公开(公告)号：US20240025848A1

公开(公告)日：2024-01-25

申请号：US18335990

申请日：2023-06-15

Applicant: The Board of Regents of The University of Texas System

Inventor： Daniel J. SIEGWART ,  Kejin ZHOU

IPC: C07C321/14 ,  A61K47/59 ,  C07C323/52 ,  A61K9/51 ,  A61K47/69 ,  A61K47/60 ,  A61K31/7105 ,  A61K48/00 ,  A61K31/7125 ,  A61K47/20 ,  A61K47/22 ,  C07D295/15

CPC classification number: C07C321/14 ,  A61K47/59 ,  C07C323/52 ,  A61K9/5146 ,  A61K47/6931 ,  A61K47/60 ,  A61K9/513 ,  A61K31/7105 ,  A61K48/0041 ,  A61K31/7125 ,  A61K47/20 ,  A61K47/22 ,  C07D295/15

Abstract: Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.

公开(公告)号：US20200333350A1

公开(公告)日：2020-10-22

申请号：US16814898

申请日：2020-03-10

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  David BOOTHMAN ,  Kejin ZHOU ,  Xiaonan HUANG ,  Yiguang WANG

IPC: G01N33/58

Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

公开(公告)号：US20170320993A1

公开(公告)日：2017-11-09

申请号：US15662184

申请日：2017-07-27

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  David BOOTHMAN ,  Kejin ZHOU ,  Xiaonan HUANG ,  Yiguang WANG

IPC: C08F293/00 ,  A61K47/68 ,  C07D311/92 ,  A61K49/00 ,  A61K47/58 ,  A61K31/352 ,  A61K31/337 ,  A61K9/50 ,  A61K9/127 ,  A61K9/107 ,  A61K31/704 ,  C08F220/34

CPC classification number: C08F293/005 ,  A61K9/1075 ,  A61K9/1273 ,  A61K9/5031 ,  A61K31/337 ,  A61K31/352 ,  A61K31/704 ,  A61K47/58 ,  A61K47/62 ,  A61K47/6811 ,  A61K47/6845 ,  A61K49/0032 ,  A61K49/005 ,  A61K49/0054 ,  A61K49/0056 ,  A61K49/0082 ,  C07D311/92 ,  C08F220/34 ,  C08F2438/01

Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

公开(公告)号：US20170100482A1

公开(公告)日：2017-04-13

申请号：US15261245

申请日：2016-09-09

Applicant: The Board of Regents of the University of Texas System

Inventor： Daniel J. SIEGWART ,  Jing HAO ,  Kejin ZHOU ,  Jason MILLER ,  Petra KOS ,  Lian XUE

IPC: A61K47/34 ,  A61K9/00 ,  A61K9/51 ,  A61K47/24 ,  C08G63/688 ,  C12N15/113 ,  A61K31/713 ,  A61K47/28

CPC classification number: A61K47/34 ,  A61K9/0019 ,  A61K9/5153 ,  A61K31/713 ,  A61K47/22 ,  A61K47/24 ,  A61K47/28 ,  C08G63/688 ,  C08G63/912 ,  C08G65/48 ,  C12N15/113 ,  C12N2310/14

Abstract: Polymers produced by ring opening polymerization which comprises an amino group that can be used in compositions to deliver a nucleic acid such as a miRNA or a siRNA. In some embodiments, compositions which comprise the polymers described herein and a nucleic acid are also provided herein. In some embodiments, these compositions are used to silence one or more genes in vivo or treat a disease or disorder.

公开(公告)号：US20240116859A1

公开(公告)日：2024-04-11

申请号：US18508192

申请日：2023-11-13

Applicant: The Board of Regents of The University of Texas System

Inventor： Daniel J. SIEGWART ,  Kejin ZHOU

IPC: C07C321/14 ,  A61K9/51 ,  A61K31/7105 ,  A61K31/7125 ,  A61K47/20 ,  A61K47/22 ,  A61K47/59 ,  A61K47/60 ,  A61K47/69 ,  A61K48/00 ,  C07C323/52 ,  C07D295/15

CPC classification number: C07C321/14 ,  A61K9/513 ,  A61K9/5146 ,  A61K31/7105 ,  A61K31/7125 ,  A61K47/20 ,  A61K47/22 ,  A61K47/59 ,  A61K47/60 ,  A61K47/6931 ,  A61K48/0041 ,  C07C323/52 ,  C07D295/15

Abstract: Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.

