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    Transapical delivery system for heart valves
    3.
    发明授权
    Transapical delivery system for heart valves 有权
    心脏瓣膜经皮递送系统

    公开(公告)号：US08475522B2

    公开(公告)日：2013-07-02

    申请号：US12835546

    申请日：2010-07-13

    申请人： Teodoro S. Jimenez ,  Walter Lee ,  Mark Dehdashtian ,  Kristopher Yee

    发明人： Teodoro S. Jimenez ,  Walter Lee ,  Mark Dehdashtian ,  Kristopher Yee

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2427 ,  A61F2/24 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/243 ,  A61F2/2433 ,  A61F2220/0016 ,  A61F2220/005 ,  A61M25/0133 ,  A61M25/0136 ,  A61M25/0138 ,  A61M25/0141 ,  A61M25/0144 ,  A61M25/0147 ,  A61M2025/015

    摘要： A delivery system for delivering a prosthetic heart valve to the aortic valve annulus. The system includes a delivery catheter having a steering mechanism thereon for delivering a balloon-expandable prosthetic heart valve to the aortic annulus in an antegrade fashion through an introducer passing into the left ventricle through its apex. The introducer may have a more floppy distal section than a proximal section to reduce trauma to the heart wall. The delivery catheter includes a deflecting segment just proximal to a distal balloon to facilitate positioning of the prosthetic heart valve in the proper orientation within the annulus. A trigger in a catheter handle may be coupled to a deflection wire that actuates the deflecting segment, while a slider in the handle controls retraction of a valve pusher. A pre-dilation valvuloplasty procedure may also be utilized.

    摘要翻译： 用于将假体心脏瓣膜递送至主动脉瓣环的输送系统。 该系统包括具有其上的转向机构的输送导管，用于通过穿过其顶点进入左心室的导引器以顺行方式将球囊可扩张的假体心脏瓣膜递送至主动脉环。 导引器可以具有比近端部分更软的远侧部分，以减少对心脏壁的创伤。 输送导管包括刚好靠近远端气囊的偏转部分，以便于假体心脏瓣膜位于环形空间内的正确取向。 导管手柄中的触发器可以联接到致动偏转段的偏转线，而手柄中的滑块控制阀推动器的缩回。 还可以使用预扩张瓣膜成形术程序。

    TRANSAPICAL DELIVERY SYSTEM FOR HEART VALVES
    4.
    发明申请
    TRANSAPICAL DELIVERY SYSTEM FOR HEART VALVES 有权
    用于心脏瓣膜的通用输送系统

    公开(公告)号：US20110015728A1

    公开(公告)日：2011-01-20

    申请号：US12835546

    申请日：2010-07-13

    申请人： Teodoro S. Jimenez ,  Walter Lee ,  Mark Dehdashtian ,  Kristopher Yee

    发明人： Teodoro S. Jimenez ,  Walter Lee ,  Mark Dehdashtian ,  Kristopher Yee

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2427 ,  A61F2/24 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/243 ,  A61F2/2433 ,  A61F2220/0016 ,  A61F2220/005 ,  A61M25/0133 ,  A61M25/0136 ,  A61M25/0138 ,  A61M25/0141 ,  A61M25/0144 ,  A61M25/0147 ,  A61M2025/015

    摘要： A delivery system and method for delivering a prosthetic heart valve to the aortic valve annulus. The system includes a delivery catheter having a steering mechanism thereon for delivering a balloon-expandable prosthetic heart valve to the aortic annulus in an antegrade fashion through an introducer passing into the left ventricle through its apex. The introducer may have a more floppy distal section than a proximal section to reduce trauma to the heart wall while preserving good operating field stability. The delivery catheter includes a deflecting segment just proximal to a distal balloon to facilitate positioning of the prosthetic heart valve in the proper orientation within the aortic annulus. A trigger in a catheter handle may be coupled to a deflection wire that actuates the deflecting segment, while a slider in the handle controls retraction of a valve pusher. The prosthetic heart valve may be installed over the existing calcified leaflets, and a pre-dilation valvuloplasty procedure may also be utilized.

