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191 条记录 (耗时 0.022 秒)

    1,2,3,4-Tetrahydroisoquinolines and the preparation thereof
    2.
    发明授权
    1,2,3,4-Tetrahydroisoquinolines and the preparation thereof 失效
    1,2,3,4-四氢异喹啉及其制备方法

    公开(公告)号：US4220647A

    公开(公告)日：1980-09-02

    申请号：US628935

    申请日：1975-11-05

    申请人： Teiji Kishimoto ,  Hiromu Kochi ,  Masayuki Kato

    发明人： Teiji Kishimoto ,  Hiromu Kochi ,  Masayuki Kato

    IPC分类号： C07D217/14 ,  A61K31/47

    CPC分类号： C07D217/14 ,  Y10S514/906

    摘要： 1,2,3,4-tetrahydroisoquinolines have the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, lower alkyl, lower alkenyl, acyl, aryl or ar(lower)alkyl, in which aryl and the aryl moiety of the ar(lower)alkyl may contain at least one substituent selected from the group consisting of halogen, lower alkoxy, amino, nitro, hydroxy, acyloxy, ar(lower)alkoxy, lower alkylenedioxy, halo(lower)alkyl, acylamino, ar(lower)alkylamino and aryl, and pharmaceutically acceptable salts thereof.

    摘要翻译： 1,2,3,4-四氢异喹啉具有下式：其中R 1和R 2各自为氢，低级烷基，低级烯基，酰基，芳基或芳（低级）烷基，其中芳基和芳基的芳基部分 （低级）烷基可含有至少一个选自卤素，低级烷氧基，氨基，硝基，羟基，酰氧基，芳基（低级）烷氧基，低级亚烷基二氧基，卤代（低级）烷基，酰氨基， 烷基氨基和芳基及其药学上可接受的盐。

    1,2,3,4-Tetrahydroisoquinolines 6.10,7,8 dihydroxy substitute-1-methylanilino and use as smooth muscle relaxants
    3.
    发明授权
    1,2,3,4-Tetrahydroisoquinolines 6.10,7,8 dihydroxy substitute-1-methylanilino and use as smooth muscle relaxants 失效
    1,2,3,4-四氢异喹啉6.10,7,8二羟基替代-1-甲基苯胺基，用作平滑肌松弛剂

    公开(公告)号：US4447436A

    公开(公告)日：1984-05-08

    申请号：US109531

    申请日：1980-01-04

    申请人： Teiji Kishimoto ,  Hiromu Kochi ,  Masayuki Kato

    发明人： Teiji Kishimoto ,  Hiromu Kochi ,  Masayuki Kato

    IPC分类号： C07D217/14 ,  A61K31/47 ,  C07D217/04

    CPC分类号： C07D217/14 ,  Y10S514/906

    摘要： 1,2,3,4-Tetrahydroisoquinolines having the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, lower alkyl, lower alkenyl, acyl, aryl or ar(lower)alkyl, in which aryl and the aryl moiety of the ar(lower)alkyl may contain at least one substituent selected from the group consisting of halogen, lower alkoxy, amino, nitro, hydroxy, acyloxy, ar(lower)alkoxy, lower alkylenedioxy, halo(lower)alkyl, acylamino, ar(lower)alkylamino and aryl, and pharmaceutically acceptable salts thereof, having a relaxant activity on smooth muscles.

    摘要翻译： 具有下式的1,2,3,4-四氢异喹啉：其中R 1和R 2各自为氢，低级烷基，低级烯基，酰基，芳基或芳（低级）烷基，其中芳基和芳基的芳基部分 （低级）烷基可含有至少一个选自卤素，低级烷氧基，氨基，硝基，羟基，酰氧基，芳基（低级）烷氧基，低级亚烷基二氧基，卤代（低级）烷基，酰氨基， 烷基氨基和芳基及其药学上可接受的盐，对平滑肌具有松弛活性。

    Cephem compounds
    4.
    发明授权
    Cephem compounds 失效
    头孢烯化合物

    公开(公告)号：US4443443A

    公开(公告)日：1984-04-17

    申请号：US213232

    申请日：1980-12-05

    申请人： Ikuo Ueda ,  Masaaki Matsuo ,  Kiyoshi Tsuji ,  Masayuki Kato

    发明人： Ikuo Ueda ,  Masaaki Matsuo ,  Kiyoshi Tsuji ,  Masayuki Kato

    IPC分类号： C07D209/48 ,  C07D257/04 ,  C07D277/20 ,  C07D295/13 ,  C07D295/205 ,  C07D501/36 ,  A61K31/545

    CPC分类号： C07D209/48 ,  C07D257/04 ,  C07D277/587 ,  C07D295/13 ,  C07D295/205 ,  Y02P20/55

    摘要： This invention relates to novel cephem compounds of high antimicrobial activity, of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group;R.sup.2 is carboxy or a protected carboxy group;A is lower alkylene which may have an oxo group;R.sup.3 is carboxy, a protected carboxy group, lower alkyl, lower alkenyl, hydroxy (lower) alkyl, phenyl (lower) alkyl, phenyl, tolyl, xylyl, cumenyl, or naphthyl; andR.sup.4 is hydrogen or lower alkoxy, and pharmaceutically acceptable salts thereof.

