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公开(公告)号:US5442060A
公开(公告)日:1995-08-15
申请号:US128250
申请日:1993-09-29
申请人: Tetsuo Jikihara , Tadashi Shirasaka , Kazuo Suzuki , Hiroko Suzuki , Masao Taniguchi , Shinya Inoue
发明人: Tetsuo Jikihara , Tadashi Shirasaka , Kazuo Suzuki , Hiroko Suzuki , Masao Taniguchi , Shinya Inoue
IPC分类号: C07C235/34 , C07C235/38 , C07C235/78 , C07C237/20 , C07D307/60 , C07D317/58 , C07D405/12 , C07D405/14 , C07D407/12 , C07D265/30 , C07D295/30
CPC分类号: C07D405/14 , C07C235/34 , C07C235/38 , C07C235/78 , C07C237/20 , C07D307/60 , C07D317/58 , C07D405/12 , C07D407/12 , C07C2101/08 , C07C2101/14
摘要: Carboxamide derivatives of the following general formula (I): ##STR1## (wherein R.sup.1 and R.sup.2 are C.sub.1 -C.sub.3 alkyl group or both taken together C.sub.1 -C.sub.3 alkylene group,R.sup.3 is hydrogen atom, dialkylamino group, etc.,R.sup.4 is hydrogen atom, C.sub.1 -C.sub.10 alkyl group,R.sup.5 is C.sub.1 -C.sub.10 alkyl group,m, n, q are an integer from 0-3,p is 0, 1,A ring is ##STR2## B ring is 5 or 6 membered nitrogen containing aromatic ring, are provided, which are useful as medicinals for treating hyperlipemia or atherosclerosis.
摘要翻译: (I)的酰胺衍生物:其中R 1和R 2是C 1 -C 3烷基或两者一起是C 1 -C 3亚烷基,R 3是氢原子,二烷基氨基等 R4是氢原子,C1-C10烷基,R5是C1-C10烷基,m,n,q是0-3的整数,p是0,1,A环是
环是5或6元含氮芳族环,其可用作治疗高脂血症或动脉粥样硬化的药物。 -
公开(公告)号:US5063247A
公开(公告)日:1991-11-05
申请号:US537302
申请日:1990-06-13
申请人: Tetsuo Sekiya , Shinya Inoue , Masao Taniguchi , Kohei Umezu , Kazuo Suzuki
发明人: Tetsuo Sekiya , Shinya Inoue , Masao Taniguchi , Kohei Umezu , Kazuo Suzuki
IPC分类号: A61K31/17 , A61K20060101 , A61P3/06 , A61P9/10 , C07C20060101 , C07C275/28 , C07C275/30 , C07C275/34 , C07C335/16
CPC分类号: C07C335/16 , C07C275/28 , C07C275/30 , C07C275/34
摘要: Novel diphenylurea derivatives represented by the following formula (I): ##STR1## wherein R.sub.1 is an alkyl group of 5 to 18 carbon atoms, each of R.sub.2 and R.sub.3 is independently an alkyl group of 1 to 5 carbon atoms, an alkoxy group of 1 to 5 carbon atoms or a halogen atom, R.sub.4 is hydrogen atom, an alkyl group of 1 to 5 carbon atoms, an alkoxy group of 1 to 5 carbon atoms or a halogen atom, and X is oxygen atom or sulfur atom, are provided.The compounds are potent in reducing the cholesterol level in serum, and useful for treating hyperlipemia and atherosclerosis.
