公开(公告)号：US20240130854A1

公开(公告)日：2024-04-25

申请号：US18538903

申请日：2023-12-13

Applicant: Tepha, Inc.

Inventor： Skander Limem ,  Fabio Felix ,  Said Rizk ,  David P. Martin ,  Simon F. Williams

IPC: A61F2/18 ,  A61F2/00 ,  A61L27/54 ,  A61L27/58

CPC classification number: A61F2/186 ,  A61F2/0059 ,  A61L27/54 ,  A61L27/58 ,  A61F2/12 ,  A61F2002/183 ,  A61F2250/0003

Abstract: Implants with fillable reservoirs have been developed that are suitable for rhinoplasty, breast reconstruction, ear reconstruction, and replacement, reconstruction or repair of other soft tissues. The implants can be filled with graft material prior to implantation. The implants are preferably made from resorbable polymers, can be tailored to provide different geometries, mechanical properties and resorption rates in order to provide more consistent surgical outcomes. The implants preferably have an interconnected network of unit cells with microporous outer layers and optionally some or all of the unit cells having at least one macropore in their outer layers. The implants can be loaded by injection with microfat, collagen, DCF, cells, bioactive agents, and other augmentation materials, prior to implantation.

公开(公告)号：US20240052528A1

公开(公告)日：2024-02-15

申请号：US18491647

申请日：2023-10-20

Applicant: Tepha, Inc.

Inventor： Amit Ganatra ,  Fabio Felix ,  Bhavin Shah ,  Matthew Bernasconi ,  Said Rizk ,  David P. Martin ,  Simon F. Williams

IPC: D01F6/62 ,  A61L17/10 ,  A61L31/06 ,  A61L31/14 ,  B29C55/00 ,  D01F8/14 ,  D01D5/08 ,  D02G3/04

CPC classification number: D01F6/625 ,  A61L17/105 ,  A61L31/06 ,  A61L31/148 ,  B29C55/005 ,  D01F8/14 ,  D01D5/08 ,  D02G3/04 ,  B29K2073/00

Abstract: Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawirg the multifilament, yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.

公开(公告)号：US11291539B2

公开(公告)日：2022-04-05

申请号：US16195144

申请日：2018-11-19

Applicant: Tepha, Inc.

Inventor： Skander Limem ,  Fabio Felix ,  Said Rizk ,  David P. Martin ,  Simon F. Williams

IPC: A61F2/18 ,  A61F2/00 ,  A61L27/54 ,  A61L27/58 ,  A61F2/12

Abstract: Implants with fillable reservoirs have been developed that are suitable for rhinoplasty, breast reconstruction, ear reconstruction, and replacement, reconstruction or repair of other soft tissues. The implants can be filled with graft material prior to implantation. The implants are preferably made from resorbable polymers, can be tailored to provide different geometries, mechanical properties and resorption rates in order to provide more consistent surgical outcomes. The implants preferably have an interconnected network of unit cells with microporous outer layers and optionally some or all of the unit cells having at least one macropore in their outer layers. The implants can be loaded by injection with microfat, collagen, DCF, cells, bioactive agents, and other augmentation materials, prior to implantation.

公开(公告)号：US20220096716A1

公开(公告)日：2022-03-31

申请号：US17482063

申请日：2021-09-22

Applicant: Tepha, Inc.

Inventor： Said Rizk ,  David P. Martin ,  Fabio Felix ,  Matthew Bernasconi ,  Bhavin Shah ,  Simon F. Williams

IPC: A61L31/06 ,  A61L27/18 ,  A61L31/14 ,  A61L31/16 ,  B29C43/28 ,  C08G63/06

Abstract: Methods to produce laminates including layers of constructs made from P4HB and copolymers thereof have been developed. These laminates may be used as medical implants, or further processed to make medical implants. The laminates are produced at a temperature equal to or greater than the softening points of the P4HB or copolymers thereof. The layers may include oriented forms of the constructs. Orientation can be preserved during lamination so that the laminate is also oriented, when the laminates are formed at temperatures less than the de-orientation temperatures of the layers. The laminate layers may include, for example, films, textiles, including woven, knitted, braided and non-woven textiles, foams, thermoforms, and fibers. The laminates preferably include one or more oriented P4HB films.