    摘要翻译： 本发明涉及高抗微生物活性的新型头孢烯化合物，其具有下式：其中R 1是氨基或被保护的氨基; R2是羧基或被保护的羧基; A是可以具有氧代基的低级亚烷基; R3是羧基，被保护的羧基，低级烷基，低级烯基，羟基（低级）烷基，苯基（低级）烷基，苯基，甲苯基，二甲苯基，枯烯基或萘基; 和R4是氢或低级烷氧基，及其药学上可接受的盐。

    Sodium salt of 4-oxo-10-(2,3-dimethylpentanamido)-4H-pyrimido[1,2-c]quinozoline-3-carbo xylic acid
    7.
    发明授权
    Sodium salt of 4-oxo-10-(2,3-dimethylpentanamido)-4H-pyrimido[1,2-c]quinozoline-3-carbo xylic acid 失效
    4-氧代-10-（2,3-二甲基戊酰氨基）-4H-嘧啶并[1,2-c]喹唑啉-3-羧酸钠盐

    公开(公告)号：US4429126A

    公开(公告)日：1984-01-31

    申请号：US384998

    申请日：1982-06-04

    申请人： Ikuo Ueda ,  Masayuki Kato ,  Masanobu Nagano

    发明人： Ikuo Ueda ,  Masayuki Kato ,  Masanobu Nagano

    IPC分类号： C07D239/94 ,  C07D239/95 ,  C07D239/96 ,  C07D265/26 ,  C07D487/04 ,  A61K31/505 ,  C07D239/80 ,  C07D471/14

    CPC分类号： C07D487/04 ,  C07D239/94 ,  C07D239/95 ,  C07D239/96 ,  C07D265/26

    摘要： Quinazoline derivatives of the formulae: ##STR1## wherein A.sup.1 is ##STR2## A.sup.2 is ##STR3## R.sup.1 is hydrogen, carboxy or esterified carboxy, R.sub.a.sup.1 and R.sub.b.sup.1 are esterified carboxy,R.sup.2 and R.sup.3 are hydrogen, alkyl, halogen, nitro, amino, alkoxy, aryloxy, alkylthio, alkylpiperazinyl, acylamino or dialkylamino which may be substituted with hydroxy,R.sup.4 is hydrogen, alkyl, hydroxy, alkoxy, alkenyloxy, dialkylamino or 2,2-dialkoxycarbonylvinylaminoR.sub.a.sup.4 is hydrogen, alkyl, hydroxy, alkoxy, alkenyloxy or dialkylamino,R.sup.5 is alkyl or alkenyl, andR.sup.6 is carboxy or esterified carboxy.

    摘要翻译： 喹啉衍生物，其结构式如下：其中A1是甲基，R1是氢，羧基或酯化的羧基，Ra1和Rb1是酯化的羧基，R2和R3是氢，烷基，卤素，硝基 ，可以被羟基取代的氨基，烷氧基，芳氧基，烷硫基，烷基哌嗪基，酰基氨基或二烷基氨基，R 4是氢，烷基，羟基，烷氧基，烯氧基，二烷基氨基或2,2-二烷氧基羰基乙烯基氨基R 4a是氢，烷基，羟基，烷氧基， 烯氧基或二烷基氨基，R 5是烷基或烯基，R 6是羧基或酯化的羧基。

    Imidazoisoquinoline compounds useful as anti-ulcerative agents
    8.
    发明授权
    Imidazoisoquinoline compounds useful as anti-ulcerative agents 失效
    咪唑并异喹啉化合物可用作抗溃疡剂

    公开(公告)号：US4738967A

    公开(公告)日：1988-04-19

    申请号：US945788

    申请日：1986-12-23

    申请人： Ikuo Ueda ,  Youichi Shiokawa ,  Masayuki Kato ,  Nobukiyo Konishi ,  Atsushi Akahane

    发明人： Ikuo Ueda ,  Youichi Shiokawa ,  Masayuki Kato ,  Nobukiyo Konishi ,  Atsushi Akahane

    IPC分类号： C07D471/04 ,  A61K31/47 ,  A61P1/04 ,  C07D487/04 ,  A61K31/40

    CPC分类号： C07D487/04

    摘要： A compound of the formula: ##STR1## wherein R.sup.1 is lower alkyl,R.sup.3 is hydrogen, halogen or ar(lower)alkoxy, andR is lower alkanoyl, nitroso, amino, carboxy, esterified carboxy, carbamoyl, hydroxycarbamoyl, haloformyl, aminomethyleneamino which may be substituted with cyano or lower alkyl, iminomethylamino which may be substituted with cyano or lower alkyl, or a group of the formula: --A--R.sup.2 in which A is lower alkylene andR.sup.2 is di(lower) alkylamino, cyano, lower alkoxy, N-containing heterocyclic group which may have suitable substituent(s), lower alkynyloxy, lower alkenyloxy, lower alkylthio, amino(lower)alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, carboxy, esterified carboxy, carbamoyl, hydroxycarbamoyl, hydroxy, lower alkanoyloxy, heterocyclicamino(lower)alkylthio having two oxo groups, hydrogen or a group of the formula: ##STR2## in which R.sup.4, R.sup.5 and R.sup.6 are each lower alkyl andX is an acid residue,and pharmaceutically acceptable salts thereof. pa The compounds are useful as anti ulcer agents.