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公开(公告)号：US20170143852A1
公开(公告)日：2017-05-25
申请号：US15369701
申请日：2016-12-05
Inventor： Jinming GAO , Gang HUANG , Tian ZHAO , Xinpeng MA , Yiguang WANG , Yang LI , Baran D. SUMER
IPC: A61K49/00 , G01N33/58 , C08F8/30 , G01N21/64 , C08F8/32 , C08F8/34 , C09B69/10 , G01N33/84 , C08F8/42
CPC classification number: A61K49/0054 , A61K49/0021 , A61K49/0032 , A61K49/0041 , C08F8/30 , C08F8/32 , C08F8/34 , C08F8/42 , C09B69/103 , C09B69/105 , C09B69/106 , C09B69/109 , G01N21/6428 , G01N21/643 , G01N21/6456 , G01N33/582 , G01N33/84 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441
Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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公开(公告)号：US20220226511A1
公开(公告)日：2022-07-21
申请号：US17614638
申请日：2020-05-28
Inventor： Jinming GAO , Baran SUMER , Tian ZHAO , Zachary T. BENNETT
Abstract: Described herein are pH responsive compounds, micelles, and compositions useful for the detection of primary and metastatic tumor tissues. Compounds described herein are imaging agents useful for the detection of primary and metastatic tumor tissue (including lymph nodes). Real-time fluorescence imaging during surgery aids surgeon in the detection of metastatic lymph nodes or delineate tumor tissue versus normal tissue, with the goal of achieving negative margins and complete tumor resection.
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Patent Agency Ranking
公开(公告)号：US20210338840A1
公开(公告)日：2021-11-04
申请号：US17231922
申请日：2021-04-15
Inventor： Jinming GAO , Gang HUANG , Tian ZHAO , Xinpeng MA , Yiguang WANG , Yang LI , Baran D. SUMER
IPC: A61K49/00 , G01N21/64 , C08F8/30 , C08F8/32 , C08F8/34 , C08F8/42 , C09B69/10 , G01N33/58 , G01N33/84
Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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公开(公告)号：US20240115741A1
公开(公告)日：2024-04-11
申请号：US18449675
申请日：2023-08-14
Inventor： Jinming GAO , Gang HUANG , Tian ZHAO , Xinpeng MA , Yiguang WANG , Yang LI , Baran D. SUMER
IPC: A61K49/00 , C08F8/30 , C08F8/32 , C08F8/34 , C08F8/42 , C09B69/10 , G01N21/64 , G01N33/58 , G01N33/84
CPC classification number: A61K49/0054 , A61K49/0021 , A61K49/0032 , A61K49/0041 , C08F8/30 , C08F8/32 , C08F8/34 , C08F8/42 , C09B69/103 , C09B69/105 , C09B69/106 , C09B69/109 , G01N21/6428 , G01N21/643 , G01N21/6456 , G01N33/582 , G01N33/84 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441
Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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公开(公告)号：US20230416457A1
公开(公告)日：2023-12-28
申请号：US18159084
申请日：2023-01-24
Inventor： Jinming GAO , Gang HUANG , Tian ZHAO , Baran D. SUMER , Xiankai SUN
CPC classification number: C08G65/007 , A61K49/0054 , G01N33/582 , G01N21/643 , G01N21/6456 , G01N33/84 , G01N2021/6441
Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH as well as a metal chelating group. In some aspects, the metal chelating group is chelated to a metal ion capable of positron emission. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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公开(公告)号：US20200087451A1
公开(公告)日：2020-03-19
申请号：US16570337
申请日：2019-09-13
Inventor： Jinming GAO , Gang HUANG , Tian ZHAO , Baran D. SUMER , Xiankai SUN
Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH as well as a metal chelating group. In some aspects, the metal chelating group is chelated to a metal ion capable of positron emission. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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公开(公告)号：US20180369424A1
公开(公告)日：2018-12-27
申请号：US16114187
申请日：2018-08-27
Inventor： Jinming GAO , Gang HUANG , Tian ZHAO , Xinpeng MA , Yiguang WANG , Yang LI , Baran D. SUMER
IPC: A61K49/00 , C09B69/10 , G01N33/84 , G01N33/58 , G01N21/64 , C08F8/42 , C08F8/34 , C08F8/32 , C08F8/30
Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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