公开(公告)号：US08548546B2

公开(公告)日：2013-10-01

申请号：US12486843

申请日：2009-06-18

申请人： Takuo Aoyagi ,  Michio Kanemoto ,  Masayoshi Fuse ,  Teiji Ukawa

发明人： Takuo Aoyagi ,  Michio Kanemoto ,  Masayoshi Fuse ,  Teiji Ukawa

IPC分类号： A61B5/00

CPC分类号： A61B5/7207 ,  A61B5/1455

摘要： A pulse oximetry includes: irradiating living tissue with a plurality of light beams of different wavelengths; receiving the light beams transmitted through or reflected from the living tissue and converting the received light beams to electric signals which correspond to the different wavelengths; time-segmenting time series data of the electric signals; calculating, with respect to each of the segmented time series data of the electric signals, a slope value of a regression line between each two of the electric signals; calculating SaO2 based on the slope value of each of the segmented time series data of the electric signals; constructing a histogram of SaO2 for each predetermined number of time segments; and obtaining a mode value from the histogram as SpO2 to be output of the pulse oximetry.

摘要翻译： 脉搏血氧测定法包括：用多个不同波长的光束照射生物体组织; 接收通过生物体组织传播或反射的光束，并将接收的光束转换成对应于不同波长的电信号; 时间分段电信号的时间序列数据; 针对电信号的每个分段时间序列数据计算每个两个电信号之间的回归线的斜率值; 根据电信号分段时间序列数据的斜率值计算SaO2; 为每个预定数量的时间段构建SaO2的直方图; 并且从直方图获得作为脉搏血氧饱和度的SpO2的模式值。

公开(公告)号：US20050049469A1

公开(公告)日：2005-03-03

申请号：US10927016

申请日：2004-08-27

申请人： Takuo Aoyagi ,  Masayoshi Fuse ,  Naoki Kobayashi ,  Teiji Ukawa

发明人： Takuo Aoyagi ,  Masayoshi Fuse ,  Naoki Kobayashi ,  Teiji Ukawa

IPC分类号： A61B5/00

CPC分类号： A61B5/14551

摘要： In a pulse oximeter for obtaining an oxygen saturation in a blood, a light emitter irradiates a living tissue with light beams having five different wavelengths. A light receiver receives respective light beams reflected from or transmitted through the living tissue, and converts the received light beams to electric signals. A first calculator calculates five attenuation changes of the living tissue based on fluctuations of the respective electric signals. A second calculator calculates at least four attenuation change ratios from the five attenuation changes. Each of the attenuation change ratios is defined by a ratio between any two of the five attenuation changes. A third calculator calculates the oxygen saturation based on the attenuation change ratios, while taking an oxygen saturation of arterial blood, an oxygen saturation of venous blood, a ratio between changes in arterial blood and venous blood, and a tissue term as four unknown values.

摘要翻译： 在用于获得血液中的氧饱和度的脉搏血氧计中，发光体用具有五个不同波长的光束照射活体组织。 光接收器接收从生物体组织反射或透过的各种光束，并将接收到的光束转换为电信号。 第一计算器基于相应的电信号的波动来计算活体组织的五个衰减变化。 第二计算器根据五个衰减变化计算出至少四个衰减变化率。 每个衰减变化率由五个衰减变化中的任何两个之间的比率定义。 第三计算器基于衰减变化率计算氧饱和度，同时采取动脉血的氧饱和度，静脉血的氧饱和度，动脉血和静脉血的变化之间的比率以及组织术语作为四个未知值。

