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公开(公告)号：USD976407S1
公开(公告)日：2023-01-24
申请号：US29735730
申请日：2020-05-22
申请人： Tepha, Inc.
设计人： Skander Limem , Said Rizk , Simon F. Williams
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公开(公告)号：US11407168B2
公开(公告)日：2022-08-09
申请号：US16437704
申请日：2019-06-11
申请人： Tepha, Inc.
发明人： Skander Limem , Reshad Bin Harun , Matthew Dubois , David P. Martin , Said Rizk
IPC分类号： B29C64/118 , B29C64/321 , B29C64/153 , B29C64/295 , B29C64/209 , B29C64/393 , B29C64/227 , B29C64/268 , A61L27/14 , A61L29/06 , B33Y10/00 , B33Y30/00 , B33Y50/02 , B33Y70/00 , B29K67/00
摘要： Methods to fabricate objects by 3D printing of poly-4-hydroxybutyrate (P4HB) and copolymers thereof have been developed. In one method, these objects are produced by continuous fused filament fabrication using an apparatus and conditions that overcome the problems of poor feeding of the filament resulting from the low softening temperature of the filament and heat creep along the fed filament. Methods using an apparatus including a heat sink, a melt tube, a heating block and nozzle, and a transition zone between the heat sink and heating block, with the melt tube extending through the heat sink, transition zone, and heat block to the nozzle are disclosed. 3D objects are also printed by fused pellet deposition (FPD), melt extrusion deposition (MED), selective laser melting (SLM), printing of slurries and solutions using a coagulation bath, and printing using a binding solution and polymer granules.
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公开(公告)号：US11291539B2
公开(公告)日：2022-04-05
申请号：US16195144
申请日：2018-11-19
申请人： Tepha, Inc.
发明人： Skander Limem , Fabio Felix , Said Rizk , David P. Martin , Simon F. Williams
摘要： Implants with fillable reservoirs have been developed that are suitable for rhinoplasty, breast reconstruction, ear reconstruction, and replacement, reconstruction or repair of other soft tissues. The implants can be filled with graft material prior to implantation. The implants are preferably made from resorbable polymers, can be tailored to provide different geometries, mechanical properties and resorption rates in order to provide more consistent surgical outcomes. The implants preferably have an interconnected network of unit cells with microporous outer layers and optionally some or all of the unit cells having at least one macropore in their outer layers. The implants can be loaded by injection with microfat, collagen, DCF, cells, bioactive agents, and other augmentation materials, prior to implantation.
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公开(公告)号：US20220096716A1
公开(公告)日：2022-03-31
申请号：US17482063
申请日：2021-09-22
申请人： Tepha, Inc.
发明人： Said Rizk , David P. Martin , Fabio Felix , Matthew Bernasconi , Bhavin Shah , Simon F. Williams
摘要： Methods to produce laminates including layers of constructs made from P4HB and copolymers thereof have been developed. These laminates may be used as medical implants, or further processed to make medical implants. The laminates are produced at a temperature equal to or greater than the softening points of the P4HB or copolymers thereof. The layers may include oriented forms of the constructs. Orientation can be preserved during lamination so that the laminate is also oriented, when the laminates are formed at temperatures less than the de-orientation temperatures of the layers. The laminate layers may include, for example, films, textiles, including woven, knitted, braided and non-woven textiles, foams, thermoforms, and fibers. The laminates preferably include one or more oriented P4HB films.
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公开(公告)号：US20220079742A1
公开(公告)日：2022-03-17
申请号：US17486886
申请日：2021-09-27
申请人： Tepha, Inc.
发明人： Skander Limem , Said Rizk , Simon F. Williams
摘要： Full contour absorbable implants for breast surgery redistribute breast volume between the breast's upper and lower poles in exact and desirable ratios. The implants preferably redistribute breast volume so that the upper pole breast volume is 20-40% of the total volume, and the lower pole breast volume is 60-80% of the total volume. The implants are also designed to provide specific curvatures to the poles of the breast, and to angulate the nipple areolar complex slightly skyward so that the patient's nipple is positioned at an angle above the nipple meridian reference line. The implants are designed to be transitory, with sufficient strength retention to allow transition from support of the breast by the implant to support by regenerated host tissue growing in and around the implants, without any significant loss of support during or subsequent to remodeling. The implants may optionally be used with permanent breast implants.
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公开(公告)号：US11160898B2
公开(公告)日：2021-11-02
申请号：US16209299
申请日：2018-12-04
申请人： Tepha, Inc.
