公开(公告)号：US08415357B2

公开(公告)日：2013-04-09

申请号：US12950297

申请日：2010-11-19

申请人： Takumi Kawabe ,  Machiyo Ishigaki ,  Takuji Sato ,  Sayaka Yamamoto ,  Yoko Hasegawa

发明人： Takumi Kawabe ,  Machiyo Ishigaki ,  Takuji Sato ,  Sayaka Yamamoto ,  Yoko Hasegawa

IPC分类号： A61K31/497 ,  A61K31/44 ,  A61K31/47

CPC分类号： A61K31/4439 ,  A61K31/4725 ,  A61K31/496 ,  C07D207/452 ,  C07D207/50 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D417/12

摘要： Novel substituted azole diones are provided that kill cells, suppress cell proliferation, suppress cell growth, abrogate the cell cycle G2 checkpoint and/or cause adaptation to G2 cell cycle arrest. Methods of making and using the invention compounds are provided. The invention provides substituted azole diones to treat cell proliferation disorders. The invention includes the use of substituted azole diones to selectively kill or suppress cancer cells without additional anti-cancer treatment. The invention includes the use of cell cycle G2-checkpoint-abrogating substituted azole diones to selectively sensitize cancer cells to DNA damaging reagents, treatments and/or other types of anti-cancer reagents.

摘要翻译： 提供了新型取代的唑类二恶英，其杀死细胞，抑制细胞增殖，抑制细胞生长，消除细胞周期G2检查点和/或引起适应G2细胞周期停滞。 提供了制备和使用本发明化合物的方法。 本发明提供取代的唑类二恶英以治疗细胞增殖障碍。 本发明包括使用取代的唑类二聚体来选择性地杀死或抑制癌细胞而无需额外的抗癌治疗。 本发明包括使用细胞周期G2-检查点 - 取代的取代唑类二恶英来选择性地使癌细胞对DNA损伤试剂，治疗和/或其它类型的抗癌试剂敏感。

公开(公告)号：US20080275057A1

公开(公告)日：2008-11-06

申请号：US12082643

申请日：2008-04-11

申请人： Takumi Kawabe ,  Machiyo Ishigaki ,  Takuji Sato ,  Sayaka Yamamoto ,  Yoko Hasegawa

发明人： Takumi Kawabe ,  Machiyo Ishigaki ,  Takuji Sato ,  Sayaka Yamamoto ,  Yoko Hasegawa

IPC分类号： A61K31/4439 ,  C07D401/12 ,  C07D215/38 ,  A61K31/496 ,  A61P35/00 ,  A61K31/4725 ,  C07D401/14

CPC分类号： A61K31/4439 ,  A61K31/4725 ,  A61K31/496 ,  C07D207/452 ,  C07D207/50 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D417/12

摘要： Novel substituted azole diones are provided that kill cells, suppress cell proliferation, suppress cell growth, abrogate the cell cycle G2 checkpoint and/or cause adaptation to G2 cell cycle arrest. Methods of making and using the invention compounds are provided. The invention provides substituted azole diones to treat cell proliferation disorders. The invention includes the use of substituted azole diones to selectively kill or suppress cancer cells without additional anti-cancer treatment. The invention includes the use of cell cycle G2-checkpoint-abrogating substituted azole diones to selectively sensitize cancer cells to DNA damaging reagents, treatments and/or other types of anti-cancer reagents.

摘要翻译： 提供了新型取代的唑类二恶英，其杀死细胞，抑制细胞增殖，抑制细胞生长，消除细胞周期G2检查点和/或引起适应G2细胞周期停滞。 提供了制备和使用本发明化合物的方法。 本发明提供取代的唑类二恶英以治疗细胞增殖障碍。 本发明包括使用取代的唑类二聚体来选择性地杀死或抑制癌细胞而无需额外的抗癌治疗。 本发明包括使用细胞周期G2-检查点 - 取代的取代唑类二恶英来选择性地使癌细胞对DNA损伤试剂，治疗和/或其它类型的抗癌试剂敏感。

公开(公告)号：US08084454B2

公开(公告)日：2011-12-27

申请号：US12082643

申请日：2008-04-11

申请人： Takumi Kawabe ,  Machiyo Ishigaki ,  Takuji Sato ,  Sayaka Yamamoto ,  Yoko Hasegawa

发明人： Takumi Kawabe ,  Machiyo Ishigaki ,  Takuji Sato ,  Sayaka Yamamoto ,  Yoko Hasegawa

