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    3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
    4.
    发明授权
    3-Amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes 有权
    3-氨基-4-苯基丁酸衍生物作为二肽基肽酶抑制剂用于治疗或预防糖尿病

    公开(公告)号：US07560455B2

    公开(公告)日：2009-07-14

    申请号：US10556805

    申请日：2004-05-10

    申请人： Tesfaye Biftu ,  Danqing Dennis Feng ,  Gui Bai Liang ,  Xiaoxia Qian

    发明人： Tesfaye Biftu ,  Danqing Dennis Feng ,  Gui Bai Liang ,  Xiaoxia Qian

    IPC分类号： A61P3/10 ,  A61K31/55 ,  C07D491/00

    CPC分类号： C07D487/04

    摘要： The pre-sent invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

    摘要翻译： 预先发明的发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂的3-氨基-4-苯基丁酸衍生物，其可用于治疗或预防其中二肽基 涉及肽酶-IV酶，如糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。