公开(公告)号：US20200276006A1

公开(公告)日：2020-09-03

申请号：US16797960

申请日：2020-02-21

Applicant: Tepha, Inc.

Inventor： Fabio Felix ,  Antonio Fosco ,  David P. Martin ,  Arikha Moses ,  Bruce Van Natta ,  Said Rizk ,  Simon F. Williams

IPC: A61F2/00 ,  B29C48/05 ,  B29C48/25 ,  A61L27/50 ,  A61L27/56 ,  A61L27/58 ,  D04H1/728 ,  A61F2/12 ,  D04H13/00 ,  A61F2/52 ,  A61L31/14

Abstract: Absorbable implants for breast surgery that conform to the breast parenchyma and surrounding chest wall have been developed. These implants support newly lifted breast parenchyma, and/or a breast implant. The implants have mechanical properties sufficient to support a reconstructed breast, and allow the in-growth of tissue into the implant as it degrades. The implants have a strength retention profile allowing the support of the breast to be transitioned from the implant to regenerated host tissue, without significant loss of support. Three-dimensional implants for use in minimally invasive mastopexy/breast reconstruction procedures are also described, that confer shape to a patient's breast. These implants are self-reinforced, can be temporarily deformed, implanted in a suitably dissected tissue plane, and resume their preformed three-dimensional shape. The implants are preferably made from poly-4-hydroxybutyrate (P4HB) and copolymers thereof. The implants have suture pullout strengths that can resist the mechanical loads exerted on the reconstructed breast.

公开(公告)号：USD803401S1

公开(公告)日：2017-11-21

申请号：US29524761

申请日：2015-04-23

Applicant: Tepha, Inc.

Designer： Skander Limem ,  Emily Stires ,  Rebecca Marciante ,  Said Rizk ,  Arikha Moses ,  Fabio Felix ,  Bruce Van Natta

公开(公告)号：US20170081784A1

公开(公告)日：2017-03-23

申请号：US15368922

申请日：2016-12-05

Applicant: Tepha, Inc.

Inventor： Amit Ganatra ,  Fabio Felix ,  Bhavin Shah ,  Matthew Bernasconi ,  Said Rizk ,  David P. Martin ,  Simon F. Williams

IPC: D01F6/62 ,  A61L31/06 ,  B29C55/00 ,  D02G3/04 ,  D01D5/08 ,  A61L17/10 ,  A61L31/14

CPC classification number: D01F6/625 ,  A61L17/105 ,  A61L31/06 ,  A61L31/148 ,  B29C55/005 ,  B29K2073/00 ,  B29K2673/00 ,  B29L2031/731 ,  D01D5/08 ,  D01F8/14 ,  D02G3/04 ,  D10B2331/04 ,  D10B2331/041 ,  D10B2401/063 ,  D10B2509/04 ,  D10B2509/08

Abstract: Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo. The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications.

公开(公告)号：US09511169B2

公开(公告)日：2016-12-06

申请号：US14279665

申请日：2014-05-16

Applicant: Tepha, Inc.

Inventor： Kai Guo ,  Fabio Felix ,  David P. Martin

IPC: A61L27/18 ,  D04H1/42 ,  A61L27/54 ,  A61L29/06 ,  A61L29/16 ,  A61L31/06 ,  A61L31/16 ,  D04H1/56 ,  D04H3/16 ,  D04H1/435 ,  D04H1/76 ,  D04H3/11 ,  D04H1/4382

CPC classification number: A61L27/18 ,  A61L27/54 ,  A61L29/06 ,  A61L29/16 ,  A61L31/06 ,  A61L31/16 ,  D04H1/42 ,  D04H1/435 ,  D04H1/4382 ,  D04H1/56 ,  D04H1/76 ,  D04H3/11 ,  D04H3/16 ,  Y10T442/60 ,  C08L67/04

Abstract: Continuous processing methods are used for making absorbable polymeric non-wovens, with anisotropic properties, improved mechanical properties and without substantial loss of polymer molecular weight during processing. The method includes producing dry spun-non wovens from a polymer, and collecting the fibers using a rotating collector plate, preferably a rotating cylinder, to collect the non-woven instead of a fiberglass stationary collector plate. The non-wovens can be used for a variety of purposes including fabrication of medical devices.