IPC分类号： A61K31/497 ,  A61K31/505 ,  A61K31/47 ,  A61K31/44 ,  C07D401/12 ,  C07D239/02 ,  C07D215/46

CPC分类号： A61K31/4439 ,  A61K31/4725 ,  A61K31/496 ,  C07D207/452 ,  C07D207/50 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D417/12

摘要： Novel substituted azole diones are provided that kill cells, suppress cell proliferation, suppress cell growth, abrogate the cell cycle G2 checkpoint and/or cause adaptation to G2 cell cycle arrest. Methods of making and using the invention compounds are provided. The invention provides substituted azole diones to treat cell proliferation disorders. The invention includes the use of substituted azole diones to selectively kill or suppress cancer cells without additional anti-cancer treatment. The invention includes the use of cell cycle G2-checkpoint-abrogating substituted azole diones to selectively sensitize cancer cells to DNA damaging reagents, treatments and/or other types of anti-cancer reagents.

摘要翻译： 提供了新型取代的唑类二恶英，其杀死细胞，抑制细胞增殖，抑制细胞生长，消除细胞周期G2检查点和/或引起适应G2细胞周期停滞。 提供了制备和使用本发明化合物的方法。 本发明提供取代的唑类二恶英以治疗细胞增殖障碍。 本发明包括使用取代的唑类二聚体来选择性地杀死或抑制癌细胞而无需额外的抗癌治疗。 本发明包括使用细胞周期G2-检查点 - 取代的取代唑类二恶英来选择性地使癌细胞对DNA损伤试剂，治疗和/或其它类型的抗癌试剂敏感。

公开(公告)号：US20110092514A1

公开(公告)日：2011-04-21

申请号：US12950297

申请日：2010-11-19

申请人： TAKUMI KAWABE ,  Machiyo Ishigaki ,  Takuji Sato ,  Sayaka Yamamoto ,  Yoko Hasegawa

发明人： TAKUMI KAWABE ,  Machiyo Ishigaki ,  Takuji Sato ,  Sayaka Yamamoto ,  Yoko Hasegawa

IPC分类号： A61K31/496 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/473 ,  A61P35/00

CPC分类号： A61K31/4439 ,  A61K31/4725 ,  A61K31/496 ,  C07D207/452 ,  C07D207/50 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D417/12

摘要： Novel substituted azole diones are provided that kill cells, suppress cell proliferation, suppress cell growth, abrogate the cell cycle G2 checkpoint and/or cause adaptation to G2 cell cycle arrest. Methods of making and using the invention compounds are provided. The invention provides substituted azole diones to treat cell proliferation disorders. The invention includes the use of substituted azole diones to selectively kill or suppress cancer cells without additional anti-cancer treatment. The invention includes the use of cell cycle G2-checkpoint-abrogating substituted azole diones to selectively sensitize cancer cells to DNA damaging reagents, treatments and/or other types of anti-cancer reagents.

摘要翻译： 提供了新型取代的唑类二恶英，其杀死细胞，抑制细胞增殖，抑制细胞生长，消除细胞周期G2检查点和/或引起适应G2细胞周期停滞。 提供了制备和使用本发明化合物的方法。 本发明提供取代的唑类二恶英以治疗细胞增殖障碍。 本发明包括使用取代的唑类二聚体来选择性地杀死或抑制癌细胞而无需额外的抗癌治疗。 本发明包括使用细胞周期G2-检查点 - 取代的取代唑类二恶英来选择性地使癌细胞对DNA损伤试剂，治疗和/或其它类型的抗癌试剂敏感。

公开(公告)号：US20100112089A1

公开(公告)日：2010-05-06

申请号：US12465536

申请日：2009-05-13

申请人： Takumi Kawabe ,  Machiyo Ishigaki ,  Takuji Sato

发明人： Takumi Kawabe ,  Machiyo Ishigaki ,  Takuji Sato

IPC分类号： A61K38/10 ,  C07K7/00 ,  A61K38/14 ,  A61K33/24 ,  A61P35/00

CPC分类号： C07K7/06 ,  A61K38/00

摘要： The present invention provides a method for the prophylaxis or treatment of cancer in a mammal, comprising administering a therapeutically effective amount of CBP501, a prodrug thereof or a pharmaceutically acceptable salt thereof to the mammal, wherein CBP501, a prodrug thereof or a pharmaceutically acceptable salt thereof is administered simultaneously with or before administration of a nucleic acid damaging agent.

