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    PROSTHETIC HEART VALVE
    1.
    发明申请
    PROSTHETIC HEART VALVE 有权
    前置心脏瓣膜

    公开(公告)号：US20120123529A1

    公开(公告)日：2012-05-17

    申请号：US13253689

    申请日：2011-10-05

    申请人： Tamir Levi ,  Son V. Nguyen ,  Netanel Benichou ,  David Maimon ,  Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Larisa Dadonkina

    发明人： Tamir Levi ,  Son V. Nguyen ,  Netanel Benichou ,  David Maimon ,  Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Larisa Dadonkina

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2433 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0036 ,  A61F2250/0097

    摘要： Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.

    摘要翻译： 公开了径向可折叠和可扩张的假体心脏瓣膜的实施例。 当安装在输送轴上时，阀架可以具有锥形轮廓，流入端部的直径小于流出端部分的直径。 阀可以包括大致V形的小叶，在框架的流入端内还原材料。 外裙可以固定到框架的流入端部分的外部，当阀门膨胀时，外裙部具有纵向松弛，并且当阀门折叠时，外裙部平放在框架上。 对角编织的内裙可以与框架轴向伸长。 相邻小叶的侧翼可以延伸穿过并固定到框架的窗框部分以形成连合。 当阀被压接到输送轴上时，窗框部分可以相对于周围的框架部分径向向内按压。

    Prosthetic heart valve
    2.
    发明授权
    Prosthetic heart valve 有权
    假心脏瓣膜

    公开(公告)号：US09393110B2

    公开(公告)日：2016-07-19

    申请号：US13253689

    申请日：2011-10-05

    申请人： Tamir S. Levi ,  Son V. Nguyen ,  Netanel Benichou ,  David Maimon ,  Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Larisa Dadonkina ,  Ron Sharoni ,  Elena Sherman

    发明人： Tamir S. Levi ,  Son V. Nguyen ,  Netanel Benichou ,  David Maimon ,  Ziv Yohanan ,  Nikolay Gurovich ,  Bella Felsen ,  Larisa Dadonkina ,  Ron Sharoni ,  Elena Sherman

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2433 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0036 ,  A61F2250/0097

    摘要： Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.

    摘要翻译： 公开了径向可折叠和可扩张的假体心脏瓣膜的实施例。 当安装在输送轴上时，阀架可以具有锥形轮廓，流入端部的直径小于流出端部分的直径。 阀可以包括大致V形的小叶，在框架的流入端内还原材料。 外裙可以固定到框架的流入端部分的外部，当阀门膨胀时，外裙部具有纵向松弛，并且当阀门折叠时，外裙部平放在框架上。 对角编织的内裙可以与框架轴向伸长。 相邻小叶的侧翼可以延伸穿过并固定到框架的窗框部分以形成连合。 当阀被压接到输送轴上时，窗框部分可以相对于周围的框架部分径向向内按压。

    PERIVALVULAR SEALING FOR TRANSCATHETER HEART VALVE
    7.
    发明申请
    PERIVALVULAR SEALING FOR TRANSCATHETER HEART VALVE 有权
    用于过渡式心脏瓣膜的密封

    公开(公告)号：US20130018458A1

    公开(公告)日：2013-01-17

    申请号：US13549068

    申请日：2012-07-13

    申请人： Ziv Yohanan ,  Nik Gurovich ,  Bella Felsen ,  Itai Pelled ,  Oded Meiri

    发明人： Ziv Yohanan ,  Nik Gurovich ,  Bella Felsen ,  Itai Pelled ,  Oded Meiri

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2436 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0065 ,  A61F2250/0069

    摘要： The present disclosure is directed to embodiments of catheter-based prosthetic heart valves, and in particular, prosthetic heart valves having sealing devices configured to seal the interface between the prosthetic valve and the surrounding tissue of the native annulus in which the prosthetic valve is implanted. In one embodiment, a prosthetic heart valve includes an annular sealing member that can be placed in a delivery orientation extending axially away from one end of the valve when the valve is in a radially compressed state. When the valve is expanded, the expansion of the frame causes the sealing member to be pulled to an operative orientation covering a portion of the frame. The present disclosure also discloses new mechanisms and techniques for mounting valve leaflets to a frame of a prosthetic heart valve.

    摘要翻译： 本公开涉及基于导管的假体心脏瓣膜的具体实施方式，特别地，具有密封装置的假体心脏瓣膜被配置为密封假体瓣膜和植入人造瓣膜的天然环带的周围组织之间的界面。 在一个实施例中，假体心脏瓣膜包括环形密封构件，当阀处于径向压缩状态时，环形密封构件能够沿轴向远离阀的一端延伸的排放方向放置。 当阀膨胀时，框架的膨胀使得密封构件被拉到覆盖框架的一部分的操作取向。 本公开还公开了将瓣膜瓣安装到假体心脏瓣膜的框架的新机构和技术。

    Perivalvular sealing for transcatheter heart valve
    8.
    发明授权
    Perivalvular sealing for transcatheter heart valve 有权
    经导管心脏瓣膜的瓣周密封

