公开(公告)号：US20070287147A1

公开(公告)日：2007-12-13

申请号：US10599367

申请日：2005-03-02

申请人： Teruyuki Nagamune ,  Akihiko Tajima ,  Yutaka Yamagata ,  Hiroyoshi Aoki

发明人： Teruyuki Nagamune ,  Akihiko Tajima ,  Yutaka Yamagata ,  Hiroyoshi Aoki

IPC分类号： C12Q1/70 ,  G01N33/53

CPC分类号： G01N33/569 ,  C12Q1/04 ,  G01N33/54366

摘要： This invention provides a method to monitor a microorganism that causes infectious disease of a laboratory animal by using a micro flow channel chip immobilized with a molecular to be tested such as an antigen or an antibody of the microorganism that causes infectious disease, the method comprises flowing serum or body fluid taken from the laboratory animal through the minute flow channel of the micro flow channel chip and detecting the antigen antibody reaction on the chip. The method of this invention enabled medical inspection of an infectious disease of a laboratory animal and microorganism monitoring of a laboratory animal, by using minute amount of animal serum or body fluid in a closed system rapidly and sensitively.

摘要翻译： 本发明提供了一种通过使用固定有被测分子的微流通道芯片来监测引起实验动物感染性疾病的微生物的方法，例如引起感染性疾病的微生物的抗原或抗体，该方法包括流动 血清或体液通过微流通芯片的微流通道从实验室动物取出，并检测芯片上的抗原抗体反应。 本发明的方法通过在密闭系统中使用微量的动物血清或体液快速且敏感地实现实验室动物的感染性疾病和实验室动物的微生物监测。

公开(公告)号：US20070202258A1

公开(公告)日：2007-08-30

申请号：US11512355

申请日：2006-08-30

申请人： Yutaka Yamagata ,  Hitoshi Ohmori ,  Hiroshi Kase ,  Hiromi Nonaka ,  Ai Kaneko ,  Kazuya Nitta

发明人： Yutaka Yamagata ,  Hitoshi Ohmori ,  Hiroshi Kase ,  Hiromi Nonaka ,  Ai Kaneko ,  Kazuya Nitta

IPC分类号： B05D1/32 ,  C25D5/00 ,  B05C5/00

CPC分类号： B01L3/0268 ,  B01J2219/0036 ,  B01J2219/00371 ,  B01J2219/00378 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00659 ,  B01J2219/00725 ,  B01L2300/0819 ,  B01L2300/0838 ,  B01L2400/027 ,  B05B5/025 ,  B05B5/087 ,  G03F1/20 ,  G03F7/12

摘要： There is provided a micro-pattern forming apparatus including an electrospraying part for applying a voltage to a solution containing a sample to electrostatically atomizing the solution; a supporting part (30) for supporting a chip (26), on which the sample in the solution electrostatically atomized by the electrospraying part, is to be deposited; and a fine mask part (24) disposed between the electrospraying part and the supporting part, having a mask pattern for being passed through by the electrostatically atomized solution in order to form a micro-pattern of the sample upon the chip, wherein the mask pattern is made from a photoresist material with concavity and convexity on the side of the supporting part.

摘要翻译： 提供一种微图形形成装置，其包括用于向含有样品的溶液施加电压的电喷雾部件以静电雾化溶液; 用于支撑芯片（26）的支撑部分（30），在其上沉积由电喷雾部分静电雾化的溶液中的样品; 以及设置在电喷雾部分和支撑部分之间的精细掩模部分（24），具有通过静电雾化溶液通过的掩模图案，以便在芯片上形成样品的微图案，其中掩模图案 由在支撑部分的侧面上具有凹凸的光致抗蚀剂材料制成。

公开(公告)号：US06723347B1

公开(公告)日：2004-04-20

申请号：US10088142

申请日：2002-03-15

申请人： Yutaka Yamagata ,  Takayuki Doen ,  Naoki Asakawa ,  Shigeyuki Takada

发明人： Yutaka Yamagata ,  Takayuki Doen ,  Naoki Asakawa ,  Shigeyuki Takada

IPC分类号： A61K914

CPC分类号： A61K9/0024 ,  A61K9/1647 ,  A61K9/19 ,  Y10S514/964

摘要： A process for conveniently producing a stable protein powder retaining the higher-order structure at a high level which comprises freezing a protein-containing solution at a cooling rate of about −300 to −10° C./min. and then drying.

