公开(公告)号：US09110305B2

公开(公告)日：2015-08-18

申请号：US12950268

申请日：2010-11-19

申请人： Tatsuki Yamada ,  Yuichi Ishikawa ,  Kengo Takeuchi

发明人： Tatsuki Yamada ,  Yuichi Ishikawa ,  Kengo Takeuchi

IPC分类号： H04N7/18 ,  G02B21/36 ,  G01N1/30

CPC分类号： G02B21/365 ,  G01N1/30

摘要： A microscope system includes an acquisition unit that obtains a specimen image acquired by capturing the specimen stained by an element identification dye that visualizes a predetermined cell constituent element and a molecule target dye that visualizes a predetermined target molecule by using a microscope; a dye amount unit that obtains dye amounts of the element identification dye and the molecule target dye that stain corresponding positions on the specimen for each pixel of the image; an element area identification unit that identifies an area of the cell constituent element based on the dye amount of the element identification dye; a condition setting unit that sets the presence or absence of the predetermined target molecule on the cell constituent element as a condition; and an extraction unit that extracts an area of a target portion that satisfies the condition based on the dye amount of the molecule target dye.

摘要翻译： 显微镜系统包括获取单元，其获取通过捕获通过使用显微镜可视化预定细胞构成元素的元素识别染料和可视化预定靶分子的分子靶染料而染色的样品而获得的标本图像; 染色量单元，其获得染色剂量，所述染料量对于图像的每个像素染色样品上的相应位置的元素识别染料和分子靶染料; 元件区域识别单元，其基于元件识别染料的染色量来识别单元构成元件的面积; 条件设定单元，其将所述细胞构成元件上的所述规定的目标分子的存在或不存在作为条件; 以及提取单元，其基于分子靶染料的染料量提取满足条件的目标部分的面积。

公开(公告)号：US20110212486A1

公开(公告)日：2011-09-01

申请号：US12950268

申请日：2010-11-19

申请人： Tatsuki Yamada ,  Yuichi Ishikawa ,  Kengo Takeuchi

发明人： Tatsuki Yamada ,  Yuichi Ishikawa ,  Kengo Takeuchi

IPC分类号： G01N33/48 ,  C12M1/34

CPC分类号： G02B21/365 ,  G01N1/30

摘要： A microscope system includes an acquisition unit that obtains a specimen image acquired by capturing the specimen stained by an element identification dye that visualizes a predetermined cell constituent element and a molecule target dye that visualizes a predetermined target molecule by using a microscope; a dye amount unit that obtains dye amounts of the element identification dye and the molecule target dye that stain corresponding positions on the specimen for each pixel of the image; an element area identification unit that identifies an area of the cell constituent element based on the dye amount of the element identification dye; a condition setting unit that sets the presence or absence of the predetermined target molecule on the cell constituent element as a condition; and an extraction unit that extracts an area of a target portion that satisfies the condition based on the dye amount of the molecule target dye.

摘要翻译： 显微镜系统包括获取单元，其获取通过捕获通过使用显微镜可视化预定细胞构成元素的元素识别染料和可视化预定靶分子的分子靶染料而染色的样品而获得的标本图像; 染色量单元，其获得染色剂量，所述染料量针对图像的每个像素染色样品上的相应位置的元件识别染料和分子靶染料; 元件区域识别单元，其基于元件识别染料的染色量来识别单元构成元件的面积; 条件设定单元，其将所述细胞构成元件上的所述规定的目标分子的存在或不存在作为条件; 以及提取单元，其基于分子靶染料的染料量提取满足条件的目标部分的面积。

公开(公告)号：US20100272334A1

公开(公告)日：2010-10-28

申请号：US12817451

申请日：2010-06-17

申请人： Tatsuki Yamada ,  Satoshi Arai ,  Yoko Yamamoto ,  Yuichi Ishikawa ,  Kengo Takeuchi

发明人： Tatsuki Yamada ,  Satoshi Arai ,  Yoko Yamamoto ,  Yuichi Ishikawa ,  Kengo Takeuchi

IPC分类号： G06T7/00

CPC分类号： G01N1/312 ,  G01N2035/00039 ,  G01N2035/00138 ,  G02B21/26 ,  G02B21/367

摘要： A microscope system includes an image acquisition unit for acquiring a spectral image of a specimen by using a microscope, a structure specifying unit for specifying an extraction target structure in the specimen, a display method specifying unit for specifying a display method of the extraction target structure, a structure extraction unit for extracting an area of the extraction target structure in the spectral image by using a reference spectrum of the extraction target structure on the basis of pixel values of each pixel included in the spectral image, a display image generator for generating a display image that represents the extraction target structure in the specimen by the display method specified by the display method specifying unit on the basis of an extraction result of the structure extraction unit, and a display processing unit for performing process for displaying the display image on a display unit.

