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公开(公告)号：US08673854B2
公开(公告)日：2014-03-18
申请号：US13293993
申请日：2011-11-10
申请人： Tatsuhiko Hirota , Kohji Ohki , Teppei Nakamura , Toshiaki Takano
发明人： Tatsuhiko Hirota , Kohji Ohki , Teppei Nakamura , Toshiaki Takano
CPC分类号： A61K38/06 , A23L33/18 , A23V2002/00 , A23V2200/326 , A23V2250/0654 , A23V2250/064 , A23V2200/32 , A23V2250/0626
摘要： The present invention provides an agent having a suppressive action against the thickening of the heart wall, a prophylactic agent for heart failure containing the above described agent, and functional foods expected to have a prophylactic effect for heart failure. The agent for suppressing heart wall thickening comprises Xaa Pro Pro as an active ingredient.
摘要翻译： 本发明提供对心脏壁增厚具有抑制作用的药剂，含有上述药剂的心力衰竭预防剂和预期具有预防心力衰竭作用的功能性食品。 用于抑制心脏壁增厚的药剂包括Xaa Pro Pro作为活性成分。
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公开(公告)号：US08367614B2
公开(公告)日：2013-02-05
申请号：US13161098
申请日：2011-06-15
CPC分类号： A61K38/018 , A23L33/175 , A23L33/18 , A23L33/19 , A61K31/198 , A61K35/20
摘要： There is provided a rheumatoid arthritis inhibitor for oral intake that has an inhibitory effect on rheumatoid arthritis and is excellent in safety. The rheumatoid arthritis inhibitor for oral intake of the present invention contains, as an active component, a casein hydrolysate containing free amino acids and peptides obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, or a mixture of free amino acids and peptides contained in the hydrolysate.
摘要翻译： 提供了对类风湿性关节炎具有抑制作用的口服摄入类风湿性关节炎抑制剂，安全性优异。 本发明的口服类风湿关节炎抑制剂作为活性成分含有含有游离氨基酸的酪蛋白水解物和通过水解动物乳酪蛋白得到的肽，其平均链长度不得大于2.1 氨基酸残基或游离氨基酸和包含在水解产物中的肽的混合物。
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公开(公告)号：US20090234097A1
公开(公告)日：2009-09-17
申请号：US12279218
申请日：2007-02-14
申请人： Tatsuhiko Hirota , Kohji Ohki
发明人： Tatsuhiko Hirota , Kohji Ohki
IPC分类号： C07K5/08
CPC分类号： C07K5/0808 , A23L33/18 , A23V2002/00 , A61K38/06 , A23V2200/326
摘要： There is provided a vasodilator having an endothelium-dependent vasodilator effect, a prophylactic of arteriosclerosis, and functional food having an endothelium-dependent vasodilator effect, which is suitable for daily and regular intake and excellent in safety. The vasodilator and the functional food according to the present invention are characterized in at least one of the tripeptides Val-Pro-Pro and Ile-Pro-Pro, or a proteolytic product containing Val-Pro-Pro and/or Ile-Pro-Pro, contained as an active component.
摘要翻译： 提供了具有内皮依赖性血管舒张作用，动脉硬化预防性和具有内皮依赖性血管扩张作用的功能性食品的血管扩张剂，其适合日常摄取和定期摄取，安全性优异。 根据本发明的血管扩张剂和功能性食品的特征在于至少一种三肽Val-Pro-Pro和Ile-Pro-Pro，或含有Val-Pro-Pro和/或Ile-Pro-Pro的蛋白水解产物 ，作为活性成分。
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公开(公告)号：US20120077735A1
公开(公告)日：2012-03-29
申请号：US13294028
申请日：2011-11-10
申请人： Tatsuhiko Hirota , Kohji Ohki , Teppei Nakamura , Toshiaki Takano
发明人： Tatsuhiko Hirota , Kohji Ohki , Teppei Nakamura , Toshiaki Takano
CPC分类号： A61K38/06 , A23L33/18 , A23V2002/00 , A23V2200/326 , A23V2250/0654 , A23V2250/064 , A23V2200/32 , A23V2250/0626
摘要： The present invention provides an agent having a suppressive action against kidney glomerular disease and renal arteriosclerosis, a prophylactic agent for renal failure containing the above described agent, and functional foods expected to have a prophylactic effect for renal failure. The agent for preventing kidney glomerular disease and renal arteriosclerosis comprises Xaa Pro Pro as an active ingredient.
摘要翻译： 本发明提供了对肾小球疾病和肾动脉硬化具有抑制作用的药剂，含有上述药物的肾衰竭预防剂和预期具有肾功能衰竭预防作用的功能性食品。 用于预防肾小球疾病和肾动脉硬化的药物包含Xaa Pro Pro作为活性成分。
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公开(公告)号：US20100167979A1
公开(公告)日：2010-07-01
申请号：US12278880
申请日：2007-02-09
CPC分类号： A61K38/018 , A23L33/175 , A23L33/18 , A23L33/19 , A61K31/198 , A61K35/20
摘要： There is provided a rheumatoid arthritis inhibitor for oral intake that has an inhibitory effect on rheumatoid arthritis and is excellent in safety. The rheumatoid arthritis inhibitor for oral intake of the present invention contains, as an active component, a casein hydrolysate containing free amino acids and peptides obtained by hydrolyzing animal milk casein to have an average chain length of not longer than 2.1 in terms of the number of amino acid residues, or a mixture of free amino acids and peptides contained in the hydrolysate.