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公开(公告)号:US5807860A
公开(公告)日:1998-09-15
申请号:US748612
申请日:1996-11-13
申请人: Shinya Inoue , Masao Taniguchi , Yoshihiro Tarao , Kazuo Suzuki , Chizuko Takahashi , Mizue Kawai , Masayuki Mitsuka
发明人: Shinya Inoue , Masao Taniguchi , Yoshihiro Tarao , Kazuo Suzuki , Chizuko Takahashi , Mizue Kawai , Masayuki Mitsuka
IPC分类号: C07D207/32 , C07D207/325 , C07D213/30 , C07D295/092 , C07D521/00 , A61K31/495 , A61K31/53 , C07D241/02 , C07D403/02
CPC分类号: C07D207/325 , C07D213/30 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/088
摘要: A compound represented by formula (I) and a salt thereof, and a hydrate and solvate thereof: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 represent independently, for example, hydrogen atom, hydroxyl group, or C.sub.1-3 alkoxy group; R.sub.4 represents, for example, C.sub.1-7 alkyl group or C.sub.3-7 cycloalkyl group; R.sub.5 and R.sub.6 represent independently, for example, hydrogen atom or C.sub.1-3 alkyl group; Y represents C.sub.1-3 alkyl group, a heterocyclic group containing 1 to 4 nitrogen atoms and 5 or 6 ring-membered atoms, or C.sub.6-10 aryl group; k represents an integer of 1 to 3; and l represents an integer of 2 to 4. These urea compounds have excellent inhibitory activities against ACAT and are useful as active ingredients of medicines for preventive and/or therapeutic treatment of hyperlipemia and atherosclerosis.
摘要翻译: 由式(I)表示的化合物及其盐及其水合物和溶剂合物:其中R 1,R 2和R 3独立地表示例如氢原子,羟基或C 1-3烷氧基 ; R4表示例如C 1-7烷基或C 3-7环烷基; R5和R6独立地表示例如氢原子或C1-3烷基; Y表示C1-3烷基,含有1至4个氮原子和5或6个环原子的杂环基或C6-10芳基; k表示1〜3的整数, l表示2〜4的整数。这些脲化合物对ACAT具有优异的抑制活性,可用作预防和/或治疗高脂血症和动脉粥样硬化的药物的活性成分。
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公开(公告)号:US5126483A
公开(公告)日:1992-06-30
申请号:US562337
申请日:1990-08-03
申请人: Tetsuo Sekiya , Shinya Inoue , Chiaki Hyodo , Hiromi Okushima , Kohei Umezu , Kazuo Suzuki
发明人: Tetsuo Sekiya , Shinya Inoue , Chiaki Hyodo , Hiromi Okushima , Kohei Umezu , Kazuo Suzuki
IPC分类号: A61K31/17 , C07C273/18 , C07C275/28
CPC分类号: C07C275/28 , C07C273/1827
摘要: Novel 1-phenylakyl-3-phenylurea derivatives represented by the following formula (I): ##STR1## wherein R.sup.1 is an alkyl group of 1 to 8 carbon atoms, an alkoxy group of 1 to 5 carbon atoms or a halogen atom, R.sup.2 is an alkyl group of 1 to 15 carbon atoms, each of R.sup.3 and R.sup.4 is independently an alkyl group of 1 to 5 carbon atoms, m is an integer of 1 to 3, and n is 0 or 1, are provided.The compounds are potent in reducing the cholesterol level in serum, and useful for treating hyperlipemia and atherosclerosis.