    摘要翻译： 用于将假体心脏瓣膜递送到主动脉瓣环的输送系统和方法。 该系统包括具有其上的转向机构的输送导管，用于通过穿过其顶点进入左心室的导引器以顺行方式将球囊可扩张的假体心脏瓣膜递送至主动脉环。 导引器可以具有比近端部分更软的远侧部分，以减少对心脏壁的创伤，同时保持良好的操作场稳定性。 输送导管包括刚好靠近远端气囊的偏转部分，以便于在主动脉瓣环内的正确取向中定位假体心脏瓣膜。 导管手柄中的触发器可以联接到致动偏转段的偏转线，而手柄中的滑块控制阀推动器的缩回。 假体心脏瓣膜可以安装在现有的钙化小叶上，并且还可以使用预扩张瓣膜成形术程序。

    Recombinant polymerases for improved single molecule sequencing
    7.
    发明授权
    Recombinant polymerases for improved single molecule sequencing 有权
    用于改进单分子测序的重组聚合酶

    公开(公告)号：US08999676B2

    公开(公告)日：2015-04-07

    申请号：US13176697

    申请日：2011-07-05

    申请人： Robin Emig ,  Lei Jia ,  Satwik Kamtekar ,  Erik Miller ,  Colleen Cutcliffe ,  Walter Lee

    发明人： Robin Emig ,  Lei Jia ,  Satwik Kamtekar ,  Erik Miller ,  Colleen Cutcliffe ,  Walter Lee

    IPC分类号： C12N15/54 ,  C12N9/00 ,  C12N9/12 ,  C12Q1/68

    CPC分类号： C12N9/1252 ,  C12N9/1241 ,  C12P19/34 ,  C12Q1/6869

    摘要： Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties can include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template.

    摘要翻译： 提供了包含重组DNA聚合酶的组合物，其包括赋予聚合酶修饰性质以增强单分子测序的氨基酸取代，插入，缺失和/或外源特征。 这种性质可以包括增强的金属离子配位，降低的核酸外切酶活性，在聚合酶动力学循环的一个或多个步骤中降低的反应速率，降低的支化部分，改变的辅因子选择性，增加的产率，增加的热稳定性，增加的准确度，增加的速度，增加的读长度， 等等。 还提供了编码具有上述表型的聚合酶的核酸，以及使用这种聚合酶制备DNA或顺序DNA模板的方法。

    AUTOMATED POWER CONTROL TO OPTIMIZE POWER CONSUMPTION AND IMPROVED WIRELESS CONNECTION
    8.
    发明申请
    AUTOMATED POWER CONTROL TO OPTIMIZE POWER CONSUMPTION AND IMPROVED WIRELESS CONNECTION 有权
    自动功率控制优化消耗功能和改进的无线连接

    公开(公告)号：US20100233975A1

    公开(公告)日：2010-09-16

    申请号：US12401570

    申请日：2009-03-10

    申请人： Mario Wu ,  Makoto Nakayama ,  John Guo ,  Jack Lieng ,  Walter Lee

    发明人： Mario Wu ,  Makoto Nakayama ,  John Guo ,  Jack Lieng ,  Walter Lee

    IPC分类号： H04B17/00 ,  H04B1/04

    CPC分类号： H04W52/52

    摘要： A method for automatically adjusting signal output power of a ZigBee wireless module. The method includes sending a signal with an output power from a transmitter of a ZigBee module to a receiver. The ZigBee module includes a power amplifier/low noise amplifier (PA/LNA) circuit. The output power can be adjusted between a minimum level and a maximum level. Additionally, the method includes generating a Link Quality Indicator (LQI) by the receiver based on the signal strength and returning the LQI to the ZigBee module. If the LQI is not within a predetermined range between a maximum value and a minimum value, the method includes adjusting the output power for sending next signal. If the output power from the transmitter has reached to the minimum level or the maximum level, the method further includes adjusting the PA/LNA circuit of the ZigBee module for maintaining the LQI within the predetermined range.

