公开(公告)号：US08747459B2

公开(公告)日：2014-06-10

申请号：US11952080

申请日：2007-12-06

申请人： Than Nguyen ,  Jacques Seguin ,  Stan Komatsu ,  Hung Nguyen ,  Georg Boertlein

发明人： Than Nguyen ,  Jacques Seguin ,  Stan Komatsu ,  Hung Nguyen ,  Georg Boertlein

IPC分类号： A61F2/24

CPC分类号： A61F2/2427 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2/915 ,  A61F2/93 ,  A61F2/95 ,  A61F2002/91591 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/0078 ,  A61F2250/0003 ,  A61F2250/0069

摘要： A prosthetic valve assembly for use in replacing a deficient native valve comprises a replacement valve supported on an expandable prosthesis frame. The valve may be delivered transluminally or transmyocardially using a thorascopic or other limited access approach using a delivery catheter. Preferably, the initial partial expansion of the valve is performed against the native valve annulus to provide adequate anchoring and positioning of the valve as the remaining portions of the valve expand. The valve may be delivered using a retrograde or antegrade approach. When delivered using a retrograde approach, a delivery catheter with a pull-back sheath may be used, while antegrade delivery is preferably performed with a delivery catheter with a push-forward sheath that releases the proximal end of the valve first.

摘要翻译： 一种用于替换不足的自然瓣膜的假体瓣膜组件包括支撑在可扩张假体骨架上的置换瓣膜。 可以使用输送导管使用胸腔镜或其他有限的进入方法来平滑地或经心肌递送瓣膜。 优选地，阀的初始部分膨胀针对天然阀环执行，以在阀的剩余部分膨胀时提供阀的适当锚固和定位。 可以使用逆行或顺行方法来递送瓣膜。 当使用逆行方法递送时，可以使用具有拉回护套的递送导管，而顺侧递送优选地使用具有首先释放瓣的近端的推进护套的递送导管进行。

公开(公告)号：US20080140189A1

公开(公告)日：2008-06-12

申请号：US11952080

申请日：2007-12-06

申请人： Than Nguyen ,  Jacques Seguin ,  Stan Komatsu ,  Hung Nguyen ,  Georg Boertlein

发明人： Than Nguyen ,  Jacques Seguin ,  Stan Komatsu ,  Hung Nguyen ,  Georg Boertlein

IPC分类号： A61F2/24

CPC分类号： A61F2/2427 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2/915 ,  A61F2/93 ,  A61F2/95 ,  A61F2002/91591 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/0078 ,  A61F2250/0003 ,  A61F2250/0069

摘要： A prosthetic valve assembly for use in replacing a deficient native valve comprises a replacement valve supported on an expandable prosthesis frame. The valve may be delivered transluminally or transmyocardially using a thorascopic or other limited access approach using a delivery catheter. Preferably, the initial partial expansion of the valve is performed against the native valve annulus to provide adequate anchoring and positioning of the valve as the remaining portions of the valve expand. The valve may be delivered using a retrograde or antegrade approach. When delivered using a retrograde approach, a delivery catheter with a pull-back sheath may be used, while antegrade delivery is preferably performed with a delivery catheter with a push-forward sheath that releases the proximal end of the valve first.

摘要翻译： 一种用于替换不足的自然瓣膜的假体瓣膜组件包括支撑在可扩张假体骨架上的置换瓣膜。 可以使用输送导管使用胸腔镜或其他有限的进入方法来平滑地或经心肌递送瓣膜。 优选地，阀的初始部分膨胀针对天然阀环执行，以在阀的剩余部分膨胀时提供阀的适当锚固和定位。 可以使用逆行或顺行方法来递送瓣膜。 当使用逆行方法递送时，可以使用具有拉回护套的递送导管，而顺侧递送优选地使用具有首先释放瓣的近端的推进护套的递送导管进行。