公开(公告)号：US07206621B2

公开(公告)日：2007-04-17

申请号：US10927016

申请日：2004-08-27

申请人： Takuo Aoyagi ,  Masayoshi Fuse ,  Naoki Kobayashi ,  Teiji Ukawa

发明人： Takuo Aoyagi ,  Masayoshi Fuse ,  Naoki Kobayashi ,  Teiji Ukawa

IPC分类号： A61B5/00

CPC分类号： A61B5/14551

摘要： In a pulse oximeter for obtaining an oxygen saturation in a blood, a light emitter irradiates a living tissue with light beams having five different wavelengths. A light receiver receives respective light beams reflected from or transmitted through the living tissue, and converts the received light beams to electric signals. A first calculator calculates five attenuation changes of the living tissue based on fluctuations of the respective electric signals. A second calculator calculates at least four attenuation change ratios from the five attenuation changes. Each of the attenuation change ratios is defined by a ratio between any two of the five attenuation changes. A third calculator calculates the oxygen saturation based on the attenuation change ratios, while taking an oxygen saturation of arterial blood, an oxygen saturation of venous blood, a ratio between changes in arterial blood and venous blood, and a tissue term as four unknown values.

摘要翻译： 在用于获得血液中的氧饱和度的脉搏血氧计中，发光体用具有五个不同波长的光束照射活体组织。 光接收器接收从生物体组织反射或透过的各种光束，并将接收到的光束转换为电信号。 第一计算器基于相应的电信号的波动来计算活体组织的五个衰减变化。 第二计算器根据五个衰减变化计算出至少四个衰减变化率。 每个衰减变化率由五个衰减变化中的任何两个之间的比率定义。 第三计算器基于衰减变化率计算氧饱和度，同时采取动脉血的氧饱和度，静脉血的氧饱和度，动脉血和静脉血的变化之间的比率以及组织术语作为四个未知值。

公开(公告)号：US06671526B1

公开(公告)日：2003-12-30

申请号：US09692044

申请日：2000-10-20

申请人： Takuo Aoyagi ,  Masayoshi Fuse ,  Sunao Takeda ,  Cheng-tai Xie ,  Michio Kanemoto

发明人： Takuo Aoyagi ,  Masayoshi Fuse ,  Sunao Takeda ,  Cheng-tai Xie ,  Michio Kanemoto

IPC分类号： A61B500

CPC分类号： A61B5/0059 ,  A61B5/14552

摘要： A probe 1 includes a light irradiating device 2 and a light receiving device 3, which are oppositely disposed sandwiching living tissue 10. The light irradiating device 2 includes a light source 5 and a scattering plate 6 located in front of the light source 5. The light receiving device 3 includes a photo diode 8 and a light scattering portion. With such an arrangement, of the attenuation of the living tissue 10, non-absorbing attenuation is free from the wavelength. A ratio of absorbing attenuation and a thickness of a blood layer is not affected by a thickness of living tissue. Further, the absorbing attenuation is not dependent on a depth of the blood layer.

摘要翻译： 探针1包括相对设置的夹持生物体组织10的光照射装置2和光接收装置3.光照射装置2包括位于光源5前方的光源5和散射板6。 光接收装置3包括光电二极管8和光散射部分。 通过这样的布置，对于生物体组织10的衰减，非吸收性衰减不受波长的影响。 吸收衰减的比例和血液层的厚度不受生物体组织的厚度的影响。 此外，吸收衰减不依赖于血液层的深度。

公开(公告)号：US5720284A

公开(公告)日：1998-02-24

申请号：US623862

申请日：1996-03-29

申请人： Takuo Aoyagi ,  Masayoshi Fuse ,  Michio Kanemoto ,  Cheng Tai Xie

发明人： Takuo Aoyagi ,  Masayoshi Fuse ,  Michio Kanemoto ,  Cheng Tai Xie

IPC分类号： A61B5/00 ,  G01N33/72

CPC分类号： A61B5/14551 ,  G01N33/721 ,  G01N33/726

摘要： Light of various wavelengths emitted from light sources and transmitted through vital tissues is converted by light sensors and current/voltage transducers, into electric signals. The signals are converted into digital values by an A/D converter. The light source emits light of a wavelength which can be optically absorbed by water. A computer obtains a ratio of variations of the digital values for each wavelength, and calculates the values of tissue terms and the hemoglobin concentration on the basis of the ratios. In the calculation, since tissue terms of the wavelengths have mutual constant relationships, an equation which is prepared so that there exists only one unknown in the tissue terms is used.

