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公开(公告)号：US20120029654A1
公开(公告)日：2012-02-02
申请号：US13255356
申请日：2010-02-08
CPC分类号： A61F2/02 , A61L27/14 , A61L27/18 , A61L27/26 , A61L27/50 , A61L27/52 , A61L27/54 , A61L27/58 , B32B5/26 , B32B2250/20 , B32B2307/7163 , B32B2307/728 , B32B2307/73 , B32B2535/00 , D01D5/003 , D04H1/435 , D04H1/72 , D04H1/728 , D04H3/005 , D04H3/009 , D04H3/011 , D04H3/02 , D04H3/073
摘要： Disclosed are an artificial dura mater and manufacturing method thereof. The artificial dura mater includes electrospun layers prepared by electrostatic spinning, at least one of which is a hydrophobic electrospun layer. Further, above the hydrophobic electrospun layer, there can be at least one hydrophilic electrospun layer. A transition layer can be further included between the hydrophobic and the hydrophilic electrospun layers. Additionally, cytokines and/or medicines can be affixed to either or both of the hydrophobic and the hydrophilic electrospun layers, by way of bio-printing. The disclosed artificial dura mater shows good biocompatibility, enhances dural tissue regeneration, achieves excellent repairing effects, prevents adhesion, allows complete absorption, has good mechanical properties, ensures low infection rates, and can be loaded with therapeutic agents.
摘要翻译： 公开了人造硬膜及其制造方法。 人造硬膜包括通过静电纺丝制备的电纺丝层，其中至少一个是疏水性电纺丝层。 此外，在疏水性电纺丝层之上，可以存在至少一个亲水性电纺丝层。 在疏水性和亲水性电纺层之间可以进一步包含过渡层。 此外，细胞因子和/或药物可以通过生物印刷固定在疏水和亲水的电纺丝层之一或两者上。 所公开的人造硬膜显示出良好的生物相容性，增强硬组织再生，实现优异的修复效果，防止粘连，允许完全吸收，具有良好的机械性能，确保低感染率，并可装载治疗剂。
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公开(公告)号：US08795708B2
公开(公告)日：2014-08-05
申请号：US13255356
申请日：2010-02-08
IPC分类号： A61F2/00
CPC分类号： A61F2/02 , A61L27/14 , A61L27/18 , A61L27/26 , A61L27/50 , A61L27/52 , A61L27/54 , A61L27/58 , B32B5/26 , B32B2250/20 , B32B2307/7163 , B32B2307/728 , B32B2307/73 , B32B2535/00 , D01D5/003 , D04H1/435 , D04H1/72 , D04H1/728 , D04H3/005 , D04H3/009 , D04H3/011 , D04H3/02 , D04H3/073
摘要： Disclosed are an artificial dura mater and manufacturing method thereof. The artificial dura mater includes electrospun layers prepared by electrostatic spinning, at least one of which is a hydrophobic electrospun layer. Further, above the hydrophobic electrospun layer, there can be at least one hydrophilic electrospun layer. A transition layer can be further included between the hydrophobic and the hydrophilic electrospun layers. Additionally, cytokines and/or medicines can be affixed to either or both of the hydrophobic and the hydrophilic electrospun layers, by way of bio-printing. The disclosed artificial dura mater shows good biocompatibility, enhances dural tissue regeneration, achieves excellent repairing effects, prevents adhesion, allows complete absorption, has good mechanical properties, ensures low infection rates, and can be loaded with therapeutic agents.
摘要翻译： 公开了人造硬膜及其制造方法。 人造硬膜包括通过静电纺丝制备的电纺丝层，其中至少一个是疏水性电纺丝层。 此外，在疏水性电纺丝层之上，可以存在至少一个亲水性电纺丝层。 在疏水性和亲水性电纺层之间可以进一步包含过渡层。 此外，细胞因子和/或药物可以通过生物印刷固定在疏水和亲水的电纺丝层之一或两者上。 所公开的人造硬膜显示出良好的生物相容性，增强硬组织再生，实现优异的修复效果，防止粘连，允许完全吸收，具有良好的机械性能，确保低感染率，并可装载治疗剂。
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