摘要翻译: 由下式(I)表示的新型1-苯基烷基-3-苯基脲衍生物:其中R 1为1〜8个碳原子的烷基,1〜5个碳原子的烷氧基或卤素原子 R 2为1〜15个碳原子的烷基,R 3和R 4各自独立地为1〜5个碳原子的烷基,m为1〜3的整数,n为1〜 是0或1。 该化合物有效降低血清中的胆固醇水平,可用于治疗高脂血症和动脉粥样硬化。
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公开(公告)号:US5202351A
公开(公告)日:1993-04-13
申请号:US643983
申请日:1991-01-22
申请人: Tetsuo Sekiya , Shinya Inoue , Chiaki Hyodo , Hiromi Okushima , Kohei Umezu , Kazuo Suzuki
发明人: Tetsuo Sekiya , Shinya Inoue , Chiaki Hyodo , Hiromi Okushima , Kohei Umezu , Kazuo Suzuki
IPC分类号: A61K31/17 , A61K31/335 , A61K31/357 , A61K31/36 , A61P3/06 , A61P9/10 , A61P43/00 , C07C275/28 , C07C275/30 , C07C275/32 , C07C335/16 , C07D317/58 , C07D319/18 , C07D321/10
CPC分类号: C07C275/28 , C07D317/58 , C07D319/18 , C07D321/10 , C07C2102/08 , C07C2102/10
摘要: A novel 1-phenylalkyl-3-phenylurea derivative represented by the following formula (I): ##STR1## wherein R.sup.1 and R.sup.5 represent independently hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.5 alkoxyl or halo; R.sup.2 represents hydrogen or C.sub.1 -C.sub.15 alkyl; R.sup.3 represents C.sub.1 -C.sub.15 alkyl or R.sup.3 represents together with R.sup.2 C.sub.2 -C.sub.9 alkylene; R.sup.4 and R.sup.5 represent independently C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxyl or halo; X represents oxygen or sulfur; Y represents --O--(CH.sub.2).sub.l --O-- wherein l is an integer of 1 to 3 or --(CH.sub.2).sub.p -- wherein p is an integer of 3 to 5; m is 0 or an integer of 1 to 5; and n is 0 or an integer of 1 to 3, is provided. The 1-phenylalkyl-3-phenylurea derivative (I) have the action of reducing cholesterol in blood by ACAT inhibition, and therefore, useful for treating hyperlipemia and atherosclerosis.
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公开(公告)号:US5353818A
公开(公告)日:1994-10-11
申请号:US172729
申请日:1993-12-27
申请人: Kazuo Suzuki , Masahiro Sumise , Kazuo Suzuki
发明人: Kazuo Suzuki , Masahiro Sumise , Kazuo Suzuki
CPC分类号: A45C13/008 , A45D40/22 , A45D2200/051
摘要: A cover is pivotably attached to a case body. Male thread portions of a multiple thread and unthreaded portions are alternately formed on a peripheral wall of a cosmetic container section of the case body. A ring is rotatably attached to the cover and externally fitted to the peripheral wall. The ring has female thread portions of a multiple thread intermittently formed. The female and male thread portions are engageable and disengageable. An inner cover made of an elastic material is attached to the lower portion of the cover so that the inner cover is brought into press contact with an open edge of the peripheral wall. A space is formed between the cover and the inner cover so that the inner cover is elastically deformed and expanded. When the female and the male thread portions are engaged with each other and the ring is rotated to a closed position, the cover approaches the case body so that the inner cover is brought into press contact with the open edge of the peripheral wall. When the temperature within the cosmetic container section is increased, the inner cover is elastically expanded upwards to increase the volume within the cosmetic container section. Thus, an increase in pressure within the cosmetic container section is suppressed.
摘要翻译: 盖可枢转地附接到壳体。 多个螺纹和无螺纹部分的阳螺纹部分交替地形成在壳体的化妆品容器部分的周壁上。 环可旋转地附接到盖并且外部装配到周壁。 该环具有间断地形成的多根螺纹的阴螺纹部分。 阴螺纹和阴螺纹部分可接合和脱离。 由弹性材料制成的内盖附接到盖的下部,使得内盖与周壁的开口边缘压接。 在盖和内盖之间形成空间,使得内盖弹性变形和膨胀。 当阴和阳螺纹部分彼此接合并且环旋转到关闭位置时,盖接近壳体,使得内盖与周壁的开口边缘压接。 当化妆品容器部分内的温度升高时,内盖弹性膨胀向上,以增加化妆品容器部分内的体积。 因此,抑制了化妆品容器部内的压力的增加。
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公开(公告)号:US09296254B2
公开(公告)日:2016-03-29
申请号:US14015565
申请日:2013-08-30
CPC分类号: B32B23/02 , B32B27/00 , B32B37/02 , B32B2307/416 , B44F1/045 , C08J7/06 , Y10T428/24777 , Y10T428/24868
摘要: A molded resin product includes a substrate made of a transparent resin, opaque coating film disposed on rear surface of the substrate except for an area set aside for a patterned portion, a transparent resin material disposed in the area set aside for the patterned portion on the rear surface of the substrate, and an opaque reflection coating or a half-reflective coating laminated to the transparent resin material. Under this configuration, the patterned portion looks as if it pops up from the rear surface of the substrate. If a half-reflective coating is used, the pattern is visible through the half-reflective coating when the pattern is viewed from the rear surface of the lid of a molded resin product.