    摘要翻译： 一种自动调整ZigBee无线模块信号输出功率的方法。 该方法包括将来自ZigBee模块的发射机的输出功率的信号发送到接收机。 ZigBee模块包括功率放大器/低噪声放大器（PA / LNA）电路。 输出功率可以在最小电平和最大电平之间进行调整。 此外，该方法包括基于信号强度由接收机生成链路质量指示符（LQI），并将LQI返回给ZigBee模块。 如果LQI不在最大值和最小值之间的预定范围内，则该方法包括调整用于发送下一个信号的输出功率。 如果来自发射机的输出功率达到最小电平或最大电平，则该方法还包括调整ZigBee模块的PA / LNA电路，以将LQI保持在预定范围内。

    Foldable/collapsible structures
    9.
    发明申请
    Foldable/collapsible structures 有权

    公开(公告)号：US20060162670A1

    公开(公告)日：2006-07-27

    申请号：US11387174

    申请日：2006-03-23

    申请人： Glen Axelrod ,  Walter Lee

    发明人： Glen Axelrod ,  Walter Lee

    IPC分类号： A01K1/03

    CPC分类号： A01K1/0245 ,  A01K1/033

    摘要： The present invention relates to a collapsible/foldable structure suitable for a variety of applications, such as an animal shelter, pet carrier transportation device, or a collapsible consumer storage container in general, such as a cooler or ice chest. The structure comprises a top roof and a bottom platform defining a top and bottom of said structure and a vertically disposed lower side section on said bottom platform. Front and rear walls are included. The structure also includes a pair of sidewalls each pivotally attached to the roof to facilitate inward collapse of the sidewalls when the sidewalls are pivoted toward the bottom platform. The sidewalls are defined by an upper and middle section including the lower vertically disposed side section, wherein the upper and middle sections are pivotally attached to one another and the middle and lower sections are pivotally attached to one another so that the upper and middle sidewall sections can be pivoted inwardly towards said bottom platform, to provide a compact collapsed condition.

    Foldable/collapsible structures
    10.
    发明授权
    Foldable/collapsible structures 有权
    可折叠/可折叠结构

    公开(公告)号：US07025019B2

    公开(公告)日：2006-04-11

    申请号：US11069429

    申请日：2005-03-01

    申请人： Glen Axelrod ,  Walter Lee

    发明人： Glen Axelrod ,  Walter Lee

    IPC分类号： A01K1/00

    CPC分类号： A01K1/0245 ,  A01K1/033

    摘要： The present invention relates to a collapsible/foldable structure suitable for a variety of applications, such as an animal shelter, pet carrier transportation device, or a collapsible consumer storage container in general, such as a cooler or ice chest. The structure comprises a top roof and a bottom platform defining a top and bottom of said structure and a vertically disposed lower side section on said bottom platform. Front and rear walls are included. The structure also includes a pair of sidewalls each pivotally attached to the roof to facilitate inward collapse of the sidewalls when the sidewalls are pivoted toward the bottom platform. The sidewalls are defined by an upper and middle section including the lower vertically disposed side section, wherein the upper and middle sections are pivotally attached to one another and the middle and lower sections are pivotally attached to one another so that the upper and middle sidewall sections can be pivoted inwardly towards said bottom platform, to provide a compact collapsed condition.

    摘要翻译： 本发明涉及一种适用于各种应用的可折叠/可折叠结构，例如动物庇护所，宠物承运人运输装置或通常的可折叠消费者存储容器，例如冷却器或冰箱。 该结构包括顶部顶部和底部平台，该底部平台限定所述结构的顶部和底部以及在所述底部平台上的垂直设置的下侧部分。 包括前后墙。 该结构还包括一对侧壁，每个侧壁各自枢转地附接到屋顶，以便当侧壁朝向底部平台枢转时便于侧壁的向内折叠。 侧壁由包括下垂直设置的侧部的上部和中部限定，其中上部和中部彼此枢转地附接，并且中部和下部彼此枢转地附接，使得中部和中部侧壁部 可以朝向所述底部平台向内枢转，以提供紧凑的折叠状态。