-
公开(公告)号：US20070275998A1
公开(公告)日：2007-11-29
申请号：US11752015
申请日：2007-05-22
IPC分类号： A61K31/445 , A61K31/655 , C07D211/54
CPC分类号： C07D211/48 , C07D211/46
摘要： A compound of Formula I are provided: wherein R is: R1 is a substituted or unsubstituted alkyl group; W1-4 are independently selected from hydrogen, substituted or unsubstituted alkyl groups, substituted or unsubstituted haloalkyl groups, substituted or unsubstituted alkanoyl groups, substituted or unsubstituted aroyl groups, or substituted or unsubstituted haloalkanoyl groups; X1-5 are independently selected from H, NO2, N3, and NH2;Y is absent or is a substituted or unsubstituted C1-alkyl group, other than carbonyl; Z is selected from a bond or NH, provided that when Z is a bond, Y is absent, and provided that when Z is NH, Y is a substituted or unsubstituted C1-alkyl group, other than carbonyl. Also provided are D-arabinitol compounds, methods for preparing such compounds and compositions of such compounds, and methods of using such compounds.
摘要翻译： 提供式I化合物：其中R是：R 1是取代或未取代的烷基; 取代或未取代的烷基，取代或未取代的烷基，取代或未取代的烷酰基，取代或未取代的芳酰基，或取代或未取代的卤代烷酰基; X 1-5独立地选自H，NO 2，N 3和NH 2; Y是 不存在或是不是羰基的取代或未取代的C 1 - 烷基; Z选自键或NH，条件是当Z为键时，Y不存在，条件是当Z为NH时，Y为取代或未取代的C 1 - 烷基，除 羰。 还提供了D-阿拉伯糖醇化合物，制备这些化合物的方法和这些化合物的组合物，以及使用这些化合物的方法。
-
公开(公告)号：US20100137365A1
公开(公告)日：2010-06-03
申请号：US12656370
申请日：2010-01-28
申请人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W.J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
发明人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W.J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
IPC分类号： A61K31/445 , A61P31/12 , A61P31/14 , C07D211/46 , C07D207/12 , C07C237/42 , A61K31/402 , A61K31/166
CPC分类号： A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
摘要翻译： 描述了长链N-烷基氨基和亚氨基化合物，其氧杂取代的衍生物和包括这些化合物的药物组合物。 长链N-烷基是C8-C16烷基。 长链N-烷基化合物及其氧杂取代的衍生物可用于治疗细胞或个体中的病毒感染，特别是乙型肝炎病毒或丙型肝炎病毒。 例如，长链N-烷基化合物或其氧杂取代的衍生物可衍生自哌啶，吡咯烷，苯胺，吡啶，吡咯或氨基酸。
-
公开(公告)号：US08450345B2
公开(公告)日：2013-05-28
申请号：US12656992
申请日：2010-02-22
IPC分类号： A61K31/445 , A61P31/20
CPC分类号： A61K31/70 , A61K31/445 , A61K31/665 , Y02A50/385
摘要： Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using iminosugars.
-
4.发明授权
公开(公告)号：US5786369A
公开(公告)日：1998-07-28
申请号：US650558
申请日：1996-05-20
IPC分类号： A61K31/131 , A61K31/445 , C07D211/46
CPC分类号： A61K31/131 , C07D211/46
摘要： A method is disclosed for inhibiting the surface expression of glycolipid receptors for bacteria by subjecting bacteria cells to an inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.
摘要翻译： 公开了通过使细菌细胞抑制有效量的1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇的N-烷基衍生物来抑制细菌的糖脂受体表面表达的方法，其中所述烷基含 2-8个碳原子。
-
公开(公告)号：US08975280B2
公开(公告)日：2015-03-10
申请号：US11752015
申请日：2007-05-22
IPC分类号： A61K31/445 , C07D211/48 , C07D211/46
CPC分类号： C07D211/48 , C07D211/46
摘要： A compound of Formula I are provided: wherein R is: R1 is a substituted or unsubstituted alkyl group; W1-4 are independently selected from hydrogen, substituted or unsubstituted alkyl groups, substituted or unsubstituted haloalkyl groups, substituted or unsubstituted alkanoyl groups, substituted or unsubstituted aroyl groups, or substituted or unsubstituted haloalkanoyl groups; X1-5 are independently selected from H, NO2, N3, and NH2; Y is absent or is a substituted or unsubstituted C1-alkyl group, other than carbonyl; Z is selected from a bond or NH, provided that when Z is a bond, Y is absent, and provided that when Z is NH, Y is a substituted or unsubstituted C1-alkyl group, other than carbonyl. Also provided are D-arabinitol compounds, methods for preparing such compounds and compositions of such compounds, and methods of using such compounds.