    公开(公告)号：US08795357B2

    公开(公告)日：2014-08-05

    申请号：US13549068

    申请日：2012-07-13

    申请人： Ziv Yohanan ,  Nik Gurovich ,  Bella Felsen ,  Itai Pelled ,  Oded Meiri

    发明人： Ziv Yohanan ,  Nik Gurovich ,  Bella Felsen ,  Itai Pelled ,  Oded Meiri

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2436 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0065 ,  A61F2250/0069

    摘要： The present disclosure is directed to embodiments of catheter-based prosthetic heart valves, and in particular, prosthetic heart valves having sealing devices configured to seal the interface between the prosthetic valve and the surrounding tissue of the native annulus in which the prosthetic valve is implanted. In one embodiment, a prosthetic heart valve includes an annular sealing member that can be placed in a delivery orientation extending axially away from one end of the valve when the valve is in a radially compressed state. When the valve is expanded, the expansion of the frame causes the sealing member to be pulled to an operative orientation covering a portion of the frame. The present disclosure also discloses new mechanisms and techniques for mounting valve leaflets to a frame of a prosthetic heart valve.

    摘要翻译： 本公开涉及基于导管的假体心脏瓣膜的具体实施方式，特别地，具有密封装置的假体心脏瓣膜被配置为密封假体瓣膜和植入人造瓣膜的天然环带的周围组织之间的界面。 在一个实施例中，假体心脏瓣膜包括环形密封构件，当阀处于径向压缩状态时，环形密封构件能够沿轴向远离阀的一端延伸的排放方向放置。 当阀膨胀时，框架的膨胀使得密封构件被拉到覆盖框架的一部分的操作取向。 本公开还公开了将瓣膜瓣安装到假体心脏瓣膜的框架的新机构和技术。

    Blood glucose level control
    9.
    发明授权
    Blood glucose level control 有权
    血糖值控制

    公开(公告)号：US08346363B2

    公开(公告)日：2013-01-01

    申请号：US11318845

    申请日：2005-12-27

    申请人： Nissim Darvish ,  Tami Harel ,  Bella Felsen

    发明人： Nissim Darvish ,  Tami Harel ,  Bella Felsen

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36007

    摘要： A pancreatic controller, comprising: a glucose sensor, for sensing a level of glucose or insulin in a body serum; at least one electrode, for electrifying an insulin producing cell or group of cells; a power source for electrifying said electrode with a pulse that does not initiate an action potential in said cell and has an effect of increasing insulin secretion; and a controller which receives the sensed level and controls said power source to electrify said electrode to have a desired effect on said level.

    摘要翻译： 一种胰脏控制器，包括：葡萄糖传感器，用于感测体内血清中的葡萄糖或胰岛素水平; 至少一个电极，用于给胰岛素产生细胞或一组细胞带电; 用于以不在所述细胞中引发动作电位的脉冲对所述电极充电并具有增加胰岛素分泌的作用的电源; 以及控制器，其接收所感测的电平并控制所述电源以使所述电极带电以对所述电平具有期望的效果。

    ELECTRICAL MUSCLE CONTROLLER AND PACING WITH HEMODYNAMIC ENHANCEMENT
    10.
    发明申请
    ELECTRICAL MUSCLE CONTROLLER AND PACING WITH HEMODYNAMIC ENHANCEMENT 有权
    电动肌肉控制器和血液动力学增强

    公开(公告)号：US20080140142A1

    公开(公告)日：2008-06-12

    申请号：US11933168

    申请日：2007-10-31

    申请人： Nissim Darvish ,  Bella Felsen ,  Itzik Shemer ,  Judith Kornfield ,  Shlomo Ben-Haim ,  Maier Fenster ,  Yuval Mika

    发明人： Nissim Darvish ,  Bella Felsen ,  Itzik Shemer ,  Judith Kornfield ,  Shlomo Ben-Haim ,  Maier Fenster ,  Yuval Mika

    IPC分类号： A61N1/08

    CPC分类号： A61N1/3627 ,  A61N1/05 ,  A61N1/0587 ,  A61N1/36514 ,  A61N1/36564

    摘要： A method of modifying the force of contraction of at least a portion of a heart chamber is provided. A non-excitatory electric field of given duration is applied, at a delay after an activation of the heart, which increase the force of contraction by at least 5%. Apparatus is also provided for pacing with hemodynamic improvement. Circuitry applies an extended pacing signal to electrodes to pace the heart, the extended pacing signal having an overall duration greater than 8 ms from a time of initiation of application of that portion of the signal that initiates action potential propagation. The signal includes a train of biphasic pulses having pulse durations of at least 1 ms, and the signal has an amplitude that is at least three times as great as a threshold for pacing the heart and that is sufficient neither for cardioversion nor for defibrillation. Other embodiments are also described.

    摘要翻译： 提供了改变心室的至少一部分的收缩力的方法。 给予持续时间的非兴奋性电场在心脏激活后延迟施加，其将收缩力增加至少5％。 还提供了用于具有血液动力学改善的起搏的装置。 电路将扩展的起搏信号施加到电极以对心脏进行调节，所述扩展起搏信号的总持续时间大于从启动动作电位传播的信号部分开始施加的时间大于8ms。 该信号包括具有至少1ms的脉冲持续时间的两列脉冲，并且该信号具有至少三倍于起搏心脏阈值的幅度，并且既不适用于心脏复律也不适用于除颤。 还描述了其它实施例。