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    Selective nerve fiber stimulation
    1.
    发明申请
    Selective nerve fiber stimulation 有权
    选择性神经纤维刺激

    公开(公告)号：US20060100668A1

    公开(公告)日：2006-05-11

    申请号：US11234877

    申请日：2005-09-22

    申请人： Tamir Ben-David ,  Shai Ayal ,  Ehud Cohen ,  Nitza Gal-On Shoham ,  Avraham Biran ,  Omry Ben-Ezra ,  Ron Dabby ,  Yossi Gross

    发明人： Tamir Ben-David ,  Shai Ayal ,  Ehud Cohen ,  Nitza Gal-On Shoham ,  Avraham Biran ,  Omry Ben-Ezra ,  Ron Dabby ,  Yossi Gross

    IPC分类号： A61N1/36 ,  A61N1/18

    CPC分类号： A61N1/36071 ,  A61N1/36114

    摘要： Apparatus is provided for treating a condition of a subject, including an electrode device, adapted to be coupled to an autonomic nerve of the subject, and a control unit. The control unit is adapted to drive the electrode device to apply to the nerve a stimulating current, which is capable of inducing action potentials in a therapeutic direction in a first set and a second set of nerve fibers of the nerve, and to drive the electrode device to apply to the nerve an inhibiting current, which is capable of inhibiting the induced action potentials traveling in the therapeutic direction in the second set of nerve fibers, the nerve fibers in the second set having generally larger diameters than the nerve fibers in the first set. Other embodiments are also described.

    摘要翻译： 提供了用于治疗受试者的状况的装置，包括适于与被检体的自主神经联接的电极装置，以及控制单元。 所述控制单元适于驱动所述电极装置向所述神经施加刺激电流，所述刺激电流能够诱导所述神经的第一组和第二组神经纤维中的治疗方向的动作电位，并驱动所述电极 能够抑制在第二组神经纤维中沿治疗方向行进的诱导作用电位的神经抑制电流的装置，第二组神经纤维中的神经纤维的直径通常大于第一组神经纤维中的神经纤维的直径 组。 还描述了其它实施例。

    Nerve stimulation techniques
    2.
    发明授权
    Nerve stimulation techniques 有权
    神经刺激技术

    公开(公告)号：US08571653B2

    公开(公告)日：2013-10-29

    申请号：US13022279

    申请日：2011-02-07

    申请人： Tamir Ben-David ,  Ehud Cohen ,  Yossi Gross ,  Shai Ayal

    发明人： Tamir Ben-David ,  Ehud Cohen ,  Yossi Gross ,  Shai Ayal

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36071 ,  A61N1/36075 ,  A61N1/36114

    摘要： A method is provided for treating heart failure in a subject in need of such treatment, including applying a stimulating current to parasympathetic nervous tissue of the subject, selected from the group consisting of: a vagus nerve and an epicardial fat pad. The stimulating current is configured to inhibit release of at least one proinflammatory cytokine sufficiently to the treat heart failure of the subject. A level of the at least one proinflammatory cytokine is measured. Optionally, the stimulating current is configured to change a level of Connexin 43 of the subject, and the level of Connexin 43 is also measured. Other embodiments are also described.

    摘要翻译： 提供了一种用于治疗需要这种治疗的受试者的心力衰竭的方法，包括向受试者的副交感神经组织施加刺激电流，所述副交感神经组织选自：迷走神经和心外膜脂肪垫。 刺激电流被配置为抑制至少一种促炎细胞因子释放足以治疗受试者的心力衰竭。 测量至少一种促炎细胞因子的水平。 可选地，刺激电流被配置为改变受试者的连接蛋白43的水平，并且还测量连接蛋白43的水平。 还描述了其它实施例。

    Electrode devices for nerve stimulation and cardiac sensing
    4.
    发明授权
    Electrode devices for nerve stimulation and cardiac sensing 有权
    用于神经刺激和心脏感知的电极装置

    公开(公告)号：US08615294B2

    公开(公告)日：2013-12-24

    申请号：US12228630

    申请日：2008-08-13

    申请人： Tamir Ben-David ,  Shai Ayal ,  Ehud Cohen ,  Yossi Gross ,  Nir Schain

    发明人： Tamir Ben-David ,  Shai Ayal ,  Ehud Cohen ,  Yossi Gross ,  Nir Schain

    IPC分类号： A61N1/00

    CPC分类号： A61N1/0556 ,  A61B5/04001 ,  A61B5/4041 ,  A61B5/6846 ,  A61N1/36114

    摘要： Apparatus is provided for application to a nerve of a subject, the apparatus comprising an electrode device, which comprises a housing, which is configured to be placed at least partially around the nerve, so as to define an outer surface of the electrode device and an inner surface that faces the nerve. The electrode device further comprises one or more first electrode contact surfaces, fixed to the inner surface of the housing, and one or more second electrode contact surfaces, fixed to the outer surface of the housing. Other embodiments are also described.

