公开(公告)号：US20110212486A1

公开(公告)日：2011-09-01

申请号：US12950268

申请日：2010-11-19

申请人： Tatsuki Yamada ,  Yuichi Ishikawa ,  Kengo Takeuchi

发明人： Tatsuki Yamada ,  Yuichi Ishikawa ,  Kengo Takeuchi

IPC分类号： G01N33/48 ,  C12M1/34

CPC分类号： G02B21/365 ,  G01N1/30

摘要： A microscope system includes an acquisition unit that obtains a specimen image acquired by capturing the specimen stained by an element identification dye that visualizes a predetermined cell constituent element and a molecule target dye that visualizes a predetermined target molecule by using a microscope; a dye amount unit that obtains dye amounts of the element identification dye and the molecule target dye that stain corresponding positions on the specimen for each pixel of the image; an element area identification unit that identifies an area of the cell constituent element based on the dye amount of the element identification dye; a condition setting unit that sets the presence or absence of the predetermined target molecule on the cell constituent element as a condition; and an extraction unit that extracts an area of a target portion that satisfies the condition based on the dye amount of the molecule target dye.

摘要翻译： 显微镜系统包括获取单元，其获取通过捕获通过使用显微镜可视化预定细胞构成元素的元素识别染料和可视化预定靶分子的分子靶染料而染色的样品而获得的标本图像; 染色量单元，其获得染色剂量，所述染料量针对图像的每个像素染色样品上的相应位置的元件识别染料和分子靶染料; 元件区域识别单元，其基于元件识别染料的染色量来识别单元构成元件的面积; 条件设定单元，其将所述细胞构成元件上的所述规定的目标分子的存在或不存在作为条件; 以及提取单元，其基于分子靶染料的染料量提取满足条件的目标部分的面积。

公开(公告)号：US20100272334A1

公开(公告)日：2010-10-28

申请号：US12817451

申请日：2010-06-17

申请人： Tatsuki Yamada ,  Satoshi Arai ,  Yoko Yamamoto ,  Yuichi Ishikawa ,  Kengo Takeuchi

发明人： Tatsuki Yamada ,  Satoshi Arai ,  Yoko Yamamoto ,  Yuichi Ishikawa ,  Kengo Takeuchi

IPC分类号： G06T7/00

CPC分类号： G01N1/312 ,  G01N2035/00039 ,  G01N2035/00138 ,  G02B21/26 ,  G02B21/367

摘要： A microscope system includes an image acquisition unit for acquiring a spectral image of a specimen by using a microscope, a structure specifying unit for specifying an extraction target structure in the specimen, a display method specifying unit for specifying a display method of the extraction target structure, a structure extraction unit for extracting an area of the extraction target structure in the spectral image by using a reference spectrum of the extraction target structure on the basis of pixel values of each pixel included in the spectral image, a display image generator for generating a display image that represents the extraction target structure in the specimen by the display method specified by the display method specifying unit on the basis of an extraction result of the structure extraction unit, and a display processing unit for performing process for displaying the display image on a display unit.

摘要翻译： 显微镜系统包括用于通过使用显微镜获取样本的光谱图像的图像获取单元，用于指定样本中的提取目标结构的结构指定单元，用于指定提取目标结构的显示方法的显示方法确定单元 一种结构提取单元，用于根据包括在所述分光图像中的每个像素的像素值，通过使用所述提取目标结构的参考光谱来提取所述光谱图像中的所述提取目标结构的区域;显示图像生成器， 显示图像，其通过基于结构提取单元的提取结果的显示方法指定单元指定的显示方法来显示样本中的提取目标结构;以及显示处理单元，用于执行将显示图像显示在 显示单元。

公开(公告)号：US09110305B2

公开(公告)日：2015-08-18

申请号：US12950268

申请日：2010-11-19

申请人： Tatsuki Yamada ,  Yuichi Ishikawa ,  Kengo Takeuchi

发明人： Tatsuki Yamada ,  Yuichi Ishikawa ,  Kengo Takeuchi

IPC分类号： H04N7/18 ,  G02B21/36 ,  G01N1/30

CPC分类号： G02B21/365 ,  G01N1/30

摘要： A microscope system includes an acquisition unit that obtains a specimen image acquired by capturing the specimen stained by an element identification dye that visualizes a predetermined cell constituent element and a molecule target dye that visualizes a predetermined target molecule by using a microscope; a dye amount unit that obtains dye amounts of the element identification dye and the molecule target dye that stain corresponding positions on the specimen for each pixel of the image; an element area identification unit that identifies an area of the cell constituent element based on the dye amount of the element identification dye; a condition setting unit that sets the presence or absence of the predetermined target molecule on the cell constituent element as a condition; and an extraction unit that extracts an area of a target portion that satisfies the condition based on the dye amount of the molecule target dye.