Abstract translation: 连续加工方法用于制造可吸收聚合无纺布，具有各向异性特性，改进的机械性能，并且在加工过程中基本上不损失聚合物分子量。 该方法包括从聚合物中生产干燥纺丝非织造织物，并使用旋转收集板（优选旋转圆筒）收集纤维，以收集无纺布而不是玻璃纤维固定收集板。 无纺布可以用于各种目的，包括制造医疗装置。

公开(公告)号：US20150057368A1

公开(公告)日：2015-02-26

申请号：US14464099

申请日：2014-08-20

Applicant: TEPHA, INC.

Inventor： Dennis Connelly ,  Fabio Felix ,  David P. Martin ,  Jon Montcrieff ,  Said Rizk ,  Simon F. Williams

IPC: C08J9/12 ,  C08G63/06 ,  A61K47/34 ,  A61K9/12 ,  A61L31/14 ,  A61L15/26 ,  A61L27/18 ,  A61L31/06 ,  A61L15/42 ,  A61L27/56 ,  C08L67/04 ,  A61L26/00

Abstract: Methods to produce substantially closed cell foams with densities less than 0.75 g/cm3, and more preferably less than 0.5 g/cm3, without substantial loss of the polymer's weight average molecular weight, have been developed. The closed cells foams have an open cell content of generally less than 50%, and more preferably an open cell content of less than 20%, and the cells have a maximum diameter of less than 5 mm. The foam may include poly-4-hydroxybutyrate or a copolymer thereof. Preferably, the foam is derived by heating a foam polymer formula to a temperature above the melt temperature of the polymer to form a melt polymer system, adding a blowing agent to produce a foamable melt, extruding the foamable melt through a die to a lower pressure to cause foaming, cooling of the foam, and solidification of the foam. These foam structures can be used for fabrication of medical products.

Abstract translation: 已经开发了生产密度小于0.75g / cm 3，更优选小于0.5g / cm 3的基本上闭合的泡孔的方法，而基本上不损失聚合物的重均分子量。 闭孔泡沫具有通常小于50％的开孔含量，更优选开细胞含量小于20％，细胞的最大直径小于5mm。 泡沫可以包括聚-4-羟基丁酸酯或其共聚物。 优选地，通过将​​泡沫聚合物配方加热到高于聚合物熔体温度的温度得到泡沫，以形成熔体聚合物体系，加入发泡剂以产生可发泡的熔体，将可发泡的熔体通过模头挤出到较低的压力 以引起发泡，泡沫的冷却和泡沫体的固化。 这些泡沫结构可用于制造医疗产品。

公开(公告)号：US11883279B2

公开(公告)日：2024-01-30

申请号：US17679995

申请日：2022-02-24

Applicant: Tepha, Inc.

Inventor： Skander Limem ,  Fabio Felix ,  Said Rizk ,  David P. Martin ,  Simon F. Williams

IPC: A61F2/18 ,  A61F2/00 ,  A61L27/54 ,  A61L27/58 ,  A61F2/12

CPC classification number: A61F2/186 ,  A61F2/0059 ,  A61L27/54 ,  A61L27/58 ,  A61F2/12 ,  A61F2002/183 ,  A61F2210/0061 ,  A61F2250/0003

Abstract: Implants with fillable reservoirs have been developed that are suitable for rhinoplasty, breast reconstruction, ear reconstruction, and replacement, reconstruction or repair of other soft tissues. The implants can be filled with graft material prior to implantation. The implants are preferably made from resorbable polymers, can be tailored to provide different geometries, mechanical properties and resorption rates in order to provide more consistent surgical outcomes. The implants preferably have an interconnected network of unit cells with microporous outer layers and optionally some or all of the unit cells having at least one macropore in their outer layers. The implants can be loaded by injection with microfat, collagen, DCF, cells, bioactive agents, and other augmentation materials, prior to implantation.