摘要翻译： 本发明提供了一种预防或治疗哺乳动物癌症的方法，包括向哺乳动物施用治疗有效量的CBP501，其前药或其药学上可接受的盐，其中CBP501，其前药或药学上可接受的盐 其与核酸损伤剂的给药同时或之前施用。

公开(公告)号：US07245388B2

公开(公告)日：2007-07-17

申请号：US10732064

申请日：2003-12-10

申请人： Hisashi Isozaki ,  Takuji Sato ,  Yoshiyuki Enomoto ,  Hiroyuki Maekawa

发明人： Hisashi Isozaki ,  Takuji Sato ,  Yoshiyuki Enomoto ,  Hiroyuki Maekawa

IPC分类号： G01B11/28

CPC分类号： G01N21/9501

摘要： A method for surface inspection, comprising the step of projecting at least two laser beams with different wavelengths to a same point to be inspected via a same projecting lens, the step of setting incident angles of the two laser beams so that fluctuations of values of reflectivity of the laser beams are complementary to each other, and the step of detecting reflected scattered light components.

摘要翻译： 一种用于表面检查的方法，包括以下步骤：通过相同的投影透镜将具有不同波长的至少两个激光束投影到相同的待检查点;设置两个激光束的入射角的步骤，使得反射率值的波动 的激光束彼此互补，并且检测反射的散射光分量的步骤。

公开(公告)号：US5242645A

公开(公告)日：1993-09-07

申请号：US721545

申请日：1991-09-13

申请人： Tai Sasamoto ,  Takehiko Miyoshi ,  Takuji Sato

发明人： Tai Sasamoto ,  Takehiko Miyoshi ,  Takuji Sato

IPC分类号： C08G63/86 ,  D01F6/62

CPC分类号： D01F6/62 ,  C08G63/86 ,  D02G3/48 ,  D10B2331/04

摘要： A rubber-reinforcing polyester fiber composed of a polyester prepared by using 30 to 150 ppm as antimony of an antimony compound and 5 to 60 ppm as germanium of a germanium compound as the polymerization catalyst. The fiber is characterized in that the terminal carboxyl group content is not larger than 25 eq/ton, diethylene glycol content (DEG) is not larger than 1.3% by weight, the intrinsic viscosity (IV) is at least 0.85, the sum (S) of the intermediate elongation and the dry heat shrinkage is lower than 8%, the product between strength and elongation (T.sqroot.E) is at least (2S+5), and the terminal modulus (TM) is not higher than 40 g/d. The polyester fiber is used as a rubber reinforcement.

摘要翻译： PCT No.PCT / JP90 / 01491 Sec。 371日期1991年9月13日 102（e）1991年9月13日PCT PCT 1990年11月15日PCT公布。 出版物WO91 / 07529 日期：1991年5月30日。一种橡胶增强聚酯纤维，其由通过使用30至150ppm作为锑化合物的锑制备的聚酯和5至60ppm作为锗化合物的锗作为聚合催化剂制备。 纤维的特征在于末端羧基含量不大于25当量/吨，二甘醇含量（DEG）不大于1.3重量％，特性粘度（IV）至少为0.85，总和（S ）的中间伸长率和干热收缩率低于8％，强度和伸长率之间的乘积（T 2ROOT E）至少为（2S + 5），并且末端模量（TM）不高于40g / d。 聚酯纤维用作橡胶增强剂。

公开(公告)号：US06204918B1

公开(公告)日：2001-03-20

申请号：US09285259

申请日：1999-04-02

申请人： Hisashi Isozaki ,  Yutaka Shida ,  Takuji Sato

发明人： Hisashi Isozaki ,  Yutaka Shida ,  Takuji Sato

IPC分类号： G01N2100

CPC分类号： G01N21/8851

摘要： An apparatus for surface inspection according to the invention comprises an irradiating optical system for throwing an irradiating light beam from a light source onto the surface of an object of inspection, a light receiving optical system for receiving a scattered light beam reflected from the surface of the object of inspection irradiated by the irradiating optical system, a photosensing portion for forming a surface data signal from the scattered light beam received by the light receiving optical system, a displacement portion for displacing the surface of the object of inspection relative to the irradiating optical system, plus the light receiving optical system, continuously in the main scanning direction and intermittently in the sub-scanning direction, and a foreign matter detecting portion for detecting a foreign matter present on the surface of the object of inspection on the basis of the maximum value level of the surface data signal and obtaining the position, in the sub-scanning direction, of the foreign matter present on the surface of the object of inspection on the basis of at least two adjoining surface data signals in the sub-scanning direction.

