公开(公告)号：US20080146901A1

公开(公告)日：2008-06-19

申请号：US11954627

申请日：2007-12-12

申请人： Takusige KATURA ,  Naoki Tanaka ,  Atsushi Maki

发明人： Takusige KATURA ,  Naoki Tanaka ,  Atsushi Maki

IPC分类号： A61B5/1455

CPC分类号： A61B5/0059 ,  A61B5/02028 ,  A61B5/6814 ,  A61B5/7207 ,  G06K9/6243

摘要： An optical measurement instrument for living body that comprises: a plurality of light irradiation means for irradiating an object being tested with light; a plurality of light reception means for detecting the light that is irradiated to the object being tested and propagates inside the object being tested; and a calculation unit for calculating hemodynamics of a plurality of factors inside the object being tested from the detection signal detected by the light reception means, wherein the calculation unit comprises: a separation calculation unit for separating a plurality of signals from the detection signals; a selection unit for calculating a correlation coefficient between a plurality of the signals separated to select a signal in which a correlation coefficient is a predetermined value or greater as a noise signal; and a reconstruction calculation unit for reconfiguring the detection signal excluding the noise signal selected by the selection unit.

摘要翻译： 一种生物体光学测量仪器，包括：多个光照射装置，用于用光照射待测物体; 多个光接收装置，用于检测照射到被测试物体上的光并在待测物体的内部传播; 以及计算单元，用于根据由光接收装置检测的检测信号计算被测物体内的多个因子的血液动力学，其中所述计算单元包括：分离计算单元，用于从所述检测信号中分离出多个信号; 选择单元，用于计算分离以选择其中相关系数为预定值或更大的信号的多个信号之间的相关系数作为噪声信号; 以及重建计算单元，用于重新配置除了由选择单元选择的噪声信号之外的检测信号。

公开(公告)号：US07285790B2

公开(公告)日：2007-10-23

申请号：US11044040

申请日：2005-01-28

申请人： Naoki Tanaka ,  Takusige Katura ,  Masashi Kiguchi ,  Hiroki Sato ,  Atsushi Maki

发明人： Naoki Tanaka ,  Takusige Katura ,  Masashi Kiguchi ,  Hiroki Sato ,  Atsushi Maki

IPC分类号： A61B5/00

CPC分类号： A61B5/16 ,  A61B5/14553 ,  A61B5/6814

摘要： A response period is determined arbitrarily. A satisfactory detecting ability may not be provided because of an artifact or the like contained in a signal. Therefore, an effective detection method and an effective display method of presenting results of detection must be developed. A series of tasks (stimuli) or a selected measurement signal is used as a reference signal, and a phase difference of any other measurement signal from the reference signal is calculated. The synchronousness of the phase of the measurement signal with the phase of the reference signal is numerically expressed. The thus obtained numerical value is statistically processed in order to numerically express a degree of reliability. Thus, a brain activity or a functional connectivity is visualized.

摘要翻译： 响应时间是任意确定的。 由于信号中包含的伪影等，不能提供令人满意的检测能力。 因此，必须开发一种提供检测结果的有效检测方法和有效的显示方法。 使用一系列任务（刺激）或所选择的测量信号作为参考信号，并且计算来自参考信号的任何其它测量信号的相位差。 测量信号的相位与参考信号的相位的同步性被数字表示。 对这样得到的数值进行统计处理，以便数值地表达可靠度。 因此，大脑活动或功能连接可视化。

公开(公告)号：US20060100525A1

公开(公告)日：2006-05-11

申请号：US11205160

申请日：2005-08-17

申请人： Takusige Katura ,  Naoki Tanaka ,  Hiroki Sato ,  Akiko Obata ,  Atsushi Maki

发明人： Takusige Katura ,  Naoki Tanaka ,  Hiroki Sato ,  Akiko Obata ,  Atsushi Maki

IPC分类号： A61B6/00

CPC分类号： A61B5/6814 ,  A61B5/0059 ,  A61B5/024 ,  A61B5/14553

摘要： A typical task assigned for measuring a brain activity signal lasts from 10 to 30 seconds. The frequency band of the Mayer wave noise signal is very close to the frequency bands of brain activity signals, a result, it is difficult to reduce the Mayer wave noise signal using a bandpass filter or a bandcut filter. Light irradiating units and light detecting units for detecting the emitted light that has been passed through or reflected within the tissue are provided. A biological signal measuring unit measures at least one of the pulsation, breathing, blood pressure, and temperature. The relationship between an optical signal obtained by the light detecting unit and a biological signal using non-linear analysis; and a computation for separating the biological noise signal from the optical signal on the basis of the obtained relationship.

