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1.发明申请公开(公告)号：US20110008357A1
公开(公告)日：2011-01-13
申请号：US12786095
申请日：2010-05-24
申请人： Tariq Ghayer , Richard W. Dixon , Michael Roguska , Michael White , Boris Labkovsky , Jochen Salfeld , Alexander Robert Duncan , Simon Mark Brocklehurst , John Mankovich , Celia Patricia Shorrock , Julia Elizabeth Thompson , Simon Nicholas Lennard
发明人： Tariq Ghayer , Richard W. Dixon , Michael Roguska , Michael White , Boris Labkovsky , Jochen Salfeld , Alexander Robert Duncan , Simon Mark Brocklehurst , John Mankovich , Celia Patricia Shorrock , Julia Elizabeth Thompson , Simon Nicholas Lennard
IPC分类号： A61K39/395 , C12P21/00 , C12N5/07 , C12N15/63 , C40B30/04 , C07K2/00 , C07K14/00 , C07K16/24 , C07H21/00 , A61P1/16 , A61P19/02 , A61P29/00 , A61P3/10 , A61P37/06 , A61P25/28 , A61P25/16 , A61P9/10 , A61P37/08 , A61P17/06 , A61P13/12 , A61P11/00 , A61P9/00 , A61P15/08 , A61P25/24 , A61P11/06 , A61P5/16 , A61P5/18 , A61P5/50
CPC分类号： C07K16/244 , A61K31/519 , A61K31/56 , A61K38/13 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , A61K39/395 , A61K31/00
摘要： Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.
摘要翻译： 提供了结合人白细胞介素-18（hIL-18）的抗体，特别是结合人IL-18表位的抗体。 抗体可以是例如完全是人抗体，重组抗体或单克隆抗体。 优选的抗体对hIL-18具有高亲和力，并在体外和体内中和hIL-18活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-18和抑制hIL-18活性，例如在患有hIL-18活性有害的病症的人类受试者中。
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2.发明申请公开(公告)号：US20130101595A1
公开(公告)日：2013-04-25
申请号：US13603968
申请日：2012-09-05
申请人： Tariq Ghayer , Richard W. Dixon , Michael Roguska , Michael White , Boris Labkovsky , Jochen Salfeld , Alexander Robert Duncan , Simon Mark Brocklehurst , John Mankovich , Celia Patricia Shorrock , Julia Elizabeth Thompson , Simon Nicholas Lennard
发明人： Tariq Ghayer , Richard W. Dixon , Michael Roguska , Michael White , Boris Labkovsky , Jochen Salfeld , Alexander Robert Duncan , Simon Mark Brocklehurst , John Mankovich , Celia Patricia Shorrock , Julia Elizabeth Thompson , Simon Nicholas Lennard
IPC分类号： C07K16/24 , A61K31/519 , A61K31/56 , A61K39/395 , A61K38/13
CPC分类号： C07K16/244 , A61K31/519 , A61K31/56 , A61K38/13 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , A61K39/395 , A61K31/00
摘要： Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.
摘要翻译： 提供了结合人白细胞介素-18（hIL-18）的抗体，特别是结合人IL-18表位的抗体。 抗体可以是例如完全是人抗体，重组抗体或单克隆抗体。 优选的抗体对hIL-18具有高亲和力，并在体外和体内中和hIL-18活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-18和抑制hIL-18活性，例如在患有hIL-18活性有害的病症的人类受试者中。
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3.发明授权公开(公告)号：US07767207B2
公开(公告)日：2010-08-03
申请号：US09780035
申请日：2001-02-09
申请人： Tariq Ghayer , Richard W. Dixon , Michael Roguska , Michael White , Boris Labkovsky , Jochen Salfeld , Alexander Robert Duncan , Simon Mark Brocklehurst , John Mankovich , Celia Patricia Shorrock , Julia Elizabeth Thompson , Simon Nicholas Lennard
发明人： Tariq Ghayer , Richard W. Dixon , Michael Roguska , Michael White , Boris Labkovsky , Jochen Salfeld , Alexander Robert Duncan , Simon Mark Brocklehurst , John Mankovich , Celia Patricia Shorrock , Julia Elizabeth Thompson , Simon Nicholas Lennard
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/244 , A61K31/519 , A61K31/56 , A61K38/13 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , A61K39/395 , A61K31/00
摘要： Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.
摘要翻译： 提供了结合人白细胞介素-18（hIL-18）的抗体，特别是结合人IL-18表位的抗体。 抗体可以是例如完全是人抗体，重组抗体或单克隆抗体。 优选的抗体对hIL-18具有高亲和力，并在体外和体内中和hIL-18活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-18和抑制hIL-18活性，例如在患有hIL-18活性有害的病症的人类受试者中。
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4.发明申请公开(公告)号：US20100104563A1
公开(公告)日：2010-04-29
申请号：US09780035
申请日：2001-02-09
申请人： Tariq Ghayer , Richard W. Dixon , Michael Roguska , Michael White , Boris Labkovsky , Jochen Salfeld , Alexander Robert Duncan , Simon Mark Brocklehurst , John Mankovich , Celia Patricia Shorrock , Julia Elizabeth Thompson , Simon Nicholas Lennard
发明人： Tariq Ghayer , Richard W. Dixon , Michael Roguska , Michael White , Boris Labkovsky , Jochen Salfeld , Alexander Robert Duncan , Simon Mark Brocklehurst , John Mankovich , Celia Patricia Shorrock , Julia Elizabeth Thompson , Simon Nicholas Lennard
CPC分类号： C07K16/244 , A61K31/519 , A61K31/56 , A61K38/13 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , A61K39/395 , A61K31/00
摘要： Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.