公开(公告)号：US09060857B2

公开(公告)日：2015-06-23

申请号：US13526951

申请日：2012-06-19

申请人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

发明人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

摘要翻译： 提供了一种心脏瓣膜假体，其具有支撑包括裙部和多个附着小叶的阀体的自膨胀多层框架。 框架在允许经皮腔内递送的收缩递送构型和具有不对称沙漏形状的扩张部署构型之间转变。 阀体裙部和小叶被构造成使得可以选择接合中心以减小施加到阀的连合处的水平力，并且有效地分布和传递沿着传单和框架的力。 或者，阀体可以用作可手术植入的置换瓣膜假体。

公开(公告)号：US20060265056A1

公开(公告)日：2006-11-23

申请号：US11433296

申请日：2006-05-12

申请人： Than Nguyen ,  Hung Nguyen ,  MyKim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

发明人： Than Nguyen ,  Hung Nguyen ,  MyKim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

公开(公告)号：US20060259136A1

公开(公告)日：2006-11-16

申请号：US11128826

申请日：2005-05-13

申请人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

发明人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

公开(公告)号：US20150127095A9

公开(公告)日：2015-05-07

申请号：US13526951

申请日：2012-06-19

申请人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

发明人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

摘要翻译： 提供了一种心脏瓣膜假体，其具有支撑包括裙部和多个附着小叶的阀体的自膨胀多层框架。 框架在允许经皮腔内递送的收缩递送构型和具有不对称沙漏形状的扩张部署构型之间转变。 阀体裙部和小叶被构造成使得可以选择接合中心以减小施加到阀的连合处的水平力，并且有效地分布和传递沿着传单和框架的力。 或者，阀体可以用作可手术植入的置换瓣膜假体。

公开(公告)号：US08226710B2

公开(公告)日：2012-07-24

申请号：US13072194

申请日：2011-03-25

申请人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

发明人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

摘要翻译： 提供了一种心脏瓣膜假体，其具有支撑包括裙部和多个附着小叶的阀体的自膨胀多层框架。 框架在允许经皮腔内递送的收缩递送构型和具有不对称沙漏形状的扩张部署构型之间转变。 阀体裙部和小叶被构造成使得可以选择接合中心以减小施加到阀的连合处的水平力，并且有效地分布和传递沿着传单和框架的力。 或者，阀体可以用作可手术植入的置换瓣膜假体。

公开(公告)号：US20110172765A1

公开(公告)日：2011-07-14

申请号：US13072194

申请日：2011-03-25

申请人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

发明人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

摘要翻译： 提供了一种心脏瓣膜假体，其具有支撑包括裙部和多个附着小叶的阀体的自膨胀多层框架。 框架在允许经皮腔内递送的收缩递送构型和具有不对称沙漏形状的扩张部署构型之间转变。 阀体裙部和小叶被构造成使得可以选择接合中心以减小施加到阀的连合处的水平力，并且有效地分布和传递沿着传单和框架的力。 或者，阀体可以用作可手术植入的置换瓣膜假体。

公开(公告)号：US07914569B2

公开(公告)日：2011-03-29

申请号：US11128826

申请日：2005-05-13

申请人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

发明人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

摘要翻译： 提供了一种心脏瓣膜假体，其具有支撑包括裙部和多个附着小叶的阀体的自膨胀多层框架。 框架在允许经皮腔内递送的收缩递送构型和具有不对称沙漏形状的扩张部署构型之间转变。 阀体裙部和小叶被构造成使得可以选择接合中心以减小施加到阀的连合处的水平力，并且有效地分布和传递沿着传单和框架的力。 或者，阀体可以用作可手术植入的置换瓣膜假体。

公开(公告)号：US09504564B2

公开(公告)日：2016-11-29

申请号：US11433296

申请日：2006-05-12

申请人： Than Nguyen ,  Hung Nguyen ,  MyKim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

发明人： Than Nguyen ,  Hung Nguyen ,  MyKim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.