发明人： David P. Martin , Said Rizk
IPC分类号： B29C51/04 , A61L15/26 , A61L27/18 , A61L27/54 , A61L31/16 , A61L27/48 , B29C51/00 , A61L29/12 , A61L31/06 , A61L31/12 , B29C51/42 , A61L29/06 , B29C51/10 , B29L31/00
摘要： Methods to produce thermoformed implants comprising poly-4-hydroxybutyrate homopolymer, copolymer, or blend thereof, including surgical meshes, have been developed. These thermoforms are preferably produced from porous substrates of poly-4-hydroxybutyrate homopolymer or copolymer thereof, such as surgical meshes, by vacuum membrane thermoforming. The porous thermoformed implant is formed by placing a porous substrate of poly-4-hydroxybutyrate homopolymer or copolymer thereof over a mold, covering the substrate and mold with a membrane, applying a vacuum to the membrane so that the membrane and substrate are drawn down on the mold and tension is applied to the substrate, and heating the substrate while it is under tension to form the thermoform. The method is particularly useful in forming medical implants of poly-4-hydroxybutyrate and copolymers thereof, including hernia meshes, mastopexy devices, breast reconstruction devices, and implants for plastic surgery, without exposing the resorbable implants to water and without shrinking the porous substrate during molding.
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公开(公告)号：US20210186702A1
公开(公告)日：2021-06-24
申请号：US17116940
申请日：2020-12-09
申请人： Tepha, Inc.
摘要： Devices to repair bone defects prevent the formation of depressions and palpable tissue at bone repair sites. The devices can be used to repair burr holes in the cranium, providing an improved cosmetic result that reduces or eliminates functional handicaps that can result from combing and hairdressing. The devices are secured in bone defects with filament elements, by expanding the device inside the bone defect, or by gluing. Tissue in-growth into the device regenerates bone at the defect site, and prevents the formation of depressions or palpable tissue. The devices preferably comprise a ceramic and poly-4-hydroxybutyrate or copolymer thereof, or a ceramic and poly(butylene succinate) or copolymer thereof.
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公开(公告)号：US20200276006A1
公开(公告)日：2020-09-03
申请号：US16797960
申请日：2020-02-21
申请人： Tepha, Inc.
发明人： Fabio Felix , Antonio Fosco , David P. Martin , Arikha Moses , Bruce Van Natta , Said Rizk , Simon F. Williams
IPC分类号： A61F2/00 , B29C48/05 , B29C48/25 , A61L27/50 , A61L27/56 , A61L27/58 , D04H1/728 , A61F2/12 , D04H13/00 , A61F2/52 , A61L31/14
摘要： Absorbable implants for breast surgery that conform to the breast parenchyma and surrounding chest wall have been developed. These implants support newly lifted breast parenchyma, and/or a breast implant. The implants have mechanical properties sufficient to support a reconstructed breast, and allow the in-growth of tissue into the implant as it degrades. The implants have a strength retention profile allowing the support of the breast to be transitioned from the implant to regenerated host tissue, without significant loss of support. Three-dimensional implants for use in minimally invasive mastopexy/breast reconstruction procedures are also described, that confer shape to a patient's breast. These implants are self-reinforced, can be temporarily deformed, implanted in a suitably dissected tissue plane, and resume their preformed three-dimensional shape. The implants are preferably made from poly-4-hydroxybutyrate (P4HB) and copolymers thereof. The implants have suture pullout strengths that can resist the mechanical loads exerted on the reconstructed breast.
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公开(公告)号：USD889655S1
公开(公告)日：2020-07-07
申请号：US29636699
申请日：2018-02-09
申请人： Tepha, Inc.
设计人： Skander Limem , Said Rizk , Simon F. Williams
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10.发明申请公开(公告)号：US20190269816A1
公开(公告)日：2019-09-05
申请号：US16290727
申请日：2019-03-01
申请人： Tepha, Inc.
发明人： Simon F. Williams , Said Rizk , David P. Martin
摘要： Resorbable implants comprising poly(butylene succinate) and copolymers thereof have been developed. The implants implants are preferably sterilized, and contain less than 20 endotoxin units per device as determined by the limulus amebocyte lysate (LAL) assay, and are particularly suitable for use in procedures where prolonged strength retention is necessary, and can include one or more bioactive agents. The implants may be made from fibers and meshes of poly(butylene succinate) and copolymers thereof, or by 3d printing, and the fibers may be oriented. Coverings and receptacles made from forms of poly(butylene succinate) and copolymers thereof have also been developed for use with cardiac rhythm management devices and other implantable devices. These coverings and receptacles may be used to hold, or partially/fully cover, devices such as pacemakers and neurostimulators. The coverings and receptacles are made from meshes, webs, lattices, non-wovens, films, fibers, and foams, and contain antibiotics such as rifampin and minocycline.
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