摘要翻译： 用于方便地制备以高水平保持高级结构的稳定的蛋白质粉末的方法，其包括以约-300至-10℃/分钟的冷却速率冷冻含蛋白质的溶液。 然后干燥。

公开(公告)号：US06478661B2

公开(公告)日：2002-11-12

申请号：US09794909

申请日：2001-02-28

申请人： Hitoshi Ohmori ,  Noboru Ebizuka ,  Yutaka Yamagata ,  Shinya Morita ,  Sei Moriyasu ,  Muneaki Asami

发明人： Hitoshi Ohmori ,  Noboru Ebizuka ,  Yutaka Yamagata ,  Shinya Morita ,  Sei Moriyasu ,  Muneaki Asami

IPC分类号： B24B100

CPC分类号： B24B53/001 ,  B24B13/015 ,  B24B19/028 ,  B24B53/02

摘要： A voltage is applied between a cylindrical cutting grindstone 2 that rotates about a vertical axis Y and a cylindrical truing grindstone 6 that rotates about a horizontal axis X. The vertical outer surface 2a and the horizontal lower surface 2b of the cutting grindstone are trued by a plasma discharge. Then without applying the voltage, the cutting grindstone 2 is trued mechanically by the truing grindstone 6, and while the outer periphery and lower surface of the cutting grindstone are dressed electrolytically, the outer periphery and lower surface are made to contact a workpiece 1 and process a micro-V groove. This method makes it possible to produce an immersion grating with a high resolution using hard, brittle materials such as germanium, gallium arsenide and lithium niobate.

摘要翻译： 在围绕垂直轴线Y旋转的圆筒形磨石2和围绕水平轴线X旋转的圆柱形修整磨石6之间施加电压。切割磨石的垂直外表面2a和水平下表面2b由 等离子体放电。 然后在不施加电压的情况下，通过修整磨石6机械地修整切割磨石2，并且当切割磨石的外周和下表面被电解时，使外周和下表面接触工件1和工艺 一个微V槽。 该方法使得可以使用诸如锗，砷化镓和铌酸锂的硬的脆性材料来生产具有高分辨率的浸没光栅。

公开(公告)号：US5628993A

公开(公告)日：1997-05-13

申请号：US294972

申请日：1994-08-24

申请人： Yutaka Yamagata ,  Katsumi Iga ,  Hiroaki Okada

发明人： Yutaka Yamagata ,  Katsumi Iga ,  Hiroaki Okada

IPC分类号： A61K9/14 ,  A61K9/00 ,  A61K9/16 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26 ,  A61K9/70 ,  A61K38/00 ,  A61K38/20 ,  A61K38/21 ,  A61K38/28 ,  A61K47/14 ,  A61K38/02

CPC分类号： A61K9/2013 ,  A61K38/2013 ,  A61K38/212 ,  A61K38/28 ,  A61K9/1617 ,  A61K9/70 ,  A61K9/0024

摘要： A parenteral pharmaceutical preparation comprises a matrix containing a physiologically active peptide or protein and a polyglycerol diester of a saturated fatty acid, and the matrix is in a solid form at room temperature. The molecular weight of the physiologically active peptide or protein is 2,000 dalton or more. The saturated fatty acid includes fatty acids having about 16 to 30 carbon atoms such as palmitic acid, stearic acid, etc. The matrix may be in a pillar or granular form. The parenteral pharmaceutical preparation can be used as an injectable solid administered subcutaneously or intramuscularly (for example, a pellet or tablet for implantation), a suppository or the like, and can release the physiologically active peptide or protein sustainedly for a prolonged period of one week or more.

摘要翻译： 肠胃外药物制剂包含含有生理活性肽或蛋白质的基质和饱和脂肪酸的聚甘油二酯，并且所述基质在室温下为固体形式。 生理活性肽或蛋白质的分子量为2,000道尔顿或更多。 饱和脂肪酸包括具有约16至30个碳原子的脂肪酸，例如棕榈酸，硬脂酸等。基质可以是柱状或颗粒形式。 肠胃外药物制剂可以用作皮下或肌肉内给药的可注射固体（例如，用于植入的丸粒或片剂），栓剂等，并且可以持续释放生理活性肽或蛋白质一周的长时间 或者更多。