摘要翻译： 显微镜系统包括用于通过使用显微镜获取样本的光谱图像的图像获取单元，用于指定样本中的提取目标结构的结构指定单元，用于指定提取目标结构的显示方法的显示方法确定单元 一种结构提取单元，用于根据包括在所述分光图像中的每个像素的像素值，通过使用所述提取目标结构的参考光谱来提取所述光谱图像中的所述提取目标结构的区域;显示图像生成器， 显示图像，其通过基于结构提取单元的提取结果的显示方法指定单元指定的显示方法来显示样本中的提取目标结构;以及显示处理单元，用于执行将显示图像显示在 显示单元。

公开(公告)号：US20100141752A1

公开(公告)日：2010-06-10

申请号：US12629547

申请日：2009-12-02

申请人： Tatsuki Yamada ,  Shinsuke Tani ,  Takeshi Otsuka ,  Satoshi Arai ,  Yuichi Ishikawa ,  Kengo Takeuchi

发明人： Tatsuki Yamada ,  Shinsuke Tani ,  Takeshi Otsuka ,  Satoshi Arai ,  Yuichi Ishikawa ,  Kengo Takeuchi

IPC分类号： G09G5/02 ,  H04N7/18 ,  G09G5/00

CPC分类号： G01N1/312 ,  G01N2035/00039 ,  G01N2035/00138 ,  G02B21/26 ,  G02B21/367

摘要： A microscope system includes an image acquiring unit that acquires a specimen image formed by capturing a specimen multi-stained by a plurality of pigments using a microscope; a pigment amount acquiring unit that acquires a pigment amount of each pigment staining a corresponding position on the specimen, for each pixel of the specimen image; and a pigment selecting unit that selects a display target pigment from the plurality of pigments. The system also includes a display image generating unit that generates a display image where a staining state of the specimen by the display target pigment is displayed, on the basis of the pigment amount of the display target pigment in each pixel of the specimen image; and a display processing unit that displays the display image on a display unit.

摘要翻译： 显微镜系统包括图像获取单元，其获取通过使用显微镜捕获多个颜料多染色的样本而形成的标本图像; 颜料量获取单元，针对样本图像的每个像素获取每个颜料的颜料量染色样品上的相应位置; 以及颜料选择单元，其从多种颜料中选择显示目标颜料。 该系统还包括显示图像生成单元，其基于样本图像的每个像素中的显示目标颜料的颜料量，生成显示目标颜料的样品的染色状态的显示图像; 以及显示处理单元，其将显示图像显示在显示单元上。

公开(公告)号：US20130102006A1

公开(公告)日：2013-04-25

申请号：US13805513

申请日：2011-06-22

申请人： Kengo Takeuchi ,  Yuichi Ishikawa ,  Hiroyuki Mano ,  Manabu Soda ,  Eirin Sai

发明人： Kengo Takeuchi ,  Yuichi Ishikawa ,  Hiroyuki Mano ,  Manabu Soda ,  Eirin Sai

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12P19/34 ,  C12Q1/68 ,  C12Q2600/156 ,  G01N33/57484

摘要： Polynucleotides which are novel causative genes for cancer are elucidated, and a detection method of the polynucleotides or polypeptides encoded by the polynucleotides, and a kit and a primer set for detection are provided, based on the knowledge gained by the elucidation. In the detection method, a fusion gene comprising part of an SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 gene and part of a ROS1 gene, or a fusion protein encoded by the fusion gene is detected. The primer set or the detection kit comprises a sense primer designed based on a portion encoding SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 and an antisense primer designed based on a portion encoding ROS1.