公开(公告)号：US20180291134A1

公开(公告)日：2018-10-11

申请号：US16006885

申请日：2018-06-13

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  David BOOTHMAN ,  Kejin ZHOU ,  Xiaonan HUANG ,  Yiguang WANG

IPC: C08F293/00 ,  A61K31/704 ,  A61K47/62 ,  A61K47/68 ,  C07D311/92 ,  A61K49/00 ,  A61K47/58 ,  A61K31/352 ,  A61K31/337 ,  A61K9/50 ,  A61K9/127 ,  A61K9/107 ,  C08F220/34

Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

公开(公告)号：US20170049911A1

公开(公告)日：2017-02-23

申请号：US15297862

申请日：2016-10-19

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming GAO ,  Kejin ZHOU ,  Baran D. SUMER

IPC: A61K49/00 ,  G01N33/50

CPC classification number: A61K49/0054 ,  A61K49/0032 ,  A61K49/0082 ,  G01N21/6486 ,  G01N33/502

Abstract: The present invention relates to pH-tunable, highly activatable multicolored fluorescent nanoplatforms and methods of using the nanoplatforms in a variety of applications including, but not limited to, investigating fundamental cell physiological processes such as pH regulation in endocytic vesicles, endosome/lysosome maturation, and effect of pH on receptor cycling and trafficking of subcellular organelles.

Abstract translation: 本发明涉及pH可调节的，高活性的多色荧光纳米平台，以及在各种应用中使用纳米平台的方法，包括但不限于研究基本细胞生理过程，如内吞泡囊中的pH调节，内体/溶酶体成熟， 以及pH对受体循环和运输亚细胞器的影响。

公开(公告)号：US20240116860A1

公开(公告)日：2024-04-11

申请号：US18508202

申请日：2023-11-13

Applicant: The Board of Regents of The University of Texas System

Inventor： Daniel J. SIEGWART ,  Kejin ZHOU

IPC: C07C321/14 ,  A61K9/51 ,  A61K31/7105 ,  A61K31/7125 ,  A61K47/20 ,  A61K47/22 ,  A61K47/59 ,  A61K47/60 ,  A61K47/69 ,  A61K48/00 ,  C07C323/52 ,  C07D295/15

CPC classification number: C07C321/14 ,  A61K9/513 ,  A61K9/5146 ,  A61K31/7105 ,  A61K31/7125 ,  A61K47/20 ,  A61K47/22 ,  A61K47/59 ,  A61K47/60 ,  A61K47/6931 ,  A61K48/0041 ,  C07C323/52 ,  C07D295/15

Abstract: Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.

公开(公告)号：US20240083842A1

公开(公告)日：2024-03-14

申请号：US18508211

申请日：2023-11-13

Applicant: The Board of Regents of The University of Texas System

Inventor： Daniel J. SIEGWART ,  Kejin ZHOU

IPC: C07C321/14 ,  A61K9/51 ,  A61K31/7105 ,  A61K31/7125 ,  A61K47/20 ,  A61K47/22 ,  A61K47/59 ,  A61K47/60 ,  A61K47/69 ,  A61K48/00 ,  C07C323/52 ,  C07D295/15

CPC classification number: C07C321/14 ,  A61K9/513 ,  A61K9/5146 ,  A61K31/7105 ,  A61K31/7125 ,  A61K47/20 ,  A61K47/22 ,  A61K47/59 ,  A61K47/60 ,  A61K47/6931 ,  A61K48/0041 ,  C07C323/52 ,  C07D295/15

Abstract: Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.

公开(公告)号：US20240043378A1

公开(公告)日：2024-02-08

申请号：US18335960

申请日：2023-06-15

Applicant: The Board of Regents of The University of Texas System

Inventor： Daniel J. SIEGWART ,  Kejin ZHOU

IPC: C07C321/14 ,  A61K47/59 ,  C07C323/52 ,  A61K9/51 ,  A61K47/69 ,  A61K47/60 ,  A61K31/7105 ,  A61K48/00 ,  A61K31/7125 ,  A61K47/20 ,  A61K47/22 ,  C07D295/15

CPC classification number: C07C321/14 ,  A61K47/59 ,  C07C323/52 ,  A61K9/5146 ,  A61K47/6931 ,  A61K47/60 ,  C07D295/15 ,  A61K31/7105 ,  A61K48/0041 ,  A61K31/7125 ,  A61K47/20 ,  A61K47/22 ,  A61K9/513

Abstract: Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.