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公开(公告)号：US20160089391A1
公开(公告)日：2016-03-31
申请号：US14864000
申请日：2015-09-24
Inventor： Hong Wang
IPC: A61K31/713 , G01N33/573 , A61K38/06 , A61K45/06 , A61K38/05
CPC classification number: A61K31/713 , A61K31/12 , A61K31/445 , A61K38/05 , A61K38/06 , A61K45/06 , G01N33/573 , G01N2333/96466 , G01N2800/32 , A61K2300/00
Abstract: The invention relates to methods and compositions for treating and preventing cardiovascular disease, including but not limited to treating and preventing endothelial dysfunction in subjects having hyperhomocysteinemia, hyperglycemia, or a combination of hyperhomocysteinemia and hyperglycemia. As endothelial dysfunction is an indicator for atherosclerosis and cardiovascular disease, this treatment has general impact for early prevention and treatment for all cardiovascular disease. In particular, the present invention relates to methods and compositions for inhibiting calpain activity.
Abstract translation: 本发明涉及用于治疗和预防心血管疾病的方法和组合物，包括但不限于治疗和预防具有高同型半胱氨酸血症，高血糖或高同型半胱氨酸血症和高血糖症的组合的受试者的内皮功能障碍。 由于内皮功能障碍是动脉粥样硬化和心血管疾病的指标，这种治疗对所有心血管疾病的早期预防和治疗具有一般影响。 特别地，本发明涉及抑制钙蛋白酶活性的方法和组合物。
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2.发明申请公开(公告)号：US20160235789A1
公开(公告)日：2016-08-18
申请号：US15044859
申请日：2016-02-16
Inventor： Hong Wang
CPC classification number: A61K45/06 , A61K35/28 , A61K48/00 , C12N5/0692
Abstract: The present invention provides an isolated population of bone marrow-derived endothelial progenitor cells (EPCs) and uses thereof for the treatment of vascular diseases.
Abstract translation: 本发明提供了分离的骨髓来源的内皮祖细胞群（EPCs）及其用于治疗血管疾病的用途。
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公开(公告)号：US09901639B2
公开(公告)日：2018-02-27
申请号：US15044859
申请日：2016-02-16
Inventor： Hong Wang
CPC classification number: A61K45/06 , A61K35/28 , A61K48/00 , C12N5/0692
Abstract: The present invention provides an isolated population of bone marrow-derived endothelial progenitor cells (EPCs) and uses thereof for the treatment of vascular diseases.
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