公开(公告)号：US20120244223A1

公开(公告)日：2012-09-27

申请号：US13491887

申请日：2012-06-08

申请人： Yutaka Tanoue ,  Tetsuya Matsuura ,  Yutaka Yamagata ,  Naoki Nagahara

发明人： Yutaka Tanoue ,  Tetsuya Matsuura ,  Yutaka Yamagata ,  Naoki Nagahara

IPC分类号： A61K9/16 ,  A61P25/18 ,  A61K31/343

CPC分类号： A61K9/0056 ,  A61K9/006 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/5015 ,  A61K31/343 ,  A61K47/26 ,  A61K47/38 ,  A61K47/40

摘要： The present invention provides a preparation with improved disintegration property, a preparation showing improved bioavailability of a medicament, production methods thereof and the like. A rapidly disintegrating preparation comprising granules comprising a medicament coated with a coating layer containing sugar or sugar alcohol; and a disintegrant. A production method of a rapidly disintegrating preparation including a step of producing granules comprising a medicament, a step of forming a coating layer containing sugar or sugar alcohol on the obtained granules and a step of mixing the coated granules with a disintegrant and molding the mixture.

摘要翻译： 本发明提供了具有改善的崩解性的制剂，显示药物的生物利用度提高的制剂，其制备方法等。 一种快速崩解制剂，其包含颗粒，其包含涂覆有含有糖或糖醇的涂层的药物; 和崩解剂。 一种快速崩解制剂的制备方法，包括生产颗粒的步骤，其包括药物，在所得颗粒上形成含有糖或糖醇的包衣层的步骤，以及将包衣颗粒与崩解剂混合并模制该混合物的步骤。

公开(公告)号：US06539642B1

公开(公告)日：2003-04-01

申请号：US09763747

申请日：2001-02-27

申请人： Sei Moriyasu ,  Yutaka Yamagata ,  Hitoshi Ohmori ,  Shinya Morita

发明人： Sei Moriyasu ,  Yutaka Yamagata ,  Hitoshi Ohmori ,  Shinya Morita

IPC分类号： G01B520

CPC分类号： G01B21/20 ,  G01B11/007 ,  G01B11/2441

摘要： A probe head 10 and a laser interferometric displacement meter 20 are provided. The probe head supports a probe 2 that is capable of contacting a workpiece 1, that is free to move in the direction of the workpiece, and drives the probe towards the workpiece. The displacement meter measures the displacement of the probe with a high accuracy without contact. The probe head 10 is also provided with a probe shaft 12 with steps 11a, 11b at intermediate portions thereof and air bearings 14a, 14b that support the probe shaft on each side of the steps. The air bearings have a high stiffness in the radial direction, and the probe shaft is made to float by using compressed air, thus the resistance of the shaft to sliding is reduced. In addition, another compressed air is supplied to the location of the step and produces a driving force in the direction of the workpiece due to the difference of cross sectional areas on each side of the step, that provides a very small load within a predetermined range. Thereby, the measuring pressure can be adjusted to a constant very small load without reducing the stiffness of the bearings of the probe, and the measuring pressures can be varied freely. Therefore, a sub-micron accuracy of about 0.1 &mgr;m can be obtained, and the equipment can be made compact and is easily applied to on-machine measurements.

摘要翻译： 提供探针头10和激光干涉位移计20。 探头支撑探头2，该探头2能够接触工件1，该工件可自由地沿工件的方向移动，并将探头驱动向工件。 位移仪可以高精度地测量探头的位移而不接触。 探针头10还设置有探针轴12，其中间部分具有台阶11a，11b，以及在台阶的每一侧支撑探针轴的空气轴承14a，14b。 空气轴承在径向上具有高刚度，并且通过使用压缩空气使探针轴浮动，从而减小了轴的滑动阻力。 此外，另一压缩空气被供给到台阶的位置，并且由于台阶两侧的横截面积的差异而在工件的方向上产生驱动力，其在预定范围内提供非常小的载荷 。 因此，可以将测量压力调整到恒定的非常小的负载，而不降低探针的轴承的刚度，并且测量压力可以自由变化。 因此，可以获得约0.1μm的亚微米精度，并且可以使设备紧凑并且容易地应用于机上测量。

公开(公告)号：US06528279B2

公开(公告)日：2003-03-04

申请号：US09852912

申请日：2001-05-11

申请人： Hideo Yokota ,  Akitake Makinouchi ,  Toshiro Higuchi ,  Yutaka Yamagata

发明人： Hideo Yokota ,  Akitake Makinouchi ,  Toshiro Higuchi ,  Yutaka Yamagata

IPC分类号： G01N130

CPC分类号： G02B21/008 ,  G02B21/0044

摘要： A sample extrusion device 12 for sequentially extruding a sample 1 in a predetermined direction, a sample cutting device 14 for sequentially cutting the extruded sample, and a con-focal image pickup device 16 for focusing an illuminating light at a section portion that was cut to pick up two-dimensional images of the cut section from a reflected light thereof are provided to reconstruct an internal structure of the sample from many two-dimensional images (continuous section images) that differ in the cutting positions. The sample can be continuously cut to continuously observe the sectional images thereof under no influence of the sample being seen transparently, the entirety of the sample can be observed in almost the same condition even though the sample is colored with a fluorescent dye, and thereby, the internal structure of the sample can be reconstructed with a high precision.