摘要翻译： 提供式I化合物：其中R是：R 1是取代或未取代的烷基; 取代或未取代的烷基，取代或未取代的烷酰基，取代或未取代的烷酰基，取代或未取代的芳酰基，或取代或未取代的卤代烷酰基; X1-5独立地选自H，NO2，N3和NH2; Y不存在或是除羰基以外的取代或未取代的C 1 - 烷基; Z选自键或NH，条件是当Z为键时，Y不存在，条件是当Z为NH时，Y为除羰基以外的取代或未取代的C 1 - 烷基。 还提供了D-阿拉伯糖醇化合物，制备这些化合物的方法和这些化合物的组合物，以及使用这些化合物的方法。
-
公开(公告)号：US20110065753A1
公开(公告)日：2011-03-17
申请号：US12873705
申请日：2010-09-01
IPC分类号： A61K31/445 , A61P31/20 , C12N5/02
CPC分类号： A61K31/445 , A61K31/452 , C07D211/46
摘要： Provided are methods of treating a disease or condition caused by or associated with a virus belonging to the Poxyiridae family using iminosugars, such as DNJ derivatives.
摘要翻译： 本发明提供了使用亚氨基糖类（例如DNJ衍生物）治疗由属于Poxyiridae家族的病毒引起或与之有关的疾病或病症的方法。
-
公开(公告)号：US07816560B1
公开(公告)日：2010-10-19
申请号：US10031145
申请日：2000-08-10
申请人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
发明人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
IPC分类号： C07C211/00 , C07C303/00 , C07C307/00 , C07C309/00
CPC分类号： A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
摘要翻译： 描述了长链N-烷基氨基和亚氨基化合物，其氧杂取代的衍生物和包括这些化合物的药物组合物。 长链N-烷基是C8-C16烷基。 长链N-烷基化合物及其氧杂取代的衍生物可用于治疗细胞或个体中的病毒感染，特别是乙型肝炎病毒或丙型肝炎病毒。 例如，长链N-烷基化合物或其氧杂取代的衍生物可衍生自哌啶，吡咯烷，苯胺，吡啶，吡咯或氨基酸。
-
公开(公告)号：US5472969A
公开(公告)日：1995-12-05
申请号：US321718
申请日：1994-10-12
IPC分类号： A61K31/131 , A61K31/445 , C07D211/46
CPC分类号： A61K31/131 , C07D211/46
摘要： A method is disclosed for inhibiting the biosynthesis of glycolipids in cells capable of producing glycolipids comprising subjecting said cells to a glycolipid inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-glucitol in which said alkyl contains from 2-8 carbon atoms.
摘要翻译： 公开了一种抑制能够产生糖脂的细胞中糖脂生物合成的方法，包括使所述细胞经受糖脂抑制有效量的1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇的N-烷基衍生物，其中 所述烷基含有2-8个碳原子。
-
公开(公告)号：US20110065752A1
公开(公告)日：2011-03-17
申请号：US12873704
申请日：2010-09-01
IPC分类号： A61K31/445 , A61P31/14 , C12N5/02
CPC分类号： A61K31/445 , A61K31/655 , C07D211/46
摘要： Provided are novel iminosugars and methods of treating and/or preventing a disease or condition caused by or associated with a virus belonging to the Orthomyxoviridae family using iminosugars, such as DNJ derivatives.
摘要翻译： 提供了新的亚氨基糖苷以及使用亚氨基二糖如DNJ衍生物治疗和/或预防由属于正粘病毒科的病毒引起或与之相关的疾病或病症的方法。
-
公开(公告)号：US20100222384A1
公开(公告)日：2010-09-02
申请号：US12656993
申请日：2010-02-22
IPC分类号： A61K31/445 , A61P31/12
CPC分类号： A61K31/445
摘要： Provided are methods of treating a disease or condition caused by or associated with a virus belonging to the Arenaviridae family using iminosugars, such as DNJ derivatives.
摘要翻译： 本发明提供了使用亚氨基二糖（例如DNJ衍生物）治疗由属于该病毒属（Arenaviridae）家族的病毒引起或与之相关的疾病或病症的方法。
-
-
-
-
-
-
-
-
-
搜索结果
29 条记录 (耗时 0.033 秒)