    摘要翻译： 提供了用于对受试者的神经施用的装置，该装置包括电极装置，该电极装置包括壳体，该壳体构造成至少部分地围绕神经放置，以限定电极装置的外表面，以及 面向神经的内表面。 电极装置还包括固定到壳体的内表面的一个或多个第一电极接触表面和固定到外壳的外表面的一个或多个第二电极接触表面。 还描述了其它实施例。

    Electrode devices for nerve stimulation and cardiac sensing
    5.
    发明申请
    Electrode devices for nerve stimulation and cardiac sensing 有权
    用于神经刺激和心脏感知的电极装置

    公开(公告)号：US20100042186A1

    公开(公告)日：2010-02-18

    申请号：US12228630

    申请日：2008-08-13

    申请人： Tamir Ben-David ,  Shai Ayal ,  Ehud Cohen ,  Yossi Gross ,  Nir Schain

    发明人： Tamir Ben-David ,  Shai Ayal ,  Ehud Cohen ,  Yossi Gross ,  Nir Schain

    IPC分类号： A61N1/36 ,  A61N1/05

    CPC分类号： A61N1/0556 ,  A61B5/04001 ,  A61B5/4041 ,  A61B5/6846 ,  A61N1/36114

    摘要： Apparatus is provided for application to a nerve of a subject, the apparatus comprising an electrode device, which comprises a housing, which is configured to be placed at least partially around the nerve, so as to define an outer surface of the electrode device and an inner surface that faces the nerve. The electrode device further comprises one or more first electrode contact surfaces, fixed to the inner surface of the housing, and one or more second electrode contact surfaces, fixed to the outer surface of the housing. Other embodiments are also described.

    摘要翻译： 提供了用于对受试者的神经施用的装置，该装置包括电极装置，该电极装置包括壳体，该壳体构造成至少部分地围绕神经放置，以限定电极装置的外表面，以及 面向神经的内表面。 电极装置还包括固定到壳体的内表面的一个或多个第一电极接触表面和固定到外壳的外表面的一个或多个第二电极接触表面。 还描述了其它实施例。

    Electrode cuffs
    6.
    发明授权
    Electrode cuffs 有权
    电极袖口

    公开(公告)号：US08718791B2

    公开(公告)日：2014-05-06

    申请号：US12947608

    申请日：2010-11-16

    申请人： Tamir Ben-David ,  Shai Ayal ,  Ehud Cohen

    发明人： Tamir Ben-David ,  Shai Ayal ,  Ehud Cohen

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0556 ,  A61N1/36114

    摘要： Apparatus is provided for application to a nerve of a subject, including an electrode cuff, which includes a housing, which is configured to be placed at least partially around the nerve so as to define an inner surface of the housing that faces the nerve. A plurality of insulating elements are coupled to the inner surface of the housing at respective insulating element longitudinal positions along the housing, such that the inner surface of the housing and pairs of the insulating elements define one or more respective cavities at respective cavity longitudinal positions along the housing. One or more electrodes are fixed to the housing in fewer than all of the cavities, such that at least one of the cavities is an empty cavity that does not have an electrode positioned therein. Other embodiments are also described.

    摘要翻译： 提供了用于施用于受试者神经的装置，包括电极箍，其包括壳体，其被构造成至少部分地围绕神经放置，以限定外壳面向神经的内表面。 多个绝缘元件在沿着壳体的相应绝缘元件纵向位置处联接到壳体的内表面，使得壳体的内表面和成对的绝缘元件在相应的腔纵向位置处限定一个或多个相应的腔 住房。 一个或多个电极在少于所有的空腔中固定到壳体，使得至少一个空腔是不具有位于其中的电极的空腔。 还描述了其它实施例。

    Electrode cuff with recesses
    7.
    发明授权
    Electrode cuff with recesses 有权
    带凹槽的电极袖口

    公开(公告)号：US08565896B2

    公开(公告)日：2013-10-22

    申请号：US12952058

    申请日：2010-11-22

    申请人： Tamir Ben-David ,  Ehud Cohen ,  Noam Gavish ,  Shai Ayal

    发明人： Tamir Ben-David ,  Ehud Cohen ,  Noam Gavish ,  Shai Ayal

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0556

    摘要： An electrode assembly includes one or more electrode contact surfaces, and a cuff, to which the contact surfaces are fixed, and which comprises an electrically insulating material, is configured to assume open and closed positions, and, when in the closed position, is shaped so as to define a plurality of planar cross sections perpendicular to a longitudinal axis of the cuff, distributed continuously along an entire length of the cuff along the longitudinal axis, such that the perpendicular cross sections define respective inner closed curves that together define an inner surface that defines and completely surrounds a volume that extends along the entire length of the cuff. The inner closed curves of at least two of the perpendicular cross sections would cross, and not merely intersect, one another if superimposed while preserving orientation and position of the perpendicular cross sections with respect to the cuff. Other embodiments are also described.