摘要翻译： 显微镜系统包括获取单元，其获取通过捕获通过使用显微镜可视化预定细胞构成元素的元素识别染料和可视化预定靶分子的分子靶染料而染色的样品而获得的标本图像; 染色量单元，其获得染色剂量，所述染料量对于图像的每个像素染色样品上的相应位置的元素识别染料和分子靶染料; 元件区域识别单元，其基于元件识别染料的染色量来识别单元构成元件的面积; 条件设定单元，其将所述细胞构成元件上的所述规定的目标分子的存在或不存在作为条件; 以及提取单元，其基于分子靶染料的染料量提取满足条件的目标部分的面积。

公开(公告)号：US20100141752A1

公开(公告)日：2010-06-10

申请号：US12629547

申请日：2009-12-02

申请人： Tatsuki Yamada ,  Shinsuke Tani ,  Takeshi Otsuka ,  Satoshi Arai ,  Yuichi Ishikawa ,  Kengo Takeuchi

发明人： Tatsuki Yamada ,  Shinsuke Tani ,  Takeshi Otsuka ,  Satoshi Arai ,  Yuichi Ishikawa ,  Kengo Takeuchi

IPC分类号： G09G5/02 ,  H04N7/18 ,  G09G5/00

CPC分类号： G01N1/312 ,  G01N2035/00039 ,  G01N2035/00138 ,  G02B21/26 ,  G02B21/367

摘要： A microscope system includes an image acquiring unit that acquires a specimen image formed by capturing a specimen multi-stained by a plurality of pigments using a microscope; a pigment amount acquiring unit that acquires a pigment amount of each pigment staining a corresponding position on the specimen, for each pixel of the specimen image; and a pigment selecting unit that selects a display target pigment from the plurality of pigments. The system also includes a display image generating unit that generates a display image where a staining state of the specimen by the display target pigment is displayed, on the basis of the pigment amount of the display target pigment in each pixel of the specimen image; and a display processing unit that displays the display image on a display unit.

摘要翻译： 显微镜系统包括图像获取单元，其获取通过使用显微镜捕获多个颜料多染色的样本而形成的标本图像; 颜料量获取单元，针对样本图像的每个像素获取每个颜料的颜料量染色样品上的相应位置; 以及颜料选择单元，其从多种颜料中选择显示目标颜料。 该系统还包括显示图像生成单元，其基于样本图像的每个像素中的显示目标颜料的颜料量，生成显示目标颜料的样品的染色状态的显示图像; 以及显示处理单元，其将显示图像显示在显示单元上。

公开(公告)号：US09109259B2

公开(公告)日：2015-08-18

申请号：US13805513

申请日：2011-06-22

申请人： Kengo Takeuchi ,  Yuichi Ishikawa ,  Hiroyuki Mano ,  Manabu Soda ,  Eirin Sai

发明人： Kengo Takeuchi ,  Yuichi Ishikawa ,  Hiroyuki Mano ,  Manabu Soda ,  Eirin Sai

IPC分类号： C12Q1/68 ,  C12P19/34 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12P19/34 ,  C12Q1/68 ,  C12Q2600/156 ,  G01N33/57484

摘要： Polynucleotides which are novel causative genes for cancer are elucidated, and a detection method of the polynucleotides or polypeptides encoded by the polynucleotides, and a kit and a primer set for detection are provided, based on the knowledge gained by the elucidation. In the detection method, a fusion gene comprising part of an SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 gene and part of a ROS1 gene, or a fusion protein encoded by the fusion gene is detected. The primer set or the detection kit comprises a sense primer designed based on a portion encoding SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 and an antisense primer designed based on a portion encoding ROS1.

摘要翻译： 阐明了作为癌症的新型致病基因的多核苷酸，并且基于通过阐明获得的知识，提供了由多核苷酸编码的多核苷酸或多肽的检测方法以及用于检测的试剂盒和引物组。 在检测方法中，检测包含SDC4，CD74，EZR，SLC34A2，LRIG3或TPM3基因和部分ROS1基因的融合基因或融合基因编码的融合蛋白。 引物组或检测试剂盒包括基于编码SDC4，CD74，EZR，SLC34A2，LRIG3或TPM3的部分设计的有义引物和基于编码ROS1的部分设计的反义引物。

公开(公告)号：US20130102006A1

公开(公告)日：2013-04-25

申请号：US13805513

申请日：2011-06-22

申请人： Kengo Takeuchi ,  Yuichi Ishikawa ,  Hiroyuki Mano ,  Manabu Soda ,  Eirin Sai

发明人： Kengo Takeuchi ,  Yuichi Ishikawa ,  Hiroyuki Mano ,  Manabu Soda ,  Eirin Sai

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12P19/34 ,  C12Q1/68 ,  C12Q2600/156 ,  G01N33/57484

摘要： Polynucleotides which are novel causative genes for cancer are elucidated, and a detection method of the polynucleotides or polypeptides encoded by the polynucleotides, and a kit and a primer set for detection are provided, based on the knowledge gained by the elucidation. In the detection method, a fusion gene comprising part of an SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 gene and part of a ROS1 gene, or a fusion protein encoded by the fusion gene is detected. The primer set or the detection kit comprises a sense primer designed based on a portion encoding SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 and an antisense primer designed based on a portion encoding ROS1.