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公开(公告)号:US09266385B2
公开(公告)日:2016-02-23
申请号:US13334576
申请日:2011-12-22
CPC分类号: B32B23/02 , B32B27/00 , B32B37/02 , B32B2307/416 , B44F1/045 , C08J7/06 , Y10T428/24777 , Y10T428/24868
摘要: A molded resin product includes a substrate made of a transparent resin, opaque coating film disposed on rear surface of the substrate except for an area set aside for a patterned portion, a transparent resin material disposed in the area set aside for the patterned portion on the rear surface of the substrate, and an opaque reflection coating or a half-reflective coating laminated to the transparent resin material. Under this configuration, the patterned portion looks as if it pops up from the rear surface of the substrate. If a half-reflective coating is used, the pattern is visible through the half-reflective coating when the pattern is viewed from the rear surface of the lid of a molded resin product.
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公开(公告)号:US09238521B2
公开(公告)日:2016-01-19
申请号:US14091746
申请日:2013-11-27
CPC分类号: B65D1/40 , B05B11/0037 , B05B11/3047 , B29C49/00 , B29L2031/7158 , B65D1/0261 , B65D1/0276 , B65D1/0292 , B65D83/00 , B65D2231/008
摘要: Disclosed is a synthetic resin container provided with an inverting, foldback bottom wall that can maintain a stable, self-supporting position while being able to minimize the amount of residual contents, and that can be formed by blow-molding, etc., and maintain the favorable producibility or low cost of the past. The synthetic resin container is provided with a bottom wall that forms the bottom of the container, and a drum section that is united to the perimeter of the bottom wall and forms a filling space M for contents on the inside, and is a synthetic resin container wherein a raised bottom is formed by inverting and folding back said bottom wall toward said drum section. Said drum section has a lower peripheral wall that touches or approaches the outer wall part of said bottom wall and forms a self-supporting base by the inversion and folding back of said bottom wall.
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10.
公开(公告)号:US08746494B2
公开(公告)日:2014-06-10
申请号:US13845601
申请日:2013-03-18
CPC分类号: B65D1/40 , B05B11/0037 , B05B11/3047 , B29C49/00 , B29L2031/7158 , B65D1/0261 , B65D1/0276 , B65D1/0292 , B65D83/00 , B65D2231/008
摘要: Disclosed is a synthetic resin container provided with an inverting, foldback bottom wall that can maintain a stable, self-supporting position while being able to minimize the amount of residual contents, and that can be formed by blow-molding, etc., and maintain the favorable producibility or low cost of the past. The synthetic resin container is provided with a bottom wall that forms the bottom of the container, and a drum section that is united to the perimeter of the bottom wall and forms a filling space M for contents on the inside, and is a synthetic resin container wherein a raised bottom is formed by inverting and folding back said bottom wall toward said drum section. Said drum section has a lower peripheral wall that touches or approaches the outer wall part of said bottom wall and forms a self-supporting base by the inversion and folding back of said bottom wall.
摘要翻译: 公开了一种合成树脂容器,其具有翻转的折回底壁,其可以保持稳定的自支撑位置,同时能够最小化残留内容物的量,并且可以通过吹塑成型等形成,并且保持 过去的有利生产力或低成本。 合成树脂容器设置有形成容器底部的底壁和与底壁的周边结合并形成用于内部的内容物的填充空间M的鼓部,并且是合成树脂容器 其中通过将所述底壁朝向所述滚筒部分翻转并折回而形成凸起的底部。 所述鼓部分具有接触或接近所述底壁的外壁部分的下周边壁,并且通过所述底壁的反转和折回而形成自支撑基部。
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