摘要翻译： 从光源发射并通过生命组织传播的各种波长的光由光传感器和电流/电压传感器转换成电信号。 信号由A / D转换器转换为数字值。 光源发射可被水光学吸收的波长的光。 计算机获得每个波长的数字值的变化率，并且基于比率来计算组织项的值和血红蛋白浓度。 在计算中，由于波长的组合项具有相互恒定的关系，所以使用准备使得在组织术语中仅存在一个未知的方程式。

公开(公告)号：US5766125A

公开(公告)日：1998-06-16

申请号：US429545

申请日：1995-04-27

申请人： Takuo Aoyagi ,  Masayoshi Fuse ,  Michio Kanemoto ,  Cheng-tai Xie ,  Naoki Kobayashi ,  Hideaki Hirahara

发明人： Takuo Aoyagi ,  Masayoshi Fuse ,  Michio Kanemoto ,  Cheng-tai Xie ,  Naoki Kobayashi ,  Hideaki Hirahara

IPC分类号： G01N21/27 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/31

CPC分类号： A61B5/14551 ,  G01N21/3151

摘要： Light beams of different wavelengths, emitted from a light generating device, are transmitted through a living tissue. The transmitted light beams are converted into electrical signals by a photoelectric transducing device. A pulsation calculating device calculates a pulsation of an absorbance of tissue of a living tissue for each wavelength on the basis of the output signal of the photoelectric transducing device. By using this, a pulsation ratio calculating device calculates the ratio of the pulsations of the absorbance values. A concentration calculating device puts the output signal of the pulsation ratio calculating device into a formula having a single unknown on the tissue term, which is constructed on the basis of the fact that a predetermined relation is present between the tissue terms of the respective wavelengths, thereby calculating a value of the tissue term and the concentration of light absorbing material in blood.

摘要翻译： 从发光装置发射的不同波长的光束通过活组织透射。 透射光束由光电转换装置转换为电信号。 脉动计算装置根据光电转换装置的输出信号，计算各波长的生物体组织的吸光度的脉动。 通过使用这一点，脉动比计算装置计算吸光度值的脉动比。 浓度计算装置将脉动比计算装置的输出信号设置在组织术语上具有单个未知数的公式中，其基于在各个波长的组织项之间存在预定关系的事实构成， 从而计算组织术语的值和血液中光吸收材料的浓度。

公开(公告)号：US06230035B1

公开(公告)日：2001-05-08

申请号：US09356521

申请日：1999-07-19

申请人： Takuo Aoyagi ,  Masayoshi Fuse ,  Chen-tai Xie ,  Michio Kanemoto

发明人： Takuo Aoyagi ,  Masayoshi Fuse ,  Chen-tai Xie ,  Michio Kanemoto

IPC分类号： A61B500

CPC分类号： A61B5/14551 ,  A61B5/14552

摘要： Irradiating device 3 of a pulse oximeter includes a scattering plate 6. Scattering light is projected into a living tissue. The diameter of the incident area is sufficiently large compared with that of a light receiving area or vice versa. Therefore, tissue terms in a theoretical formula of &PHgr; which represents a ratio of changes of optical densities of tissue measured with two wavelengths are not dependent on the wavelength. The digital processor 10 calculates an oxygen saturation by substituting &PHgr; measured into simultaneous equations.

摘要翻译： 脉搏血氧计的照射装置3包括散射板6.散射光投射到活体组织中。 与光接收区域相比，入射面积的直径足够大，反之亦然。 因此，理论公式中的组织术语＆PHgr; 其表示用两个波长测量的组织的光密度变化的比率不依赖于波长。 数字处理器10用“PHgr”代替氧饱和度; 测量为联立方程。

公开(公告)号：US5313940A

公开(公告)日：1994-05-24

申请号：US882960

申请日：1992-05-14

申请人： Masayoshi Fuse ,  Cheng T. Xie ,  Takuo Aoyagi

发明人： Masayoshi Fuse ,  Cheng T. Xie ,  Takuo Aoyagi

IPC分类号： A61B5/024 ,  A61B5/00

CPC分类号： A61B5/6826 ,  A61B5/02416 ,  A61B5/6838

摘要： A photo-electric pulse measuring probe includes a pair of supporting members which have a light emitting element and a light receiving element adjacent first end portions thereof, respectively, in such a manner that the light emitting element and the light receiving elements are confronted with each other, and which are swingably coupled to each other at the other end portions thereof. The light emitting element and the light receiving element are covered with elastic members, respectively, and wavy surfaces are formed in the mating surfaces of the elastic members, respectively, so that a user's finger is supported by a number of points during measurement.

