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公开(公告)号：US20210338840A1
公开(公告)日：2021-11-04
申请号：US17231922
申请日：2021-04-15
Inventor： Jinming GAO , Gang HUANG , Tian ZHAO , Xinpeng MA , Yiguang WANG , Yang LI , Baran D. SUMER
IPC: A61K49/00 , G01N21/64 , C08F8/30 , C08F8/32 , C08F8/34 , C08F8/42 , C09B69/10 , G01N33/58 , G01N33/84
Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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公开(公告)号：US20200087451A1
公开(公告)日：2020-03-19
申请号：US16570337
申请日：2019-09-13
Inventor： Jinming GAO , Gang HUANG , Tian ZHAO , Baran D. SUMER , Xiankai SUN
Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH as well as a metal chelating group. In some aspects, the metal chelating group is chelated to a metal ion capable of positron emission. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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Patent Agency Ranking
公开(公告)号：US20180369424A1
公开(公告)日：2018-12-27
申请号：US16114187
申请日：2018-08-27
Inventor： Jinming GAO , Gang HUANG , Tian ZHAO , Xinpeng MA , Yiguang WANG , Yang LI , Baran D. SUMER
IPC: A61K49/00 , C09B69/10 , G01N33/84 , G01N33/58 , G01N21/64 , C08F8/42 , C08F8/34 , C08F8/32 , C08F8/30
Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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公开(公告)号：US20170143852A1
公开(公告)日：2017-05-25
申请号：US15369701
申请日：2016-12-05
Inventor： Jinming GAO , Gang HUANG , Tian ZHAO , Xinpeng MA , Yiguang WANG , Yang LI , Baran D. SUMER
IPC: A61K49/00 , G01N33/58 , C08F8/30 , G01N21/64 , C08F8/32 , C08F8/34 , C09B69/10 , G01N33/84 , C08F8/42
CPC classification number: A61K49/0054 , A61K49/0021 , A61K49/0032 , A61K49/0041 , C08F8/30 , C08F8/32 , C08F8/34 , C08F8/42 , C09B69/103 , C09B69/105 , C09B69/106 , C09B69/109 , G01N21/6428 , G01N21/643 , G01N21/6456 , G01N33/582 , G01N33/84 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441
Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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公开(公告)号：US20170049911A1
公开(公告)日：2017-02-23
申请号：US15297862
申请日：2016-10-19
Inventor： Jinming GAO , Kejin ZHOU , Baran D. SUMER
CPC classification number: A61K49/0054 , A61K49/0032 , A61K49/0082 , G01N21/6486 , G01N33/502
Abstract: The present invention relates to pH-tunable, highly activatable multicolored fluorescent nanoplatforms and methods of using the nanoplatforms in a variety of applications including, but not limited to, investigating fundamental cell physiological processes such as pH regulation in endocytic vesicles, endosome/lysosome maturation, and effect of pH on receptor cycling and trafficking of subcellular organelles.
Abstract translation: 本发明涉及pH可调节的，高活性的多色荧光纳米平台，以及在各种应用中使用纳米平台的方法，包括但不限于研究基本细胞生理过程，如内吞泡囊中的pH调节，内体/溶酶体成熟， 以及pH对受体循环和运输亚细胞器的影响。
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公开(公告)号：US20240115741A1
公开(公告)日：2024-04-11
申请号：US18449675
申请日：2023-08-14
Inventor： Jinming GAO , Gang HUANG , Tian ZHAO , Xinpeng MA , Yiguang WANG , Yang LI , Baran D. SUMER
IPC: A61K49/00 , C08F8/30 , C08F8/32 , C08F8/34 , C08F8/42 , C09B69/10 , G01N21/64 , G01N33/58 , G01N33/84
CPC classification number: A61K49/0054 , A61K49/0021 , A61K49/0032 , A61K49/0041 , C08F8/30 , C08F8/32 , C08F8/34 , C08F8/42 , C09B69/103 , C09B69/105 , C09B69/106 , C09B69/109 , G01N21/6428 , G01N21/643 , G01N21/6456 , G01N33/582 , G01N33/84 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441
Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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公开(公告)号：US20230416457A1
公开(公告)日：2023-12-28
申请号：US18159084
申请日：2023-01-24
Inventor： Jinming GAO , Gang HUANG , Tian ZHAO , Baran D. SUMER , Xiankai SUN
CPC classification number: C08G65/007 , A61K49/0054 , G01N33/582 , G01N21/643 , G01N21/6456 , G01N33/84 , G01N2021/6441
Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH as well as a metal chelating group. In some aspects, the metal chelating group is chelated to a metal ion capable of positron emission. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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