公开(公告)号：US06482864B1

公开(公告)日：2002-11-19

申请号：US09319023

申请日：1999-05-28

申请人： Yutaka Yamagata ,  Masafumi Misaki ,  Susumu Iwasa

发明人： Yutaka Yamagata ,  Masafumi Misaki ,  Susumu Iwasa

IPC分类号： A61K4732

CPC分类号： A61K9/1647 ,  A61K38/27 ,  Y10S514/964

摘要： A method for producing a sustained-release preparation, which comprises dispersing a physiologically active polypeptide into an organic solvent solution of a biodegradable polymer and removing the organic solvent, wherein the polypeptide is a powder obtained by lyophilizing an aqueous solution of the polypeptide which solution has a water-miscible organic solvent and/or a volatile salt; which improves the ease of handling of the physiologically active polypeptide powder in the process for producing the preparation; which makes it possible to industrially produce the sustained-release preparation in large scale; which provides a sustained-release preparation showing high and stable concentration of the active component in blood in long term, low initial release ratio of the physiologically active polypeptide, and high entrapment ratio of the polypeptide into the sustained-release preparation.

摘要翻译： 一种缓释制剂的制备方法，其包括将生理活性多肽分散到生物可降解聚合物的有机溶剂溶液中并除去有机溶剂，其中所述多肽是通过将多肽溶液冻干得到的粉末 水混溶性有机溶剂和/或挥发性盐; 这提高了在制备该制剂的过程中易于处理生理活性多肽粉末; 这使得可以大规模地工业生产缓释制剂; 其提供持续释放制剂，其显示出高生产活性多肽的长期，低的初始释放比例以及所述多肽进入缓释制剂的高滞留比，从而高效稳定血液中活性成分的浓度。

公开(公告)号：US5750100A

公开(公告)日：1998-05-12

申请号：US734636

申请日：1996-10-21

申请人： Yutaka Yamagata ,  Katsumi Iga ,  Hiroaki Okada

发明人： Yutaka Yamagata ,  Katsumi Iga ,  Hiroaki Okada

IPC分类号： A61K9/14 ,  A61K9/00 ,  A61K9/16 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26 ,  A61K9/70 ,  A61K38/00 ,  A61K38/20 ,  A61K38/21 ,  A61K38/28 ,  A61K47/14 ,  A61K38/02

CPC分类号： A61K9/2013 ,  A61K38/2013 ,  A61K38/212 ,  A61K38/28 ,  A61K9/1617 ,  A61K9/70 ,  A61K9/0024

摘要： A parenteral pharmaceutical preparation comprises a matrix containing a physiologically active peptide or protein and a polyglycerol diester of a saturated fatty acid, and the matrix is in a solid form at room temperature. The molecular weight of the physiologically active peptide or protein is 2,000 dalton or more. The saturated fatty acid includes fatty acids having about 16 to 30 carbon atoms such as palmitic acid, stearic acid, etc. The matrix may be in a pillar or granular form. The parenteral pharmaceutical preparation can be used as an injectable solid administered subcutaneously or intramuscularly (for example, a pellet or tablet for implantation), a suppository or the like, and can release the physiologically active peptide or protein sustainedly for a prolonged period of one week or more.

摘要翻译： 肠胃外药物制剂包含含有生理活性肽或蛋白质的基质和饱和脂肪酸的聚甘油二酯，并且所述基质在室温下为固体形式。 生理活性肽或蛋白质的分子量为2,000道尔顿或更多。 饱和脂肪酸包括具有约16至30个碳原子的脂肪酸，例如棕榈酸，硬脂酸等。基质可以是柱状或颗粒形式。 肠胃外药物制剂可以用作皮下或肌肉内给药的可注射固体（例如，用于植入的丸粒或片剂），栓剂等，并且可以持续释放生理活性肽或蛋白质一周的长时间 或者更多。