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49 条记录 (耗时 0.048 秒)

    Unsymmetrical cyclic diamine compound
    5.
    发明授权
    Unsymmetrical cyclic diamine compound 失效
    不对称环状二胺化合物

    公开(公告)号：US06552188B2

    公开(公告)日：2003-04-22

    申请号：US09893699

    申请日：2001-06-29

    申请人： Tatsuhiko Kodama ,  Masahiro Tamura ,  Toshiaki Oda ,  Yukiyoshi Yamazaki ,  Masahiro Nishikawa ,  Shunji Takemura ,  Takeshi Doi ,  Yoshinori Kyotani

    发明人： Tatsuhiko Kodama ,  Masahiro Tamura ,  Toshiaki Oda ,  Yukiyoshi Yamazaki ,  Masahiro Nishikawa ,  Shunji Takemura ,  Takeshi Doi ,  Yoshinori Kyotani

    IPC分类号： A61K31496

    CPC分类号： C07D213/81 ,  C07D213/36 ,  C07D213/82 ,  C07D401/12

    摘要： Cyclic diamine compounds of formula (1) are disclosed: wherein A is (CH2)n, (CH2)n—CH═CH, CO—(CH2)n or CO—(CH2)n—CH═CH, in which n is a number of 0 to 3; Z represents a formula (2) or (3): in which R1, R2, R4, R5 and R6 are individually a hydrogen atom, alkyl group, alkoxy group, halogen atom or nitro group; R3is a hydrogen atom, alkyl group, alkoxy group, halogen atom, nitro group, naphthyl group, or phenyl group which may be substituted by 1 to 3 substituents selected from the group consisting of alkyl groups, alkoxy groups, halogen atoms, a nitro group and a phenyl group; and X and Y are individually CH or a nitrogen atom; and m is 1 or 2; an acid-addition salt thereof, or a hydrate thereof, and a medicine containing such a compound.

    摘要翻译： 公开了式（1）的环二胺化合物：其中A是（CH 2）n，（CH 2）n -CH = CH，CO-（CH 2）n或CO-（CH 2）n -CH = CH，其中n是 数字0到3; Z表示式（2）或（3）：其中R1，R2，R4，R5和R6分别为氢原子，烷基，烷氧基，卤素原子或硝基; R3是氢原子，烷基，烷氧基，卤素原子，硝基，萘基或可以被1〜3个选自烷基，烷氧基，卤原子，硝基的取代基取代的苯基 和苯基; X和Y分别是CH或氮原子; m为1或2;其酸加成盐或其水合物，以及含有这种化合物的药物。

    Cyclic diamine compound with 5-membered ring groups
    7.
    发明授权
    Cyclic diamine compound with 5-membered ring groups 失效
    具有5元环基团的环状二胺化合物

    公开(公告)号：US06472386B1

    公开(公告)日：2002-10-29

    申请号：US09893682

    申请日：2001-06-29

    申请人： Tatsuhiko Kodama ,  Masahiro Tamura ,  Toshiaki Oda ,  Yukiyoshi Yamazaki ,  Masahiro Nishikawa ,  Takeshi Doi ,  Yoshinori Kyotani

    发明人： Tatsuhiko Kodama ,  Masahiro Tamura ,  Toshiaki Oda ,  Yukiyoshi Yamazaki ,  Masahiro Nishikawa ,  Takeshi Doi ,  Yoshinori Kyotani

    IPC分类号： A61K31551

    CPC分类号： C07D231/12 ,  C07D233/64 ,  C07D261/08 ,  C07D263/32 ,  C07D277/28 ,  C07D277/46 ,  C07D333/20 ,  C07D401/14 ,  C07D403/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

    摘要： A compound of formula (1): wherein A is a single bond, C≡C, CONH or NHCO; W is a carbon atom or a nitrogen atom; X is CH, a nitrogen atom, an oxygen atom or a sulfur atom; Y is CH, CHR1, in which R1 is a hydrogen atom, or a lower alkyl, hydroxy lower alkyl, lower alkoxy-lower-alkyl, aryl, aryl-lower-alkyl or heteroaryl-lower-alkyl group, a nitrogen atom, an oxygen atom, a sulfur atom or NR2, in which R2 is a hydrogen atom, or a lower alkyl, hydroxy lower alkyl, lower alkoxy-lower-alkyl, aryl, aryl-lower-alkyl or heteroaryl-lower-alkyl group; Z is a nitrogen atom, an oxygen atom, a sulfur atom, CH or NR3, in which R3 is a hydrogen atom, or a lower alkyl, hydroxy lower alkyl, lower alkoxy-lower-alkyl, aryl, aryl-lower-alkyl or heteroaryl-lower-alkyl group; m is 1 or 2; and n is a number of 1 to 5, with the proviso that one or two of W, X, Y and Z are heteroatoms; an acid-addition salt thereof, or a hydrate thereof. The compounds have inhibitory effects on cell adhesion and are useful for prevention or treatment of diseases such as allergy, asthma, rheumatism, arteriosclerosis and inflammation.

    摘要翻译： 式（1）的化合物：其中A是单键，C = C，CONH或NHCO; W是碳原子或氮原子; X是CH，氮原子，氧原子或硫原子; Y是CH，CHR1，其中R1是氢原子，或低级烷基，羟基低级烷基，低级烷氧基 - 低级 - 烷基，芳基，芳基 - 低级 - 烷基或杂芳基 - 低级 - 烷基，氮原子， 氧原子，硫原子或NR 2，其中R2是氢原子，或低级烷基，羟基低级烷基，低级烷氧基 - 低级 - 烷基，芳基，芳基 - 低级 - 烷基或杂芳基 - 低级 - 烷基; Z是氮原子，氧原子，硫原子，CH或NR 3，其中R3是氢原子，或低级烷基，羟基低级烷基，低级烷氧基 - 低级 - 烷基，芳基，芳基 - 低级 - 烷基或 杂芳基 - 低级烷基; m为1或2; 并且n是1至5的数，条件是W，X，Y和Z中的一个或两个是杂原子; 其酸加成盐或其水合物。 这些化合物对细胞粘附具有抑制作用，可用于预防或治疗诸如过敏，哮喘，风湿病，动脉硬化和炎症等疾病。