摘要翻译： 阐明了作为癌症的新型致病基因的多核苷酸，并且基于通过阐明获得的知识，提供了由多核苷酸编码的多核苷酸或多肽的检测方法以及用于检测的试剂盒和引物组。 在检测方法中，检测包含SDC4，CD74，EZR，SLC34A2，LRIG3或TPM3基因和部分ROS1基因的融合基因或融合基因编码的融合蛋白。 引物组或检测试剂盒包括基于编码SDC4，CD74，EZR，SLC34A2，LRIG3或TPM3的部分设计的有义引物和基于编码ROS1的部分设计的反义引物。

公开(公告)号：US09109259B2

公开(公告)日：2015-08-18

申请号：US13805513

申请日：2011-06-22

申请人： Kengo Takeuchi ,  Yuichi Ishikawa ,  Hiroyuki Mano ,  Manabu Soda ,  Eirin Sai

发明人： Kengo Takeuchi ,  Yuichi Ishikawa ,  Hiroyuki Mano ,  Manabu Soda ,  Eirin Sai

IPC分类号： C12Q1/68 ,  C12P19/34 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12P19/34 ,  C12Q1/68 ,  C12Q2600/156 ,  G01N33/57484

摘要： Polynucleotides which are novel causative genes for cancer are elucidated, and a detection method of the polynucleotides or polypeptides encoded by the polynucleotides, and a kit and a primer set for detection are provided, based on the knowledge gained by the elucidation. In the detection method, a fusion gene comprising part of an SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 gene and part of a ROS1 gene, or a fusion protein encoded by the fusion gene is detected. The primer set or the detection kit comprises a sense primer designed based on a portion encoding SDC4, CD74, EZR, SLC34A2, LRIG3, or TPM3 and an antisense primer designed based on a portion encoding ROS1.

摘要翻译： 阐明了作为癌症的新型致病基因的多核苷酸，并且基于通过阐明获得的知识，提供了由多核苷酸编码的多核苷酸或多肽的检测方法以及用于检测的试剂盒和引物组。 在检测方法中，检测包含SDC4，CD74，EZR，SLC34A2，LRIG3或TPM3基因和部分ROS1基因的融合基因或融合基因编码的融合蛋白。 引物组或检测试剂盒包括基于编码SDC4，CD74，EZR，SLC34A2，LRIG3或TPM3的部分设计的有义引物和基于编码ROS1的部分设计的反义引物。

公开(公告)号：US08812754B2

公开(公告)日：2014-08-19

申请号：US12813891

申请日：2010-06-11

申请人： Kentaroh Sugawara ,  Shinichi Akahane ,  Hiroki Yano ,  Yuichi Ishikawa

发明人： Kentaroh Sugawara ,  Shinichi Akahane ,  Hiroki Yano ,  Yuichi Ishikawa

IPC分类号： G06F3/00 ,  H04L12/28

CPC分类号： H04L49/10

摘要： A network relay device includes a packet buffer for temporarily storing a received packet, and a packet buffer control section for changing an effective buffer number depending on the received amount of packet. When a traffic amount is small, the packet buffer control section reduces the power consumption by stopping the feeding of power or the supply of clock to a part of the packet buffers. The network relay device further includes plural table memories storing a table for deciding the transfer destination of packet, and a table memory control section for changing an effective table number according to a required number of table entries. When the required table entry number is small, the table memory control section reduces the power consumption by stopping the feeding of power or the supply of clock to a part of the table memories.

摘要翻译： 网络中继装置包括用于临时存储接收到的分组的分组缓冲器，以及用于根据接收到的分组数量改变有效缓冲器数目的分组缓冲器控制部分。 当业务量小时，分组缓冲器控制部分通过停止向一部分分组缓冲器供电或提供时钟来降低功耗。 网络中继装置还包括多个表存储器，其存储用于决定分组的传送目的地的表，以及表存储器控制部，用于根据所需的表条目数来更改有效的表号。 当所需的表格入口号小时，表存储器控制部分通过停止向台式存储器的一部分供电或提供时钟来降低功耗。

公开(公告)号：USD694194S1

公开(公告)日：2013-11-26

申请号：US29408233

申请日：2011-12-08

申请人： Manabu Takahashi ,  Kazuyuki Tsukimori ,  Shigenobu Fukui ,  Yuichi Ishikawa ,  Hiroyuki Moriyama ,  Shinya Katsube

