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公开(公告)号：US09808488B2
公开(公告)日：2017-11-07
申请号：US14479385
申请日：2014-09-08
Inventor： Benjamin Dekel , Orit Harari-Steinberg
CPC classification number: A61K35/22 , C12N5/0686 , C12N5/0687 , C12N5/0696 , C12N15/85 , C12N2500/90 , C12N2501/06 , C12N2501/065 , C12N2501/415 , C12N2506/25
Abstract: Isolated populations of fetal renal stem cells and progenitor cells are provided. Also provided are methods of generating and using these isolated populations of cells.
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Patent Agency Ranking
公开(公告)号：US09770469B2
公开(公告)日：2017-09-26
申请号：US14027256
申请日：2013-09-16
Inventor： Benjamin Dekel , Orit Harari-Steinberg
CPC classification number: A61K35/22 , C12N5/0686 , C12N5/0687 , C12N5/0696 , C12N15/85 , C12N2500/90 , C12N2501/06 , C12N2501/065 , C12N2501/415 , C12N2506/25
Abstract: A method of reprogramming a differentiated renal cell towards a progenitor phenotype is disclosed. The method comprises up-regulating in the differentiated renal cell an expression of at least one pluripotency associated gene and/or at least one renal stem cell associated gene, thereby reprogramming the differentiated renal cell towards a progenitor phenotype. Cell populations generated thereby and uses thereof are also disclosed.
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公开(公告)号：US12134650B2
公开(公告)日：2024-11-05
申请号：US17263251
申请日：2019-07-25
Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd. , Tageza Biopharmaceuticals Ltd.
Inventor： Benjamin Dekel , Orit Harari-Steinberg , Sanja Goldberg
IPC: A61K35/17 , A61K47/68 , C07K16/28 , C12Q1/6886 , G01N33/574
Abstract: Methods of treating cancer are provided. Accordingly, there is provided a method of treating cancer in a subject in need thereof, the method comprising administering to the subject an effective amount of an agent capable of (i) specifically binding GABRA2, the agent comprising a therapeutic moiety; and/or (ii) downregulating activity and/or expression of said GABRA2. Also provided are compositions, article of manufactures and methods of diagnosing cancer and monitoring cancer treatment.
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公开(公告)号：US10883994B2
公开(公告)日：2021-01-05
申请号：US15320847
申请日：2015-06-25
Inventor： Benjamin Dekel , Orit Harari-Steinberg
IPC: G01N33/574 , G01N33/50 , A61K31/275 , C12Q1/6886
Abstract: A method of identifying cancer stem cell markers in a human primary tumor is disclosed. The method comprises: (a) in vivo passaging the primary tumor; and (b) comparing a level of at least one antigen in a first population of passaged tumor cells of the primary tumor with a second population of tumor cells of the primary tumor, wherein an increase in the amount of the antigen in the first population of tumor cells as compared to the amount of the antigen in the second population of tumor cells is indicative of a cancer stem cell marker in the human primary tumor.
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公开(公告)号：US10465004B2
公开(公告)日：2019-11-05
申请号：US15109173
申请日：2015-01-01
Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd. , Ramot at Tel-Aviv University Ltd.
Inventor： Benjamin Dekel , Naomi Pode-Shakked , Orit Harai-Steinberg , Michal Mark-Danieli , Einav Vax
Abstract: The invention provides antibodies or an antigen-binding portion thereof, which recognize the human Frizzled 7 receptor. Further, the invention provides methods of using these antibodies for the treatment cancer in a subject.
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公开(公告)号：US20180346882A1
公开(公告)日：2018-12-06
申请号：US16045784
申请日：2018-07-26
Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. , RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Benjamin Dekel , Orit Harari-Steinberg , Ella Buzhor
IPC: C12N5/071
CPC classification number: C12N5/0686 , C12N2500/90 , C12N2501/11 , C12N2501/115 , C12N2501/33 , C12N2501/392 , C12N2533/40
Abstract: A method of generating a nephrospheroid is disclosed. The method comprises culturing human adult kidney cells in a culture medium under non-adherent conditions. Uses thereof and other renal cell populations are also disclosed.
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