11）的内部。

公开(公告)号：US07247147B2

公开(公告)日：2007-07-24

申请号：US10415997

申请日：2001-11-08

申请人： Takuji Nishide ,  Kohei Fukaya ,  Masato Hashiba

发明人： Takuji Nishide ,  Kohei Fukaya ,  Masato Hashiba

IPC分类号： A61M29/00

CPC分类号： A61M25/104 ,  A61M25/0045 ,  A61M25/0054

摘要： The medical balloon catheter of the present invention comprises a catheter shaft composed of a distal end shaft and a proximal end shaft and a balloon on the distal end of the distal end shaft, wherein the proximal end shaft is composed of a single member and the distal end portion of the proximal end shaft is lower in rigidity than the other parts thereof. The present invention also provides a medical balloon catheter having a structure in which a tube for passing a guidewire inside thereof is arranged so as to pass inside the balloon and the balloon and tube are fused together in the vicinity of the distal end of the catheter, wherein the ratio of the outer diameter of the small-diameter portion on the distal end side of the tube to the outer diameter of the proximal end portion is no less than 0.85.

摘要翻译： 本发明的医用气囊导管包括由前端轴和近端轴构成的导管轴和远端轴的远端上的气囊，其中，近端轴由单个构件和远端构成 近端轴的端部刚性低于其他部分。 本发明还提供一种医疗气囊导管，其具有将导线内部通过的管布置成在气囊内部通过的结构，并且气球和管在导管的远端附近熔合在一起， 其中，所述管的前端侧的小直径部的外径与所述基端部的外径之比为0.85以上。

公开(公告)号：US08105259B2

公开(公告)日：2012-01-31

申请号：US11816697

申请日：2006-02-21

申请人： Ichiro Michishita ,  Takuji Nishide

发明人： Ichiro Michishita ,  Takuji Nishide

IPC分类号： A61M37/00

CPC分类号： A61M25/007 ,  A61M25/0029 ,  A61M25/0041 ,  A61M2025/0031 ,  A61M2025/0037 ,  A61M2025/0039 ,  A61M2027/004

摘要： The present invention provides a catheter for extraction that can efficiently extract blood flowing in coronary sinus from coronary artery through coronary vein and has the same operability as catheters used in conventional PCI. The present invention also provides a catheter for extracorporeal circulation that can lessen an introduction number of devices for blood access as little as possible and reduce further the burden to a patient, in addition to the same operability as the catheters used in the conventional PCI. The catheter for extraction is equipped with blood extracting lumen in an inside and equipped with a hub at a proximal end portion, and when a minimum sectional area to a circumferential direction of the blood extracting lumen is referred to as S1 and immersion side length is referred to as L1, an equivalent diameter D1 satisfies the formula defined by D1=(4×S1)/L1 and the equivalent diameter D1 is at 1.80 mm. The catheter for extracorporeal circulation also has blood extracting lumen extending from the distal end to the proximal end and blood return lumen extending from the proximal end of the catheter to a fixed length distal end.

摘要翻译： 本发明提供一种用于提取的导管，其可以有效地从冠状动脉通过冠状静脉提取在冠状窦中流动的血液，并且具有与常规PCI中使用的导管相同的可操作性。 本发明还提供一种用于体外循环的导管，除了与常规PCI中使用的导管相同的可操作性之外，其可以尽可能少地减少用于血液通过的装置的引入数量，并且进一步减轻对患者的负担。 用于提取的导管在内部配备有血液提取腔，并且在近端部配备有轮毂，并且当将取血腔的圆周方向的最小截面积称为S1，并且参考浸没侧长度 作为L1，当量直径D1满足由D1 =（4×S1）/ L1定义的公式，当量直径D1为1.80mm。 用于体外循环的导管还具有从远端延伸到近端的血液提取腔和从导管的近端延伸到固定长度的远端的血液回流腔。

公开(公告)号：US07244250B2

公开(公告)日：2007-07-17

申请号：US10520236

申请日：2003-07-28

申请人： Shogo Miki ,  Takuji Nishide ,  Masayuki Takatera ,  Sakiko Hanita

发明人： Shogo Miki ,  Takuji Nishide ,  Masayuki Takatera ,  Sakiko Hanita

IPC分类号： A61M25/00

CPC分类号： A61M25/0029 ,  A61B17/3207 ,  A61B2017/22039 ,  A61B2017/22041 ,  A61B2017/22079 ,  A61M25/0068 ,  A61M25/0071 ,  A61M25/0169 ,  A61M2025/0177 ,  A61M2025/0183 ,  A61M2025/1056

摘要： Provided is an aspiration catheter which does not require a large-scale device, has a largest possible aspiration lumen, and is sufficiently flexible to track tortuous blood vessels following a guidewire, thereby being easily advanced to a target site to be treated.In the aspiration catheter, the tip of the main shaft is obliquely cut, the distal end of the guidewire shaft is positioned at the distal end of the main shaft or protrudes from the distal end of the main shaft in the distal direction, and the relationships 0.5≦L2/L1 and L2−L1≦5 mm are satisfied, wherein L1 is the length of the obliquely cut portion of the main shaft in the longitudinal direction of the catheter, and L2 is the length from the proximal end of the guidewire shaft to the distal end of the main shaft.