公开(公告)号：US08311600B2

公开(公告)日：2012-11-13

申请号：US11954627

申请日：2007-12-12

申请人： Takusige Katura ,  Naoki Tanaka ,  Atsushi Maki

发明人： Takusige Katura ,  Naoki Tanaka ,  Atsushi Maki

IPC分类号： A61B5/1455

CPC分类号： A61B5/0059 ,  A61B5/02028 ,  A61B5/6814 ,  A61B5/7207 ,  G06K9/6243

摘要： An optical measurement instrument for living body includes: a plurality of light irradiation means for irradiating an object being tested with light; a plurality of light reception means for detecting the light that is irradiated to the object being tested and propagates inside the object being tested; and a calculation unit for calculating hemodynamics of a plurality of factors inside the object being tested from the detection signal detected by the light reception means, wherein the calculation unit includes a separation calculation unit for separating a plurality of signals from the detection signals; a selection unit for calculating a correlation coefficient between a plurality of the signals separated to select a signal in which a correlation coefficient is a predetermined value or greater as a noise signal; and a reconstruction calculation unit for reconfiguring the detection signal excluding the noise signal selected by the selection unit.

摘要翻译： 一种用于生物体的光学测量仪器包括：多个光照射装置，用于用光照射被测物体; 多个光接收装置，用于检测照射到被测试物体上的光并在待测物体的内部传播; 以及计算单元，用于根据由光接收装置检测的检测信号计算被测物体内的多个因子的血液动力学，其中所述计算单元包括分离计算单元，用于从所述检测信号中分离出多个信号; 选择单元，用于计算分离以选择其中相关系数为预定值或更大的信号的多个信号之间的相关系数作为噪声信号; 以及重建计算单元，用于重新配置除了由选择单元选择的噪声信号之外的检测信号。

公开(公告)号：US07565192B2

公开(公告)日：2009-07-21

申请号：US11205160

申请日：2005-08-17

申请人： Takusige Katura ,  Naoki Tanaka ,  Hiroki Sato ,  Akiko Obata ,  Atsushi Maki

发明人： Takusige Katura ,  Naoki Tanaka ,  Hiroki Sato ,  Akiko Obata ,  Atsushi Maki

IPC分类号： A61B5/00

CPC分类号： A61B5/6814 ,  A61B5/0059 ,  A61B5/024 ,  A61B5/14553

摘要： A typical task assigned for measuring a brain activity signal lasts from 10 to 30 seconds. The frequency band of the Mayer wave noise signal is very close to the frequency bands of brain activity signals, a result, it is difficult to reduce the Mayer wave noise signal using a bandpass filter or a bandcut filter. Light irradiating units and light detecting units for detecting the emitted light that has been passed through or reflected within the tissue are provided. A biological signal measuring unit measures at least one of the pulsation, breathing, blood pressure, and temperature. The relationship between an optical signal obtained by the light detecting unit and a biological signal using non-linear analysis; and a computation for separating the biological noise signal from the optical signal on the basis of the obtained relationship.

摘要翻译： 分配给测量大脑活动信号的典型任务持续10到30秒。 梅耶尔波噪声信号的频带非常接近脑活动信号的频带，结果是难以使用带通滤波器或带通滤波器来减少梅耶波噪声信号。 提供了用于检测已经通过或反射在组织内的发射光的光照射单元和光检测单元。 生物信号测量单元测量脉动，呼吸，血压和温度中的至少一个。 由光检测单元获得的光信号与使用非线性分析的生物信号之间的关系; 以及基于所获得的关系从生物噪声信号与光信号分离的计算。