摘要翻译： 提供了对类风湿性关节炎具有抑制作用的口服摄入类风湿性关节炎抑制剂，安全性优异。 本发明的口服类风湿关节炎抑制剂作为活性成分含有含有游离氨基酸的酪蛋白水解物和通过水解动物乳酪蛋白得到的肽，其平均链长度不得大于2.1 氨基酸残基或游离氨基酸和包含在水解产物中的肽的混合物。
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公开(公告)号：US20100022748A1
公开(公告)日：2010-01-28
申请号：US12567628
申请日：2009-09-25
申请人： Tatsuhiko Hirota , Kohji Ohki , Teppei Nakamura , Toshiaki Takano
发明人： Tatsuhiko Hirota , Kohji Ohki , Teppei Nakamura , Toshiaki Takano
CPC分类号： A61K38/06 , A23L33/18 , A23V2002/00 , A23V2200/326 , A23V2250/0654 , A23V2250/064 , A23V2200/32 , A23V2250/0626
摘要： The present invention provides an agent having a suppressive action against kidney glomerular disease and renal arteriosclerosis, a prophylactic agent for renal failure containing the above described agent, and functional foods expected to have a prophylactic effect for renal failure. The agent for preventing kidney glomerular disease and renal arteriosclerosis comprises Xaa Pro Pro as an active ingredient.
摘要翻译： 本发明提供了对肾小球疾病和肾动脉硬化具有抑制作用的药剂，含有上述药物的肾衰竭预防剂和预期具有肾功能衰竭预防作用的功能性食品。 用于预防肾小球疾病和肾动脉硬化的药物包含Xaa Pro Pro作为活性成分。
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7.发明申请AGENT FOR PREVENTING ARTERIOSCLEROSIS, AGENT FOR SUPPRESSING VASCULAR INTIMAL THICKENING AND AGENT FOR IMPROVING VASCULAR ENDOTHELIAL FUNCTION 审中-公开用于预防神经功能障碍的药剂，用于抑制血管内增生的药剂和用于改善血管内皮功能的药剂公开(公告)号：US20090299036A1
公开(公告)日：2009-12-03
申请号：US12279240
申请日：2007-02-14
申请人： Tatsuhiko Hirota , Teppei Nakamura , Kohji Ohki , Akihiro Masuyama , Toshiaki Takano , Toshikazu Yoshikawa , Yuji Naito , Hiroshi Ichikawa , Satomi Akagiri
发明人： Tatsuhiko Hirota , Teppei Nakamura , Kohji Ohki , Akihiro Masuyama , Toshiaki Takano , Toshikazu Yoshikawa , Yuji Naito , Hiroshi Ichikawa , Satomi Akagiri
IPC分类号： C07K5/08 , C07D207/16 , C07K14/47
CPC分类号： C07K5/0808 , A23L33/18 , A61K38/00 , C07K5/06034 , C07K5/0606 , C07K5/06078 , C07K5/06086 , C07K5/06095 , C07K5/06104 , C07K5/081 , C07K14/4732 , C12R1/225
摘要： There is provided an agent having at least one of an improving effect on vascular endothelial functions and an inhibitory effect on vascular intimal thickening, as well as a prophylactic of arteriosclerosis, which have excellent safety, improve functions associated with the vascular endothelium, have effects of preventing various diseases associated with vascular endothelial functions and of inhibiting vascular intimal thickening, and may be expected to provide prophylactic effect on arteriosclerosis or the like. The agents of the present invention contain, as an active component: (a) Xaa-Pro-Pro, (b) a hydrolysate of animal milk casein containing Xaa-Pro-Pro, or a concentrate thereof, or (c) a fermentation product containing Ile-Pro-Pro and/or Val-Pro-Pro obtained by fermenting a starting material containing milk protein with a bacterial strain of the species Lactobacillus helveticus.
摘要翻译： 提供了具有对血管内皮功能的改善作用和对血管内膜增厚的抑制作用以及具有优异安全性，改善与血管内皮相关的功能的动脉硬化预防中的至少一种的药剂，其具有 预防与血管内皮功能相关的各种疾病和抑制血管内膜增厚，并且可以预期对动脉硬化等提供预防效果。 本发明的药剂含有：（a）Xaa-Pro-Pro，（b）含有Xaa-Pro-Pro或其浓缩物的动物乳酪蛋白的水解产物，或（c）发酵产物 含有Ile-Pro-Pro和/或Val-Pro-Pro，其通过用瑞士乳杆菌种的细菌菌株发酵含有乳蛋白的原料而获得。
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