摘要翻译： 根据本发明的用于表面检查的装置包括：照射光学系统，用于将来自光源的照射光束投射到检查对象的表面上;光接收光学系统，用于接收从所述光源的表面反射的散射光束; 由照射光学系统照射的检查对象物，用于由受光光学系统接收的散射光形成表面数据信号的光敏部分，用于使检查对象的表面相对于照射光学系统移位的位移部分 加上受光光学系统，在主扫描方向上连续地并且在副扫描方向上间歇地，以及异物检测部分，用于根据最大值检测存在于检查对象表面上的异物 水平的表面数据信号并获得位置，在sub sca 基于在副扫描方向上的至少两个邻接表面数据信号存在于检查对象表面上的异物的方向。

公开(公告)号：US4987030A

公开(公告)日：1991-01-22

申请号：US253135

申请日：1988-10-04

申请人： Isoo Saito ,  Takuji Sato ,  Koichi Kubota ,  Masaharu Yamamoto

发明人： Isoo Saito ,  Takuji Sato ,  Koichi Kubota ,  Masaharu Yamamoto

IPC分类号： D01F8/12 ,  D01F8/14

CPC分类号： D01F8/12 ,  D01F8/14 ,  Y10S57/902 ,  Y10T428/2929 ,  Y10T428/2931

摘要： A conjugated fiber having a sheath-core conjugated structure comprising a polyester core component composed mainly of polyethylene terephthalate and a polyamide sheath component composed mainly of polyhexamethylene adipamide, is disclosed, which has excellent mechanical properties such as a high tenacity, a high modulus, and an improved dimensional stability, and an improved adhesion to a rubber, especially a high-temperature adhesion, an improved heat resistance in a rubber, and a high fatigue resistance, and thus is useful as an industrial material. By adopting a high-speed spinning procedure in the fiber preparing process, the peel resistance in the interface of the sheath-core conjugated structure is greatly improved, and the following valuable characteristics not possessed by conventional conjugated yarns can be obtained:(1) Excellent adhesion and high-temperature adhesion comparable to those of a polyamide, which cannot be obtained in a polyester.(2) High modulus and dimensional stability comparable to those of a polyester, which cannot be obtained in a polyamide.(3) A heat resistance in a rubber and a fatigue resistance superior to those of a polyester.

摘要翻译： 公开了一种具有鞘芯共轭结构的复合纤维，其包含主要由聚对苯二甲酸乙二醇酯组成的聚酯芯组分和主要由聚己二酰己二胺组成的聚酰胺鞘组分，其具有优异的机械性能，例如高强度，高模量和 改进的尺寸稳定性，以及改进的对橡胶的粘合性，特别是高温粘合性，橡胶中耐热性提高，抗疲劳性高，因此可用作工业材料。 通过在纤维制备方法中采用高速纺丝方法，大大提高了皮芯共轭结构界面的剥离强度，可以得到常规共轭纱不具有以下有价值的特性：（1）优异 粘合性和高温粘合性与聚酯中不能得到的聚酰胺相当。 （2）与在聚酰胺中不能获得的聚酯相比，高模量和尺寸稳定性。 （3）橡胶中的耐热性和耐聚酯的耐疲劳性。

公开(公告)号：US4781457A

公开(公告)日：1988-11-01

申请号：US715571

申请日：1985-03-25

申请人： Satoshi Hirano ,  Takuji Sato ,  Hiroshi Nishikatsu

发明人： Satoshi Hirano ,  Takuji Sato ,  Hiroshi Nishikatsu

IPC分类号： G01C15/00 ,  G01C9/12

CPC分类号： G01C15/004

摘要： A laser surveying equipment includes a laser beam luminous section, a suspending reflection member suspended in such a manner as to reflect laser beam radiated from the laser beam luminous section upward and always to direct the optical axis of such reflected light in the perpendicular direction, and a projection lens system adapted to project the laser beam after forming it into a generally parallel flux of light. A rotary reflection member can be rotatably arranged in order to displace by approximately 90 degree an optical path of parallel flux of light obtained from the projection lens system and to scan the parallel flux of light toward a surveying object within a horizontal plane.

摘要翻译： 激光测量设备包括激光束发光部分，悬挂反射部件，以将从激光束发光部分照射的激光束向上方反射的方式悬挂，并且始终将这种反射光的光轴沿垂直方向引导;以及 投影透镜系统，其适于在将激光束成形为大致平行的光束之后投射激光束。 旋转反射构件可以可旋转地布置以便从投影透镜系统获得的平行光束的光路大约90度位移，并且在水平面内扫描平行的光束向测量对象。