设计人： Manabu Takahashi ,  Kazuyuki Tsukimori ,  Shigenobu Fukui ,  Yuichi Ishikawa ,  Hiroyuki Moriyama ,  Shinya Katsube

公开(公告)号：US08583912B2

公开(公告)日：2013-11-12

申请号：US11850899

申请日：2007-09-06

申请人： Yuichi Ishikawa ,  Toshio Koide

发明人： Yuichi Ishikawa ,  Toshio Koide

IPC分类号： H04L29/06

CPC分类号： H04L9/0833 ,  H04L9/0838 ,  H04L2209/601

摘要： In a client terminal of a communication system, a cipher session establishing section establishes a cipher session use connection between the client terminal as a source client terminal and a relay server by transmitting/receiving a cipher session establishment message between the source client terminal and the relay server, and notifies header information contained in a cipher session header to the relay server. A shared key managing section holds a client shared key with a destination client terminal, A data enciphering section performs encipherment of a data and/or MAC (Message Authentication Code) calculation of the data by using the client shared key and to output the performing result as a client cipher data. A message producing section produces a data communication message including a cipher data field in which the client cipher data is inserted and a non-cipher data field in which the cipher session header containing the header information is inserted. A transmitting section transmits the data communication messages destined to the destination client terminal to the relay server by using the cipher session use connection.

摘要翻译： 在通信系统的客户终端中，密码会话建立单元通过在源客户终端和中继站之间发送/接收加密会话建立消息来建立作为源客户终端的客户终端与中继服务器之间的加密会话使用连接 服务器，并将包含在密码会话报头中的报头信息通知给中继服务器。 共享密钥管理部分与目的客户终端保持客户端共享密钥，数据加密部分通过使用客户端共享密钥对数据进行数据和/或MAC（消息认证码）的计算，并输出执行结果 作为客户端密码数据。 消息产生部分产生包括其中插入客户端密码数据的密码数据字段的数据通信消息和其中插入包含标题信息的密码会话报头的非加密数据字段。 发送部通过使用密码会话使用连接将发往目的地客户终端的数据通信消息发送给中继服务器。

公开(公告)号：US20120235098A1

公开(公告)日：2012-09-20

申请号：US13501306

申请日：2010-12-07

申请人： Yuichi Ishikawa ,  Koji Tanoue ,  Takatoshi Fujino

发明人： Yuichi Ishikawa ,  Koji Tanoue ,  Takatoshi Fujino

IPC分类号： H01B1/00 ,  H01B1/20 ,  B32B5/16 ,  B82Y40/00 ,  B82Y30/00

CPC分类号： C01G15/006 ,  B82Y30/00 ,  C01B19/002 ,  C01G3/006 ,  C01P2002/50 ,  C01P2002/72 ,  C01P2004/03 ,  C01P2004/52 ,  C01P2004/64 ,  C01P2006/40 ,  C01P2006/80 ,  H01L21/02568 ,  H01L21/02601 ,  H01L21/02628 ,  H01L31/0322 ,  Y02E10/541 ,  Y02P70/521 ,  Y10T428/2982

摘要： Chalcogen compound powder containing Cu—In—Ga—Se and having an average particle diameter (DSEM) of 80 nm or less and a low content of carbon is obtained by forming a mixed solvent by mixing together at least any one of a mixture of copper salt and indium salt, a composite hydroxide of copper and indium, and a composite oxide of copper and indium, any one of selenium and a selenium compound, and a solvent having a boiling point of 250° C. or less, and heating the mixed solvent to a temperature of 220° C. to 500° C. A thin film containing Cu—In—Ga—Se and having low resistance is obtained by using paste of the chalcogen compound powder.

摘要翻译： 通过将混合溶剂混合在一起混合至少一种铜的混合物，得到含Cu-In-Ga-Se的平均粒径（DSEM）为80nm以下且碳含量低的硫族化合物粉末 盐和铟盐，铜和铟的复合氢氧化物，以及铜和铟的复合氧化物，硒和硒化合物中的任何一种，以及沸点为250℃或更低的溶剂，加热混合 溶剂至220℃至500℃的温度。通过使用硫属化合物粉末的糊料获得含有Cu-In-Ga-Se并且具有低电阻的薄膜。