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    1,2,3,4-Tetrahydroisoquinolines and the preparation thereof
    2.
    发明授权
    1,2,3,4-Tetrahydroisoquinolines and the preparation thereof 失效
    1,2,3,4-四氢异喹啉及其制备方法

    公开(公告)号：US4220647A

    公开(公告)日：1980-09-02

    申请号：US628935

    申请日：1975-11-05

    申请人： Teiji Kishimoto ,  Hiromu Kochi ,  Masayuki Kato

    发明人： Teiji Kishimoto ,  Hiromu Kochi ,  Masayuki Kato

    IPC分类号： C07D217/14 ,  A61K31/47

    CPC分类号： C07D217/14 ,  Y10S514/906

    摘要： 1,2,3,4-tetrahydroisoquinolines have the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, lower alkyl, lower alkenyl, acyl, aryl or ar(lower)alkyl, in which aryl and the aryl moiety of the ar(lower)alkyl may contain at least one substituent selected from the group consisting of halogen, lower alkoxy, amino, nitro, hydroxy, acyloxy, ar(lower)alkoxy, lower alkylenedioxy, halo(lower)alkyl, acylamino, ar(lower)alkylamino and aryl, and pharmaceutically acceptable salts thereof.

    摘要翻译： 1,2,3,4-四氢异喹啉具有下式：其中R 1和R 2各自为氢，低级烷基，低级烯基，酰基，芳基或芳（低级）烷基，其中芳基和芳基的芳基部分 （低级）烷基可含有至少一个选自卤素，低级烷氧基，氨基，硝基，羟基，酰氧基，芳基（低级）烷氧基，低级亚烷基二氧基，卤代（低级）烷基，酰氨基， 烷基氨基和芳基及其药学上可接受的盐。

    1,2,3,4-Tetrahydroisoquinolines 6.10,7,8 dihydroxy substitute-1-methylanilino and use as smooth muscle relaxants
    3.
    发明授权
    1,2,3,4-Tetrahydroisoquinolines 6.10,7,8 dihydroxy substitute-1-methylanilino and use as smooth muscle relaxants 失效
    1,2,3,4-四氢异喹啉6.10,7,8二羟基替代-1-甲基苯胺基，用作平滑肌松弛剂

    公开(公告)号：US4447436A

    公开(公告)日：1984-05-08

    申请号：US109531

    申请日：1980-01-04

    申请人： Teiji Kishimoto ,  Hiromu Kochi ,  Masayuki Kato

    发明人： Teiji Kishimoto ,  Hiromu Kochi ,  Masayuki Kato

    IPC分类号： C07D217/14 ,  A61K31/47 ,  C07D217/04

    CPC分类号： C07D217/14 ,  Y10S514/906

    摘要： 1,2,3,4-Tetrahydroisoquinolines having the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, lower alkyl, lower alkenyl, acyl, aryl or ar(lower)alkyl, in which aryl and the aryl moiety of the ar(lower)alkyl may contain at least one substituent selected from the group consisting of halogen, lower alkoxy, amino, nitro, hydroxy, acyloxy, ar(lower)alkoxy, lower alkylenedioxy, halo(lower)alkyl, acylamino, ar(lower)alkylamino and aryl, and pharmaceutically acceptable salts thereof, having a relaxant activity on smooth muscles.

    摘要翻译： 具有下式的1,2,3,4-四氢异喹啉：其中R 1和R 2各自为氢，低级烷基，低级烯基，酰基，芳基或芳（低级）烷基，其中芳基和芳基的芳基部分 （低级）烷基可含有至少一个选自卤素，低级烷氧基，氨基，硝基，羟基，酰氧基，芳基（低级）烷氧基，低级亚烷基二氧基，卤代（低级）烷基，酰氨基， 烷基氨基和芳基及其药学上可接受的盐，对平滑肌具有松弛活性。