    摘要翻译： 一种电极组件包括一个或多个电极接触表面，以及一个接触表面被固定在其上并且包括电绝缘材料的箍带构造成呈现开和关的位置，并且当处于关闭位置时， 以便限定垂直于袖带的纵向轴线的多个平面横截面，其沿着所述袖带的整个长度沿着所述纵向轴线连续分布，使得所述垂直横截面限定相应的内部闭合曲线，所述内部闭合曲线一起限定内部表面 其限定并完全围绕沿袖带的整个长度延伸的体积。 至少两个垂直横截面的内部闭合曲线将彼此交叉而不是彼此相交，如果在保持相对于袖带的垂直横截面的取向和位置的情况下叠加。 还描述了其它实施例。

    Electrode assembly for nerve control
    9.
    发明授权
    Electrode assembly for nerve control 有权
    用于神经控制的电极组件

    公开(公告)号：US08116881B2

    公开(公告)日：2012-02-14

    申请号：US11978776

    申请日：2007-10-29

    申请人： Ehud Cohen ,  Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra

    发明人： Ehud Cohen ,  Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0551 ,  A61N1/0556 ,  A61N1/36114

    摘要： Apparatus is provided for applying current to a nerve, including a housing, configured to be placed in a vicinity of the nerve. At least one electrode is fixed to the housing such that the at least one electrode does not come in direct physical contact with the nerve when the housing is placed in the vicinity of the nerve, and such that the electrode surrounds greater than 180 degrees of a circumference of the nerve after the placement of the housing. Two end insulating elements are fixed to the housing such that the at least one electrode is between the end insulating elements, and the end insulating elements come in contact or practically in contact with the nerve when the housing is placed in the vicinity of the nerve. Other embodiments are also described.

    摘要翻译： 提供了用于将电流施加到神经的装置，包括被配置为放置在神经附近的壳体。 至少一个电极被固定到壳体，使得当壳体放置在神经附近时，至少一个电极不会与神经直接物理接触，并且使得电极围绕大于180度的 放置外壳后神经的周长。 两个端部绝缘元件固定到壳体上，使得至少一个电极位于端部绝缘元件之间，并且当壳体放置在神经附近时，端部绝缘元件接触或实际上与神经接触。 还描述了其它实施例。

    Parasympathetic stimulation for treating ventricular arrhythmia
    10.
    发明授权
    Parasympathetic stimulation for treating ventricular arrhythmia 有权
    副交感神经刺激治疗室性心律失常

    公开(公告)号：US07904151B2

    公开(公告)日：2011-03-08

    申请号：US11975407

    申请日：2007-10-19

    申请人： Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra ,  Ehud Cohen

    发明人： Tamir Ben-David ,  Shai Ayal ,  Omry Ben-Ezra ,  Ehud Cohen

    IPC分类号： A61N1/39

    CPC分类号： A61N1/36114 ,  A61N1/3621

    摘要： Apparatus is provided including an implantable sensor, adapted to sense an electrical parameter of a heart of a subject, and a first control unit, adapted to apply pulses to the heart responsively to the sensed parameter, the pulses selected from the list consisting of: pacing pulses and anti-arrhythmic energy. The apparatus further includes an electrode device, adapted to be coupled to a site of the subject selected from the list consisting of: a vagus nerve of the subject, an epicardial fat pad of the subject, a pulmonary vein of the subject, a carotid artery of the subject, a carotid sinus of the subject, a coronary sinus of the subject, a vena cava vein of the subject, a right ventricle of the subject, and a jugular vein of the subject; and a second control unit, adapted to drive the electrode device to apply to the site a current that increases parasympathetic tone of the subject and affects a heart rate of the subject. The first and second control units are not under common control. At least one of the control units is adapted to coordinate an aspect of its operation with an aspect of operation of the other control unit. Other embodiments are also described.

    摘要翻译： 提供了包括适于感测对象的心脏的电参数的可植入传感器和适于响应于所感测的参数向心脏施加脉冲的第一控制单元，从列表中选择的脉冲包括：起搏 脉冲和抗心律变能。 所述装置还包括电极装置，适于耦合到选自以下列表的对象的部位：包括受试者的迷走神经，受试者的心外膜脂肪垫，受试者的肺静脉，颈动脉 受试者的颈动脉窦，受试者的冠状窦，受试者的腔静脉，受试者的右心室和受试者的颈静脉; 以及第二控制单元，其适于驱动所述电极装置向所述部位施加增加所述受试者的副交感神经紧张并影响所述受试者的心率的电流。 第一和第二控制单元不在一般控制之下。 控制单元中的至少一个适于将其操作的一个方面与其他控制单元的操作的一个方面协调。 还描述了其它实施例。