摘要翻译： 阐明了作为癌症的新型致病基因的多核苷酸，并且基于通过阐明获得的知识，提供了由多核苷酸编码的多核苷酸或多肽的检测方法以及用于检测的试剂盒和引物组。 在检测方法中，检测包含SDC4，CD74，EZR，SLC34A2，LRIG3或TPM3基因和部分ROS1基因的融合基因或融合基因编码的融合蛋白。 引物组或检测试剂盒包括基于编码SDC4，CD74，EZR，SLC34A2，LRIG3或TPM3的部分设计的有义引物和基于编码ROS1的部分设计的反义引物。

公开(公告)号：US20120162499A1

公开(公告)日：2012-06-28

申请号：US13330139

申请日：2011-12-19

申请人： Kengo Takeuchi

发明人： Kengo Takeuchi

IPC分类号： H04N5/232

CPC分类号： H04N5/23212 ,  G02B7/102 ,  G02B7/36 ,  G03B13/36

摘要： The focus detection accuracy of a focus detection device that employs an external AF sensor unit having a pair of line sensors that are each comprised of multiple unit line sensors is improved. The individual line sensors are arranged so that the center of the field of view of an imaging optical system at a predetermined subject distance, at which field-of-view adjustment for causing the field of view of the imaging optical system and the field of view of a focus-detection optical system to match has been carried out, corresponds to the center of one of the multiple unit line sensors included in the individual line sensors.

摘要翻译： 利用具有由多个单位线传感器组成的一对线传感器的外部AF传感器单元的焦点检测装置的焦点检测精度得到改善。 各个线路传感器被布置成使得成像光学系统的视野的中心处于预定的被摄体距离处，在该目标距离处，用于使成像光学系统的视场和视场的视场调整 已经执行的匹配对焦检测光学系统的对应于各行传感器中包括的多个单元线传感器之一的中心。

公开(公告)号：US07545433B2

公开(公告)日：2009-06-09

申请号：US11145045

申请日：2005-06-03

申请人： Kengo Takeuchi

发明人： Kengo Takeuchi

IPC分类号： H04N5/232

CPC分类号： H04N5/23212

摘要： An image pickup apparatus which is capable of accurately detecting a blur of a shot image. AF evaluation values are calculated before and after shooting for recording an image representing the subject image in a recording medium is performed. The correlation between the AF evaluation values calculated before the shooting and the signal indicative of the focus generated after the shooting is determined. It is determined whether the correlation is lower than a first threshold value and higher than a second threshold value.

摘要翻译： 能够准确地检测拍摄图像的模糊的摄像装置。 在拍摄之前和之后计算AF评估值，以在记录介质中记录表示被摄体图像的图像。 确定在拍摄之前计算的AF评估值与表示拍摄后产生的焦点的信号之间的相关性。 确定相关性是否低于第一阈值并且高于第二阈值。

公开(公告)号：US07184376B2

公开(公告)日：2007-02-27

申请号：US10781740

申请日：2004-02-20

申请人： Kengo Takeuchi

发明人： Kengo Takeuchi

IPC分类号： G11B5/09

CPC分类号： H04N21/433 ,  G11B27/105 ,  G11B27/11 ,  G11B2220/2562 ,  H04N5/781 ,  H04N5/85 ,  H04N5/93 ,  H04N21/42646 ,  H04N21/42661 ,  H04N21/4325

摘要： A reproducing apparatus for detecting a reproduction stop date when reproduction of image data is stopped in the past, and for determining a reproduction start position in the image data on a basis of the reproduction stop date, and further for starting the reproduction of the image data from the determined reproduction start position in response to an instruction of starting reproduction.

摘要翻译： 一种用于在过去停止图像数据的再现时检测再现停止日期的再现装置，并且用于基于再现停止日期确定图像数据中的再现开始位置，并且还用于开始图像数据的再现 响应于开始再现的指令从所确定的再现开始位置。

公开(公告)号：US20050270409A1

公开(公告)日：2005-12-08

申请号：US11145045

申请日：2005-06-03

申请人： Kengo Takeuchi

发明人： Kengo Takeuchi

IPC分类号： H04N5/225 ,  H04N5/232 ,  H04N101/00

CPC分类号： H04N5/23212

摘要： An image pickup apparatus which is capable of accurately detecting a blur of a shot image. AF evaluation values are calculated before and after shooting for recording an image representing the subject image in a recording medium is performed. The correlation between the AF evaluation values calculated before the shooting and the signal indicative of the focus generated after the shooting is determined. It is determined whether the correlation is lower than a first threshold value and higher than a second threshold value.

摘要翻译： 能够准确地检测拍摄图像的模糊的摄像装置。 在拍摄之前和之后计算AF评估值，以在记录介质中记录表示被摄体图像的图像。 确定在拍摄之前计算的AF评估值与表示拍摄后产生的焦点的信号之间的相关性。 确定相关性是否低于第一阈值并且高于第二阈值。