公开(公告)号：US20060006343A1

公开(公告)日：2006-01-12

申请号：US11044040

申请日：2005-01-28

申请人： Naoki Tanaka ,  Takusige Katura ,  Masashi Kiguchi ,  Hiroki Sato ,  Atsushi Maki

发明人： Naoki Tanaka ,  Takusige Katura ,  Masashi Kiguchi ,  Hiroki Sato ,  Atsushi Maki

IPC分类号： A61B8/06

CPC分类号： A61B5/16 ,  A61B5/14553 ,  A61B5/6814

摘要： A response period is determined arbitrarily. A satisfactory detecting ability may not be provided because of an artifact or the like contained in a signal. Therefore, an effective detection method and an effective display method of presenting results of detection must be developed. A series of tasks (stimuli) or a selected measurement signal is used as a reference signal, and a phase difference of any other measurement signal from the reference signal is calculated. The synchronousness of the phase of the measurement signal with the phase of the reference signal is numerically expressed. The thus obtained numerical value is statistically processed in order to numerically express a degree of reliability. Thus, a brain activity or a functional connectivity is visualized.

摘要翻译： 响应时间是任意确定的。 由于信号中包含的伪影等，不能提供令人满意的检测能力。 因此，必须开发一种提供检测结果的有效检测方法和有效的显示方法。 使用一系列任务（刺激）或所选择的测量信号作为参考信号，并且计算来自参考信号的任何其它测量信号的相位差。 测量信号的相位与参考信号的相位的同步性被数字表示。 对这样得到的数值进行统计处理，以便数值地表达可靠度。 因此，大脑活动或功能连接可视化。

公开(公告)号：US07171250B2

公开(公告)日：2007-01-30

申请号：US11010668

申请日：2004-12-14

申请人： Tsuyoshi Yamamoto ,  Atsushi Maki ,  Takusige Katura ,  Hideo Kawaguchi

发明人： Tsuyoshi Yamamoto ,  Atsushi Maki ,  Takusige Katura ,  Hideo Kawaguchi

IPC分类号： A61B5/00

CPC分类号： A61B5/14553 ,  A61B5/0042 ,  A61B2562/0233 ,  A61B2562/046

摘要： An image generating methodology for displaying brain activation areas with improved accuracy in a living body light measurement system for generating an image of the changes in blood volume of the brain. A spatial intensity distribution of changes in blood volume can be generated by detecting brain activation in many sampling points, and a spatial interpolation process is executed on this data. A threshold process is executed on the distribution to extract the distribution of coordinates having a signal intensity of at least the predetermined threshold. The displacement between the brain activation area and the maximal location of the distribution is stored in a recording unit of the system in order to compensate for the distribution extracted by the threshold process. Accordingly, brain activation areas can be estimated with greater location accuracy, and the diagnosis and medial treatment for brain diseases can likewise be executed with greater accuracy.

摘要翻译： 一种用于在生物体光测量系统中显示脑激活区域以提高准确度的图像产生方法，用于产生脑的血容量变化的图像。 通过检测许多采样点的大脑激活可以产生血容量变化的空间强度分布，并对该数据执行空间插值处理。 对分布执行阈值处理以提取具有至少预定阈值的信号强度的坐标分布。 大脑激活区域和分布的最大位置之间的位移被存储在系统的记录单元中，以便补偿由阈值处理提取的分布。 因此，可以以更高的定位精度估计脑激活区域，并且同样可以更准确地执行脑疾病的诊断和内侧治疗。

公开(公告)号：US07150717B2

公开(公告)日：2006-12-19

申请号：US10764561

申请日：2004-01-27

申请人： Takusige Katura ,  Atsushi Maki ,  Masashi Kiguchi

发明人： Takusige Katura ,  Atsushi Maki ,  Masashi Kiguchi

IPC分类号： A61B5/00

CPC分类号： A61B5/4884 ,  A61B5/02055 ,  A61B5/021 ,  A61B5/0261 ,  A61B5/0816 ,  A61B5/14553

摘要： Disclosed is an optical measurement apparatus for a living body to provide a means for measuring blood flow activity within a short time inside the body, even if the test subject cannot distinguish between the active task period and the rest period. An optical measurement apparatus for a living body comprises a light irradiating section, and a light detecting section for detecting light transmitting through or reflected from the interior of the body. The concentration of carbon dioxide gas taken into the body is controlled by the respiration of the test subject and the resulting change in output from the light detecting section is then evaluated.