摘要翻译： 提供了结合人白细胞介素-18（hIL-18）的抗体，特别是结合人IL-18表位的抗体。 抗体可以是例如完全是人抗体，重组抗体或单克隆抗体。 优选的抗体对hIL-18具有高亲和力，并在体外和体内中和hIL-18活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-18和抑制hIL-18活性，例如在患有hIL-18活性有害的病症的人类受试者中。
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公开(公告)号：US20120244168A1
公开(公告)日：2012-09-27
申请号：US13401559
申请日：2012-02-21
申请人： Jochen Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida M. Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas W. Warne , Angela Myles , John Gawain Elvin , Alexander Robert Duncan , Elaine Joy Derbyshire , Sara Carmen , Stephen Smith , Thor Las Holtet , Sarah Leila Du Fou
发明人： Jochen Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida M. Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas W. Warne , Angela Myles , John Gawain Elvin , Alexander Robert Duncan , Elaine Joy Derbyshire , Sara Carmen , Stephen Smith , Thor Las Holtet , Sarah Leila Du Fou
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/244 , A61K9/0019 , A61K38/208 , A61K39/00 , A61K39/3955 , A61K39/39591 , A61K45/06 , A61K47/20 , A61K47/22 , A61K47/26 , A61K2039/505 , C07K14/5434 , C07K16/00 , C07K16/18 , C07K2317/21 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/94 , Y10S514/863 , Y10S514/885 , Y10S514/886
摘要： Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.
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公开(公告)号：US20080305114A1
公开(公告)日：2008-12-11
申请号：US12121615
申请日：2008-05-15
申请人： Jochen Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida M. Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas W. Warner , Angela Myles , John Gawain Elvin , Alexander Robert Duncan , Elaine Joy Derbyshire , Sara Carmen , Stephen Smith , Thor Las Holtet , Sarah Leila Du Fou
发明人： Jochen Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida M. Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas W. Warner , Angela Myles , John Gawain Elvin , Alexander Robert Duncan , Elaine Joy Derbyshire , Sara Carmen , Stephen Smith , Thor Las Holtet , Sarah Leila Du Fou
IPC分类号： A61K39/395 , A61P37/00
CPC分类号： C07K16/244 , A61K9/0019 , A61K38/208 , A61K39/00 , A61K39/3955 , A61K39/39591 , A61K45/06 , A61K47/20 , A61K47/22 , A61K47/26 , A61K2039/505 , C07K14/5434 , C07K16/00 , C07K16/18 , C07K2317/21 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/94 , Y10S514/863 , Y10S514/885 , Y10S514/886
摘要： Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.
摘要翻译： 公开了特异性结合人白细胞介素-12（hIL-12）的人抗体，优选重组人抗体。 优选的抗体对hIL-12具有高亲和力，并在体外和体内中和hIL-12活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 本发明的抗体或抗体部分可用于检测hIL-12和抑制hIL-12活性，例如在患有hIL-12活性有害的病症的人类受试者中。 用于表达本发明的重组人抗体的核酸，载体和宿主细胞以及合成重组人抗体的方法也包括在本发明中。
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7.发明授权Human antibodies that bind the P40 subunit of human IL-12 and methods for using the same 有权结合人IL-12的P40亚基的人抗体及其使用方法公开(公告)号：US09035030B2
公开(公告)日：2015-05-19
申请号：US13401559
申请日：2012-02-21
申请人： Jochen Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida M. Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas W. Warne , Angela Myles , John Gawain Elvin , Alexander Robert Duncan , Elaine Joy Derbyshire , Sara Carmen , Stephen Smith , Thor Las Holtet , Sarah Leila Du Fou
发明人： Jochen Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida M. Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas W. Warne , Angela Myles , John Gawain Elvin , Alexander Robert Duncan , Elaine Joy Derbyshire , Sara Carmen , Stephen Smith , Thor Las Holtet , Sarah Leila Du Fou
IPC分类号： C07K16/24 , C12P21/08 , A61K39/395 , A61K39/00 , C07K16/18 , C07K16/00 , C07K14/54 , A61K38/20
CPC分类号： C07K16/244 , A61K9/0019 , A61K38/208 , A61K39/00 , A61K39/3955 , A61K39/39591 , A61K45/06 , A61K47/20 , A61K47/22 , A61K47/26 , A61K2039/505 , C07K14/5434 , C07K16/00 , C07K16/18 , C07K2317/21 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/94 , Y10S514/863 , Y10S514/885 , Y10S514/886
摘要： Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.