摘要翻译： 提供了一种不需要大规模装置的抽吸导管，具有最大可能的吸液腔，并且具有足够的柔性以跟踪导丝跟踪曲折的血管，从而容易地前进到待治疗的目标部位。 在吸引导管中，主轴的前端倾斜切割，导丝轴的前端位于主轴的远端，或者在远端方向上从主轴的远端突出， 0.5 <= L 2 / L 1和L 2 -L 1 <= 5mm，其中L 1是主轴在导管的纵向方向上的倾斜切割部分的长度，L 2是长度 从导丝轴的近端到主轴的远端。

公开(公告)号：US08088121B2

公开(公告)日：2012-01-03

申请号：US11573549

申请日：2005-07-29

申请人： Takuji Nishide ,  Osamu Kikugawa ,  Shogo Miki

发明人： Takuji Nishide ,  Osamu Kikugawa ,  Shogo Miki

IPC分类号： A61M25/00 ,  A61M29/00

CPC分类号： A61M25/104 ,  A61M25/0054 ,  A61M25/1006 ,  A61M2025/0063 ,  A61M2025/0183

摘要： A catheter enabling an increase in operability when the catheter is inserted from the outside to the inside of a body and capable of remarkably reducing the risk of damage to shafts even in an unforeseen accident without complicating steps and increasing production cost. The catheter comprises at least the distal side shaft formed of a resin tube, the rear end side shaft with a higher rigidity than that of the distal side shaft, and a guide wire lumen. The catheter is characterized in that a core wire is disposed therein to adjust a flexibility so that the rear end portion of the distal side shaft is harder than the distal end portion of the distal side shaft and softer than the rear end side shaft, and the core wire is fixed to the distal side shaft near the rear end side opening part of the guide wire lumen and at a part of the rear end side portion of the distal end shaft.

摘要翻译： 导管能够在将导管从外部插入到身体内部时能够增加操作性，并且即使在意外事故中也能够显着降低轴的损坏风险，而不会使步骤复杂化并增加生产成本。 所述导管至少包括由树脂管形成的远端侧轴，所述后端侧轴具有比所述远侧侧的轴高的刚性，以及导丝管腔。 导管的特征在于，芯线设置在其中以调节柔性，使得远端侧轴的后端部比前端侧轴的前端部硬，并且比后端侧轴更软， 芯线固定在导丝管腔的后端侧开口部附近的远端侧轴线和远端轴的后端侧部的一部分。

公开(公告)号：US20090270802A1

公开(公告)日：2009-10-29

申请号：US11573549

申请日：2005-07-29

申请人： Takuji Nishide ,  Osamu Kikugawa ,  Shogo Miki

发明人： Takuji Nishide ,  Osamu Kikugawa ,  Shogo Miki

IPC分类号： A61M29/00

CPC分类号： A61M25/104 ,  A61M25/0054 ,  A61M25/1006 ,  A61M2025/0063 ,  A61M2025/0183

摘要： A catheter enabling an increase in operability when the catheter is inserted from the outside to the inside of a body and capable of remarkably reducing the risk of damage to shafts even in an unforeseen accident without complicating steps and increasing production cost. The catheter comprises at least the distal side shaft formed of a resin tube, the rear end side shaft with a higher rigidity than that of the distal side shaft, and a guide wire lumen. The catheter is characterized in that a core wire is disposed therein to adjust a flexibility so that the rear end portion of the distal side shaft is harder than the distal end portion of the distal side shaft and softer than the rear end side shaft, and the core wire is fixed to the distal side shaft near the rear end side opening part of the guide wire lumen and at a part of the rear end side portion of the distal end shaft.

摘要翻译： 导管能够在将导管从外部插入到身体内部时能够增加操作性，并且即使在意外事故中也能够显着降低轴的损坏风险，而不会使步骤复杂化并增加生产成本。 所述导管至少包括由树脂管形成的远端侧轴，所述后端侧轴具有比所述远侧侧的轴高的刚性，以及导丝管腔。 导管的特征在于，芯线设置在其中以调节柔性，使得远侧侧轴的后端部比前端侧轴的前端部硬，并且比后端侧轴更软， 芯线固定在导丝管腔的后端侧开口部附近的远端侧轴线和远端轴的后端侧部的一部分。