公开(公告)号：US11492368B2

公开(公告)日：2022-11-08

申请号：US16903173

申请日：2020-06-16

Applicant: The Board of Regents of the University of Texas System

Inventor： Zhijian Chen ,  Lijun Sun ,  Jiaxi Wu ,  Heping Shi ,  Chuo Chen

IPC: C07H21/02 ,  A61K39/39 ,  A61K31/7084 ,  C12Q1/6876 ,  C12Q1/25 ,  G01N33/573 ,  G01N33/564 ,  A61K39/00

Abstract: Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2′3-cGAMP, 2′2-cGAMP, 3′2′-cGAMP and 3′3′-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies, and diagnostics.