摘要翻译： 公开了特异性结合人白细胞介素-12（hIL-12）的人抗体，优选重组人抗体。 优选的抗体对hIL-12具有高亲和力，并在体外和体内中和hIL-12活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 本发明的抗体或抗体部分可用于检测hIL-12和抑制hIL-12活性，例如在患有hIL-12活性有害的病症的人类受试者中。 用于表达本发明的重组人抗体的核酸，载体和宿主细胞以及合成重组人抗体的方法也包括在本发明中。
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公开(公告)号：US20120308514A1
公开(公告)日：2012-12-06
申请号：US13429104
申请日：2012-03-23
申请人： Jochen Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida M. Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas W. Warne , Angela Myles , John Gawain Elvin , Alexander Robert Duncan , Elaine Joy Derbyshire , Sara Carmen , Stephen Smith , Thor Las Holtet , Sarah Leila Du Fou
发明人： Jochen Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida M. Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas W. Warne , Angela Myles , John Gawain Elvin , Alexander Robert Duncan , Elaine Joy Derbyshire , Sara Carmen , Stephen Smith , Thor Las Holtet , Sarah Leila Du Fou
IPC分类号： A61K39/395 , A61K38/19 , A61P19/02 , A61P1/00 , A61P1/04 , A61P9/10 , A61P11/06 , A61P13/12 , A61P1/16 , A61P25/28 , A61P25/16 , A61K38/20 , A61P3/10
CPC分类号： C07K16/244 , A61K9/0019 , A61K38/208 , A61K39/00 , A61K39/3955 , A61K39/39591 , A61K45/06 , A61K47/20 , A61K47/22 , A61K47/26 , A61K2039/505 , C07K14/5434 , C07K16/00 , C07K16/18 , C07K2317/21 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/94 , Y10S514/863 , Y10S514/885 , Y10S514/886
摘要： Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.
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公开(公告)号：US06914128B1
公开(公告)日：2005-07-05
申请号：US09534717
申请日：2000-03-24
申请人： Jochen Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida M. Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas W. Warne , Angela Myles , John Gawain Elvin , Alexander Robert Duncan , Elaine Joy Derbyshire , Sara Carmen , Thor Las Holtet , Sarah Leila Du Fou , Stephen Smith
发明人： Jochen Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida M. Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas W. Warne , Angela Myles , John Gawain Elvin , Alexander Robert Duncan , Elaine Joy Derbyshire , Sara Carmen , Thor Las Holtet , Sarah Leila Du Fou , Stephen Smith
CPC分类号： C07K16/244 , A61K9/0019 , A61K38/208 , A61K39/00 , A61K39/3955 , A61K39/39591 , A61K45/06 , A61K47/20 , A61K47/22 , A61K47/26 , A61K2039/505 , C07K14/5434 , C07K16/00 , C07K16/18 , C07K2317/21 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/94 , Y10S514/863 , Y10S514/885 , Y10S514/886
摘要： Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.
摘要翻译： 公开了特异性结合人白细胞介素-12（hIL-12）的人抗体，优选重组人抗体。 优选的抗体对hIL-12具有高亲和力，并在体外和体内中和hIL-12活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 本发明的抗体或抗体部分可用于检测hIL-12和抑制hIL-12活性，例如在患有hIL-12活性有害的病症的人类受试者中。 用于表达本发明的重组人抗体的核酸，载体和宿主细胞以及合成重组人抗体的方法也包括在本发明中。
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公开(公告)号：US20120213792A1
公开(公告)日：2012-08-23
申请号：US13418049
申请日：2012-03-12
申请人： Jochen Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida M. Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas W. Warne , Angela Myles , John Gawain Elvin , Alexander Robert Duncan , Elaine Joy Derbyshire , Sara Carmen , Stephen Smith , Thor Las Holtet , Sarah Leila Du Fou
发明人： Jochen Salfeld , Michael Roguska , Michael Paskind , Subhashis Banerjee , Daniel Tracey , Michael White , Zehra Kaymakcalan , Boris Labkovsky , Paul Sakorafas , Geertruida M. Veldman , Amy Venturini , Angela Widom , Stuart Friedrich , Nicholas W. Warne , Angela Myles , John Gawain Elvin , Alexander Robert Duncan , Elaine Joy Derbyshire , Sara Carmen , Stephen Smith , Thor Las Holtet , Sarah Leila Du Fou
IPC分类号： A61K39/395 , A61P1/04 , A61P19/02 , A61P37/00 , A61P17/06
CPC分类号： C07K16/244 , A61K9/0019 , A61K38/208 , A61K39/00 , A61K39/3955 , A61K39/39591 , A61K45/06 , A61K47/20 , A61K47/22 , A61K47/26 , A61K2039/505 , C07K14/5434 , C07K16/00 , C07K16/18 , C07K2317/21 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/94 , Y10S514/863 , Y10S514/885 , Y10S514/886
摘要： Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.
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