摘要翻译： 光电脉冲测量探头包括分别具有发光元件和光接收元件的第一端部的一对支撑构件，使得发光元件和光接收元件分别与每个 并且在其另一端部可摆动地彼此耦合。 发光元件和受光元件分别被弹性构件覆盖，并且分别在弹性构件的配合表面中形成波状表面，使得用户的手指在测量期间由多个点支撑。

公开(公告)号：US5278627A

公开(公告)日：1994-01-11

申请号：US835505

申请日：1992-02-14

申请人： Takuo Aoyagi ,  Masayoshi Fuse ,  Yoshiaki Shindo ,  Masayuki Kato

发明人： Takuo Aoyagi ,  Masayoshi Fuse ,  Yoshiaki Shindo ,  Masayuki Kato

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/024 ,  A61B5/1455 ,  A61B5/1495 ,  G01N21/27 ,  G01N33/00 ,  G01N33/487 ,  G01N33/48

CPC分类号： G01N21/274 ,  A61B5/02427 ,  A61B5/14551 ,  A61B5/1495 ,  A61B2560/0233

摘要： An apparatus for calibrating a pulse oximeter which can improve the repetitivity of measured values for calibration tests and which can calibrate the pulse oximeter with a high reliability. A tissue model having a light-absorbing characteristic approximated to that of the tissue of a living body is inserted into a space between a light-emitting section and a light-receiving section of a measuring probe that is connected to the pulse oximeter, and a blood model having a light-absorbing characteristic that is approximated to that of the blood is moved within the tissue model so as to enter into or exit from the space between the light-emitting section and the light-receiving section.

摘要翻译： 用于校准脉搏血氧计的装置，其可以提高校准测试的测量值的重复性，并且可以以高可靠性校准脉搏血氧计。 将具有近似于生物体组织的光吸收特性的组织模型插入连接到脉搏血氧计的测量探针的发光部分和光接收部分之间的空间中，并且 具有近似于血液的光吸收特性的血液模型在组织模型内移动，以进入或离开发光部分和光接收部分之间的空间。

公开(公告)号：US08024021B2

公开(公告)日：2011-09-20

申请号：US11511476

申请日：2006-08-29

申请人： Takuo Aoyagi ,  Masayoshi Fuse ,  Naoki Kobayashi

发明人： Takuo Aoyagi ,  Masayoshi Fuse ,  Naoki Kobayashi

IPC分类号： A61B5/1455

CPC分类号： A61B5/14551 ,  A61B5/7207

摘要： To measure oxygen saturation in blood, living tissue is irradiated with a first light beam having a first wavelength and a second light beam having a second wavelength. A first electrical signal is generated from the first light beam reflected from or transmitted through the tissue. A second electrical signal is generated from the second light beam reflected from or transmitted through the tissue. The first electrical signal is divided into a plurality of first segments, each including a part of the first electrical signal for a predetermined time period. The second electrical signal is divided into a plurality of second segments, each including a part of the second electrical signal for the predetermined time period. A gradient of a regression line is calculated between every one of the first segments and an associated one of the second segments, thereby obtaining a plurality of gradients.

摘要翻译： 为了测量血液中的氧饱和度，用具有第一波长的第一光束和具有第二波长的第二光束照射活组织。 从从组织反射或透过组织的第一光束产生第一电信号。 从从组织反射或透过组织的第二光束产生第二电信号。 第一电信号被分成多个第一段，每个第一段包括第一电信号的一部分预定时间段。 第二电信号被分成多个第二段，每个第二段包括预定时间段的第二电信号的一部分。 在第一段和第二段中的每一个之间计算回归线的梯度，从而获得多个梯度。