摘要翻译： 公开了一种生物体的光学测量装置，即使被检体不能区分活动任务期间和休止期间，也能够在体内短时间内测定血液流动活动的手段。 用于生物体的光学测量装置包括光照射部分和用于检测透射到身体内部或从身体内部反射的光的光检测部分。 进入身体的二氧化碳气体的浓度由受检对象的呼吸控制，然后评估所得到的光检测部分的输出变化。

公开(公告)号：US20050192490A1

公开(公告)日：2005-09-01

申请号：US11010668

申请日：2004-12-14

申请人： Tsuyoshi Yamamoto ,  Atsushi Maki ,  Takusige Katura ,  Hideo Kawaguchi

发明人： Tsuyoshi Yamamoto ,  Atsushi Maki ,  Takusige Katura ,  Hideo Kawaguchi

IPC分类号： G01N21/17 ,  A61B5/00 ,  A61B10/00

CPC分类号： A61B5/14553 ,  A61B5/0042 ,  A61B2562/0233 ,  A61B2562/046

摘要： An image generating methodology for displaying brain activation areas with improved accuracy in a living body light measurement system for generating an image of the changes in blood volume of the brain. A spatial intensity distribution of changes in blood volume can be generated by detecting brain activation in many sampling points, and a spatial interpolation process is executed on this data. A threshold process is executed on the distribution to extract the distribution of coordinates having a signal intensity of at least the predetermined threshold. The displacement between the brain activation area and the maximal location of the distribution is stored in a recording unit of the system in order to compensate for the distribution extracted by the threshold process. Accordingly, brain activation areas can be estimated with greater location accuracy, and the diagnosis and medial treatment for brain diseases can likewise be executed with greater accuracy.

摘要翻译： 一种用于在生物体光测量系统中显示脑激活区域以提高准确度的图像产生方法，用于产生脑的血容量变化的图像。 通过检测许多采样点的大脑激活，可以产生血容量变化的空间强度分布，并对该数据执行空间插值处理。 对分布执行阈值处理以提取具有至少预定阈值的信号强度的坐标的分布。 大脑激活区域和分布的最大位置之间的位移被存储在系统的记录单元中，以便补偿由阈值处理提取的分布。 因此，可以以更高的定位精度估计脑激活区域，并且同样可以更准确地执行脑疾病的诊断和内侧治疗。

公开(公告)号：US20070287922A1

公开(公告)日：2007-12-13

申请号：US11696295

申请日：2007-04-04

申请人： Naoki Tanaka ,  Atsushi Maki ,  Takushige Katsura

发明人： Naoki Tanaka ,  Atsushi Maki ,  Takushige Katsura

IPC分类号： A61B5/02

CPC分类号： A61B5/0261 ,  A61B5/021 ,  A61B5/02416 ,  A61B5/6814

摘要： A living body measurement system including a cerebral blood volume measurement unit for measuring a regional cerebral blood volume of a subject, an arterial pressure/heart rate measurement unit for measuring an arterial pressure and/or a heart rate of the subject, an analysis unit for analyzing signals measured by the cerebral blood volume measurement unit and the arterial pressure/heart rate measurement unit, an extraction unit for extracting information concerning a regional cerebral vascular state of the subject on the basis of an output of the analysis unit, and a display unit for displaying a measurement result measured by the cerebral blood volume measurement unit and/or the arterial pressure/heart rate measurement unit, an analysis result analyzed by the analysis unit, or an extraction result extracted by the extraction unit.

摘要翻译： 一种生物体测量系统，包括用于测量对象的局部脑血容量的脑血容量测量单元，用于测量受试者的动脉压和/或心率的动脉压/心率测量单元，用于 分析由脑血容量测量单元和动脉压/心率测量单元测量的信号，提取单元，用于根据分析单元的输出提取关于对象的区域性脑血管状态的信息;以及显示单元 用于显示由脑血容量测量单元和/或动脉压/心率测量单元测量的测量结果，由分析单元分析的分析结果或由提取单元提取的提取结果。